MEDE Medecision (MM)

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CUSIP No. 58406P102 13G/A Page 2 of 9 Pages
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 1. NAMES OF REPORTING PERSONS

 Great Point Partners, LLC

 I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

 37-1475292

 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 (a) [_]

 (b) [_]

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 3. SEC USE ONLY



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 4. CITIZENSHIP OR PLACE OF ORGANIZATION

 USA

 NUMBER OF SHARES 5. SOLE VOTING POWER
 BENEFICIALLY 0
 OWNED BY EACH 6. SHARED VOTING POWER
 REPORTING PERSON 1,797,297
 WITH 7. SOLE DISPOSITIVE POWER
 0

 8. SHARED DISPOSITIVE POWER
 1,797,297

 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 1,797,297

 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
 SHARES (See Instructions) [_]

 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 11.0%

 12. TYPE OF REPORTING PERSON (See Instructions)

 OO

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CUSIP No. 58406P102 13G/A Page 3 of 9 Pages
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 Dr. Jeffrey R. Jay, M.D.

 I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 (a) [_]

 (b) [_]

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 3. SEC USE ONLY



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 4. CITIZENSHIP OR PLACE OF ORGANIZATION

 USA

 NUMBER OF SHARES 5. SOLE VOTING POWER
 BENEFICIALLY 0
 OWNED BY EACH 6. SHARED VOTING POWER
 REPORTING PERSON 1,797,297
 WITH 7. SOLE DISPOSITIVE POWER
 0

 8. SHARED DISPOSITIVE POWER
 1,797,297

 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 1,797,297

 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
 SHARES (See Instructions) [_]

 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 11.0%

 12. TYPE OF REPORTING PERSON (See Instructions)

 IN

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CUSIP No. 58406P102 13G/A Page 4 of 9 Pages
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 Mr. David Kroin

 I.R.S. IDENTIFICATION NO. OF ABOVE PERSON (ENTITIES ONLY):

 2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

 (a) [_]

 (b) [_]

--------------------------------------------------------------------------------
 3. SEC USE ONLY



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 4. CITIZENSHIP OR PLACE OF ORGANIZATION

 USA

 NUMBER OF SHARES 5. SOLE VOTING POWER
 BENEFICIALLY 0
 OWNED BY EACH 6. SHARED VOTING POWER
 REPORTING PERSON 1,797,297
 WITH 7. SOLE DISPOSITIVE POWER
 0

 8. SHARED DISPOSITIVE POWER
 1,797,297

 9. AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 1,797,297

 10. CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN
 SHARES (See Instructions) [_]

 11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 11.0%

 12. TYPE OF REPORTING PERSON (See Instructions)

 IN

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CUSIP No. 58406P102 13G/A Page 5 of 9 Pages
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 ITEM 1.

 (a) Name of Issuer

 MEDecision, Inc.

 (b) Address of Issuer's Principal Executive Offices

 601 Lee Road, Chesterbrook Corporate Center, Wayne, PA 19087

 ITEM 2.

 (a) Name of Person Filing

 Great Point Partners, LLC
 Dr. Jeffrey R. Jay, M.D.
 Mr. David Kroin

 The Rerting Persons have entered into a Joint Filing Agreement,
 dated May 22, 2008, a copy of which is filed with this Schedule
 13G/A as Exhibit A, pursuant to which the Reporting Persons have
 agreed to file this statement jointly in accordance with the
 provisions of Rule 13d-1(k)(1) under the Act.

 (b) Address of Principal Business Office, or if none, Residence

 The address of the principal business office of each of the
 Reporting Persons is

 165 Mason Street, 3rd Floor
 Greenwich, CT 06830

 (c) Citizenship

 Great Point Partners, LLC is a limited liability company organized
 under the laws of the State of Delaware. Dr. Jeffrey R. Jay, M.D. is
 a citizen of the United States. Mr. David Kroin is a citizen of the
 United States.

 (d) Title of Class of Securities

 Common Stock

 (e) CUSIP Number

 58406P102

 ITEM 3. IF THIS STATEMENT IS FILED PURSUANT TO SS.240.13D-1(B) OR
 240.13D-2(B) OR (C), CHECK WHETHER THE PERSON FILING IS A:

 Not Applicable.

 (a) [_] Broker or dealer registered under Section 15 of the Act
 (15 U.S.C. 78o)

 (b) [_] Bank as defined in Section 3(a)(6) of the Act
 (15 U.S.C. 78c).

 (c) [_] Insurance company as defined in Section 3(a)(19) of the
 Act (15. U.S.C. 78c).

 (d) [_] Investment Company registered under Section 8 of the
 Investment Company Act of 1940 (15 U.S.C. 80a-8).

 (e) [_] An investment adviser in accordance with
 ss.240.13d-1(b)(1)(ii)(E).

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CUSIP No. 58406P102 13G/A Page 6 of 9 Pages
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 (f) [_] An employee benefit plan or endowment fund in
 accordance with ss.240.13d-1(b)(1)(ii)(F).

 (g) [_] A parent holding company or control person in accordance
 with ss.240.13d-1(b)(1)(ii)(G).

 (h) [_] A savings associations as defined in Section 3(b) of the
 Federal Deposit Insurance Act (12 U.S.C. 1813).

 (i) [_] A church plan that is excluded from the definition of an
 investment company under Section 3(c)(14) of the
 Investment Company Act of 1940 (15 U.S.C. 80a-3).

 (j) [_] Group, in accordance with ss.240.13d-1(b)(1)(ii)(J).

 ITEM 4. OWNERSHIP


 Great Point Partners, LLC ("Great Point") is the investment manager
 of Biomedical Value Fund, L.P. ("BVF"), and by virtue of such status
 may be deemed to be the beneficial owner of the 970,542 shares of
 Common Stock of the Issuer owned by BVF (the "BVF Shares"). Each of
 Dr. Jeffrey R. Jay, M.D. ("Dr. Jay"), as senior managing member of
 Great Point, and Mr. David Kroin ("Mr. Kroin"), as special managing
 member of Great Point, has voting and investment power with respect
 to the BVF Shares, and therefore may be deemed to be the beneficial
 owner of the BVF Shares.

 Great Point is the investment manager of Biomedical Offshore Value
 Fund, Ltd. ("BOVF"), and by virtue of such status may be deemed to
 be the beneficial owner of the 826,755 shares of Common Stock of the
 Issuer owned by BOVF (the "BOVF Shares"). Each of Dr. Jay, as senior
 managing member of Great Point, and Mr. David Kroin, as special
 managing member of Great Point, has voting and investment power with
 respect to the BOVF Shares, and therefore may be deemed to be the
 beneficial owner of the BOVF Shares.

 Great Point, Dr. Jay and Mr. Kroin disclaim beneficial ownership of
 the BVF Shares and the BOVF Shares, except to the extent of their
 respective pecuniary interest.

 Provide the following information regarding the aggregate number and
 percentage of the class of securities of the issuer identified in
 Item 1.

 1. GREAT POINT PARTNERS, LLC

 (a) Amount beneficially owned: 1,797,297

 (b) Percent of class: 11.0%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote: - 0 -

 (ii) Shared power to vote or to direct the vote:
 1,797,297

 (iii) Sole power to dispose or to direct the disposition
 of: - 0 -

 (iv) Shared power to dispose or to direct the disposition
 of: 1,797,297

 2. DR. JEFFREY R. JAY, M.D.

 (a) Amount beneficially owned: 1,797,297
 (b) Percent of class: 11.0%

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CUSIP No. 58406P102 13G/A Page 7 of 9 Pages
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 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote: - 0 -

 (ii) Shared power to vote or to direct the vote:
 1,797,297

 (iii) Sole power to dispose or to direct the disposition
 of: - 0 -

 (iv) Shared power to dispose or to direct the disposition
 of: 1,797,297

 3. MR. DAVID KROIN

 (a) Amount beneficially owned: 1,797,297

 (b) Percent of class: 11.0%

 (c) Number of shares as to which the person has:

 (i) Sole power to vote or to direct the vote: - 0 -

 (ii) Shared power to vote or to direct the vote:
 1,797,297

 (iii) Sole power to dispose or to direct the disposition
 of: - 0 -

 (iv) Shared power to dispose or to direct the disposition
 of: 1,797,297

 ITEM 5. OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS

 Not Applicable.

 ITEM 6. OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON:

 See Item 4.

 ITEM 7. IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED
 THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY

 Not Applicable.

 ITEM 8. IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP

 Not Applicable.

 ITEM 9. NOTICE OF DISSOLUTION OF GROUP

 Not Applicable.

 ITEM 10. CERTIFICATION

By signing below I certify that, to the best of my knowledge and belief, the
securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of
the securities and were not acquired and are not held in connection with or as
participant in any transaction having that purpose or effect.

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CUSIP No. 58406P102 13G/A Page 8 of 9 Pages
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 SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify
that the information set forth in this statement is true, complete and correct.

Date: May 22, 2008

 GREAT POINT PARTNERS, LLC

 By: /s/ DR. JEFFREY R. JAY, M.D.
 ---------------------------------
 Dr. JEFFREY R. JAY, M.D.,
 as senior managing member

 /s/ DR. JEFFREY R. JAY, M.D.
 --------------------------------------
 DR. JEFFREY R. JAY, M.D.

 /s/ MR. DAVID KROIN
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 MR. DAVID KROIN