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| Data | Nome del titolare | Azioni transazionate | Intervallo di valore ($) | Tipo di transazione | Intervallo di prezzo ($) | Azioni a fine dichiarazione | % di variazione |
|---|---|---|---|---|---|---|---|
| 2026-04-18 | Ms. Patrice Eadon BonfiglioIndependent Non-Executive Director | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 836,00 | - |
| 2026-04-18 | Ms. Patrice Eadon BonfiglioIndependent Non-Executive Director | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 836,00 | 108,48% |
| 2026-04-18 | Dr. Paul CohenInsider | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 836,00 | - |
| 2026-04-18 | Dr. Paul CohenInsider | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 836,00 | 108,48% |
| 2026-04-18 | Mr. Keith L. HornIndependent Non-Executive Director | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 836,00 | 108,48% |
| 2026-04-18 | Mr. Keith L. HornIndependent Non-Executive Director | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 836,00 | - |
| 2026-04-18 | Dr. Odysseas D. KostasIndependent Non-Executive Chairperson of the Board | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 836,00 | 108,48% |
| 2026-04-18 | Dr. Odysseas D. KostasIndependent Non-Executive Chairperson of the Board | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 836,00 | - |
| 2026-04-18 | Ms. Diane E. SullivanIndependent Non-Executive Director | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 836,00 | 108,48% |
| 2026-04-18 | Ms. Diane E. SullivanIndependent Non-Executive Director | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 836,00 | - |
| 2026-04-18 | Mr. Oliver O'ConnorInsider | 400,00 | 0,00 | Derivative Exercise and Retained Stock | - | 801,00 | 99,75% |
| 2026-04-18 | Mr. Oliver O'ConnorInsider | -438,00 | 6,56k | Derivative Exercise and Sale | 14,98 | 801,00 | - |
| 2026-04-18 | Mr. Louis E. SterlingIndependent Non-Executive Director | 435,00 | 0,00 | Derivative Exercise and Retained Stock | - | 4,12k | 11,81% |
| 2026-04-18 | Mr. Louis E. SterlingIndependent Non-Executive Director | -403,00 | 6,04k | Derivative Exercise and Sale | 14,98 | 4,12k | - |
| 2026-04-01 | Mr. Peter L. FishmanSenior VP & CFO | 63,00 | 0,00 | Derivative Exercise and Retained Stock | - | 6,22k | 1,02% |
| 2026-04-01 | Mr. Peter L. FishmanSenior VP & CFO | -62,00 | 896,52 | Derivative Exercise and Sale | 14,46 | 6,22k | - |
| 2026-01-31 | Dr. David KeenanExec. VP & COO | 2,00k | 0,00 | Derivative Exercise and Retained Stock | - | 11,71k | 20,55% |
| 2026-01-31 | Dr. David KeenanExec. VP & COO | -2,18k | 33,66k | Derivative Exercise and Sale | 15,42 | 11,71k | - |
| 2026-01-31 | Mr. Peter L. FishmanSenior VP & CFO | 1,08k | 0,00 | Derivative Exercise and Retained Stock | - | 6,16k | 21,22% |
| 2026-01-31 | Mr. Peter L. FishmanSenior VP & CFO | -1,32k | 20,32k | Derivative Exercise and Sale | 15,42 | 6,16k | - |
| 2026-01-31 | Mr. Aaron D. BergCEO, President & Director | 1,88k | 0,00 | Derivative Exercise and Retained Stock | - | 82,60k | 2,33% |
| 2026-01-31 | Mr. Aaron D. BergCEO, President & Director | -2,30k | 35,44k | Derivative Exercise and Sale | 15,42 | 82,60k | - |
| 2026-01-31 | Dr. Steven B. KetchumExec. VP, President of Research & Development and Chief Scientific Officer | 1,88k | 0,00 | Derivative Exercise and Retained Stock | - | 40,88k | 4,83% |
| 2026-01-31 | Dr. Steven B. KetchumExec. VP, President of Research & Development and Chief Scientific Officer | -2,30k | 35,42k | Derivative Exercise and Sale | 15,42 | 40,88k | - |
| 2026-01-02 | Dr. Steven B. KetchumExec. VP, President of Research & Development and Chief Scientific Officer | 1,65k | 0,00 | Derivative Exercise and Retained Stock | - | 39,00k | 4,41% |
| 2026-01-02 | Dr. Steven B. KetchumExec. VP, President of Research & Development and Chief Scientific Officer | -2,04k | 28,49k | Derivative Exercise and Sale | 13,96 | 39,00k | - |
| 2026-01-02 | Mr. Jonathan N. ProvoostExec. VP, Chief Legal & Compliance Officer and Secretary | 2,20k | 0,00 | Derivative Exercise and Retained Stock | - | 2,20k | - |
| 2026-01-02 | Mr. Jonathan N. ProvoostExec. VP, Chief Legal & Compliance Officer and Secretary | -1,49k | 20,77k | Derivative Exercise and Sale | 13,96 | 2,20k | - |
| 2026-01-02 | Dr. David KeenanExec. VP & COO | 1,76k | 0,00 | Derivative Exercise and Retained Stock | - | 9,71k | 22,16% |
| 2026-01-02 | Dr. David KeenanExec. VP & COO | -1,93k | 26,89k | Derivative Exercise and Sale | 13,96 | 9,71k | - |
| 2026-01-02 | Mr. Peter L. FishmanSenior VP & CFO | 1,09k | 0,00 | Derivative Exercise and Retained Stock | - | 5,08k | 27,36% |
| 2026-01-02 | Mr. Peter L. FishmanSenior VP & CFO | -1,36k | 18,93k | Derivative Exercise and Sale | 13,96 | 5,08k | - |
| 2025-08-01 | Mr. Peter L. FishmanSenior VP & CFO | 152,00 | 0,00 | Derivative Exercise and Retained Stock | - | 3,99k | 3,96% |
| 2025-08-01 | Mr. Peter L. FishmanSenior VP & CFO | -160,00 | 2,32k | Derivative Exercise and Sale | 14,52 | 3,99k | - |
| 2025-06-26 | Mr. Aaron D. BergCEO, President & Director | 36,64k | 0,00 | Derivative Exercise and Retained Stock | - | 80,71k | 83,12% |
| 2025-06-26 | Mr. Aaron D. BergCEO, President & Director | -38,36k | 609,97k | Derivative Exercise and Sale | 15,90 | 80,71k | - |
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