Anavex Life Sciences Corporation (AVXL) Quote

Nice find, georgejjl 👏

"The results show a statistically significant deceleration in cognitive decline associated with Alzheimer's, marking a pivotal advancement in the pursuit of effective treatments for this debilitating condition using blarcamesine or Anavex 2-73."

https://www.sciencetimes.com/amp/articles/50071/20240508/anavex-life-sciences-alzheimers-treatment-brings-hope-to-millions.htm

NEWS

Anavex Life Sciences Alzheimer's Treatment Brings Hope to Millions

“…As the pursuit of effective treatments for Alzheimer's continues, the outcomes reflected by the company's blarcamesine study could signal a paradigm shift in the management of this condition.…”

https://www.sciencetimes.com/amp/articles/50071/20240508/anavex-life-sciences-alzheimers-treatment-brings-hope-to-millions.htm

Good luck and GOD bless,

Oh, he’s in a fantasy world alright.

Thanks Tom Interesting nearly the same amount of shares right on the end the day as yesterday. 80K and 77K today. Yesterday it dropped the price 3.88 to 3.71 and today it raised the price from 3.69 to 3.71. Then in the post hours we are back up to $3.80.

Maybe tomorrow we get some real news. Or maybe not.
John k9uwa

Yeah because Missling has been spot on when speaking since he’s been CEO

Is this a soft lie compared to your usual? How many dupes do you think fell for this one today?

Only retail shareholders would ask hard (but totally appropriate) questions like these. Analysts won’t do it because they hope that someday Anavex will do banking business with their firms. Is it any wonder Missling doesn’t allow shareholders to ask questions on the quarterly calls?

go avxl may not meet your composition standards but at least he’s got it right and isn’t living in a fantasy world.

Either you didn’t read the full story or you just assumed no one would. Typical.

This knucklehead is particularly bad, a "biologist" deluding himself and others about "secret research". Be careful with public message boards, folks. There's a lot of nonsense here.

Be investors.

that is why TBSD can't get NDA

FIRE TBSD FOR CHANGE

EX-COO already jump ship

Another masterpiece of writing with cogent analysis. You are good.

then George pumping 3-71

George is TBSD partner

TBSD failed AD , RETT

TBSD use POS REVIEW to hide

I'm talking about future hires total pay packages. There's a lot of competition for good ones. You need to look at the big picture not focus on Missling angst. We are likely going to see more officers needed so why hamstring the company ahead what could be a huge ramp up to market approval. Like I said who added it for a vote?

He is ineffective. Zero analysts on the call just junior placeholders

that's crap. Missling controls 7m shares that's plenty for a guy with no results.

Pfizer Stock Is Near An 11-Year Low

https://finance.yahoo.com/m/9a6f7dfd-febf-37fb-912a-e0504d778fbc/pfizer-stock-is-near-an.html

Anavex Life Sciences appears to be doing better than Pfizer.

Good luck and GOD bless,

Tomorrow Misleading will have one of the best ever CC....I guarantee it...

That “someone who has to inform the street” is our CEO. Since he has proven himself to be a bumbling fool, there is zero chance of this happening while he is still employed in this position.

His incompetence should have been evident after 5 years. We’ve held onto this turkey 4 years too long.

Time to go, Missling. You have royally sucked as our company’s CEO.

falconer--" blarcamesine is both safe and effective in the prevention"--great post--again---now someone needs to "inform the street" of this fact !!!They are still unaware!

Restricting the golden parachute could limit the talent Anavex may other wise be able to get (poach). My question is who is behind and why Anavex.

Too bad someone can't hack the CC and put in Serious hardball questions.

ie

Can the shareholders have an update on EVERYTHING.

RETT STATUS
PDD TRIAL STATUS
PROGRESS WITH FDA STATUS
FRAGILE X STATUS
RARE DISEASE SECRET STATUS

WHY DO THEY NEED GOLDEN PARACHUTES WHEN WE HAVE NO REVENUE

WHY TOUTAIN LEFT AND PLAN FOR SUCCESSION.

These are delusional babble. Your underlying numerology compulsion can be treated.

There's no "secret anti-aging research". This is biotech, not knucklehead fantasy. Be careful.

Good points, all of them.

For those watching the price action...
This week , and last, have been good examples of the bleeding down game, step by step, reaches a target, then bounces up a step or two, then hits resistance, most recently 3.95,3.85 area, and begins to roll over and start the downward tumble and bleeding down again. This week the roll over tumble continued today. Hitting a key support step at 3.65, critical to hold around this 3.60 area now. The next one down is 3.55. Resistance overhead now waits around 3.80 to watch for the next roll over and selling down again. But this is a key battle zone for the trading bots, here bulls need to hold 3.60 support area (3.65-3.50) and rally strong again to target 4 dollars-4.40 as a good finished rally wave. However, The resistance that capped 3.98, then rolled over this week, now retesting 3.65...the roll over tumble has won the round, and now looks to empower resistance around 3.80. The 3.60 support zone should face more testing in the coming days. And if it fails and price returns to test 3.40/3.25... it's a win for the bears and they won't stop there, but should be driven to try sending price to the major target zone 3.00-2.90-2.80-2.70.
The next clue comes by watching the resistance at 3.80, and support at 3.55 area. This week's roll over today, comes after last week's mildly bullish bounces, which showed bullish potential...IF support would hold here now at 3.60 area. It's crunch time now for longs to see buying enter here if they want to see any rally recovery continue into the 4's. Otherwise, to see price rolling over again at resistance, 3.80 is next, and bleeding back down lower again, is the downward pattern ... heading to retest 3.25 and looking at 3.00/2.90. This is how the tumble lower/bounce and roll over/ bleed down lower pattern is done. Watch resistance around 3.80 now, watch support around 3.60 now. The battle is still ongoing.

Yes, falconer, I agree that it is extremely unlikely that have not undertaken the anti-aging tests on animals that you suggest. I doubt Missling would have dropped that "potentially anti-aging" comment he made in one of his more recent presentations were they not engaging in that sort of pre-clinical research.

What? Blarcamesine As An OTC Prophylactic?
...it's a pill [blarcamesine] and no side effects to speak of. They could sell it for $5./pill and bring $2. down to their bottom line. Now think for prophylactic use at 100,000,000/week worldwide.
For those wary of speculative or “too far” statements considering potential AVXL share-price outcomes, stop reading this right now. Go no further. Be advised, my comments here are not for you. Don’t buy any AVXLs. Stay away from Anavex Life Sciences Corp. Invest only in US Treasuries. Be safe. Start-up biotechs aren’t for people like yourselves.

What about blarcamesine as a general-purpose anti-aging prophylactic; a cheap, safe “supplement” (well, drug) that could (eventually) be purchased over the counter (no prescription), then taken daily to slow or obviate both normal and pathogenic aging of the central nervous system; thereby preventing, delaying, or minimizing the symptoms of Alzheimer’s, Parkinson’s, and other, similar CNS diseases?

Is there any actual evidence that CNS disease prophylaxis can be induced by blarcamesine? Or, even that the drug is profoundly safe?

First, the safety issue.

A multitude of published clinical studies of blarcamesine are freely available. A multitude of blarcamesine studies in both murines (lab rodents) and humans have failed to reveal any “AE’s,” adverse events — serious “side effects.” In direct contrast to existing, FDA-approved drugs that treat CNS diseases.

Blarcamesine is safe and well-tolerated. No evidence whatsoever to the contrary.

But is there any evidence that blarcamesine can actually provide CNS and geriatric disease prophylaxis; the prevention of these conditions? A search of PubMed for “blarcamesine” and “prophylaxis” will yield nothing. Simply, there are no published studies validating blarcamesine’s prophylactic powers. End of the story.

Except....

The medical researchers connected to or employed by Anavex Life Sciences Corp aren’t ignorant of contemporary methods and protocols commonly used to test for prophylaxis. Every medical research grad student learns of these protocols and test animals. Read through this PDF for an introduction to the animals used in anti-aging research. Especially, learn about the easy-to use roundworm Caenorhabditis elegans.
https://www.afar.org/imported/AFAR_INFOAGING_GUIDE_ANIMALMODELS_2016.pdf

Simply, Anavex Life Sciences Corp, after investigators have signed NDAs (non-disclosure agreements), has had all sorts of in-house studies done with blarcamesine in transgenic C. elegans roundworms, organisms with the genes for various human CNS diseases . They’ve likely also done studies on transgenic lab rodents, rats and mice.

Quietly, Anavex knows what they have. When the time is right, they will announce what their anti-aging and CNS disease prophylaxis studies have revealed. Those studies will show that, indeed, with its unique, upstream mechanisms of action, blarcamesine is both safe and effective in the prevention, delay, or weakening of the diseases of aging and the central nervous system.

Now, comfort yourself. Go back and follow the sloping decline of the AVXL share price.

“You’ll get nothing, and like it!” my mother always said.

I'm expecting NOTHING. That's all we ever get.

Get ready for tomorrow!!!

SURPRISE!!!

Good luck and GOD bless,

Not only is WS completely corrupted. Naked shorting is probably hitting peak levels as the SEC is just another 3 letter agency working on behalf of the industry they should be regulating. The FDA still works for BP. And the prospect that a tiny biotechnology will garner a large percentage of the neurological disease market, eliminating lucrative revenues for their partners, is hard for them to wrap their head around. But I still maintain this is the best drug the Neuro industry has ever seen, because it's a pill and no side effects to speak of. They could sell it for $5./pill and bring $2. down to their bottom line. Now think for prophylactic use at 100,000,000/week worldwide.

I suppose that’s true. Some may not the two last posts I saw. If you didn’t see them, trust me, you didn’t miss anything.

Depends on which last two you see
after ignore filter.
And others are borderline tbd….

Can anyone say with a straight face that the last two posters are any better than your favorite board pariah?

Approval or Buyout…

Neither.

BOD fighting to Keep GOLDEN PARACHUTES as they plan to
Exit

He authored his own compensation package, BOD rubber stamped it. He knew he won't be able to get drug approved, hence lousy milestones for his option vesting. Guy is crook and very cleaver.

Everybody should vote “FOR” on Proposal #4 to prevent Missling from stealing more from Shareholders if ousted.
No Golden Pachute for that MoFo!!

all options he has were given just for starting or finishing trials regardless of approval which we have NONE.

If you follow George you are nuts based on his track record. 2 things move the stock. Approval or Buyout.Period.

Nidan I know you are long. However, there is a method called short. Anavex is a "Event" driven stock. When there is garunteed long spaces of time traders have a garunteed safer period period of time to short.

Due to Missling's (IB background) poor communication, poor planning, poor trial creation, he leaves the shareholders open to be slaughtered.

Look at ANVS as an example. Unless a buyout goes down....it's as easy as printing money.

Proposal 4, limiting golden parachute, Misleading (and BOD, which is nothing but CEO, others are rubber stamp) are against it, and their reasoning is:

"By including long-term incentive awards in the calculation of the proposed limit on severance or termination benefits, the proposal is overly broad, not consistent with market practice, and would place us at a significant disadvantage in terms of attracting and retaining executive talent."

I believe they mean attracting crooks like TGD , accountant, model and IR...don't worry crooks will come.

Why are AVXL stock holders being put through this now? WS is corrupted, IMO.

It's good for people to see the market they are investing in. good that you joined this board, WGT are here to help other gullible investor to navigate this shark infested water. One day this snake oil will see the light of the day, Misleading's hands are tied with model, hence slow pace of submission. He already said he has millions and millions of pages , and his goal is to submit one page/day, submission takes time, don't worry about Misleading's longevity, his fountain of youth drug is already helping him. He has promised same drug to WGT crowd once it is approved, free of cost.

TL;DR Wait for another 10year for snake oil to cook....

"In clinical trials, patients with two copies of the APOE4 variant have much higher rates of brain bleeding and swelling associated with the treatment.
The findings suggest they should be treated at a younger age because "we know they're very, very likely to progress to impairment quickly," she said.
Dr. Samuel Gandy, an Alzheimer's researcher at Mount Sinai in New York, said the findings stress the need to enroll APOE4 homozygotes into trials designed to prevent the disease before they develop symptoms. Sperling is conducting one such trial."

Like with A2-73?????????????????

Unsure how reaffirming, for those not quite as competent as they portray themselves,
timing and the "rules of engagement" for Market action(s) is perceived as a "hedge".

However, youth and over confidence are two "virtues" that are often devoured by the true Market.

So if June 28 is a big day and that is when the shorts will be covering, what happens if Anavex produces some big news in the same timeframe?

The Russell reconstitution proportions are already set based on April 30 Market cap. So, +/- 5 million shares (half of R2000 fund and related fund holdings) will change hands on June 28 from index funds to others. The efficient way for that transfer to occur without affecting price is for an existing short to agree in advance to but those shares (retail can't absorb those numbers in one day without plunge in price). The price of the exchange will be closing price on June 30. If SP is below 3.75 May 17, then the XBI will dump all 5 M shares in a similar fashion (opposite of 2021 when XBI purchased millions of share upon market cap > 500 MM.)

Lets say some of this happens: peer review that is very positive and is in a premier publication, EMA submission for AD, FDA guidance or submission as well, potential accelerated approval from both EMA and FDA, partnership ( less likely but not out of the question ), PDD trial start, etc

Peer review , PDD trial start are unlikely to move price much. EMA ACCEPTANCE of an MAA application could have a larger affect (submission means little). Partnership of course could be huge if terms are good and buyout makes the entire discussion moot. In those cases, the June 28 settlement will be at a higher price -- but the proportion of the R2000 total market cap is based on April 30 closing not June 28 so shares will be sold. If an event occurs before May 17 (or if random drift keeps price > 3.75) then XBI will keep AVXL in index. I expect a tight trading range over the next 7 weeks.

Regardless great news at any time will increase SP, whether or not institutions own 35% or 20% of the stock.

Could the company be planning to release all this news like the shorts have planned for the Russell selling to cover. Could this be a major short squeeze like George has been touting?

Is Missling selling shares at a reduced price over the last couple months (with mild dilution) with the knowledge of great news? He's a bottom tier CEO but not that incompetent. You are, of course, free to listen to any of the posters here you choose.

How does the layman plan for what could happen.

Due diligence, pay attention to key dates, try to avoid magical thinking, diversify, be willing and able to accept the risk taken.

So Doc, thanks for the explanation below as to what may be happening with the shorts and why the stock price is stuck where it is. So if June 28 is a big day and that is when the shorts will be covering, what happens if Anavex produces some big news in the same timeframe? Lets say some of this happens: peer review that is very positive and is in a premier publication, EMA submission for AD, FDA guidance or submission as well, potential accelerated approval from both EMA and FDA, partnership ( less likely but not out of the question ), PDD trial start, etc. You get the idea. There is a ton of pent up news that is just waiting for release. Could the company be planning to release all this news like the shorts have planned for the Russell selling to cover. Could this be a major short squeeze like George has been touting? Or is that just wishful thinking? How does the layman plan for what could happen. Thanks in advance.

Of course there will be news. Anavex will issue a quarterly new release tomorrow. That is a given. Congratulations ahead of time on being right. The real question is: Will there be something potentially newsworthy announced that will be a substantive, market moving inflection point? On that score, the answer is likely not.

You promote precision medicine (not that precision medicine is relevant to Anavex) but you traffic in non-precise language in order to not be wrong. So here’s your chance to provide a more precise forecast. What constitutes real “news” in your mind? Please be precise.

Here’s my prediction: Tomorrow will be another non-event that will frustrate many shareholders who are anxiously awaiting something truly meaningful.