TIDMACPH 
 
 
 
 
NOTIFICATION OF MAJOR HOLDINGS (to be sent to the relevant issuer and 
 to the FCA in Microsoft Word format if possible)(i) 
--------------------------------------------------------------------------------------------------------- 
 
1a. Identity of the issuer or the underlying 
 issuer of existing shares to which 
 voting rights are attached(ii) :                                     Acacia Pharma 
-----------------------------------------------  -------------------------------------------------------- 
1b. Please indicate if the issuer is a non-UK issuer (please mark with 
 an "X" if appropriate) 
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Non-UK issuer 
--------------------------------------------------------------------------------------  ----------------- 
2. Reason for the notification (please mark the appropriate box or boxes 
 with an "X") 
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An acquisition or disposal of voting rights 
--------------------------------------------------------------------------------------  ----------------- 
An acquisition or disposal of financial instruments 
--------------------------------------------------------------------------------------  ----------------- 
An event changing the breakdown of voting rights                                                X 
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Other (please specify)(iii) : 
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3. Details of person subject to the notification obligation(iv) 
Name                                             Gilde Healthcare II Management BV 
City and country of registered office 
 (if applicable)                                 Utrecht, the Netherlands 
4. Full name of shareholder(s) (if different from 3.)(v) 
--------------------------------------------------------------------------------------------------------- 
Name                                             Gilde Healthcare II Sub-Holding BV 
-----------------------------------------------  -------------------------------------------------------- 
City and country of registered office 
 (if applicable)                                 Utrecht, the Netherlands 
-----------------------------------------------  -------------------------------------------------------- 
5. Date on which the threshold was 
 crossed or reached(vi) :                        14/1/2020 
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6. Date on which issuer notified (DD/MM/YYYY):   14/1/2020 
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7. Total positions of person(s) subject to the notification obligation 
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                                                 % of voting rights 
                           % of voting rights    through financial                      Total number 
                           attached to shares    instruments (total    Total of both     of voting rights 
                             (total of 8. A)     of 8.B 1 + 8.B 2)    in % (8.A + 8.B)   of issuer(vii) 
-----------------------  ----------------------  ------------------  -----------------  ----------------- 
Resulting situation 
 on the date on 
 which threshold 
 was crossed or 
 reached                                 26.52%                                 26.52%         63,882,865 
-----------------------  ----------------------  ------------------  -----------------  ----------------- 
Position of previous 
 notification (if 
 applicable)                             30.87%                                 30.87% 
-----------------------  ----------------------  ------------------  -----------------  ----------------- 
 
 
 
 
 
 
 
 
 8. Notified details of the resulting situation on the date on which the 
 threshold was crossed or reached(viii) 
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A: Voting rights attached to shares 
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Class/type of 
 shares 
 ISIN code (if 
 possible)           Number of voting rights(ix)                   % of voting rights 
------------------- 
                            Direct                Indirect                                                       Indirect 
                      (Art 9 of Directive   (Art 10 of Directive                 Direct                    (Art 10 of Directive 
                         2004/109/EC)           2004/109/EC)               (Art 9 of Directive                 2004/109/EC) 
                           (DTR5.1)              (DTR5.2.1)               2004/109/EC) (DTR5.1)                 (DTR5.2.1) 
------------------   --------------------  ----------------------  -----------------------------------  -------------------------- 
GB00BYWF9Y76                   16,943,822                                                       26.52% 
-------------------  --------------------  ----------------------  -----------------------------------  -------------------------- 
 
 
SUBTOTAL 8. A                         16,943,822                                                                            26.52% 
-------------------  --------------------------------------------  --------------------------------------------------------------- 
 
B 1: Financial Instruments according to Art. 13(1)(a) of Directive 2004/109/EC 
 (DTR5.3.1.1 (a)) 
---------------------------------------------------------------------------------------------------------------------------------- 
Type of financial    Expiration            Exercise/               Number of voting                     % of voting rights 
 instrument           date(x)               Conversion Period(xi)   rights that may be 
                                                                    acquired if the instrument 
                                                                    is 
                                                                    exercised/converted. 
-------------------  --------------------  ----------------------  -----------------------------------  -------------------------- 
 
 
 
                                           SUBTOTAL 8. B 1 
                                           ----------------------  -----------------------------------  -------------------------- 
 
B 2: Financial Instruments with similar economic effect according to Art. 
 13(1)(b) of Directive 2004/109/EC (DTR5.3.1.1 (b)) 
---------------------------------------------------------------------------------------------------------------------------------- 
Type of financial   Expiration             Exercise/               Physical or cash  Number of          % of voting rights 
 instrument          date(x)               Conversion              settlement(xii)    voting rights 
                                           Period (xi) 
------------------  ---------------------  ----------------------  ----------------                     -------------------------- 
 
 
 
                                                                   SUBTOTAL 8.B.2 
                                                                   ----------------                     -------------------------- 
 
 
 
 
 
 
 
 
9. Information in relation to the person subject to the notification obligation 
 (please mark the 
 applicable box with an "X") 
Person subject to the notification obligation is not controlled by 
 any natural person or legal entity and does not control any other 
 undertaking(s) holding directly or indirectly an interest in the (underlying) 
 issuer(xiii)                                                                                   X 
Full chain of controlled undertakings through which the voting rights 
 and/or the 
 financial instruments are effectively held starting with the ultimate 
 controlling natural person or legal entity(xiv) (please add additional 
 rows as necessary) 
-----------------------------------------------------------------------------------  ----------------------- 
                                                             % of voting rights 
                                                              through financial 
                              % of voting rights              instruments if it         Total of both if 
                               if it equals or is            equals or is higher      it equals or is higher 
                           higher than the notifiable        than the notifiable       than the notifiable 
       Name(xv)                    threshold                      threshold                 threshold 
----------------------  -------------------------------  --------------------------  ----------------------- 
Gilde Healthcare 
 II Management BV                                26.52%                                               26.52% 
----------------------  -------------------------------  --------------------------  ----------------------- 
 
 
 
 
 
10. In case of proxy voting, please identify: 
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Name of the proxy holder 
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The number and % of voting rights held 
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The date until which the voting rights 
 will be held 
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11. Additional information(xvi) 
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Place of completion  Utrecht, the Netherlands 
-------------------  ------------------------ 
Date of completion   14/01/2019 
-------------------  ------------------------ 
 
 
 
 
 
 
 
 
Annex: Notification of major holdings (to be filed with the FCA only) 
-------------------------------------------------------------------------------- 
 
A: Identity of the person subject to the notification obligation 
-------------------------------------------------------------------------------- 
Full name (including legal form for 
 legal entities)                              Gilde Healthcare II Management BV 
-------------------------------------------  ----------------------------------- 
Contact address (registered office           Newtonlaan 91, 3584 BP Utrecht, the 
 for legal entities)                                     Netherlands 
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E-Mail                                         healthcare@gildehealthcare.com 
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Phone number / Fax number                                          0031302192565 
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Other useful information 
 (at least legal representative for 
 legal persons) 
-------------------------------------------  ----------------------------------- 
 
B: Identity of the notifier, if applicable 
-------------------------------------------------------------------------------- 
Full name 
-------------------------------------------  ----------------------------------- 
Contact address 
-------------------------------------------  ----------------------------------- 
E-Mail 
-------------------------------------------  ----------------------------------- 
Phone number / Fax number 
-------------------------------------------  ----------------------------------- 
Other useful information (e.g. functional 
relationship with the person or legal 
entity subject to the notification 
obligation) 
-------------------------------------------  ----------------------------------- 
 
C: Additional information 
-------------------------------------------------------------------------------- 
 
 
 
   Please send the completed form together with this annex to the FCA at 
the following email 
 
   address: Majorshareholdings@fca.org.uk. Please send in Microsoft Word 
format if possible. 
 
 
 
   Notes 
 
   (i) Please note that national forms may vary due to specific national 
legislation (Article 3(1a) of Directive 2004/109/EC) as for instance the 
applicable thresholds or information regarding capital holdings. 
 
   (ii) Full name of the legal entity and further specification of the 
issuer or underlying issuer, provided it is reliable and accurate (e.g. 
address, LEI, domestic number identity). Indicate in the relevant 
section whether the issuer is a non UK issuer. 
 
   (iii) Other reason for the notification could be voluntary notifications, 
changes of attribution of the nature of the holding (e.g. expiring of 
financial instruments) or acting in concert. 
 
   (iv) This should be the full name of (a) the shareholder; (b) the 
natural person or legal entity acquiring, disposing of or exercising 
voting rights in the cases provided for in DTR5.2.1 (b) to (h)/ Article 
10 (b) to (h) of Directive 2004/109/EC; (c) all parties to the agreement 
referred to in Article 10 (a) of Directive 2004/109/EC (DTR5.2.1 (a)) or 
(d) the holder of financial instruments referred to in Article 13(1) of 
Directive 2004/109/EC (DTR5.3.1). 
 
   As the disclosure of cases of acting in concert may vary due to the 
specific circumstances (e.g. same or different total positions of the 
parties, entering or exiting of acting in concert by a single party) the 
standard form does not provide for a specific method how to notify cases 
of acting in concert. 
 
   In relation to the transactions referred to in points (b) to (h) of 
Article 10 of Directive 2004/109/EC (DTR5.2.1 (b) to (h)), the following 
list is provided as indication of the persons who should be mentioned: 
 
   - in the circumstances foreseen in letter (b) of Article 10 of that 
Directive (DTR5.2.1 (b)), the natural person or legal entity that 
acquires the voting rights and is entitled to exercise them under the 
agreement and the natural person or legal entity who is transferring 
temporarily for consideration the voting rights; 
 
   - in the circumstances foreseen in letter (c) of Article 10 of that 
Directive (DTR5.2.1 (c)), the natural person or legal entity holding the 
collateral, provided the person or entity controls the voting rights and 
declares its intention of exercising them, and natural person or legal 
entity lodging the collateral under these conditions; 
 
   - in the circumstances foreseen in letter (d) of Article 10 of that 
Directive (DTR5.2.1 (d)), the natural person or legal entity who has a 
life interest in shares if that person or entity is entitled to exercise 
the voting rights attached to the shares and the natural person or legal 
entity who is disposing of the voting rights when the life interest is 
created; 
 
   - in the circumstances foreseen in letter (e) of Article 10 of that 
Directive (DTR5.2.1 (e)), the controlling natural person or legal entity 
and, provided it has a notification duty at an individual level under 
Article 9 (DTR 5.1), under letters (a) to (d) of Article 10 of that 
Directive (DTR5.2.1 (a) to (d)) or under a combination of any of those 
situations, the controlled undertaking; 
 
   - in the circumstances foreseen in letter (f) of Article 10 of that 
Directive (DTR5.2.1 (f)), the deposit taker of the shares, if he can 
exercise the voting rights attached to the shares deposited with him at 
his discretion, and the depositor of the shares allowing the deposit 
taker to exercise the voting rights at his discretion; 
 
   - in the circumstances foreseen in letter (g) of Article 10 of that 
Directive (DTR5.2.1 (g)), the natural person or legal entity that 
controls the voting rights; 
 
   - in the circumstances foreseen in letter (h) of Article 10 of that 
Directive (DTR5.2.1 (h)), the proxy holder, if he can exercise the 
voting rights at his discretion, and the shareholder who has given his 
proxy to the proxy holder allowing the latter to exercise the voting 
rights at his discretion (e.g. management companies). 
 
   (v) Applicable in the cases provided for in Article 10 (b) to (h) of 
Directive 2004/109/EC (DTR5.2.1 (b) to (h). This should be the full name 
of the shareholder who is the counterparty to the natural person or 
legal entity referred to in Article 10 of that Directive (DTR5.2) unless 
the percentage of voting rights held by the shareholder is lower than 
the lowest notifiable threshold for the disclosure of voting rights 
holdings in accordance with national practices (e.g. identification of 
funds managed by management companies). 
 
   (vi) The date on which threshold is crossed or reached should be the 
date on which the acquisition or disposal took place or the other reason 
triggered the notification obligation. For passive crossings, the date 
when the corporate event took effect. 
 
   (vii) The total number of voting rights shall be composed of all the 
shares, including depository receipts representing shares, to which 
voting rights are attached even if the exercise thereof is suspended. 
 
   (viii) If the holding has fallen below the lowest applicable threshold 
in accordance with national law, please note that it might not be 
necessary in accordance with national law to disclose the extent of the 
holding, only that the new holding is below that threshold. 
 
   (ix) In case of combined holdings of shares with voting rights attached 
"direct holding" and voting rights "indirect holding", please split the 
voting rights number and percentage into the direct and indirect columns 
-- if there is no combined holdings, please leave the relevant box 
blank. 
 
   (x) Date of maturity/expiration of the financial instrument i.e. the 
date when right to acquire shares ends. 
 
   (xi) If the financial instrument has such a period -- please specify 
this period -- for example once every 3 months starting from [date]. 
 
   (xii) In case of cash settled instruments the number and percentages of 
voting rights is to be presented on a delta-adjusted basis (Article 
13(1a) of Directive 2004/109/EC) (DTR 5.3.3.A). 
 
   (xiii) If the person subject to the notification obligation is either 
controlled and/or does control another undertaking then the second 
option applies. 
 
   (xiv) The full chain of controlled undertakings starting with the 
ultimate controlling natural person or legal entity has to be presented 
also in the cases, in which only on subsidiary level a threshold is 
crossed or reached and the subsidiary undertaking discloses the 
notification as only thus the markets get always the full picture of the 
group holdings. In case of multiple chains through which the voting 
rights and/or financial instruments are effectively held the chains have 
to be presented chain by chain leaving a row free between different 
chains (e.g.: A, B, C, free row, A, B, D, free row, A, E, F etc.). 
 
   (xv) The names of controlled undertakings through which the voting 
rights and/or financial instruments are effectively held have to be 
presented irrespectively whether the controlled undertakings cross or 
reach the lowest applicable threshold themselves. 
 
   (xvi) Example: Correction of a previous notification. 
 
 
 
 

(END) Dow Jones Newswires

January 14, 2020 05:08 ET (10:08 GMT)

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