FORM 3
        
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

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Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934 or Section 30(h) of the Investment Company Act of 1940
                      

1. Name and Address of Reporting Person *

Stonepine Capital Management, LLC		 2. Date of Event Requiring Statement (MM/DD/YYYY)
5/6/2021 

 3. Issuer Name and Ticker or Trading Symbol

CHIASMA, INC [CHMA]
(Last)        (First)        (Middle)

919 NW BOND STREET, SUITE 204		 4. Relationship of Reporting Person(s) to Issuer (Check all applicable)

_____ Director                          ___X___ 10% Owner
_____ Officer (give title below)        _____ Other (specify below)
(Street)

BEND, OR 97703      

(City)              (State)              (Zip)
5. If Amendment, Date Original Filed(MM/DD/YYYY)
 

6. Individual or Joint/Group Filing(Check Applicable Line)

_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person

Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		2. Amount of Securities Beneficially Owned
(Instr. 4)		3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 6770000 I See Note 1 (1)

Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivate Security
(Instr. 4)		2. Date Exercisable and Expiration Date
(MM/DD/YYYY)		3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		4. Conversion or Exercise Price of Derivative Security5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date ExercisableExpiration DateTitleAmount or Number of Shares
Explanation of Responses:
(1) The filers are Stonepine Capital Management, LLC ("Stonepine"), Stonepine Capital, L.P. (the "Partnership"), Jon M. Plexico and Timothy P. Lynch. Stonepine is the general partner and investment adviser of the Partnership. Mr. Plexico and Mr. Lynch are Stonepine's managers and control persons. These securities are held directly by the Partnership for the benefit of its investors and are indirectly beneficially owned by Stonepine, as the general partner and investment adviser of the Partnership, and by Mr. Plexico and Mr. Lynch, as Stonepine's control persons. Stonepine is filing this Form 3 for itself and the other filers. The filers are filing this Form 3 jointly, but not as a group, and each expressly disclaims membership in a group within the meaning of Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended. Each filer disclaims beneficial ownership of these securities except to the extent of that filer's pecuniary interest therein.
Reporting Owners
Reporting Owner Name / Address
Relationships
Director10% OwnerOfficerOther
Stonepine Capital Management, LLC
919 NW BOND STREET, SUITE 204
BEND, OR 97703
X
Signatures
Timothy P. Lynch, Managing Member of Stonepine Capital Management, LLC5/14/2021
**Signature of Reporting PersonDate
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