SFNC Simmons First National Corporation

Simmons First National Corporation (Nasdaq:SFNC) today announced it expects to release first quarter 2010 earnings prior to the market opening on Thursday, April 15, 2010, followed by a live conference call to review this information beginning at 3:00 p.m. Central Time. Interested persons can listen to this call by dialing 1-800-854-4175 (United States and Canada only) and asking for the Simmons First National Corporation conference call. A replay of the call will be available through 5:00 p.m. Central Time on April 22, 2010, by dialing 1-800-642-1687. The passcode for the replay is 63848859. In addition, the call will be available live or in recorded version on the Company's website at www.simmonsfirst.com.

Simmons First National Corporation is a financial holding company with eight community banks in Pine Bluff, Lake Village, Jonesboro, Rogers, Searcy, Russellville, El Dorado, and Hot Springs, Arkansas.  The Company's eight banks conduct financial operations from 88 offices, of which 84 are financial centers, in 47 communities.

The Simmons First National Corporation logo is available at http://www.globenewswire.com/newsroom/prs/?pkgid=4819

CONTACT: Simmons First National Corporation

David W. Garner, Senior Vice President and

Investor Relations Officer

(870) 541-1000