Preciouslife1
2 hours ago
You may have heard about potential safety concerns with 1st generation #CAR-T therapies. While new regulatory considerations unfold, there are already exciting biotech developments underway to present alternatives. #LNP #mRNA can be used as the transformative drug substance to equip cells with new chimeric antigen receptors! The pace of novel cancer treatment is not slowing down.
Researchers from the Fraunhofer Institute for Cell Therapy and Immunology recently partnered with scientists from Precision NanoSystems Inc. to publish this fascinating paper: "Lipid Nanoparticles Outperform Electroporation in mRNA-based CAR T Cell Engineering."
In this work, they showed that:
1) LNPs outperform electroporation in delivering CAR-mRNA to T cells
2) LNPs result in less cytotoxicity and slower T cell proliferation, enhancing the safety profile of CAR T.
3) the functionality of LNP-engineered CAR T cells is comparable to those modified through viral vectors, but with reduced T cell exhaustion.
4) LNPs offer a scalable and cost-effective alternative for CAR T cell engineering, presenting a promising avenue for safer and more efficient cancer treatments.
📓 Check out the article: https://lnkd.in/eiW6pHuE
In case you missed it: a March issue of American Society of Gene & Cell Therapy's Molecular Therapy journal featured a model of an LNP in recognition of this team's recent publication and breakthrough work.
Reni Kitte, Martin Rabel, Reka Geczy, Stella Park, Stephan Fricke, Ulrike KΓΆhl, Sandy Tretbar
cowtown jay
2 days ago
There remains the indication for which lenzilumab was intended, and in which it has demonstrated tremendous promise. And I hope that lenz will be very successful in treating cancers, such as CMML.
But there remains two realities. First is, that the world has no safe and effective covid preventative. And secondly, there is no variant-agnostic therapeutic for covid, let alone one that could imbue an appropriate immune response against future infections.
The fact that excess deaths are attributed to mRNA vaccines, WHICH ARE STILL BEING ADMINISTERED AND ENCOURAGED, is another reason that the Novavax vaccine, in it's best form, has to be brought to market, with it's lenz enhancement. In less than a year, excess deaths from mRNA vaccines have cost more lives than all the soldiers lost in all the battles, combined, in the US.
And we are welcoming illegal immigrants by the tens of thousands, even though their countrymen have already been discovered operating biotechs on our soil, designed to spread covid and a variety of lethal diseases across our land.
The tracks on which the train has left don't just run one way. And at the least, we need to be prepared for when the train returns.
cowtown jay
2 days ago
I think management is working on the application of their lenz/vaccine/anti-viral patented process. Novavax is the only US-based covid vaccine manufacturer with a traditional vaccine, which I think would be compatible for use with lenz as an enhancement.
If Humanigen has about $4M worth of lenz in-process of being manufactured, that might be enough for a re-formulated version of lenz to be administered either orally or subcutaneously, along with millions, even tens of millions, of Nuvaxovid vaccines.
I can only tell you what I think management may be working on. This is it, in large part.
cowtown jay
3 days ago
Regarding "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)."
"Early reports from studies with patients with long COVID suggests a constellation of symptoms with similarities to another chronic medical illness-myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A review study comparing and contrasting ME/CFS with reported symptoms of long COVID may yield mutualistic insight into the characterization and management of both conditions."
https://pubmed.ncbi.nlm.nih.gov/33925784/
I listened to an interview of Dr. Pierre Kory, who discussed Long Covid (which he says is mainly Long Vax), and says that what we're calling Long Covid is the same, or about the same, as ME/CSF, and he mentioned that Epstein-Barr was another similar indication. And I got to thinking about lenzilumab being considered for this, at one point. But more specifically, I wondered HOW lenz may be effective in treatment of this indication. Despite the similarities of Long Covid to mono, how would lenz improve CFS in patients with HLA from mono?
But he also said something of more importance to Humanigen and the shareholders. As we noted in real time, both Lancet and Thorax took exceptionally long times to complete the publications of their peer reviews, even though the results of both were stellar. Dr. Kori also noted issues regarding the medical journals, and went so far as to state his opinion that this is now where the degradation of the medical field starts. Further, he went on to say that RFK, Jr., said that he would summon the chief editors of the medical journals into his office, if elected, and file RICO charges against them, if they didn't restore integrity to their publications.
So, I think this could be further evidence of management's conviction, and lenzilumab's safety and efficacy, if Dr. Kori is right. Management may have had to fight to get fair and honest assessments of lenzilumab's performance. Something caused the extremely lengthy review times, and lenz is a profit killer for Pfizer and Moderna.
I had earlier reported an interview of Steve Kirsch, whose study revealed that autism is totally caused by vaccines, and has been, for years.
What these doctors are saying is important.
However, Tucker conducted both interviews. I think it's irrelevant to the information being conveyed by the doctors. But in this post, I included an NIH corroborative study to help focus on the subject.
ArcherNebula411
4 days ago
The feb 29 2024 bank summary closing balance as $1,914,245 but if you deduct the $1,265,831 deposits which are the 1 million DIP loan and 265,831 unidentified deposits probably refunds. it only has $914,000 in cash as of feb 29 2024. It paid out or wired out or embezzled out over $991,504 while in chapter 11 bankruptcy. over $350,000 is to some unknown creditor in the US or fake account. which it didn't have to pay because it is in chapter 11.
cowtown jay
4 days ago
I'd like to think that macro-level medical considerations do not have a hand in what transpires here. But as I look forward to a pathway of consensus regarding mRNA vaccines, I also anticipate that a new division will develop in regards to the WHO's role in dictating how our healthcare system functions in the United States. So things may get worse before they get better, if they are able to get better. I'm not optimistic. I don't trust our own federal government to represent our interest, and I suspect a WHO-directed role in the US and world-wide will have an unfortunate amount of support from the British and American public. Objectivity could become further constrained, especially on a small biotech message board.
Let's hope for the best, Brother! For the medical community to awaken to the value of lenz as a traditional vaccine-enhancement, as well as a therapeutic, will be a good thing!
ArcherNebula411
5 days ago
Why would anyome pay you .40 cents for yoru shares when it's worth only .0001/share
all the assets are sold and only value is some cash and is less than 1 million and dwindling You assume that under chapter 11, the company can delaying making any payments. in one month the company wired out 991,000 to creditors which didn't have to. why pay the lawyer fees anything. for what. The company has less than 1.6 million left and if this continues and henry madrid keeps wiring money out there is no money in the shell company other than shell company with an empty 'promise' that taran may pay you fools any money if the ip patent is approved by FDA. that was bought for nothing. I don't understand why taran wold even loan 1 million to file for chapter. loans like that is for real business with real business operations. the company only has 4 employees and can fire everyone and not pay any creditors and walk and don't appear in court. the person who is in contempt of court is henry madrid. for wiring out money to himself to some swiss bank for $350,000 and another in $60,000 it owes to some lawyer for what.? pushing and filing some papers. As for as chapter 11, this is a disaster for hgenq as an 'entity' it's loss all its asssets which was worth over 2 billion and sold for nothing and still owes moeny. and still management embezzling corporate cash. and these guys lieke dtgoody and cowtown jay ,,they are delusional and too detached to this hgenq ticker like it's emotional attachment to something and still believes it has value. like an expired lottery ticket. your hgen lottery ticket expired worthless.face reality. you've been skewed. but they won't accept reality..
cowtown jay
5 days ago
Actually, I have begun 'ignoring' this guy (or these guys) when I see them arrive with a brand new nickname, and an agenda. I see the material on stocktwits, and I gain nothing by seeing it again here. Historically, I never had any poster on ignore, despite so many people advising me to ignore this poster, or that one, over the years. But, Ihub offers the 'ignore' function, and for these virgin antagonists, I use the option to ignore them. There are other, more important issues to focus on.
cowtown jay
5 days ago
Actually, Chaplain, I haven't deleted any of the posts, lately, many of which were mine. DTG hasn't, either.
If there is a problem, then there is also a reason for the problem.
And any such problem is beyond my authority to fix. I've tried, to the extent that I can. The present situation is unfortunate, and I hope we can return to the fairly good order we had.
Preciouslife1
5 days ago
SERIOUSLY MODERATORS, YOU HAVE ALLOWED THIS ONCE GOOD BOARD TO BECOME AN ABSOLUTE JOKE WITH THIS "AN411" CLOWN TO POST AND SPEW ENDLESSLY AND WHEN I "GET TO" SHOW THE INCREDULOUS PAID BASHER NEGATIVITY OF THE CLOWN, MY POSTS GET DELETED ... I AM A SHAREHOLDER, THIS CLOWN WANTS YOU ALL TO SUFFER, TO WALLOW IN YOUR LOSSES ON PAPER TIL NOW . . . . . NOT A GREAT JOB MODS, REALLY YOU CEDED THE BOARD TO A SWAMP DWELLING NON SHAREHOLDER NARCISSIST!!!!! _____ 42 POSTS ON A NEWLY CREATED MARCH 21st BASHER AGENDA
ArcherNebula411
5 days ago
The post-bankruptcy amount balance the company still owed is $385,051 as of feb 29 2024
The post-bankruptcy amount balance the company still owed was $229,800 as of jan 31 ,2024
how the balance still ow $155,251 more in debt after chapter 11===legal fees.
What is the point of paying all these legal fees for?
If it was person declaring bankruptcy, they just walk and tell the FAKE creditor 'claims' to get lost. The company has no revenues why even have ron barlian the board of directors and henry madrid as CFO..there is only 4 employees. left.