TIDMMTFB

RNS Number : 5301X

Motif Bio PLC

01 September 2020

Motif Bio plc

("Motif Bio" or the "Company")

Final Results

Motif Bio plc (AIM: MTFB) announces its final results for the year ended 31 December 2019.

Posting of Annual Report & Notice of AGM

Motif Bio confirms that the Annual Report and Accounts, Notice of Annual General Meeting ('AGM') and Proxy Form will be posted to shareholders today, with both available for download from the Company's website at www.motifbio.com

The Company's AGM is to be held at 11am BST on 30 September 2020 at 201 Temple Chambers, 3-7 Temple Avenue, London, EC4Y 0DT, United Kingdom.

The health of our shareholders, employees and stakeholders is extremely important to us and, accordingly, in light of the Covid-19 pandemic, the Board has arranged for a quorum to be present at the Meeting and no other shareholders, advisers or other guests will be allowed to attend the Meeting in person. Anyone seeking to attend the Meeting who has not been specifically invited by the Board for the purposes of forming a quorum will be refused entry.

Shareholders are requested to therefore submit their votes, in respect of the business to be discussed, via proxy as early as possible. Shareholders should appoint the Chair of the Meeting as their proxy. If a shareholder appoints someone else as their proxy, that proxy will not be able to attend the Meeting in person or cast the shareholder's vote.

Shareholders can return their proxy vote by post, online or (for CREST members) through CREST.

Notice of Interim Results

The Company expect to release its Interim Results, for the six months ended 30 June 2020 no later than end of October 2020.

Bruce Williams, Chairman of Motif Bio, said: "On behalf of the Board I wish to express our appreciation for the valued support and patience of Motif's various stakeholders as we endeavor to execute a reverse takeover to generate long term shareholder value."

This announcement contains inside information for the purposes of Article 7 of Regulation (EU) 596/2014.

For further information please contact:

 
 
   Motif Bio plc                                   ir@motifbio.com 
 Jonathan Gold (President and Chief 
  Business Officer) 
 
 SP Angel Corporate Finance LLP (NOMAD 
  & BROKER)                                   +44 (0) 20 3470 0470 
 David Hignell/Caroline Rowe (Corporate 
  Finance) 
 Vadim Alexandre/Abigail Wayne (Sales 
  & Broking) 
 
 Walbrook PR Ltd. (UK FINANCIAL PR 
  & IR)                                       +44 (0) 20 7933 8780 
 Paul McManus/ Lianne Cawthorne            motifbio@walbrookpr.com 
 

Forward-Looking Statements

When used in this Press Release, the words or phrases "intends," "anticipates," "expected to be" or similar expressions are intended to identify "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements are subject to certain risks and uncertainties including, but not limited to, changes in economic conditions in the Company's market area, changes in policies by regulatory agencies, fluctuations in interest rates, competition that could cause actual results to differ materially from historical earnings and those presently anticipated or projected, and other risks described in the Company's filings with the Securities and Exchange Commission. The Company cautions readers not to place undue reliance on any such forward-looking statements, which speak only as of the date made. The Company advises readers that the factors listed above could affect the Company's financial performance and could cause the Company's actual results for future periods to differ materially from any opinions or statements expressed with respect to future periods in any current statements. The Company does not undertake, and specifically disclaims any obligation, to publicly release the result of any revision which may be made to any forward-looking statements to reflect events or circumstances after the date of such statements or to reflect the occurrence of anticipated or unanticipated events.

Chairman ' s Statement

2019 wa s a challenging year for Motif Bio plc and its wholly-owned operating subsidiary Motif BioSciences, Inc. (collectively, the ' Group ' ). I n the face of a challenging commercial market for approved anti biotics, t he capital markets were not willing to support the significant costs of generating additional data to advance iclaprim to approval and with the additional complication s of having senior debt that coul d not be serviced under its original terms, the Group determined that the best way to deliver value for shareholders was to undertake a restructuring.

In November 2019, shareholders approved the restructuring, which was designed to provide value to shareholders if the iclaprim asset is monetised at a value above the funds owed to the Group's senior lender. Further, the restructuring led to the discontinuance of operations of Motif BioSciences, Inc. and released the Company from obligations under the subsidiary's loan agreement. The restructuring led the Company to be classified as an AIM Rule 15 Cash Shell and to explore the potential of a Reverse Takeover ('RTO') Transaction. The Board has been actively exploring RTO transactions and engaging with potential RTO candidates. The Board is continuing to work towards completing an RTO transaction before January 2021, when the Company's shares will be de-listed absent an RTO or other qualifying transaction.

On behalf of the Board I wish to express our appreciation for the valued support and patience of Motif's various stakeholders as we endeavor to secure a suitable RTO to generate long term shareholder value. In addition, I would like to express my appreciation for the dedicated Motif team and to my fellow current and former Board members for their support.

Bruce Williams

Chairman

1 September 2020

Strategic Report

The Directors present their Strategic Report for the year ended 31 December 2019.

In 2019, the strategy for the Group changed as a result of an unfavorable regulatory outcome with the Group's antibiotic product candidate, iclaprim, along with challenging equity capital markets for companies with antibiotic products. In 2019 and early 2020, a number of the Company's larger peer companies filed for Bankruptcy including Achaogen (formerly NASDAQ: AKAO), Aradigm (formerly NASDAQ: ARDM), and Melinta (formerly NASADAQ: MLTA). On the back of iclaprim's regulatory setback in Q1 2019, and in the face of the regulatory and capital market challenges for Motif and its peers, Motif was able to execute a lender and shareholder supported restructuring.

We believe the restructuring optimized value for shareholders in what was a difficult environment. Under the restructuring, in any monetization of iclaprim, the Company's subsidiary is entitled to any proceeds above the balance owed to Hercules, the subsidiary's lender, at the time of the monetisation. Further, shareholders can benefit from the possibility that the Company, now unencumbered by its previous guarantee of the subsidiary's loan, may be able to complete an RTO and deliver additional value to shareholders. While the Board continues to advance discussions with RTO candidates, there is no assurance that the Company will be able to complete an RTO or other qualifying transaction before the end of January 2021.

AIM Rule 15 Cash Shell Status

Pursuant to the successful completion of the restructuring, as announced on 28 January 2020 and described in the financial statements in Notes 1, the Company was reclassified as an AIM Rule 15 cash shell. As such, the Company is required to make an acquisition, or acquisitions, which constitutes a reverse takeover under AIM Rule 14 to continue to be listed on the AIM Market of the London Stock Exchange. In July 2020, the London Stock Exchange suspended trading in the Company's AIM securities pursuant to AIM Rule 40.

The AIM rules provide that the Company will have an additional six months from the suspension date to complete a qualifying transaction. If the Company does not complete a qualifying transaction by 28 January 2021, the Company's shares will be delisted from the AIM market.

NASDAQ Capital Market

From November 2016 until December 2019, Motif had American Depository Shares (ADS's) and ADS warrants that were traded on the NASDAQ Capital Market. After review and careful consideration of the administrative burden and costs and benefits of being a Nasdaq-listed, reporting company, as well as the uncertainties of the Company being able to re-gain and maintain compliance with the Nasdaq requirements for continued listing, the Company made the decision to voluntarily delist, its ADS' and ADS warrants from the NASDAQ Capital Market, effective December 2019.

Financial Overview

The Company's wholly-owned subsidiary, Motif BioSciences Inc., has been reported as discontinued operations in the consolidated statements of comprehensive loss and the related assets and liabilities have been presented as held-for-sale in the consolidated balance sheet as of 31 December 2019. These changes have been made for all periods presented. In January 2020, the Company determined that it no longer has control of Motif BioSciences Inc. in accordance with IFRS 10 Consolidated Financial Statements. As a result, the Company will not consolidate Motif BioSciences Inc. in future financial periods.

Discontinued Operations

The net loss from discontinued operations for the year ended 31 December 2019 was US $10.4 million (2018: loss of US $18.8 million).

The discontinued operations had total liabilities of US $11.6 million (2018: US $21.7 million) and total assets of a nominal value (2018: US $11.8 million). The liabilities are comprised of US $7.7 million owed to Hercules, including end of term fee, and US $3.9 million of vendor and related obligations.

Continuing Operations

The net gain from continuing operations for the year ended 31 December 2019 was US $4.2 million (2018: gain of US $4.8 million).

The continuing operations had total liabilities of US $0.4 million (2018: US $6.0 million) and total assets of US $0.8 million (2018: US $0.7 million). The liabilities are comprised of US $0.2 million of vendor and related obligations and US $0.2 million in derivative warrant obligations.

Going Concern

As of 31 December 2019, the Company had US $0.7 million in cash. As of 31 July 2020, the Company had US $0.8 million of cash. The Company may require additional capital in the future. To the extent that the company raises additional funds by issuing equity securities, its existing stockholders may experience significant dilution.

The Company's wholly owned subsidiary, Motif BioSciences, Inc., is reported as discontinued operations and had US $7.3 million owed under its loan facility with Hercules as of 31 December 2019. The Company was relieved from its obligation to guarantee the loan effective January 2020 (Note 14).

As an AIM Rule 15 cash shell, the Company's ability to continue as a going concern is dependent on its ability to secure additional capital to fund it in conjunction with an RTO or other suitable transaction. The Company's shares were suspended from trading on AIM on 29 July 2020 pursuant to AIM Rule 40. If the Company is unable to identify a suitable reverse takeover transaction for re-admission of trading on AIM by January 2021, the listing of the Company's common shares would be cancelled on or about 28 January 2021.

These financial statements have been prepared under the assumption that the Group and Company will continue as a going concern. However, as of the date these financial statements were approved, the Company can provide no assurance that a RTO transaction or additional capital will be available when required and/or on acceptable terms. Due to the Group's and Company's recurring and expected continuing operating losses, the Directors have concluded there is a material uncertainty which may cast significant doubt on the Group's and Company's ability to continue as a going concern for at least one year from the date of issuance of these financial statements. The financial statements do not include any adjustments that might result from this uncertainty.

Section 172 statement

The Company's Section 172 statement is set out in the Corporate Governance Report on pages 10 to 11.

Jonathan E. Gold

Executive Director, President & Chief Business Officer

1 September 2020

Motif Bio plc

Consolidated statements of comprehensive loss

For the years ended 31 December 2019 and 2018

(in thousands, except share and per share data)

 
                                                                                  Year          Year 
                                                                                 ended         ended 
                                                                              31 December   31 December 
                                                                                  2019          2018 
                                                                        Note  US $ (000's)  US $ (000's) 
                                                                        ----  ------------  ------------ 
                                                                                              Restated 
Continuing operations 
 
General and administrative 
 expenses...............................................                 5         (1,246)       (1,747) 
 
Research and development                                                                 -             - 
expenses............................................... 
                                                                              ------------  ------------ 
 
Operating loss 
 ..................................................................... 
 ...............                                                                   (1,246)       (1,747) 
 
Interest 
 income............................................................... 
 ...................                                                     5               5             3 
 
Net foreign exchange gains 
 (losses).................................................                              49          (64) 
 
Gain (loss) from revaluation of derivative 
 liabilities........................                                     15          5,427         6,654 
                                                                              ------------  ------------ 
 
Gain (loss) before income 
 taxes.......................................................                        4,235         4,846 
 
Income tax 
 expense.............................................................. 
 .............                                                           8               -             - 
                                                                              ------------  ------------ 
 
Net gain (loss) from continuing operations 
 ......................................                                              4,235         4,846 
                                                                              ------------  ------------ 
 
Comprehensive gain (loss) from continuing operations 
 ...................                                                                 4,235         4,846 
                                                                              ============  ============ 
 
Comprehensive loss from discontinued 
 operations..........................                                    3        (10,378)      (18,831) 
                                                                              ------------  ------------ 
 
Total comprehensive loss for the year 
 .............................................                                     (6,143)      (13,985) 
                                                                              ============  ============ 
 
 
Net earnings (loss) per share - basic 
 ................................................                        9 
Continuing 
 operations........................................................... 
 .............                                                                        0.01          0.02 
Discontinued 
 operations........................................................... 
 .........                                                                          (0.03)        (0.07) 
                                                                              ============  ============ 
Net earnings (loss) per share - diluted 
 .............................................                           9 
Continuing 
 operations........................................................... 
 .............                                                                        0.01             - 
Discontinued 
 operations........................................................... 
 .........                                                                          (0.03)        (0.07) 
                                                                              ============  ============ 
Weighted average number of ordinary shares 
................................. 
Basic................................................................ 
 ...................................                                           350,993,002   284,530,534 
Diluted.............................................................. 
 ..................................                                            350,993,002   287,131,688 
                                                                              ============  ============ 
 

The notes are an integral part of the consolidated financial statements.

Motif Bio plc

Consolidated statements of financial position

As at 31 December 2019 and 2018

(in thousands)

 
                                                                            31 December 2019  31 December 2018 
                                                                      Note    US $ (000's)      US $ (000's) 
                                                                      ----  ----------------  ---------------- 
ASSETS 
Non-current assets 
Intangible 
 assets............................................................. 
 ...................                                                   10                  -             6,196 
Other 
 non-current........................................................ 
 ......................                                                                    -                18 
                                                                            ----------------  ---------------- 
Total non-current 
 assets............................................................. 
 .......                                                                                   -             6,214 
                                                                            ----------------  ---------------- 
Current assets 
Cash and cash 
 equivalents........................................................ 
 .........                                                             12                663            12,279 
Prepaid expenses and other 
 receivables...........................................                11                145               231 
                                                                            ----------------  ---------------- 
Total current 
 assets............................................................. 
 ..............                                                                          808            12,510 
                                                                            ----------------  ---------------- 
Held-for-sale 
Non-current and current assets held for 
 sale...................................                               3                  37                 - 
 
Total 
 assets............................................................. 
 ...........................                                                             845            18,724 
                                                                            ================  ================ 
 
LIABILITIES 
Non-current liabilities 
Term loan, net of current 
 portion......................................................         14                  -            10,131 
Other non-current 
 liabilities........................................................ 
 ......                                                                14                  -               196 
                                                                            ----------------  ---------------- 
Total non-current 
 liabilities........................................................ 
 .......                                                                                   -            10,327 
                                                                            ----------------  ---------------- 
Current liabilities 
Trade payables and accrued 
 liabilities..............................................             13                214             7,207 
Derivative 
 liabilities........................................................ 
 ...................                                                   15                227             5,789 
Term loan, current 
 portion............................................................ 
 ....                                                                  14                  -             4,327 
                                                                            ----------------  ---------------- 
Total current 
 liabilities........................................................ 
 ..............                                                                          441            17,323 
                                                                            ----------------  ---------------- 
Held-for-sale 
Non-current and current liabilities held for 
 sale...............................                                   3              11,605                 - 
 
  Total liabilities 
  .................................................................. 
  .................                                                                   12,046            27,650 
                                                                            ================  ================ 
 
Net asset (liabilities) 
 ................................................................... 
 ......                                                                             (11,201)           (8,926) 
                                                                            ================  ================ 
 
EQUITY 
Share 
 capital............................................................ 
 ..........................                                            17              4,777             4,032 
Share 
 premium............................................................ 
 ......................                                                               97,003            93,456 
Group reorganization 
 reserve............................................................                   9,938             9,938 
Accumulated 
 deficit............................................................ 
 ...............                                                                   (122,919)         (116,352) 
                                                                            ----------------  ---------------- 
 
Total deficit 
 ................................................................... 
 ....................                                                               (11,201)           (8,926) 
                                                                            ================  ================ 
 

The financial statements were approved by the Board of Directors and authorized for issue on

1 September 2020 . They were signed on its behalf by:

Director

Bruce Williams

Motif Bio plc

Consolidated statements of changes in equity

For the years ended 31 December 2019 and 2018

(in thousands)

 
                                                                     Group 
                                        Share         Share      reorganization  Accumulated 
                                       capital       premium        reserve        deficit        Total 
                               Note  US $ (000's)  US $ (000's)   US $ (000's)   US $ (000's)  US $ (000's) 
                               ----  ------------  ------------  --------------  ------------  ------------ 
 
Balance at 31 December 2017 
 ...........................                3,589        80,873           9,938     (103,308)       (8,908) 
                                     ============  ============  ==============  ============  ============ 
 
Loss for the 
 year........................ 
 .........................                      -             -               -      (13,985)      (13,985) 
                                     ------------  ------------  --------------  ------------  ------------ 
Total comprehensive loss for 
 the year...............                        -                             -      (13,985)      (13,985) 
Issue of share 
 capital..................... 
 .....................          17            433        12,989               -             -        13,422 
Cost of 
 issuance.................... 
 ............................ 
 ..                             17              -         (749)               -             -         (749) 
Exercise of share options and 
 warrants.............          15             10           343               -             -           353 
Share-based 
 payments.................... 
 ...................            16              -             -               -           941           941 
                                     ------------  ------------  --------------  ------------  ------------ 
 
Balance at 31 December 2018 
 ...........................                4,032        93,456           9,938     (116,352)       (8,926) 
                                     ============  ============  ==============  ============  ============ 
 
Loss for the 
 year........................ 
 .........................                      -             -               -       (6,143)       (6,143) 
                                     ------------  ------------  --------------  ------------  ------------ 
Total comprehensive loss for 
 the year...............                        -                             -       (6,143)       (6,143) 
Issue of share 
 capital..................... 
 .....................          17            738         3,569               -             -         4,307 
Cost of 
 issuance.................... 
 ............................ 
 ..                             17              -         (317)               -             -         (317) 
Exercise of share options and 
 warrants.............          15              7           295               -             -           302 
Share-based 
 payments.................... 
 ...................            16              -             -               -         (424)         (424) 
                                     ------------  ------------  --------------  ------------  ------------ 
 
Balance at 31 December 2019 
 ...........................                4,777        97,003           9,938     (122,919)      (11,201) 
                                     ============  ============  ==============  ============  ============ 
 

(A) The amounts related to discontinued operations have not been segregated and remain included in the major equity. Accordingly, the Consolidated Statements of Changes in Equity include the results of continuing and discontinued operations.

Motif Bio plc

Consolidated statements of cash flows

For the years ended 31 December 2019 and 2018

(in thousands)

 
                                                                                   Year ended    Year ended 
                                                                                  31 December   31 December 
                                                                                    2019 (A)      2018 (A) 
                                                                            Note  US $ (000's)  US $ (000's) 
                                                                            ----  ------------  ------------ 
 
Operating activities 
 
Operating loss for the 
 year...................................................................               (9,778)      (18,623) 
Adjustments to reconcile net loss to net cash used in activities: 
 
Share-based 
 payments................................................................. 
 ........                                                                    16          (424)           941 
Warrant issued for services 
 performed...............................................                    15              -             - 
Loss on 
 impairment............................................................... 
 ...............                                                             10          6,196             - 
Interest 
 received................................................................. 
 ..................                                                                         45            97 
Changes in operating assets and liabilities: 
   Prepaid expenses and other 
    receivables..........................................                                   97            91 
   Trade payables and accrued 
    liabilities.............................................                           (3,119)       (3,952) 
                                                                                  ------------  ------------ 
 
Net cash used in operating 
 activities...................................................                         (6,983)      (21,446) 
 
Financing activities 
......................................................................... 
...... 
 
Proceeds from issue of share 
 capital...................................................                  17          4,307        13,422 
Costs of issuance of share 
 capital........................................................             17          (317)         (749) 
Proceeds from exercise of warrants and 
 options................................                                     15            244           145 
Proceeds from issuance of term 
 loan..................................................                      14              -             - 
Costs of issuance of term 
 loan.............................................................           14              -             - 
Principal payments under term 
 loan....................................................                    14        (8,134)             - 
Interest 
 paid..................................................................... 
 .....................                                                       14          (785)       (1,585) 
                                                                                  ------------  ------------ 
 
Net cash provided by financing 
 activities.............................................                               (4,685)        11,233 
                                                                                  ------------  ------------ 
 
Net change in 
 cash..................................................................... 
 ..........                                                                           (11,668)      (10,213) 
Cash, beginning of the 
 year..................................................................                 12,279        22,651 
Effect of foreign exchange rate 
 changes.............................................                                       84         (159) 
                                                                                  ------------  ------------ 
 
Cash, end of the year 
 ......................................................................... 
 ...                                                                                       695        12,279 
                                                                                  ============  ============ 
 

(A) The cash flows related to discontinued operations have not been segregated and remain included in the major classes of assets and liabilities. Accordingly, the Consolidated Statements of Cash Flows include the results of continuing and discontinued operations.

1. General information

Motif Bio plc is domiciled in England and Wales having originally been incorporated on November 20, 2014 as Motif Bio Limited, a private company, with company registration number 09320890. On 1 April 2015, the Company was re-registered as a public company limited by shares and changed its name to Motif Bio plc. The Company's registered office is at: 201 Temple Chambers, 3-7 Temple Avenue, London EC4Y 0DT, U.K.

The Company's ordinary shares are listed on the AIM Market ("AIM") of the London Stock Exchange plc. On 28 January 2020, the Company announced that it was reclassified as an AIM Rule 15 Cash Shell and, as such, was required to make an acquisition or acquisitions which constitute(s) a reverse takeover under AIM Rule 14 within six months to continue to have its shares traded on the AIM market. On 29 July 29 2020, the London Stock Exchange suspended the trading in the Company's AIM listed ordinary shares pursuant to AIM Rule 40. The AIM rules provide that the Company has an additional six months from the suspension date to complete a qualifying transaction. If the Company does not complete a qualifying transaction by 28 January 2021, the Company's shares will be delisted from the AIM market.

From November 2016 until December 2019, the Company had American Depository Shares ("ADS's") and ADS warrants that were traded on the NASDAQ Capital Market. Effective December 2019 following a voluntary delisting, the Company's ADS's and ADS warrants are no longer traded on the NASDAQ Capital Market.

Motif BioSciences Inc. was incorporated in the US State of Delaware on 2 December 2003 and has its registered office at 251 Little Falls Drive, Wilmington, Delaware, 19808. On 1 April 2015, Motif BioSciences Inc. became a wholly owned subsidiary of the Company by way of a group reorganization by plan of merger. Motif BioSciences Inc. was the operating subsidiary of the Group and was shut down as part of the corporate restructuring approved by the Company's Shareholders in November 2019. As a result, Motif BioSciences Inc. has been reported as discontinued operations in the consolidated statements of comprehensive loss and the related assets and liabilities have been presented as held-for-sale in the consolidated balance sheet as of 31 December 2019. These changes have been applied for all periods presented.

The consolidated financial statements include the accounts of Motif Bio plc and its wholly owned subsidiary, Motif BioSciences Inc. (together, the "Group"). Motif BioSciences Inc. is reported as discontinued operations as at 31 December 2019. Unless otherwise noted, information contained within these notes to the consolidated financial statements relates to continuing operations. As of the date these financial statements are issued, the Company is not certain as to the manner and timing of disposal. Refer to Note 3 for additional information on discontinued operations.

The financial statements were approved by the Board of Directors on 1 September 2020.

Going concern

The Company had US $0.7 million and US $0.6 million in cash as of 31 December 2019 and 2018, respectively. The Company may require additional capital in the future. To the extent that the company raises additional funds by issuing equity securities, its existing stockholders may experience significant dilution.

The Company's wholly owned subsidiary, Motif BioSciences, Inc., is reported as discontinued operations and had US $7.3 million owed under its loan facility with Hercules Capital Inc. (Hercules) as of 31 December 2019. Effective 27 January 2020, the Company was relieved from a loan guarantee that it had originally provided at the origination of the Hercules the loan (Note 14).

The Company's Directors are focused on sourcing an appropriate reverse takeover candidate for the Company. There is no assurance that the effort will be successful to source and/or complete a reverse takeover transaction. In addition, as of the date these financial statements were approved, the Company can provide no assurance that additional capital will be available if/when required and/or on acceptable terms.

The Directors have concluded that these conditions, including recurring and expected continuing operating losses, indicate a material uncertainty that may cast a significant doubt about the Company's ability to continue as a going concern and, therefore, that it may be unable to realize its assets and discharge its liabilities in the normal course of business.

The financial statements have been prepared on the basis that the Company is a going concern, which contemplates the continuity of normal business activity, realization of assets and settlement of liabilities in the normal course of business. Should the entity not be able to continue as a going concern, it may be required to realize its assets and discharge its liabilities other than in the ordinary course of business, and at amounts that differ from those stated in the financial statements. The financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or liabilities that might be necessary should the Company not continue as a going concern.

Significant and recent events

On 27 January 2020, the Company and its wholly owned subsidiary, Motif BioSciences Inc. completed the conditions and actions described below. The actions were detailed in a circular dated 25 October 2019 and approved by the Company's Shareholders at a general meeting held on 14 November 2019.

The Company and its wholly owned subsidiary, Motif BioSciences Inc. amended the existing credit agreement with the subsidiary's lender Hercules Capital, Inc. (or Hercules) by entering into an Amendment and Release agreement.

Pursuant to the terms of the Amendment and Release agreement:

-- Hercules relinquished the loan guarantee provided by the Company and relieved Motif Bio plc of obligations to Hercules related to the November 2017 Hercules Loan to Motif BioSciences Inc.;

-- Motif BioSciences Inc. granted Hercules a perfected security interest in all its intellectual property related to the iclaprim asset; and

-- Hercules agreed with Motif BioSciences Inc. to certain forbearance provisions under the Loan Agreement through to June 2020.

The agreement specified that Hercules claim is only for the amount due to them including accrued interest and fees, and that this applies in all circumstances including if Hercules forecloses on the iclaprim asset.

The Company also granted to Hercules warrants over an aggregate of 121,337,041 ordinary shares of 0.01 pence ("Ordinary Shares"), representing a total of 25 per cent of the Company's then outstanding share capital. These warrants will expire on 27 January 2025 and have an exercise price of 0.42 pence per share.

The Company separately granted SP Angel Corporate Finance LLP warrants over 7,142,857 Ordinary Shares in connection with its service as placing agent on a conditional placing initially announced on 2 October 2019. The conditional placing and the issuance of these warrants was subject to shareholder approval and was approved on 14 November 2019. These warrants will expire on 27 January 2025 and have an exercise price of 0.68 pence per share.

Motif BioSciences, Inc. ceased all operations in 2019 and had engaged Tamarack Associates in 2019 to facilitate the sale of iclaprim and other assets of Motif BioSciences Inc.

In January 2020, John Palmer of Tamarack Associates was appointed as the sole Executive Officer of Motif BioSciences Inc. and Bernadette Barron of Barron Business Consultants was appointed as the sole, independent non-executive officer of Motif BioSciences Inc. Concurrent with these appointments, Graham Lumsden, Jonathan Gold, and David Huang resigned as officers of Motif BioSciences Inc. and Graham Lumsden resigned as director of the Company.

Former directors of Motif Bio plc, Dr. Craig Albanese, Charlotta Ginman, Zaki Hosny, Dr. Mary Lake Polan, and Andrew Powell forfeited all previously outstanding vested and non-vested options and outstanding Board fees in 2019 when they stood down from the Board of Directors. In exchange for their forfeiture, the Company issued to each of the above named former directors a warrant option to purchase up to 1,200,000 ordinary shares at an exercise price of 0.24 pence per share that will expire on 27 January 2025. The remaining continuing directors also forfeited all outstanding vested and non-vested options in 2019.

On 4 May 2020, the Company made the following directorate changes:

   --      Chris Wardhaugh was appointed as a Non-Executive Director; 

-- Jonathan Gold, the Company's then Chief Financial Officer, was appointed as President and Chief Business Officer; and

-- Graham Lumsden, the Company's then Chief Executive Officer, stepped down from his role as CEO and become a Non-Executive Director.

On 5 May 2020, the Company announced the placement of 162,500,000 new ordinary shares at 0.4 pence per share for net proceeds of $0.76 million.

On 29 July 2020, the London Stock Exchange suspended trading in the Company's AIM listed ordinary shares pursuant to AIM Rule 40. The AIM rules provide that the Company has an additional six months from the suspension date to complete a qualifying transaction. If the Company does not complete a qualifying transaction by 28 January 2021, the Company's shares will be delisted from the AIM market.

Significant events during and prior to 2019

On 14 November 2019, the Company's shareholders approved a corporate restructuring, including the underlying tenets of the amendment to the loan agreement with Hercules Capital Inc. (or Hercules) described above. Additional details of the corporate restructure are listed below.

-- Each of the Company's Ordinary Shares of 1 penny par value were divided into one New Ordinary Share of 0.01 pence par value and one deferred share of 0.99 pence. The deferred shares have no rights and the Company did not issue any share certificates or credit CREST accounts in respect of them. The deferred shares are not admitted to trading on AIM and have no rights to participate in the profits of the Company. In the event of a wind-down or dissolution of the Company, the deferred shares shall be entitled to participate in the dissolution of the Company's assets that are in excess of GBP GBP 1 trillion.

-- The number of New Ordinary Shares in issue and held by each Shareholder, was equal to the number of existing Ordinary Shares in issue immediately prior to the Share Capital Reorganisation. Only the nominal value changed with respect to the New Ordinary Share. The New Ordinary Shares will continue to carry the same rights as those attached in the previously existing Ordinary Shares, save for the reduction in nominal value.

-- The outstanding conditions relating to the conditional Placing to raise GBP600,000 (US $0.73 million), before expenses by way of the issue of 142,857,143 Placing Shares (as first announced by the Company on 2 October 2019) were satisfied. As previously described, the Company also agreed to grant SP Angel Corporate Finance LLP warrants over 7,142,857 Ordinary Shares in connection with its service as placing agent for this raise.

On 14 February 2019, the Group receive a Complete Response Letter (CRL) from the U.S. Food & Drug Administration (FDA) regarding the New Drug Application (NDA) for iclaprim for the treatment of Acute Bacterial Skin and Skin Structure Infections. Following the receipt of the CRL, the Group evaluated potential options to address the deficiencies and met with the FDA on 3 May 2019 and 19 September 2019. The Group continues to believe that a regulatory pathway may be available for the iclaprim asset. However, a path forward will likely require a partner with a lower cost of capital and/or other strategic synergies to be viable.

On 25 March 2019, the Group placed 45,000,000 new ordinary shares at 0.06 pence per share and received US $3.3 million of net proceeds.

On 17 May 2018, the Group placed 32,258,064 new ordinary shares at 0.31 pence per share and received US $12.7 million of net proceeds.

On 19 January 2018, the Group filed a "universal" shelf registration statement on Form F-3 with the SEC, which was declared effective by the SEC on 31 January 2018. The Company filed to withdraw the shelf registration on 23 December 2019.

   2.    Significant accounting policies 
   a.     Basis of preparation 

The accounting policies set out below have been applied consistently to all periods presented in this financial information. The accounting policies have been applied consistently across the Group.

The financial statements have been prepared in accordance with International Financial Reporting Standards ("IFRS") as adopted by the European Union and with the Companies Act 2006 applicable to companies reporting under IFRS. This basis of preparation describes how the financial statements have been prepared in accordance with IFRS. The financial statements have been prepared under the historical cost convention as modified for financial instruments (including derivative instruments) at fair value through the statement of comprehensive loss. A summary of the significant Group accounting policies is set out below.

The preparation of financial statements in conformity with IFRS requires the use of estimates and assumptions that affect the reported amounts of assets and liabilities at the date of the financial information and the reported amounts of revenue and expenses during the period. Although these estimates are based on management's best knowledge of the amount, event or actions, actual results ultimately may differ from those estimates.

The Company has taken advantage of the exemption in Section 408 of the Companies Act 2006 to not present its own Statement of Comprehensive Loss.

a. New and amended standards effective from 1 January 2019

IFRS 16, Leases - Effective date - 1 1 January 2019 - IFRS 16 replaces IAS 17. It eliminates the distinction between classification of leases as finance or operating leases for lessees. The adoption of IFRS 16 did not have a significant impact on the Group's net results or net assets and any future impact would be primarily dependent on future leasing transactions, if any.

b. New and amended standards effective from 1 January 2018

IFRS 2, Share-based Payments (as amended) was adopted with an effective date of 1 January 2018. IFRS 2 related to the classification and measurement of share-based payment transactions. The amendments were intended to eliminate diversity in practice regarding (i) accounting for cash-settled share-based payment transactions that include a performance condition, (ii) share-based payments in which the manner of settlement is contingent on future events, (iii) share-based payments settled net of tax withholdings, and (iv) modification of share-based payment transactions from cash-settled to equity-settled. The impact of the adoption of this guidance did not have a material impact on the Group's 2018 and 2019 consolidated financial statements and any future impact would be primarily dependent on future modifications to share-base payment awards, if any.

IFRS 9, Financial Instruments (as revised in 2014) was adopted with an effective date of 1 January 2018. IFRS 9 includes revised guidance on the classification and measurement of financial instruments, a new expected credit loss model for calculating impairment on financial assets, and new general hedge accounting requirements. The adoption of this guidance did not have an impact on the Group's 2018 and 2019 consolidated financial statements and any future impact would be primarily dependent on future financial instrument transactions, if any. In particular, the Group has evaluated the impact of the new accounting standard on the intercompany receivable position within the Company's statement of financial position and determined that there is no expected credit loss to be recorded.

IFRS 15, Revenue from Contracts with Customers was adopted with an effective date of 1 January 2018. IFRS 15 establishes a comprehensive guideline for determining when to recognize revenue and how much revenue to recognize. The Group currently has no revenues. However, all applicable revenues generated by the Group prospectively will be accounted for in accordance with IFRS 15, or, where applicable, other relevant guidance.

On 1 January 2017, the Group adopted amendments to IAS 7, Disclosure Initiative. The amendments require disclosures that enable users of financial statements to evaluate changes in liabilities arising from financing activities, including both changes arising from cash flow and non-cash changes. The only balance sheet liability for which cash flows are classified as financing activities is the term loan, as amended, with Hercules Capital Inc. The net movement in period end balances are further detailed in Note 14.

c. New standard and interpretation not yet effective.

The new standards that are potentially relevant to the group are discussed below.

IFRS 3- Business Combination. The amendments confirm that a business must include inputs and a process, and clarified that the process must be substantive and the inputs and process must together significantly contribute to creating outputs. The amendment also narrowed the definition of a business and included tests that make it easier to conclude whether a business or group of assets was acquired. Any future impact of adopting the amendment would be primarily dependent on future acquisition transactions, if any.

Principles of consolidation

Subsidiaries are all entities (including structured entities) over which the Group has control. The Group controls an entity when the Group is exposed to, or has rights to, variable returns from its involvement with the entity and has the ability to affect those returns through its power to direct the activities of the entity. Subsidiaries are fully consolidated from the date on which control is transferred to the Group. They are deconsolidated from the date that control ceases. All intercompany transactions, balances, and unrealized gains on transactions between Group companies are eliminated.

The Company's wholly-owned subsidiary, Motif BioSciences Inc., has been reported as discontinued operations in the consolidated statements of comprehensive loss and the related assets and liabilities have been presented as held-for-sale in the consolidated balance sheet as of 31 December 2019. These changes have been made for all periods presented. Based on the subsequent event on 27 January 2017, and other operational changes that occurred in 2019 and early 2020, the Company determined that as at 27 January 2017 it no longer had an ability to direct the activities of Motif BioSciences Inc. Based on its assessment the Company determined that it no longer has control of Motif BioSciences Inc. in accordance with IFRS 10 Consolidated Financial Statements in May 2020. As a result, the Company will not consolidate Motif BioSciences Inc. in reportable financial periods commencing in 2020.

When the Group ceases to consolidate because of a loss of control, any retained interest in the entity is remeasured to its fair value with the change in carrying value recognized in profit or loss. The fair value becomes the initially carrying amount for the purposes of subsequently accounting for the retained interest as an associate, joint venture, or financial asset.

The consolidated financial statements as of and for the periods presented include the accounts of Motif Bio plc and its wholly owned subsidiary, Motif BioSciences Inc. (the Group). Unless otherwise noted, information contained within these notes to the consolidated financial statements relates to continuing operations. Refer to Note 2 and Note 3 for additional information on discontinued operations.

   b.   Segment reporting 

The chief operating decision-maker is considered to be the Board of Directors of Motif Bio plc. The chief operating decision-maker allocates resources and assesses performance of the business and other activities at the operating segment level. In addition, they review the IFRS consolidated financial statements.

The chief operating decision-maker had determined that the Company currently has one segment-to support its strategy as an AIM 15 cash shell entity focused on sourcing a reverse-take-over candidate. In 2019 prior to the wind-down of Motif BioSciences Inc., the Company had one segment to support the development and commercialization of pharmaceutical formulations.

   c.   Foreign currency translation 

(a) Functional and Presentation Currency

Items included in the financial statements of each of the Group's entities are measured using the currency of the primary economic environment in which the entity operates ("the functional currency"). The consolidated financial statements are presented in United States Dollars (US $), which is Motif Bio plc's functional and presentation currency.

(b) Transactions and balances

Foreign currency transactions are translated into the functional currency using the exchange rates at the dates of the transactions. Foreign exchange gains and losses resulting from the settlement of such transactions and from the translation of monetary assets and liabilities denominated in foreign currencies at year-end exchange rates are generally recognized in the statement of comprehensive loss. They are deferred in equity if they relate to qualifying cash flow hedges and qualifying net investment hedges or are attributable to part of the net investment in a foreign operation.

Foreign exchange gains and losses that relate to borrowings are presented in the statement of profit or loss, within finance costs. All other foreign exchange gains and losses are presented in the statement of comprehensive loss on a net basis within other income or other expenses.

Non-monetary items that are measured at fair value in a foreign currency are translated using the exchange rates at the date when the fair value was determined. Translation differences on assets and liabilities carried at fair value are reported as part of the fair value gain or loss. For example, translation differences on non-monetary assets and liabilities such as equities held at fair value are recognized in profit or loss as part of the fair value gain or loss and translation differences on non-monetary assets such as equities classified as available-for-sale financial assets are recognized in other comprehensive income.

d. Research and development costs

Expenditure on drug development activities are expensed. No activities met the requirements for capitalization. The Group and Company do not expect to incur any research and development costs in the foreseeable future.

The Group's past preclinical studies and clinical trials have been performed utilizing third-party contract research organizations ("CROs") and other vendors. For preclinical studies, the significant factors used in estimating accruals include the percentage of work completed to date and contract milestones achieved. For clinical trial expenses, the significant factors used in estimating accruals include the number of patients enrolled, duration of enrollment, percentage of work completed to date and contract milestones achieved.

   e.   Intangible assets 

Intangible assets acquired separately from a business are initially stated at cost, net of any amortization and any provision for impairment. Where a finite useful life of the acquired intangible asset cannot be determined, the asset is not subject to amortization but is tested for impairment annually or more frequently whenever events or changes in circumstances indicate that the carrying amount may not be recoverable.

   f.   Impairment of non-financial assets 

Assets that have an indefinite useful life are not subject to amortization and are tested annually in the second half of each fiscal year for impairment, or more frequently if events or changes in circumstances indicate that they might be impaired. Other assets are tested for impairment whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. An impairment loss is recognized for the amount by which the asset's carrying amount exceeds its recoverable amount. The recoverable amount is the higher of an asset's fair value less costs of disposal and value in use. For the purposes of assessing

impairment, assets are grouped at the lowest levels for which there are separately identifiable cash inflows which are largely independent of the cash inflows from other assets or groups of assets (cash-generating units). Non-financial assets other than goodwill that suffered an impairment are reviewed for possible reversal of the impairment at the end of each reporting period.

   g.   Financial instruments-initial recognition and subsequent measurement 

A financial instrument is any contract that gives rise to a financial asset of one entity and a financial liability or equity instrument of another entity.

a) Financial assets, initial recognition and measurement

All financial assets are recognized initially at fair value plus, in the case of financial assets not recorded at fair value through profit or loss, transaction costs that are attributable to the acquisition of the financial asset. The Group includes intercompany asset and investment accounts as financial assets. Transaction costs of financial assets carried at fair value reported in profits and loss (FVPL) are expensed in profit or loss.

The group's financial assets include the intercompany receivable balance in the Company balance sheet.

b) Financial liabilities, initial recognition and measurement

Financial liabilities are classified, at initial recognition, as financial liabilities at fair value through profit or loss. All financial liabilities are recognized initially at fair value and, in the case of loans and borrowings and payables, net of directly attributable transaction costs.

The Group's financial liabilities include trade and other payables, loans and borrowings and warrants classified as liabilities. The Group includes intercompany liability accounts as financial liabilities.

c) Subsequent measurement

The measurement of financial liabilities depends on their classification. Financial liabilities at fair value through profit or loss include financial liabilities held for trading and financial liabilities designated upon initial recognition as at fair value through profit or loss.

Financial assets at fair value through profit or loss are subsequently carried at amortized cost as the Group's and Company's assets are held within a business model whose objective is to collect the contractual cash flows and the contractual terms give rise to cash flows that are solely payments of principal and interest.

   h.   Financial assets and liabilities 

Financial assets and financial liabilities are included in the Group's and Company's balance sheet when the Group becomes a party to the contractual provisions of the instrument. Financial assets are derecognized when the rights to receive cash flows from the investments have expired or have been transferred and the Group has transferred substantially all risks and rewards of ownership.

Fair value disclosures

The Group's cash, prepaid expenses and other current assets and trade and other payables are stated at their respective historical carrying amounts, which approximates fair value due to their short-term nature. These are measured at fair value using Level 1 inputs. The Group's derivative liabilities are measured at fair value using Level 1 or 2 inputs. See discussion in Note 15 on the inputs utilized in the Black-Scholes option pricing model and for a roll-forward of the derivative liability from 31 December 2018 to 31 December 2019. The Group determined that the book value of the Hercules Loan Agreement (Note 14) approximates its fair value as of 31 December 2019 due the proximity of the transaction date and the interest being tied to the U.S. Prime Rate. There were no transfers between fair value levels during the years ended 31 December 2019 or 2018.

There were no non-recurring fair value measurements for the years ended 31 December 2019 or 2018.

When measuring the fair value of an asset or a liability, the Group uses observable market data as far as possible. Fair values are categorized into different levels in a fair value hierarchy based on the inputs used in the valuation techniques as follows:

   --      Level 1:  quoted prices (unadjusted) in active markets for identical assets or liabilities. 

-- Level 2: inputs other than quoted prices included in Level 1 that are observable for the asset or liability, either directly (i.e. as prices) or indirectly (i.e. derived from prices).

-- Level 3: inputs for the asset or liability that are not based on observable market data (unobservable inputs).

Non-derivative financial instruments

Cash and cash equivalents

Cash and cash equivalents include bank balances, demand deposits, and other short-term, highly liquid investments (with less than three months to maturity) that are readily convertible into a known amount of cash and are subject to an insignificant risk of fluctuations in value.

Financial liabilities and equity

The Group classifies an instrument, or its component parts, on initial recognition as a financial liability or an equity instrument in accordance with the substance of the contractual arrangement and the definitions of a financial liability and an equity instrument.

An instrument is classified as a financial liability when it is either (i) a contractual obligation to deliver cash or another financial asset to another entity; or (ii) a contract that will or may be settled in the Group's own equity instruments and is a non-derivative for which the Group is, or may be, obliged to deliver a variable number of the Group's own equity instruments or a derivative that will, or may be, settled other than by the exchange of a fixed amount of cash or another financial asset for a fixed number of the Group's own equity instruments. Incremental costs directly attributable to the issue of new ordinary shares or options are shown in equity as a deduction, net of tax, from the proceeds.

An equity instrument is defined as any contract that evidences a residual interest in the assets of an entity after deducting all its liabilities. An instrument is an equity instrument only if the issuer has an unconditional right to avoid settlement in cash or another financial asset.

Trade payables and accrued liabilities

Trade payables and accrued liabilities are obligations to pay for goods or services that have been acquired in the ordinary course of business from or rendered by suppliers. All are classified as current liabilities if payment is due within one year or less (or in the normal operating cycle of the business if longer). If not, they are presented as non-current liabilities.

Trade payables and accrued liabilities are initially measured at fair value, and, where applicable, are subsequently measured at amortized cost, using the effective interest rate method.

Equity instruments

Equity instruments issued by the Company are recorded at the proceeds received. Direct issuance costs are processed as a deduction on equity.

Derivative financial instruments

The Group does not have a policy of engaging in speculative transactions, nor does it issue or hold financial instruments for trading purposes.

The Group has entered into financing arrangements that include the issuance of warrants. These warrants may be considered derivative financial instruments based on the terms of the agreements.

Derivatives are initially recognized at fair value on the date a derivative contract is entered into and are subsequently re-measured at their fair value. The resulting gain or loss is recognized in the consolidated statement of comprehensive loss, as the Group currently does not apply hedge accounting.

Impairment of financial assets

Starting 1 January 2018, the Group assesses on a forward looking basis the expected credit losses associated with its debt instruments carried at amortized cost. The impairment methodology applied depends on whether there has been a significant increase in credit risk. An expected credit losses model replaces the incurred loss impairment model used in IAS 39.

The accounting policy applied under IAS 39 in previous accounting periods is described below.

The Group assessed at the end of each reporting period whether there was objective evidence that a financial asset or group of financial assets is impaired. A financial asset or a group of financial assets is impaired and impairment losses are incurred only if there is objective evidence of impairment as a result of one or more events that occurred after the initial recognition of the asset (a "loss event") and that loss event (or events) has an impact on the estimated future cash flows of the financial asset or group of financial assets that can be reliably estimated.

   j.   Share-based payment transactions 

The fair value of options and warrants granted to employees, Directors, and consultants is recognized as an expense, with a corresponding increase in equity, over the period in which the option and warrant holders become unconditionally entitled to the options and warrants unless incremental and directly attributable to an equity transaction in which case it is deducted from equity. The fair value of the options and warrants granted is measured using an option valuation model, taking into account the terms and conditions upon which the options were granted.

   k .     Financial income and expenses 

Financial income comprises interest receivable on funds invested. Financial expenses comprise interest payable.

Interest income and interest payable are recognized in the statement of comprehensive loss as they accrue, using the effective interest method.

   l .      Taxation 

Tax on the profit or loss for the year comprises current and deferred tax. Tax is recognized in the consolidated statement of comprehensive loss except to the extent that it relates to items recognized directly in equity, in which case it is recognized in equity.

Current tax is the expected tax payable on the taxable income for the period, using tax rates enacted or substantively enacted at the balance sheet date and any adjustment to tax payable in respect of previous years.

Deferred tax is provided on temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for taxation purposes. The following temporary differences are not provided for: the initial recognition of goodwill; the initial recognition of assets or liabilities that affect neither accounting nor taxable profit other than in a business combination; and differences relating to investments in subsidiaries to the extent that they will probably not reverse in the foreseeable future. The amount of deferred tax provided is based on the expected manner of realization or settlement of the carrying amount of assets and liabilities, using tax rates enacted or substantively enacted at the balance sheet date.

A deferred tax asset is recognized only to the extent that it is probable that future taxable profits will be available against which the temporary difference can be utilized.

   m.    Earnings per share 

The Company presents basic and diluted earnings per share (EPS) data for its shares. Basic EPS is calculated by dividing the profit or loss attributable to shares of the Company by the weighted average number of shares outstanding during the period. Diluted EPS is determined by adjusting the profit or loss attributable to shareholders and the weighted average number of shares outstanding for the effects of all dilutive potential shares, which comprise share options and warrants granted to employees and non-employees. Refer to Note 9 for calculation of EPS for all periods presented.

n. Non-current assets or disposal groups held-for-sale and discontinued operations

Non-current assets or disposal groups are classified as held-for-sale if their carrying amount will be recoverable principally through a sale transaction, not through continuing use. The condition is regarded as met only when the sale is highly probable and the asset is available for immediate sale in its present condition.

These assets may be a component of an entity, a disposal group or an individual non-current asset. Upon initial classification as held-for sale, non-current assets and disposal groups are recognised at the lower of carrying amount and fair values less cost to sell.

A discontinued operation is a significant distinguishable component of the Group's business that is available for sale in its immediate condition pursuant to a single formal plan, and which represents a separate major line of business or geographical area of operation. Classification as a discontinued operation occurs upon disposal or when the operation meets the criteria to be classified as held-for-sale.

The profit or loss on sale of a discontinued operation is determined from the formalized discontinuance date. Discontinued operations are separately recognised in the financial statements once management has made a commitment to discontinue the operation without a realistic possibility of withdrawal which should be expected to qualify for recognition as a completed sale within one year of classification.

   o.   Borrowings 

Borrowings are recognized initially at fair value, net of transaction costs incurred. Borrowings are subsequently measured at amortized cost. Any difference between the proceeds (net of transaction costs) and the redemption amount is recognized in profit or loss over the period of the borrowings using the effective interest method.

   p.   Equity 

The Company classifies an instrument, or its component parts, on initial recognition as a financial liability or an equity instrument in accordance with the substance of the contractual arrangement and the definitions of a financial liability and an equity instrument.

An instrument is classified as a financial liability when it is either (i) a contractual obligation to deliver cash or another financial asset to another entity; or (ii) a contract that will, or may be, settled in the Company's own equity instruments and is a non-derivative for which the Company is, or may be, obliged to deliver a variable number of the Company's own equity instruments or a derivative that will or may be settled other than by the exchange of a fixed amount of cash or another financial asset for a fixed number of the Company's own equity instruments.

Incremental costs directly attributable to the issue of new ordinary shares or options are shown in equity as a deduction, net of tax, from the proceeds.

An equity instrument is defined as any contract that evidences a residual interest in the assets of an entity after deducting all of its liabilities. An instrument is an equity instrument only if the issuer has an unconditional right to avoid settlement in cash or another financial asset.

Ordinary Shares

Ordinary shares are classified as equity. Incremental costs directly attributable to the issue of new shares or options are shown in equity as a deduction from the proceeds

   q.   Critical accounting estimates and judgments 

In preparing the financial information, the Directors make judgments on how to apply the Group's accounting policies and make estimates about the future. The critical judgments that have been made in arriving at the amounts recognized in the financial information and the key sources of estimation uncertainty that have a significant risk of causing a material adjustment to the carrying value of assets and liabilities in the next financial year, are discussed below:

Discontinued Operations

The Directors used judgement to determine whether Motif BioSciences Inc. met the criteria as held-for-sale and classified as discontinued operations. Considerations included in the Directors' assessment include, but are not limited to, the publicly communicated wind-down of the entity and the Company's subsequent loss of control of the entity.

Subsequent Events

The Directors evaluate all events occurring after the reporting period dated to evaluate whether evidence of conditions existed or rose after the reporting period date. The Directors determined that 27 January 2017 events (Note 1) had substantial evidence that that conditions existed prior to reporting period date, including, but not exclusively, the results of the November General Meeting where Shareholders approved the proposed corporate restructuring and wind-down of Motif BioSciences Inc. The financial impact of the 27 January 2017 events was considered adjusting events as of 31 December 2019.

Valuation of the iclaprim assets (Judgement and Estimate)

The Directors use their judgment to determine a fair value of the iclaprim intangible asset based upon the consideration paid, the nature of the asset, industry statistics, future potential, and other relevant factors. An asset's acquisition cost or the consideration transferred by the acquiring entity is assumed to be equal to the fair value of the net assets acquired unless contrary evidence exists. These fair values are tested for impairment on an annual basis or when a triggering event has occurred. The assessment includes multiple quantitative and qualitative factors and estimates regarding future cash flows. The projected future cash flows are also used to support the carrying value of the investment and intercompany receivable balances recognised on the Company's Statement of Financial Position. Refer to Note 10 for discussion on the Company's assessment and impairment charge recorded.

Research and development expenditures (Judgement)

Research and development expenditures were not capitalized because the criteria for capitalization are not met. At each balance sheet date, the Group estimates the level of service performed by the vendors and the associated costs incurred for the services performed.

Share based payments and fair value of warrants (Estimate)

The Directors have to make judgments when deciding on the variables to apply in arriving at an appropriate valuation of share based compensation and warrants, including appropriate factors for volatility, risk-free interest rate, and applicable future performance conditions and exercise patterns.

   3.   Discontinued operations 

The Company's wholly-owned subsidiary Motif BioSciences Inc. has been reported as discontinued operations in the consolidated statements of comprehensive loss and the related assets and liabilities have been presented as held-for-sale in the consolidated balance sheet as of 31 December 2019 (Note 1). As set out in note 1, on 14 November 2019 the Company's Shareholders approved the actions detailed in a circular dated 25 October 2019 which had the effect that Motif BioSciences, Inc. ceased all operations and engaged Tamarack Associates to facilitate the sale of iclaprim and other assets of Motif BioSciences Inc for the benefit of the subsidiary's lender, Hercules Capital, Inc. (or Hercules). The consequent amendments to the existing credit agreement with Hercules and the Amendment and Release agreement were completed on 27 January 2020. Effective 27 January 2017, the Company was relieved from a loan guarantee that it had originally provided at the origination of the Hercules loan. Based on the subsequent event on 27 January 2017, and other operational changes that occurred in 2019 and early 2020 described in note 1, the directors consider that it is unlikely that significant changes to the disposal plan will be made or that the plan will be withdrawn even if Hercules forecloses on the iclaprim asset. The directors also consider that the Company, as at 27 January 2017, no longer had an ability to direct the activities of Motif BioSciences Inc. Based on its assessment the Company determined that it no longer has control of Motif BioSciences Inc. in accordance with IFRS 10 Consolidated Financial Statements. As a result, the Company will not consolidate Motif BioSciences Inc. in reportable financial periods commencing in 2020.

The information presented in this footnote summarizes the financial information for Motif BioSciences Inc.

   a.   Operating activity (discontinued operations) 

The following table summarizes the major line items that are included in the consolidated statements of comprehensive loss for the years ending 31 December 2019 and 2018.

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
 
Gain on settlement of contract disputes (1) ..............................                 2,418             - 
General and administrative expenses......................................                (2,738)       (5,889) 
Research and development expenses.....................................                   (2,016)      (10,988) 
Loss on impairment (2) 
 ..................................................................                      (6,196)             - 
Interest 
 income........................................................................... 
 .                                                                                            40           110 
Interest 
 expense..........................................................................       (1,905)       (2,160) 
Net foreign exchange gains (losses)..........................................                 19           104 
Income tax 
 expenses...................................................................                   -           (9) 
                                                                                    ------------  ------------ 
Net loss from discontinued operations                                                   (10,378)      (18,831) 
                                                                                    ------------  ------------ 
Comprehensive loss from discontinued operations                                         (10,378)      (18,831) 
                                                                                    ------------  ------------ 
 
 

(1) The gain resulted from the Group's settlement of disputed obligations billed by its contract research organization.

(2) Loss on impairment reflects the write-down of the iclaprim intangible asset (Note 10).

b. Breakdown of expenses by nature (discontinued operations)

The following table details the nature of expenses for the years ending 31 December 2019 and 2018.

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
General and administrative expenses 
Employee salary and benefits expenses, including share-based 
 payments.......................................................................           1,385         2,677 
Legal and professional 
 fees........................................................                                597         2,217 
Investor and public relations and related fees ......................                        315           628 
Other 
 expenses......................................................................... 
 ...                                                                                         441           367 
                                                                                    ------------  ------------ 
                                                                                           2,738         5,889 
 
Research and development costs 
Employee salary and benefits expenses, including share-based 
 payments.......................................................................             765         1,154 
Contract research organization expenses...............................                         -             - 
Chemistry and manufacturing development and other non-clinical development 
 ..............................................................                              274         3,444 
Other research and development costs (1) ...............................                     986         6,391 
                                                                                    ------------  ------------ 
                                                                                           2,016        10,988 
 

(1) Other research and development costs incurred during 2018 were primarily comprised of regulatory and related preparatory activities for the iclaprim product candidate.

c. Finance income and costs (discontinued operations)

The following table details the nature of expenses for the years ending 31 December 2019 and 2018.

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
Finance income 
Interest from financial 
 assets.....................................................                                  40           110 
                                                                                    ------------  ------------ 
                                                                                              40           110 
                                                                                    ------------  ------------ 
 
Finance costs 
Interest expense (Note 14)........................................................       (1,079)       (1,585) 
Accretion of end of term payment (Note 14).........................                        (234)         (174) 
Amortization of deferred financing costs (Note 14)..............                           (592)         (401) 
                                                                                    ------------  ------------ 
                                                                                         (1,905)       (2,160) 
                                                                                    ------------  ------------ 
Net finance 
 costs..........................................................................         (1,865)       (2,050) 
                                                                                    ------------  ------------ 
 
   d.   Financial position (discontinued operations) 

The following table summarizes the carrying amounts of major classes of assets and liabilities of discontinued operations for each of the periods presented on the consolidated statements of financial position.

 
                                                                                       As at         As at 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
Assets 
Prepaid expenses and other receivables................................                         5            77 
Cash and cash 
 equivalents..........................................................                        32        11,719 
                                                                                    ------------  ------------ 
Total current assets                                                                          37        11,796 
 
Intangible assets                                                                              -         6,196 
Intangible assets (Note 
 10).........................................................                                  -            18 
Other 
 non-current...................................................................... 
 .                                                                                             -         6,214 
                                                                                    ------------  ------------ 
 
Total assets                                                                                  37        18,010 
                                                                                    ------------  ------------ 
 
Liabilities 
Trade payable and accrued liabilities.......................................               3,874         7,029 
Term loan, current 
 portion.........................................................                          3,536         4,327 
                                                                                    ------------  ------------ 
Total current liabilities                                                                  7,410        11,356 
 
Term loan, net of current portion.............................................             3,765        10,131 
Other non-current 
 liabilities......................................................                           430           196 
                                                                                    ------------  ------------ 
Total non-current liabilities                                                              4,195        10,327 
                                                                                    ------------  ------------ 
 
Total liabilities                                                                         11,605        21,683 
                                                                                    ------------  ------------ 
 
   e.   Cash flows (discontinued operations) 

The following table summarizes the cash flows carrying amounts of major classes of assets and liabilities of discontinued operations for each of the periods presented on the consolidated statements of financial position.

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
---------------------------------------------------------------------------------   ------------  ------------ 
Net cash used in 
 operations.......................................................................       (5,736)      (20,043) 
Net cash provided by investing activities (from parent)........................            2,880        11,322 
Net cash used in by financing 
 activities....................................................                          (8,919)       (1,585) 
                                                                                    ------------  ------------ 
Net change in 
 cash............................................................................. 
 ..........                                                                             (11,775)      (10,306) 
Cash, beginning of the 
 year........................................................................             11,719        22,022 
                                                                                    ------------  ------------ 
Effect of foreign exchange rate 
 changes..................................................                                    88             3 
                                                                                    ------------  ------------ 
Cash at the end of the 
 year.........................................................................                32        11,719 
                                                                                    ------------  ------------ 
 
 
   f.   Contractual maturities of financial liabilities (discontinued operations) 
 
                                                             Between 1    Between 2 
                                                  < 1 year  and 2 years  and 5 years  Over 5 years  Total 
                                                    US $       US $         US $          US $       US $ 
-----------------------------------------------   --------  -----------  -----------  ------------  ------ 
At 31 December 2019 
Trade payables and accrued liabilities(1) 
 ...........                                         3,874            -            -             -   3,874 
Term Loan and other non-current (Note 14)            3,830        3,901            -             -   7,731 
                                                  --------  -----------  -----------  ------------  ------ 
                                                     7,704        3,901            -             -  11,605 
                                                  --------  -----------  -----------  ------------  ------ 
 
At 31 December 2018 
-----------------------------------------------   --------  -----------  -----------  ------------  ------ 
Trade payables and accrued 
 liabilities............                             7,029            -            -             -   7,029 
Term Loan and other non-current (Note 14)            4,655        5,642        5,133             -  15,430 
                                                  --------  -----------  -----------  ------------  ------ 
                                                    11,684        5,642        5,133             -  22,459 
                                                  --------  -----------  -----------  ------------  ------ 
 

(1) Trade payables at 31 December 2019 include $2.2 million invoiced outside of terms by Motif BioSciences Inc.'s supplier of active pharmaceutical ingredient.

   4.   Financial risk management (Group and Company) 

This note explains the Group's exposure to financial risks and how these risks could affect the Group's future financial performance.

   a.   Credit risk 

Credit risk arises from cash and cash equivalents, deposits with banks and financial institutions, and if a counterparty will default on its contractual obligations resulting in financial loss to the Group.

The credit risk on liquid funds is limited because cash balances are held with bank and financial institutions with credit-ratings assigned by international credit-rating agencies. All deposits are held with banks that have a minimum S&P rating of A or A-3 for short term deposits.

At 31 December 2019, no current asset receivables were aged over three months. No receivables were impaired.

   b.   Liquidity risk 

Liquidity risk is the risk that the Group will not be able to meet its financial obligations as they become due. The principal risk to which the Group is exposed is liquidity risk. See discussion in Note 1 as it relates to the Group's and Company's ability to continue as a going concern.

The Group has financed its operations to date using cash raised through the issuance of debt and equity. The Directors acknowledge that uncertainty remains over the ability of the Group to have the resources to fully support the Company's foreseeable operating needs as an AIM Rule 15 cash shell. To fund these activities and maintain business operations, the Group may need additional funding. An inability to obtain additional funding could have a negative impact on the Company's prospects (Note 1).

   c.   Market risk 

Foreign currency risk

The Group undertakes certain transactions denominated in foreign currencies. Hence, exposures to exchange rate fluctuations arise. Exchange rate exposures are managed by minimizing the balance of foreign currencies to cover expected cash flows during periods where there is strengthening in the value of the foreign currency. The Group holds part of its cash resources in US dollars and British pounds sterling. The valuation of the cash fluctuates along with the US dollar/sterling exchange rate. No hedging of this risk is undertaken.

The carrying amounts of foreign currency denominated monetary net assets at the reporting date are as follows:

 
                                                                           31 December 2019  31 December 2018 
     (in thousands)                                                              US $              US $ 
                                                                           ----------------  ---------------- 
    Sterling - Cash....................................................                 655               491 
 

The exchange rate between British Pound and the United States Dollar at 31 December 2019 and 2018 was 1.33 and 1.28, respectively. A change in foreign currency exchange rates may have a significant impact on the profit or losses of the Group.

Interest rate risk (Continuing Operations)

The Company's exposure to interest rate risk is limited to interest earned on the cash and cash equivalent balances which were US $0.7 million at 31 December 2019.

Interest rate risk (Discontinued Operations)

Motif BioSciences Inc.'s exposure to interest rate risk is limited to and its financing vulnerabilities on the Hercules loan, which has an interest rate tied to a margin the US prime rate over 4.5% (with a floor of 10%), equating to 10.75% as of 31 December 2019. The interest rate at 31 December 2019 was 10.75%. A change in interest rates may have a significant impact on the profit or losses of Motif BioSciences Inc. The Hercules loan and associated interest rate risk are presented as part of discontinued operations for all periods presented. (Note 3 and Note 14).

   d.   Capital risk management 

The Directors define capital as the total equity of the Group. The Directors' objectives when managing capital are to safeguard the Group's ability to continue as a going concern in order to provide returns for shareholders and benefits for other stakeholders and to maintain an optimal structure to reduce the cost of capital. In order to maintain an optimal capital structure, the Directors may adjust the amount of dividends paid to shareholders, return capital to shareholders and issue new shares to reduce debt.

   5.    Other income and expense items (Company) 

This note provides a breakdown of the items included in other income, finance income and expenses by nature for the years ended 31 December 2019 and 2018.

a. Breakdown of expenses by nature (Company)

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
---------------------------------------------------------------------------------   ------------  ------------ 
General and administrative expenses 
Employee salary and benefits expenses, including share-based 
 payments.......................................................................              11           387 
Director 
 fees............................................................................. 
 ....                                                                                        247           562 
Director, legal and professional fees........................................                586           398 
Investor and public relations and related fees ......................                         32           549 
Other 
 expenses......................................................................... 
 ...                                                                                         370           121 
                                                                                    ------------  ------------ 
                                                                                           1,246         1,747 
                                                                                    ------------  ------------ 
 

Auditors' Remuneration (Group (1) and Company)

 
                                                                                        2019          2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
---------------------------------------------------------------------------------   ------------  ------------ 
Fees paid/payable to the company's auditors and its associates for the audit of 
 the parent 
 company and consolidated financial 
 statements...........................................                                        47            70 
 
  *    Audit of the Group's overseas filings (1) 
       ....................................                                                    -           254 
 
  *    Audit related assurance services (1) 
       ...........................................                                             -           113 
                                                                                    ------------  ------------ 
                                                                                              47           437 
                                                                                    ------------  ------------ 
 

(1) Fees incurred by the Group to support overseas filings and related services are not expected to be part of continuing operations.

c. Finance income and cost (Company)

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
Finance income 
Interest from financial 
 assets.....................................................                                   5             3 
                                                                                    ------------  ------------ 
                                                                                               5             3 
                                                                                    ------------  ------------ 
 
Finance costs 
Interest 
expense..........................................................................              -             - 
                                                                                    ------------  ------------ 
                                                                                               -             - 
                                                                                    ------------  ------------ 
Net finance 
 income......................................................................                  5             3 
                                                                                    ------------  ------------ 
 
   6.   Employee numbers and costs (Group and discontinued operations) 

The monthly average number of persons employed by the Group (including Executive Directors but excluding Non-Executive Directors) and key management personnel during the year, analyzed by category, was as follows:

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
                                                                                    ------------  ------------ 
Executive 
 Directors....................................................................                 2             2 
                                                                                    ------------  ------------ 
Key management personnel....................................................                   4             5 
                                                                                    ------------  ------------ 
Total(1)                                                                                       6             7 
                                                                                    ------------  ------------ 
 

(1) The Company had no employees in 2019 and 2018 and only one employee in 2017.

The aggregate payroll costs of Executive Directors and key management personnel were as follows:

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
Short-term benefits: 
Wages and salaries(1) 
 ..................................................................                        2,528         3,040 
Social security and other employer costs..............................                       144           234 
Share-based payments(2) (3) 
 ........................................................                                  (424)           941 
                                                                                    ------------  ------------ 
                                                                                           2,248         4,215 
                                                                                    ------------  ------------ 
 

(1) Wages and salaries presented are that of the Group. It is expected that a portion will be part of continuing operations.

(2) The total share-based payments recorded in 2019 reflect the benefit received from the forfeitures of outstanding and unvested options (Note 16).

(3) The total share-based payments do not reflect the out-of-period adjustment recorded in 2017 (Note 16).

   7.   Directors' remuneration (Group) 

On 14 November 2019, the Company's shareholders approved the Group's proposed corporate restructuring (Note 1). As part of the restructuring directors Dr. Craig Albanese, Charlotta Ginman, Zaki Hosny, Dr. Mary Lake Polan, and Andrew Powell resigned from the board and all directors forfeited all previously outstanding vested and non-vested option and waived accrued cash fees owed at that time.

The table below summarizes the director's cash remuneration for the periods presented.

 
                                       Salaries                     Social         2019         2018 
                                       and fees      Bonuses       Security       Total         Total 
                                     US $ (000's)  US $ (000's)  US $ (000's)  US $ (000's)  US $(000's) 
                                     ------------  ------------  ------------  ------------  ----------- 
Executive 
Graham Lumsden(2) 
 ..................................       446,250             -        17,813       464,063      726,639 
Jonathan Gold(1)(2) 
 .................................. 
 ...                                      600,000             -        18,388       618,388      881,517 
Non-executive..................... 
...................... 
Robert Bertoldi(3) 
 .................................. 
 ....                                           -             -             -             -      134,563 
Richard Morgan(4) 
 .................................. 
 ...                                       56,750             -             -        56,750      113,500 
Charlotta Ginman(5) 
 ..................................        43,472             -             -        43,472       69,680 
Zaki Hosny(5) 
 .................................. 
 ............                              32,625             -             -        32,625       62,500 
Mary Lake Polan(5) 
 .................................. 
 ..                                        30,000             -             -        30,000       60,000 
Bruce Williams(4) 
 .................................. 
 .....                                     48,625             -             -        48,625       64,000 
Craig T. Albanese(5) 
 .................................. 
 .                                         35,000             -             -        35,000       57,500 
                                     ------------  ------------  ------------  ------------  ----------- 
                                        1,292,722             -        36,201     1,328,923    2,169,899 
                                     ------------  ------------  ------------  ------------  ----------- 
 

(1) The compensation listed above is for Mr. Gold's services as Executive Director and Chief Financial Officer in 2018 and 2019. Mr. Gold assumed the executive role of Chief Financial Officer on 2 February 2018.

(2) The compensation for Dr. Lumsden and Mr. Gold excludes US $8,400 and US $8,400 in employer provided 401k pension contribution during 2019 and US $8,100 and US $8,100 during 2018.

(3) Effective 16 July 2018, Mr. Bertoldi resigned from the Board of Directors. Mr. Bertoldi continued to provide consultancy services under the terms of the consultancy agreement with Amphion Innovation plc until 31 December 2018. Mr. Bertoldi received no compensation is 2019.

(4) Effective 18 March 2019, Richard Morgan resigned from the Board of Directors and his role as Chairman. Bruce Williams was appointed interim Chairman of the Board at that time.

(5) Members' resignation effective 15 November 2019 (Note 1).

The compensation for Board members continuing in 2020 is outlined below by individual.

Bruce Williams is to receive a monthly salary of US $2,500 and is entitled to receive an additional monthly salary of US $2,500 that is deferred and payable only upon the occurrence of a reverse takeover transaction. or similar transaction.

Graham Lumsden, in his capacity as Non-Executive Director, is to receive a monthly salary of US $1,250 and is entitled to receive an additional monthly salary of US $2,500 that is deferred and payable only upon the occurrence of a reverse takeover transaction or similar transaction. Further, as a result of his executive service earlier to May 2020, Dr. Lumsden is entitled to an additional US $100,000 that is deferred and payable only upon the occurrence of a reverse takeover transaction or similar transaction.

Chris Wardhaugh, appointed as a Non-Executive Director on 4 May 2020, is to receive a monthly salary of GBP1,000 (GBP) and is entitled to receive an additional monthly salary of GBP2,000 (GBP) that is deferred and payable only upon the occurrence of a reverse takeover transaction or similar transaction.

Jonathan Gold, in his capacity as Chief Financial Officer, President and Chief Business Officer and Executive Director is to receive a monthly salary of US $25,000 and is entitled to receive an additional monthly salary of US $25,000 that is deferred and payable only upon the occurrence of a reverse takeover transaction or similar transaction.

   8.    Income tax expense (Group and Company) 

Recognized in the consolidated statement of comprehensive loss:

 
                                                                                 Year ended        Year ended 
                                                                                   Dec 31,           Dec 31, 
(in thousands)                                                                       2019              2018 
Current tax expense                                                             US $ (000's)      US $ (000's) 
-------------------------------------------------------------------------       ------------      ------------ 
U.K. corporation 
taxes.................................................................... 
...........                                                                                -                 - 
Overseas taxes (1) 
 ............................................................................. 
 ...........                                                                               -                 9 
                                                                                ------------      ------------ 
                                                                                           -                 9 
                                                                                ------------      ------------ 
 

(1) The overseas taxes are not expected to be incurred as part of continuing operations.

The main rate of U.K. corporation tax was reduced from 21% to 19% from 1 April 2015 and has been reflected in these consolidated financial statements.

The tax expense recognized for the years ended 31 December 2019 and 2018 is lower than the standard rate of corporation tax in the U.K. of 19%. The differences are reconciled below:

 
(in thousands)                                                                   2019             2018 
Reconciliation of effective tax rate:                                        US $ (000's)     US $ (000's) 
------------------------------------------------------------------------   ----------------   ------------ 
Loss on ordinary activities before 
 taxation..........................................                                 (6,144)       (13,976) 
                                                                               ------------   ------------ 
U.K. Corporation tax at 
 19%....................................................................                720            921 
Overseas tax at higher 
 rate.....................................................................          (2,179)        (3,953) 
Effects of: 
Unrecognized 
 losses...................................................................... 
 ...........                                                                        (1,375)        (3,032) 
Other adjustments-overseas 
 taxes........................................................                            -              9 
                                                                               ------------   ------------ 
Total tax charge 
 ............................................................................ 
 .............                                                                            -              9 
                                                                               ------------   ------------ 
 
 

The Company has a net deferred tax asset of US $18 million related to net cumulative operating losses of US $106 million, which includes the impairment charges relating to the Company's operating receivable from and investment in its discontinued subsidiary Motif BioSciences, Inc. The Group has US $ 128.9 million of cumulative net operating losses generated as of 31 December 2019. Net operating loss are subject to review and possible adjustment by taxing authorities and may become subject to an annual limitation, which could limit the amount of tax attributes that can be utilized annually to offset future taxable income or tax liabilities. There is no assurance as to the extent and timing of the Company's or Group's ability to realize the possible tax benefits derived from cumulative net operating losses.

   9.    Loss per share (Group) 

Basic loss per share is calculated by dividing the loss attributable to equity holders of the Group by the weighted average number of shares in issue during the year. Diluted EPS is computed by dividing net income (loss) by the weighted average of all potentially diluted share of common stock that were outstanding during the periods presented.

The treasury stock method is used in the calculation of diluted EPS for potentially dilutive liability classified options and warrants, which assumes that any proceeds received from the exercise of in-the-money options and warrants, would be used to purchase common shares at the average market prices for the period.

The following table shows the derivation of loss per share for continuing operations.

 
                                                                                      Year ended       Year ended 
                                                                                         Dec 31,          Dec 31, 
                                                                                          2019             2018 
(in thousands, except share and per share data)                                          US $             US $ 
                                                                                      -----------      ----------- 
Basic - continuing operations 
Net 
 gain............................................................................... 
 ...........................                                                                4,235            4,846 
Basic weighted average shares in 
 issue...................................................                             350,993,002      284,530,534 
                                                                                      -----------      ----------- 
Basic earnings per 
 share.............................................................................          0.01             0.02 
 
Basic - discontinued operations 
Net 
 loss............................................................................... 
 ...........................                                                             (10,378)         (18,831) 
Basic weighted average shares in 
 issue...................................................                             350,993,002      284,530,534 
                                                                                      -----------      ----------- 
Basic loss per 
 share.............................................................................. 
 .......                                                                                   (0.03)           (0.07) 
                                                                                      -----------      ----------- 
 
 
 
Diluted - continuing operations 
Net 
 gain............................................................................. 
 .............................                                                            4,235        4,846 
Effect of dilutive securities: liability-classified 
 warrants.......................                                                              -      (6,654) 
                                                                                    -----------  ----------- 
Diluted net 
 gain/(loss)...................................................................... 
 ...........                                                                              4,235      (1,808) 
                                                                                    -----------  ----------- 
 
Weighted average shares in issue - 
 basic................................................                              350,993,002  284,530,534 
Incremental dilutive shares from liability-classified warrants (treasury stock 
 method).........................................................................             -    2,601,154 
                                                                                    -----------  ----------- 
Weighted average shares in issue - diluted 
 ...........................................                                        350,993,002  287,131,688 
                                                                                    -----------  ----------- 
Diluted net 
 loss............................................................................. 
 ................                                                                          0.01            - 
                                                                                    -----------  ----------- 
Diluted - discontinued operations 
Net 
 loss............................................................................. 
 .............................                                                         (10,378)     (18,831) 
Weighted average shares in issue - diluted 
 ...........................................                                        350,993,002  287,131,688 
                                                                                    -----------  ----------- 
Diluted net 
 loss............................................................................. 
 ................                                                                        (0.03)       (0.07) 
                                                                                    -----------  ----------- 
 
 

The following potentially dilutive securities outstanding at 31 December 2019 and 2018 have been excluded from the computation of diluted weighted average shares outstanding, as they would be antidilutive.

 
                                                                                           2019        2018 
                                                                                        ----------  ---------- 
Warrants............................................................................. 
 .............                                                                          54,154,709  12,878,944 
Share 
 options.............................................................................. 
 ....                                                                                    3,778,563  18,387,038 
                                                                                        ----------  ---------- 
                                                                                        57,933,272  31,265,982 
                                                                                        ----------  ---------- 
 
   10.    Intangible assets (Group and Discontinued Operations) 

(in thousands)

 
As of 31 December 2017 
Cost.................................................................................................... 
 ..................................................                                                          6,196 
Accumulated amortization and 
impairment..................................................................................                     - 
                                                                                                           ------- 
Net book amount at 31 December 
 2017.......................................................................................                 6,196 
Additions............................................................................................... 
..............................................                                                                   - 
Amortization 
charge.................................................................................................. 
........................                                                                                         - 
                                                                                                           ------- 
Net book amount at 31 December 2018 
 .....................................................................................                       6,196 
                                                                                                           ------- 
 
As of 31 December 2018 
Cost.................................................................................................... 
 ..................................................                                                          6,196 
Accumulated amortization and 
impairment..................................................................................                     - 
                                                                                                           ------- 
Net book amount at 31 December 
 2018.......................................................................................                 6,196 
Additions............................................................................................... 
..............................................                                                                   - 
Impairment 
 charge.................................................................................................. 
 ..........................                                                                                (6,196) 
                                                                                                           ------- 
Net book amount at 31 December 2019 
 .....................................................................................                           - 
                                                                                                           ------- 
 

In connection with the group restructuring in 2015, Motif BioSciences Inc. acquired the assets owned by Nuprim Inc. a Maryland corporation, related to iclaprim. Group recorded an intangible asset of US $6.2 million, or the estimated fair value of the net assets acquired. The intangible asset was considered an in-process research and development asset that was not yet available for commercial use. As such, no amortization was previously recorded.

The Group performs an impairment test over the indefinite lived asset on an annual basis or when a triggering event has occurred. As the result of receipt of a Complete Response Letter from U.S. Food & Drug Administration ("FDA") and the Type A meeting held with the FDA on 3 May 2019 and subsequent FDA meetings, the Group concluded a triggering event occurred and as a result conducted an interim impairment test for iclaprim as of 30 June 2019. In performing the test, the Group developed a discounted cash flow model, which utilized assumptions including, but not limited to, probability of success, market size and related growth assumptions, market share and related growth assumptions, expected period of treatment, pricing, patent life, operating costs, and a discount rate reflective of market conditions and Group specific risk. Our approach to assigning values to each of our assumptions used within the impairment test, are consistent with external sources of data, further adjusted for specific considerations given the uncertainty described below. The aforementioned discounted cash flow model and related assumptions took into account the conditions that existed at 30 June 2019 including the concerns raised by the FDA included in the minutes of the 3 May 2019 meeting, the uncertainty regarding the results of the Type B meeting held on 19 September 2019, which were not be fully known until the minutes to the meeting were available, and whether it would result in a reasonable path forward, as well as the uncertainty surrounding the Groups ability to find a strategic partner on acceptable terms to support the continued clinical advancement for iclaprim. The assessment also analyzed the impact of changes to the discount rate and probability of success. The sensitivity analysis evaluated favorable and unfavorable changes with a minimum range of 10%. The sensitivity did not have a meaningful impact to the Group's assessment. The Group estimated that the net present value of the cash flows of the Group's indefinite lived intangible asset was a nominal amount. As a result of the interim impairment assessment, the Group recorded a non-cash impairment charge equal to the full net carrying value as of 30 June 2019. The Group reassessed the impairment test as of 31 December 2019, including the evaluation of potential events and circumstances through the issuance date of these financial statements, and determined that intangible asset continues to be impaired.

   11.    Prepaid expenses and other receivables (Company) 
 
                                                                             Year end       Year end 
                                                                            31 Dec 2019    31 Dec 2018 
Amounts due within one year                                                 US $ (000's)   US $ (000's) 
                                                                           -------------  ------------- 
Prepayments and other receivables.....................................               145            154 
                                                                           ------------- 
                                                                                     145            154 
                                                                           -------------  ------------- 
 
 

The maximum exposure to credit risk at the end of each reporting period is the fair value of each class of receivables set out above. The Company held no collateral as security. The Directors estimate that the carrying value of receivables approximated their fair value.

   12.    Cash and cash equivalents (Company) 
 
                                                                                Year end       Year end 
                                                                               31 Dec 2019    31 Dec 2018 
                                                                               US $ (000's)   US $ (000's) 
                                                                              -------------  ------------- 
Cash and cash equivalents at bank........................................               663            560 
                                                                              ------------- 
                                                                                        663            560 
                                                                              -------------  ------------- 
 
 
   13.    Financial liabilities (Company) 
 
                                                                                      Year end       Year end 
                                                                                     31 Dec 2019    31 Dec 2018 
Amounts due within one year                                                          US $ (000's)   US $ (000's) 
                                                                                    -------------  ------------- 
Trade 
 payables......................................................................... 
 .                                                                                            119              - 
Accrued 
 expenses...................................................................                   95            178 
Derivative liabilities (Note 15)................................................              227          5,789 
                                                                                    -------------  ------------- 
                                                                                              441          5,967 
                                                                                    -------------  ------------- 
 
 

The Directors estimate that the carrying value of trade and accrued expenses approximated their fair value. Trade payables are generally payable on normal trade terms, usually 30 days.

   14.    Interest bearing loans and borrowings (Discontinued operations) 
 
                                                                                   31 Dec 2019   31 Dec 2018 
                                                                                   US $ (000's)  US $ (000's) 
                                                                                   ------------  ------------ 
Term loan, non-current ....................................................               3,541        10,345 
Unamortized deferred financing costs...........................                               -         (214) 
Payment-in-kind interest..................................................                   24             - 
                                                                                   ------------  ------------ 
    Net non-current............................................................           3,765        10,131 
                                                                                   ------------  ------------ 
 
Term loan, current portion...............................................                 3,325         4,655 
Unamortized deferred financing costs...........................                               -         (328) 
Payment-in-kind interest..................................................                  211             - 
    Net current portion......................................................             3,536         4,327 
                                                                                   ------------  ------------ 
 
Total term loan obligation.................................................               7,301        14,458 
                                                                                   ------------  ------------ 
 

On 15 November 2017, the Group entered into a credit agreement (the "Hercules Loan Agreement") for up to US $20 million in debt financing with Hercules Capital, Inc. ("Hercules"). Pursuant to the credit agreement, Hercules agreed to loan the Group up to US $20.0 million in two tranches. The first tranche of US $15.0 million was drawn down at closing. The milestones for the second tranche of US $5.0 million were not achieved and no further funds were drawn down.

The original terms included an initial interest-only period of 15 months; a 30-month capital and interest repayment period thereafter; an interest rate tied to a margin the US prime rate over 4.5% (with a floor of 10%), equating to 10.75% as of 31 December 2019, and customary security over all assets of the Group, except for intellectual property where there is a negative pledge. Under the credit agreement, the Group issued Hercules warrants to purchase up to 73,452 of its ADS (each representing 20 ordinary shares) at an exercise price of US $9.53 per ADS, representing 3.5% warrant coverage of the total loan facility. In connection with the Hercules Loan Agreement closing, the Group incurred US $0.5 million in fees and issued warrants with a fair value of approximately $0.4 million. Both items are classified as a direct reduction from the Hercules Loan Agreement balance and were previously being amortized over the life of the Loan using the effective interest rate method. In connection with the Amended and Release Agreement dated 27 January 2017, the remaining balance of capitalized fees and warrants issued at origination was fully amortized as of 31 December 2019. The Group is also subject to an end of term charge equal to 2.15% of the total loan capacity, or US $0.43 million. The end of term charge is payable upon loan maturity or the date that the Group prepays the outstanding loan balance. The entire amount of the end of term charge was fully accrued for at 31 December 2019.

The Hercules Loan Agreement was amended effective on 17 February, 22 March, 31 July, and 30 August 2019. Pursuant to the amendments, the Group made early repayments of US $7.5 million and received an interest-only period on the remaining loan balance for the period from March 2019 through June 2019 and the months of August 2019 and September 2019. All prepayment charges for the remaining term of the loan were waived. In connection with the amendments to the Hercules Loan Agreement, the Group incurred US $0.05 in fees and recorded a US $0.06 million modification loss. The fees were classified as a direct reduction from the Loan balance and will be amortized over the life of the loan and the modification loss was recorded as interest expense with a corresponding adjustment to the Loan balance. As of 31 December 2019, all unamortized financing costs and modification loss were fully amortized.

On 30 September 2019, the Company announced that it reached an agreement in principle to amend the Hercules Loan Agreement in a manner that may allow the shareholders of Motif Bio plc to benefit from the monetization of the iclaprim asset, while relieving the Company of its guarantee of the loan. The proposed restructuring and amendment were approved by shareholder vote on 14 November 2019. The Amendment and Release Agreement was signed on 27 January 2017 and is treated as an adjusting subsequent event (Note 1). Pursuant to the terms of the Amendment and Release agreement:

-- Hercules relinquished the loan guarantee provided by the Company and agreed to relieve Motif Bio plc of obligations to Hercules related to the November 2017 Hercules Loan to Motif BioSciences Inc.;

-- Motif BioSciences Inc. granted Hercules a perfected security interest in all its intellectual property;

-- Interest payable for the period October 2019 to May 2020 accrued as paid-in-kind and added to the outstanding principal balance on each interest date; and

-- Hercules provided a forbearance provision regarding compliance certificates and default provisions to June 2020.

The Company granted to Hercules warrants over an aggregate of 121,337,041 ordinary shares of 0.01 pence par value ("Ordinary Shares"), representing a total of 25 per cent of the Company's then outstanding share capital. These warrants will expire on 27 January 2025 and have an exercise price of 0.42 pence per share. The warrants previously issued to Hercules on 14 November 2017 to purchase 73,452 American Depositary Shares were cancelled as a result of the amendment. All outstanding discounts and modification loss were amortized to a nil value and the end of term fee was fully accrued for as of 31 December 2019 as a result of the amendment.

The Hercules Loan Agreement, as amended, subjects the Group's formerly controlled subsidiary Motif Biosciences, Inc. to various affirmative and restrictive covenants, including a perfected pledge on intellectual property.

15. Warrants (Group and Company)

Warrant activity

The Group has issued warrants for services performed and in conjunction with various equity financings. The Group's warrants represent ordinary shares or ADS and have either a Pounds Sterling or US Dollar exercise price. The ADS warrants are exercisable to purchase ADS's, which each represent 20 ordinary shares. Depending on the terms of the warrant agreements, the ordinary share or ADS warrants are classified as either equity or a liability. Liability classified warrants are remeasured each reporting period, with changes in fair value recorded in the statements of comprehensive loss. The following is a summary of the Group's warrant activity during the year ended 31 December 2019:

 
                                                                      Weighted Average 
                                          Number of Warrants           Exercise Price 
                                      --------------------------  ------------------------ 
                                      Ordinary shares     ADS      Ordinary shares    ADS 
                                      ---------------  ---------  -----------------  ----- 
Outstanding as of 1 January 2019           21,915,552  1,336,354     GBP      0.273  $8.08 
Granted                                   127,337,041          -     GBP      0.004      - 
Cancelled                                           -  (123,425)                  -  $8.61 
Exercised                                   (830,780)          -     GBP      0.228      - 
                                      ---------------  ---------          ---------   ---- 
Outstanding as of 31 December 2019         21,915,552  1,336,354     GBP      0.273  $8.02 
                                      ---------------  ---------          ---------   ---- 
 

The Group's warrants outstanding and exercisable as of 31 December 2019 were as follows:

 
Type of Warrant Outstanding   Number Outstanding and Exercisable   Exercise Price   Expiration Date 
----------------------------  ----------------------------------  ----------------  ---------------- 
Ordinary shares (1)                                      724,705  GBP GBP     0.20   April 2, 2020 
Ordinary shares (1)                                    1,082,384  GBP GBP     0.50   July 21, 2020 
Ordinary shares (2)                                   10,317,252  GBP GBP    0.322  23 November 2021 
ADS (2)(3)                                             1,202,902  US $        8.03  23 November 2021 
Ordinary shares (1)                                    8,960,431  GBP GBP     0.20   April 2, 2025 
ADS (2)(3)                                                10,000  US $        7.26   July 31, 2022 
Ordinary shares (1)(4)                                 7,142,857  GBP GBP    0.007  27 January 2025 
Ordinary shares (2)(4)                               121,337,047  GBP GBP    0.004  27 January 2025 
Ordinary shares (2)(4)                                 6,000,000  GBP GBP    0.002  27 January 2025 
 

(1) Warrants totalling 17,910,377 of ordinary shares are equity classified.

(2) Warrants totalling 137,654,293 of ordinary shares and 1,212,902 of ADS are liability classified.

(3) Each ADS represents 20 ordinary shares.

(4) Warrants totalling 134,479,904 of ordinary shares were issued on 27 January 2017. The accounting treatment thereof was recorded as of December31, 2019 as an adjusting subsequent event (Note 1).

Liability classified warrants

ADS warrants

On 23 November 2016, the Group closed an initial U.S. offering of 2,438,491 ADS and 1,219,246 ADS warrants at a price of US $6.98 per ADS/Warrant combination. Each ADS represents 20 ordinary shares. The warrants have an exercise price of US $8.03 per ADS and expire on 23 November 2021. In the event the Group failed to maintain the effectiveness of its Registration Statement and a Restrictive Legend Event has occurred, the warrant shall only be exercisable on a cashless basis. This would result in variability in the number of shares issued and therefore, the warrants were designated as a financial liability carried at fair value through profit and loss. On issuance of the ADS warrants, the Group recorded a derivative liability of US $3.8 million using the Black-Scholes model. The Group develops its own assumptions for use in the Black-Scholes option pricing model that do not have observable inputs or available market data to support the fair value. This method of valuation involves using inputs such as the fair value of the Group's common stock, stock price volatility of comparable companies, the contractual term of the warrants, risk free interest rates and dividend yields. November 26, 2019, the Company notified NASDAQ Capital Market of its intention to delist the ADS shares and ADS warrants from trading. The ADS shares and ADS warrants were voluntarily delisted from trading in December 2019. Due to the nature of these inputs, the valuation of the warrants is considered Level 1 and 2 measurements.

On 1 August 2017, the Group issued to a third party a warrant to purchase up to 60,000 ADSs at an exercise price of US $7.26 per ADS. The warrant vested 5,000 ADSs at issuance, with the remaining 55,000 ADSs vesting upon satisfaction of various performance conditions related to the Group's stock price and trading volumes. A total of 10,000 ADSs were vested and outstanding as of 30 June 2019. The performance conditions related to remaining 50,000 ADSs were not achieved. The vested warrants may be exercised on a cashless basis and expire on 31 July 2022. Exercising on a cashless basis would result in variability in the number of shares issued and therefore, the warrants were designated as a financial liability carried at fair value through profit and loss. On issuance of the ADS warrants, the Group recorded a derivative liability of $0.1 million using the Black-Scholes model.

At issuance, the following assumptions were used in the Black-Scholes model.

On 14 November 2017, in conjunction with the Hercules Loan Agreement, the Group issued to Hercules a warrant to purchase up to 73,452 ADSs at an exercise price of US $9.53 per ADS, representing 3.5% warrant coverage of the total loan facility. The warrant may be exercised on a cashless basis, and is immediately exercisable through 14 November 2022. Exercising on a cashless basis would result in variability in the number of shares issued and therefore, the warrants were designated as a financial liability carried at fair value through profit and loss. On issuance of the ADS warrants, the Group recorded a derivative liability of US $0.4 million using the Black-Scholes model. These warrants were cancelled in connection with the 27 January 2017 amendment to the Hercules Loan Agreement (Note 14).

At 31 December 2019 and 2018, the liability classified ADS warrants had a fair value of US $ nil and $3.9 million using the following weighted-average assumptions in the Black-Scholes model:

 
                                                                                          31 December  31 December 
                                                                                              2019         2018 
                                                                                          -----------  ----------- 
 
Share price (US $)(1) 
 ....................................................................................... 
 ....                                                                                            0.10         6.59 
Exercise price (US 
 $)..................................................................................... 
 ....                                                                                            8.08         8.08 
Expected 
 volatility............................................................................. 
 ................                                                                                92 %         75 % 
Number of periods to 
 exercise.......................................................................                 1.90         2.98 
Risk-free 
 rate................................................................................... 
 ...................                                                                           1.58 %       2.46 % 
Expected 
 dividends.............................................................................. 
 .............                                                                                      -            - 
 
 

(1) Effective December 2019 following a voluntary delisting, the Company's ADS shares are no longer traded on the NASDAQ Capital Market. The share price utilized represent the Company's ordinary share price at 31 December 2019 adjusted to reflect the conversion to ADS equivalents and conversion to the U.S. dollar.

Ordinary warrants

On 23 November 2016, the Group placed 22,863,428 ordinary shares together with 11,431,714 warrants over ordinary shares at a price of GBP0.28 per share/warrant combination. The warrants have an exercise price of GBP0.322 per warrant and expire on 23 November 2021. As the Group has not maintained an effective Registration Statement, the warrant is now only exercisable on a cashless basis. This results in variability in the number of shares issued and therefore, the warrants were designated as a financial liability carried at fair value through profit and loss. On issuance of the warrants, the Group recorded a derivative liability of US $1.8 million using the Black-Scholes model.

On 27 January 2017, the Company granted to Hercules Capital Inc. warrants over an aggregate of 121,337,041 ordinary shares. These warrants will expire on 27 January 2025 and have an exercise price of 0.42 pence per share. The Company also granted warrants over 6,000,000 ordinary shares to certain former board members at an exercise price of 0.24 pence per share that will expire on 27 January 2025. This issuance of these warrants is presented as an adjusting subsequent event (Note 2 and Note 20).

At 31 December 2019 and 2018, the liability classified ordinary warrants had a fair value of US $0.2 million and $2.0 million using the following weighted-average assumption in the Black-Scholes model:

 
                                                                                          31 December  31 December 
                                                                                              2019         2018 
                                                                                          -----------  ----------- 
 
Share price 
 (GBP).................................................................................. 
 ............                                                                                   0.002         0.31 
Weighted exercise price 
 (GBP).......................................................................                   0.028        0.322 
Expected 
 volatility............................................................................. 
 ................                                                                                85 %         74 % 
Number of periods to 
 exercise.......................................................................                 4.77         2.90 
Risk-free 
 rate................................................................................... 
 ...................                                                                           1.68 %       2.46 % 
Expected 
 dividends.............................................................................. 
 .............                                                                                      -            - 
 

The following is a summary of the Group's liability classified warrant activity, including both ADS and Ordinary warrants, during the years ended 31 December 2019 and 2018:

 
(in thousands)                                                                                          Fair value 
Liability classified warrants                                                                              US $ 
-----------------------------------------------------------------------------------------------------   ---------- 
 
Balance at 1 January 2018.........................................................................          12,626 
Issued during the 
year................................................................................                             - 
Exercised during the year..........................................................................           (84) 
Impact of foreign exchange.......................................................................             (99) 
Gain from revaluation of derivative liabilities........................................                    (6,654) 
                                                                                                        ---------- 
Balance at 31 December 2018.................................................................                 5,789 
Issued during the 
year................................................................................                             - 
Exercised during the year..........................................................................           (55) 
Impact of foreign exchange.......................................................................             (80) 
Gain from revaluation of derivative liabilities........................................                    (5,427) 
                                                                                                        ---------- 
Balance at 31 December 2019 .................................................................                  227 
                                                                                                        ---------- 
 
   16.    Share based payments (Group and Company) 

Motif Bio plc adopted a Share Option Plan (the "New Plan") on 1 April 2015. The exercise price for each option will be established at the discretion of the Board provided that the exercise price for each option shall not be less than the nominal value of the relevant shares if the options are to be satisfied by a new issue of shares by the Group and provided that the exercise price per share for an option shall not be less than the fair market value of a share on the effective date of grant of the option. Options will be exercisable at such times or upon such events and subject to such terms, conditions and restrictions as determined by the Board on grant date. However, no option shall be exercisable after the expiration of ten years after the effective date of grant of the option.

 
                                                                                                Weighted average 
                                                                                   Number of     exercise price 
                                                                                 share options        US $ 
                                                                                 -------------  ---------------- 
 
Outstanding at 31 December 2017 
 ...........................................................................        17,065,534        0.32 
Granted during the 
 year.......................................................................... 
 .....................                                                               5,050,000        0.49 
Forfeited during the 
 year.......................................................................... 
 ...................                                                               (2,656,116)        0.34 
Cancelled during the 
 year.......................................................................... 
 .......................                                                             (946,644)        0.56 
Exercised during the year 
 .............................................................................. 
 .............                                                                       (125,736)        0.14 
                                                                                 ------------- 
                                                Outstanding at 31 December 2018 
    ...........................................................................     18,387,038        0.34 
Granted during the 
 year.......................................................................... 
 .....................                                                                 100,000        0.11 
Forfeited during the year(1) 
 .............................................................................. 
 ............                                                                     (14,549,544)        0.34 
Cancelled during the 
 year.......................................................................... 
 .......................                                                             (158,931)        0.56 
Exercised during the year                                                                              - 
.............................................................................. 
.............                                                                                - 
Expired during the                                                                                     - 
year.......................................................................... 
......................                                                                       - 
                                                                                 ------------- 
                                                Outstanding at 31 December 2019 
    ...........................................................................      3,778,563        0.50 
                                                                                 ------------- 
Exercisable at 31 December 2019 
 .............................................................................       3,778,563        0.50 
                                                                                 ------------- 
 

(1) The options forfeited during 2019 were related to the corporate restructuring approved by the Company's shareholders at a general meeting held on 14 November 2019.

The range of exercise prices of the options at 31 December 2019 was US $0.14 - $0.91. The weighted remaining average contractual term of options outstanding at 31 December 2019 and 2018 was 3.5 years and 6.7 years, respectively. Subsequent to 31 December 2019, options for 3,024,138 ordinary shares were forfeited. As of the date these financial statements, options for 745,425 ordinary shares are outstanding.

The total expense recognized for the years arising from stock-based payments are as follows:

 
                                                                                     Year ended    Year ended 
                                                                                     31 Dec 2019   31 Dec 2018 
(in thousands)                                                                      US $ (000's)  US $ (000's) 
                                                                                    ------------  ------------ 
General and administrative 
 expense......................................................                             (309)           750 
Research and development 
 expense.....................................................                              (115)           191 
                                                                                    ------------  ------------ 
Total share-based payment (gain) 
 expense...........................................                                        (424)           941 
                                                                                    ------------  ------------ 
 

For the year ended 31 December 2019, the Company recorded a net gain of $0.4 million due to the forfeitures that occurred during the period.

   17.     Share capital (Company) 

On 14 November 2019, each of the Company's ordinary shares of 1 pence par value were divided into one New Ordinary Share of 0.01 pence par value and one deferred share of 0.99 pence stated value. The deferred shares have no rights and the Company did not issue any share certificates or credit CREST accounts in respect of them. The deferred shares are not admitted to trading on AIM and have no rights to participate in the profits of the Company. In the event of a wind-down or dissolution of the Company, the deferred shares shall be entitled to participate pari-passu in the dissolution of the Company's assets that are in excess of GBP GBP 1 trillion.

The number of New Ordinary Shares in issue and held by each Shareholder at the time of the Share Capital Reorganisation, was equal to the number of existing Ordinary Shares in issue immediately prior to the Share Capital Reorganisation. Only the nominal value changed with respect to the New Ordinary Share. The New Ordinary Shares will continue to carry the same rights as those attached in the previously existing Ordinary Shares, save for the reduction in nominal value.

The net effect is that the par value for the Company's ordinary shares changed to 0.01 pence as a result of this sub-division.

 
Allotted, called up and fully paid:                                                      Number     US $ (000's) 
------------------------------------------------------------------------------------   -----------  ------------ 
(in thousands, except share data) 
 
Ordinary shares in issue at 31 December 
 2017.......................................................................           263,519,128         3,589 
   Issued: 
       Ordinary shares of 1p 
        each......................................................................... 
        .......................                                                            757,315             9 
       Ordinary shares of 1p 
        each......................................................................... 
        .......................                                                         32,258,064           433 
       Ordinary shares of 1p 
        each......................................................................... 
        .......................                                                            125,736             1 
 
Ordinary shares in issue at 31 December 2018(1) 
 .....................................................................                 296,660,243         4,032 
                                                                                       -----------  ------------ 
    Issued: 
       Ordinary shares of 1p each(1) 
        ............................................................................. 
        .................                                                                  830,780             7 
       Ordinary shares of 1p each(1) 
        ............................................................................. 
        .................                                                               45,000,000           594 
       Ordinary shares of .01p 
        each......................................................................... 
        ...................                                                            142,857,143           144 
 
Ordinary shares in issue at 31 December 
 2019.......................................................................           485,348,166         4,777 
                                                                                       -----------  ------------ 
 
Deferred shares at 31 December 2019(1) 
 ...................................................................................   342,491,023             - 
                                                                                       -----------  ------------ 
 

(1) On 14 November 2019, each ordinary share of 1 pence were divided into one New Ordinary Share of 0.01 pence par value and one deferred share of 0.99 pence stated value, as previously described .

D uring 2019, 830,780 ordinary shares were issued upon the exercise of warrants.

On 25 March 2019, the Group placed 45,000,000 new ordinary shares at 6 pence per share and received US $3.3 million of net proceeds.

On 18 November 2019, the Group 142,857,143 new ordinary shares at 0.42 pence per share and received US $0.7 million of net proceeds.

During 2018, 757,315 ordinary shares were issued upon the exercise of warrants.

On 17 May 2018, the Group placed 32,258,064 new ordinary shares at GBP0.31 per share. The Company raised US $13.4 million in gross proceeds and incurred US $0.7 milling of issuance costs in connection with this offering. These issuance costs, which include placement fees, are recorded as a reduction in equity.

In June 2018, 125,736 ordinary shares were issued upon the exercise of a stock option.

Share premium represents the excess over nominal value of the fair value consideration received for equity shares net of expenses of the share issue

The Deferred shares were issued pursuant to a corporate restructuring and consequent capital reorganisation approved by the Company's shareholders on 14 November 2019 in accordance with which each Ordinary Share of 1 penny was subdivided into one new ordinary share of 0.01 pence and one deferred share of 0.99 pence. The deferred shares have no rights to participate in the profits of the company and the Company has not issued any share certificates or credited CREST accounts in respect of them. The deferred shares were not admitted to trading on AIM.

Retained deficit represents accumulated losses.

The group re-organization reserve arose when Motif Bio plc became the parent of the Group in 2015. Being a common control transaction and, therefore, outside the scope of IFRS 3, it was accounted for as a group re-organization and not a business combination. The re-organization reserve can be derived by calculating the difference between the nominal value of the shares in Motif Bio plc issued to the former shareholders in Motif BioSciences Inc. and the share capital and share premium of Motif BioSciences Inc. at the date of the merger. The nominal value of the Company shares was used in the calculation of the reorganization reserve.

18. Subsidiaries

 
                                                                                         Method used 
                                       Country of      Percentage    Percentage         to account for 
Company name                         incorporation    shareholding  voting power          investment 
----------------------------------   --------------   ------------  ------------  -------------------------- 
Motif BioSciences                                                                        Consolidation 
 Inc................                   Delaware, USA       100%          100%       (discontinued operations) 
 

The principal activity of Motif BioSciences, Inc. was proprietary drug discovery research and development. Motif BioSciences Inc. was incorporated in the US State of Delaware on 2 December 2003 and has its registered office at 251 Little Falls Drive, Wilmington, Delaware, 19808. Motif BioSciences Inc. has been reported as discontinued operations in the consolidated statements of comprehensive loss and the related assets and liabilities have been presented as held-for-sale in the consolidated balance sheet as of 31 December 2019. These changes have been applied for all periods presented. Based on the subsequent event on 27 January 2017, the Company determined at that time that it no longer had the ability to direct the activities of Motif BioSciences Inc. Based on its assessment the Company determined that it no longer has control of Motif BioSciences Inc. in accordance with IFRS 10 Consolidated Financial Statements. As a result, the Company will not consolidate Motif BioSciences Inc. in future financial periods.

The Company evaluated the investment and intercompany receivable balances for impairment as of the 31 December 2019. Based on the Group's iclaprim intangible asset in 2019 and the operations of Motif BioSciences Inc. being discontinued, the Company determined that the probability of recovering both balances was unlikely. As a result, the Company recorded an impairment charge equal to the full amount of the respective balances as of 31 December 2019.

   19.    Related party transactions 

Transactions with Amphion Innovations plc and Amphion Innovations US, Inc.

At 31 December 2018, Amphion Innovations plc and its wholly owned subsidiary, Amphion Innovations US, Inc., or collectively, the Amphion Group, owned 8.51% of the issued ordinary shares in Motif Bio plc. In addition, the Amphion Group previously provided funding for the activities of Motif BioSciences Inc. through the issue of convertible interest bearing loan notes, which were converted to shares in December 2016. Richard Morgan and Robert Bertoldi were Directors of both the Company and Amphion Innovations plc in the period. Transactions between the Group and the Amphion Group are disclosed below:

Advisory and Consultancy Agreement with Amphion Innovations US, Inc.

On 1 April 2015, the Group entered into an Advisory and Consultancy Agreement with Amphion Innovations US, Inc. The consideration for the services is US $120,000 per annum. The agreement was amended in December 2016 so that either party may terminate the agreement at any time, for any reason, upon giving the other party ninety-days advance written notice. The Group paid $120,000 to Amphion Innovations US, Inc. during each year ending 31 December 2018, 2017 and 2016 in accordance with the terms of the agreement. The agreement was terminated as of 31 December 2018.

Consultancy Agreement with Amphion Innovations plc

On 1 April 2015, the Group entered into a Consultancy Agreement with Amphion Innovations plc for the services of Robert Bertoldi, an employee of Amphion Innovations plc. The consideration for his services was US $5,000 per month. On 1 November 2015, the consideration was increased to US $180,000 per annum. On 1 July 2016, the consideration decreased to US $75,000 per annum. The agreement was for an initial period of 12 months and would automatically renew each year on the anniversary date unless either party notifies the other by giving 90-days written notice prior to expiration. The agreement was amended in December 2016 so that either party may terminate the agreement at any time, for any reason, upon giving the other party ninety-days advance written notice. In July 2017, the Group amended the consulting agreement with Amphion Innovations plc to increase the annual consideration to $125,000 to better reflect Robert Bertoldi's time commitment to the Group with and effective date of 1 January 2017. The Group paid Robert Bertoldi US $125,000 during the years ended 31 December 2018 and 2017 in accordance with the terms of the agreement. The agreement was terminated as of 31 December 2018.

   20.    Subsequent events 

On 27 January 2017, the Company and its wholly owned subsidiary, Motif BioSciences Inc. completed the conditions and actions described in Note 1 as approved by the Company's Shareholders at a general meeting held on 14 November 2019, the circular of which was dated 25 October 2019. Refer to Note 1 for a description of the completed conditions and actions. The Board evaluated these events and determined that sufficient conditions existed at the end of the reporting period and recorded the event as if occurred as of 31 December 2019. Refer to Note 1 for further details.

On 4 May 2020, the Company made the following directorate changes:

   --      Chris Wardhaugh was appointed as a Non-Executive Director; 

-- Jonathan Gold, the Company's Chief Financial Officer, was appointed as President and Chief Business Officer; and

-- Graham Lumsden, the Company's Chief Executive Officer, stepped down from his role as CEO and become a Non-Executive Director.

On 5 May 2020, the Company placed 162,500,000 new ordinary shares at GBP0.004 per share and received US $0.76 million of net proceeds.

On 29 July 2020, the London Stock Exchange suspended the trading in the Company's AIM securities pursuant to AIM Rule 40. The AIM rules provide that the Company will have an additional six months from the suspension date to complete a qualifying transaction. If the Company does not complete a qualifying transaction by 28 January 2021, the Company's shares will be delisted from the AIM market.

On 7 August 2020, Motif BioSciences, Inc. received a notice from its lender Hercules Capital Inc. ('Hercules') as to their intention to foreclose on the collateral, of intellectual property of iclaprim. Under the terms and condition of the Amended and Restated Loan Agreement (Note 14), Hercules claim is to be only for the amount due to them including accrued interest and fees, and that this applies even in circumstances where Hercules forecloses on the iclaprim asset.

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September 01, 2020 02:00 ET (06:00 GMT)

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