FORM 4
[ ] Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).         
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES
                                                                                  
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OMB Number: 3235-0287
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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

MAKRIS GEORGE JR		 2. Issuer Name and Ticker or Trading Symbol

SIMMONS FIRST NATIONAL CORP [ SFNC ] 		5. Relationship of Reporting Person(s) to Issuer (Check all applicable)

__X__ Director                    _____ 10% Owner
__X__ Officer (give title below)    _____ Other (specify below)
Executive Chairman
(Last)          (First)          (Middle)

SIMMONS FIRST NATIONAL CORP., 501 MAIN STREET		 3. Date of Earliest Transaction (MM/DD/YYYY)

1/20/2023
(Street)

PINE BLUFF, AR 71601
(City)        (State)        (Zip)
4. If Amendment, Date Original Filed (MM/DD/YYYY)

 
 6. Individual or Joint/Group Filing (Check Applicable Line)

_X _ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3) 		2. Trans. Date 2A. Deemed Execution Date, if any 3. Trans. Code
(Instr. 8) 		4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5) 		5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4) 		6. Ownership Form: Direct (D) or Indirect (I) (Instr. 4) 7. Nature of Indirect Beneficial Ownership (Instr. 4)
Code V Amount (A) or (D) Price
SFNC Common Stock 1/20/2023  A  18616 (1)A$0.00 565462 (2)D  
SFNC Common Stock 1/20/2023  F  8619 (3)D$22.87 556843 D  
SFNC Common Stock         12000 I By Trust 
SFNC Common Stock         9270 I By IRA 
SFNC Common Stock         10990 I By IRA (Spouse) 

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 3)		2. Conversion or Exercise Price of Derivative Security3. Trans. Date3A. Deemed Execution Date, if any4. Trans. Code
(Instr. 8)		5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)		6. Date Exercisable and Expiration Date7. Title and Amount of Securities Underlying Derivative Security
(Instr. 3 and 4)		8. Price of Derivative Security
(Instr. 5)		9. Number of derivative Securities Beneficially Owned Following Reported Transaction(s) (Instr. 4)10. Ownership Form of Derivative Security: Direct (D) or Indirect (I) (Instr. 4)11. Nature of Indirect Beneficial Ownership (Instr. 4)
CodeV(A)(D)Date ExercisableExpiration DateTitleAmount or Number of Shares
Restricted Stock Unit  (4)1/20/2023  A   43803     (5) (5)SFNC Common Stock 43803 $0 43803 D  
Explanation of Responses:
(1) Settlement of performance share units (PSUs) that were granted on 02/27/2020, based on achievement of performance goals during the requisite performance period.
(2) Includes 845 shares acquired by the Reporting Person pursuant to the Issuer's Employee Stock Purchase Plan.
(3) Shares withheld upon vesting of PSUs to satisfy tax withholding obligations.
(4) Each Restricted Stock Unit represents a contingent right to receive one share of Simmons First National Corporation common stock.
(5) 14,601 Restricted Stock Units vest on January 20, 2024; 14,601 Restricted Stock Units vest on January 20, 2025; and 14,601 Restricted Stock Units vest on January 20, 2026. SFNC shares will be delivered within 30 days of vesting. Events such as retirement, death, disability and other specified events in the agreement may result in earlier vesting.

Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
MAKRIS GEORGE JR
SIMMONS FIRST NATIONAL CORP.
501 MAIN STREET
PINE BLUFF, AR 71601		X
Executive Chairman
Signatures
/s/ George Makris, Jr. by Natalie Gassiott1/24/2023
**Signature of Reporting PersonDate
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
*If the form is filed by more than one reporting person, see Instruction 4(b)(v).
**Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note:File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB control number.
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