Revance Therapeutics Inc (RVNC) Quote

Sometimes being David is just not good enough against Goliath…..

Just picked up some more shares

It’s crazy how a failed initial launch can cost 90 percent drop of the share price

30k shares used to be 1mm plus

Now just 100k

Crazy good deal

can we close green today? :)

Ms Dtox has been kindly and at personal risk trying to convey the situation from inside the company. For that, she's been accused of being an ABBV shill and 'full of it' among others. The stock is approaching $3. How about some gratitude and self reflection for a change?

There's nobody here who doesn't know what the trials showed.

Ptosis is CD?

Did you mean Dysphagia? Even one poster commented that injection technique and injection location in the muscle have changed over the years for CD injections.

.”Like other Neurotoxins individual results vary. Improved skin texture/tone is the big differentiator for me personally.”

Wow! Individual results vary!! Such a profound comment, which by the way can be applied to any drug, investment or even diet. It sure sounds familiar. Say, did you watch a lot of TV commercials before posting? Is that where you got the idea?

Ms.Dtox, sure sounds like you are still working for Allergan. It is very telling that you are unable or unwilling to acknowledge the bigger difference between Daxxify and Botox. That clinical trial data and real world data show that Daxxify's effects last close to twice as long based on as the median duration as Botox. Real world data is also coming back and indicating that Daxxify acts quicker than Botox. Add in that Ptosis was far less frequently with Daxxify in CD than with Botox and that is another win for Daxxify.

Favor, since you work at Revance, can you please tell IT/web design to remove Jessica from IR website. I dialed the number and a payroll associate picked up…

I stand by what I said on 3/31/24 .”Like other Neurotoxins individual results vary. Improved skin texture/tone is the big differentiator for me personally.”

When I worked for Allergan we used Lippe Taylor for some but not all ads and marketing materials. We did create and produce our own marketing materials and photo shoots and social media campaigns about 30 percent of the time with success.

Consumers remember in the moment what is right in front of them and this is cringeworthy.

Consumers remember what works for them or what they hear works for their friends and associates.

Sad, but true to all :(
Wonder what Erica’s budget is for 2024?

Enhanced and streamlined organizational structure:
— With the appointment of Erica Jordan as Chief Commercial Officer in the fourth quarter of 2023, the commercial organization was restructured to integrate and “streamline marketing, sales, commercial operations, professional part-nerships, strategy, data analytics and professional engagement functions”. The new structure is designed to support the company's strategic priorities by enhancing execution and performance while improving efficiencies.

Tried to ascertain 23’ Marketing/Advertising budget
( 10k), but as you know S,G & A* doesn’t get broken out by segment( doesn’t matter anyway, different model this year) last year: $297,732
($223,934–2022)

*SG&A expenses include most expenses related to running a business outside of
COGS. This includes salaries, rent, utilities, “advertising, marketing”, technology, and supplies not used in manufacturing.

Well, only couple weeks before Q1, so strap in , LFG !!! RVNC

Allergan has a great strategy here. They’ve got deep enough pockets to hire million dollar influencers (Kris Jenner promoting Botox gift cards) and they keep it more grassroots with casting calls. Revance is using C tier influencers because of budget constraints and the scripting/performance at that level can feel contrived.

Sounds like Allergan is scared and panicking. A superior product like Daxxify doesn't need to try and sway people with big advertising spending.

Ms.Dtox, for someone whose financial well-being is so tied up in RVNC you sure love to dis RVNC every chance you get. I don't think I ever read you say anything positive about RVNC or about Daxxify. Let's put aside your continuing attacks on RVNC management for a second. Do you at least think Daxxify is superior to Botox?

Allergan has always used and uses external marketing agencies for all of their ads and marketing materials! Botox has a product manager and assistant product manager…2 people. The assistant is the fill in for the product manager when they move to another job!

Allergan is most likely seeing a slow erosion of Botox sales and they are using influencers to try and slow the erosion! Remember, it cost $5 full load cost to produce a vial of Botox and AbbVie sells it for $656 per vial. Botox is the cash cow of aesthetics so AbbVie wants that profit at ALL costs!

It’s kind of embarrassing that a year ago Daxxify was presented as an elite allocated product to create FOMO demand and now Daxxify is being pitched by a minor mom influencer, it’s like we don’t even know who or what we are. Vogue and Time Magazine and the pendulum swing to this? Consumers remember in the moment what is right in front of them and this is cringeworthy. 😕

Allergan has a great strategy here. They’ve got deep enough pockets to hire million dollar influencers (Kris Jenner promoting Botox gift cards) and they keep it more grassroots with casting calls. Revance is using C tier influencers because of budget constraints and the scripting/performance at that level can feel contrived. There is no marketing team left, so everything we see in near future will be outside agency generated with the agency fee taking the biggest bite out of marketing budget. There is no effective strategy in place at this time.

Marketing heating up in this space! Revance can’t let guard down, should be an interesting 2nd half, 2024

https://www.fiercepharma.com/marketing/abbvie-starts-open-casting-call-next-faces-botox-ads-doubling-down-pitch-everyday-users

I agree… perhaps so we remember it. 🙃

I think that ad is pretty annoying actually.

New DAXXIFY ad… ‘different’
https://www.instagram.com/reel/C6HC2SlO3xX/?igsh=c3I2YWN2dmlqeDEx

Oracle is moving its headquarters to Nashville. Hopefully, Foley will rent out the 18th floor with 2 bars and change his title to Commercial Real Estate Broker! This is a perfect time for Foley to resign as the RVNC CEO and move to a job which matches his skill set! Commercial Relator. 🥳🥳🥳

Daxxify is simply a better product in the market. Now with proper marketing strategy, sales should improve steadily.

The upside for here is just enormous even assuming very conservative market share

Don’t understand the continuous selling at all.

Daxxify dysphagia rates reported at 2.7 to 4.2%:

https://www.biospace.com/article/releases/u-s-fda-approves-first-therapeutic-indication-for-revance-s-daxxify-daxibotulinumtoxina-lanm-for-injection-for-the-treatment-of-cervical-dystonia/

Based on the ASPEN OLS study, symptoms continued to improve with successive DAXXIFY® treatments at doses up to 300U, while adverse events remained low.15-16 In particular, dysphagia rates (difficulty swallowing) remained low (2.7% for ASPEN-1 and 4.2% for ASPEN-OLS), further supporting DAXXIFY’s safety profile.15-16

Botox at 19%

https://www.botoxone.com/cervical-dystonia#:~:text=The%20most%20frequently%20reported%20adverse,%2C%20and%20headache%20(11%25).

The most frequently reported adverse reactions following injection of BOTOX for cervical dystonia include dysphagia (19%), upper respiratory infection (12%), neck pain (11%), and headache (11%).

I would expect that dysphagia rates with botox have dropped over time as technique has improved.

Revance also detailed Dysphagia rates in their presentation at the shareholder meeting last September and I believe that presentation is available on the Investor relation page of their website.

I can’t find the page where it shows a side by side comparison. That’s what you stated.

Still have not answered my question about your background.

Please review the clinical trials!

Why would Daxi have lower adverse events and Daxi injectors are being instructed to inject Daxi directly into the intended muscle! Daxi attaches very quickly to the neuron and does not spread! Versus Botox injection technique for the glabellar area which on the top side of the muscle knowing Botox will spread and cause adverse events.

Compare the 2 injection patterns published! Daxi just published their updated pattern versus the Botox pattern!

Now you know why Botox must be higher and why it takes up to 14 days to get the full effect! The Botox active ingredient floats around for several days and some finds the neurons..half of the active ingredient attaches to other tissues!

Is that your expert opinion as to why there is more adverse events or is that from clinical experience?

Yes, there is no head to head comparison published! One must compare the data from both PI’s.

Allergan will never tell patients that their active toxin floats around for up to 2 weeks in the patient’s tissues! Easy to understand why Daxi with the same active ingredient as Botox gives the patient double the duration of Botox. The Botox active ingredient attaches to many other areas and half never finds the neurons! The Botox active ingredient attached to areas not intended! That is why Botox has higher adverse events than Daxi in every clinical application!

The peptide in Daxi is the magic!

I did. I don’t see the head to head comparison. I understand the peptide portion of Daxi.

So are you just making a claim or a comparison?

It’s not as easy as you think.

Please review the PI for both Botox and Daxi for CD and compare!

There are many unhappy RVNC employees who have lost money with the SP. The SP will correct itself as RVNC sales grow and expenses are managed which will show profits! Foley is a hatchet man and reworked the RVNC business model with the new price of Daxi!

Daxi will be released early in May for CD. There are already orders for CD so shipments will happen immediately!

Cosmetic Daxi sales will continue to grow as the sales team works hard to teach accounts how to inject Daxi, make more profit and give patients an improved toxin experience.

Where does it state that in the PI?

Which section? Can you point me to that part of the clinical study?

Would love to read that. I’m kind of nerdy like that.

Please review the adverse events for Botox vs Daxi for CD! The Botox activate ingredient floates around in the tissue for up to 2 weeks and some attaches to the neuron..some goes elsewhere! The peptide in Daxi is attracted to the neuron and begins to attach immediately..nothing floating around after 5 days.

This is why injectors of Botox tell their patients to keep their head up and no exercise immediately after. They know Botox floats everywhere and that is why Botox has higher adverse events than Daxi!

That simple!

@Emannow - I find that where there is smoke there is fire on these posts....worth reading what's being said on the inside pharma co chat boards. Most people don't know this exists but it does. https://www.cafepharma.com/boards/forums/revance-biotech.1254/

You are completely making a false claim about adverse events.

Interesting… Todays extended hours volume nearly the same as the daily volume.

I thought he meant advertising events

This is why Botox has so many adverse events!… I did not know that Botox causes more adverse events per se.

Spoke to a Derm office who was a 100% Botox office for 15 yrs. They are now charging $7.75 per unit for Daxi and $14 per unit for Botox. Their patients love Daxi and are willing to pay an additional $60 per treatment ( 80 units of Daxi vs 40 units of Botox) to receive the quick onset, double the duration of Botox and improve peptide skin tone! The Daxi patient onset is 3 days versus Botox at 12 days. Do patients really want that Botox Toxin floating around in their tissue for 2 weeks? This is why Botox has so many adverse events!

The injector makes an extra $500 to $750 profit per day injecting Daxi vs Botox.

This is a win for both patients and injectors. Of course, more injectors will continue to switch to Daxi. Injectors make more profit per hour!!!

Lots of new clinics advertising…
Yes, I agree…that is my experience also.

Lots of new clinics advertising the addition of Daxxify every week. Allergan and Galderma's kickback crony CosmeticMDs can deceive their clients for only so long.

This drawdown might yet turn out to be a blessing for the believers.

Actually, I haven't drawn down my position overall. I buy back after the wash period passes. So far I have been able to buy back at lower price so have more shares each time. We will have to see whether or not that was a foolish move.

This drawdown might yet turn out to be a blessing for the believers. We will see in couple years.

either way, shorts have been right along from close to 40pps to now below 4

Can't hide from that fact. 😩

The only "positive" on my end is most of my earlier buys were in the teens and I have been able to generate some losses to offset capital gains.

One thing for sure, if the fundamental is there, this stock will bounce one day and we will go up many folds in a year

Worst case is this gets sold at basement price and Foley hands over all upside to buyers

Ian is either pretty smart if he is pretending to be dumb to tick people off or he is actually naive

Can’t tell

But either way, shorts have been right along from close to 40pps to now below 4

Does your post contain any facts?

If so, provide some links.

What?? I stated a series of facts. Do you want a link showing that there was a total eclipse of the sun over much of the US recently?

The first is that the Fed isn’t continuing to tighten. It stopped some time ago and is waiting for the right time to cut rates.

Do you actually want a link to that? It has been in all the news. Okay, here.

https://tradingeconomics.com/united-states/interest-rate

https://www.nytimes.com/2024/03/20/business/fed-meeting-interest-rates.html

Second, inflation is under control as it was reading just above the Fed’s 2% target.

Do you want a link to that? It has been in all the news.


As far as inflation, it was supply chain bottlenecks as we came out of the pandemic combined with disruptions in the energy markets and in geopolitical stability due to Russia’s war on Ukraine that drove the inflation spikes. Corporate greed now is driving a portion of inflation now.

Do you want a link showing that supply chain issues were the driver of inflation?? Oh give me a freaking break. Don't you read the news?

Do you want a link showing that Russia's invasion of Ukraine roiled the energy markets and generated geopolitical instabilities? Oh give me a freaking break. Don't you read the news?

Do you want a link showing that corporate greed is during inflation? It has been in all the news.

https://www.theguardian.com/business/2024/jan/19/us-inflation-caused-by-corporate-profits?utm_term=65aa7257ea2501ec1a892c80b1b2e848&utm_campaign=GuardianTodayUS&utm_source=esp&utm_medium=Email&CMP=GTUS_email

Does your post contain any facts?

If so, provide some links.

Interesting post but it contains key factual errors. The first is that the Fed isn’t continuing to tighten. It stopped some time ago and is waiting for the right time to cut rates. Second, inflation is under control as it was reading just above the Fed’s 2% target. As far as inflation, it was supply chain bottlenecks as we came out of the pandemic combined with disruptions in the energy markets and in geopolitical stability due to Russia’s war on Ukraine that drove the inflation spikes. Corporate greed now is driving a portion of inflation now.


As far as ENTA, you didn’t follow it but feel you need to comment on its current low state. Many people including myself profited from it’s HepC drugs and some of us invested some of that money back as ENTA price dropped, one of them is myself.

Of course Revance Therapeutics will survive. Highly respected dermatologists tout DAXXIFY as A Best in Class Product and the first true innovation in the space in 30 years. Management has adjusted its marketing strategy. Engage with customers through competitive pricing and enhanced messaging that highlights DAXXIFY’s unique peptide formulation, long duration, fast onset and improved skin quality appearance. New patients love the product. Daxi sales should exceed expectations going forward. RHA Collections sales are solid, more excellent products with high growth potential. ADD in potential partnerships and marketing opportunities outside the US.

Milton Friedman (Nobel prize winner for economics) famously said: “Inflation is always and everywhere a monetary phenomenon, in the sense that it is and can be produced only by a more rapid increase in the quantity of money than in output.”

For more than a decade, the fed gave money away for free or close to it and flooded the market with decade of quantitative easing or excess liquidity. . Those days are now over.

The fed is aggressively tightening and will continue to do so until inflation is definitely under control. This is definitely not the utopia emerging biotechs have become accustomed to.

Roy’s Blindspot appears to be managerial competence. MNTA lost its IP for two potential blockbusters in a row before investors were rescued by JNJ. I never followed.Enanta, I don’t know whether that was a managerial mistake or simply having a pipeline which became obsolete prior to enough approvals. … or something else.

The RVNC perma bulls Seem to be utterly disgusted with Foley. Not a good indicator for any company.

If the company is not profitable in a year, it may never be able to get there. …. And Roy’s track record in picking fabulous management is far from stellar.

Is it can take more than 10% of the toxin market within a year, it will probably survive.