| 2026-02-17 | Mr. Gregg RussoChief HR Officer | 476,00 | 0,00 | Derivative Exercise and Retained Stock | - | 476,00 | - |
| 2026-02-17 | Mr. Gregg RussoChief HR Officer | -211,00 | 0,00 | Derivative Exercise and Sale | - | 476,00 | - |
| 2026-01-05 | Mr. Richard John DalyPresident, CEO & Director | 31,53k | 0,00 | Derivative Exercise and Retained Stock | - | 271,27k | 13,15% |
| 2026-01-05 | Mr. Richard John DalyPresident, CEO & Director | -10,58k | 0,00 | Derivative Exercise and Sale | - | 271,27k | - |
| 2026-01-05 | Mr. Michael W. KalbExec. VP, Treasurer & CFO | 5,06k | 0,00 | Derivative Exercise and Retained Stock | - | 13,67k | 58,78% |
| 2026-01-05 | Mr. Michael W. KalbExec. VP, Treasurer & CFO | -2,08k | 0,00 | Derivative Exercise and Sale | - | 13,67k | - |
| 2025-12-29 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | 4,83k | 0,00 | Derivative Exercise and Retained Stock | - | 14,34k | 50,77% |
| 2025-12-29 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | -3,84k | 0,00 | Derivative Exercise and Sale | - | 14,34k | - |
| 2025-12-29 | Mr. Richard John DalyPresident, CEO & Director | 810,00 | 0,00 | Derivative Exercise and Retained Stock | - | 239,74k | 0,34% |
| 2025-12-29 | Mr. Richard John DalyPresident, CEO & Director | -524,00 | 0,00 | Derivative Exercise and Sale | - | 239,74k | - |
| 2025-12-29 | Mr. Donald A. DenkhausIndependent Director | 1,33k | 0,00 | Derivative Exercise and Retained Stock | - | 498,77k | 0,27% |
| 2025-12-29 | Mr. Brian ElsberndCCO & Chief Legal Officer | 4,04k | 0,00 | Derivative Exercise and Retained Stock | - | 242,50k | 1,70% |
| 2025-12-29 | Mr. Brian ElsberndCCO & Chief Legal Officer | -2,62k | 0,00 | Derivative Exercise and Sale | - | 242,50k | - |
| 2025-12-29 | Dr. Steven R. MillerExec. VP, COO & Chief Scientific Officer | 14,00k | 0,00 | Derivative Exercise and Retained Stock | - | 1,09M | 1,30% |
| 2025-12-29 | Ms. Molly HarperLead Independent Director | 1,33k | 0,00 | Derivative Exercise and Retained Stock | - | 3,69k | 56,53% |
| 2025-12-29 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | 19,55k | 0,00 | Derivative Exercise and Retained Stock | - | 4,17M | 0,47% |
| 2025-12-29 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | -6,79k | 0,00 | Derivative Exercise and Sale | - | 4,17M | - |
| 2025-12-29 | Dr. Preethi SundaramChief Strategy Officer | 4,30k | 0,00 | Derivative Exercise and Retained Stock | - | 54,80k | 8,51% |
| 2025-12-29 | Dr. Preethi SundaramChief Strategy Officer | -2,37k | 0,00 | Derivative Exercise and Sale | - | 54,80k | - |
| 2025-12-29 | Dr. David S. TierneyIndependent Director | 1,33k | 0,00 | Derivative Exercise and Retained Stock | - | 383,31k | 0,35% |
| 2025-12-12 | Ms. Molly HarperLead Independent Director | -20,00k | 350,76k | Derivative Exercise and Sale | 5,78 - 23,73 | 2,36k | - |
| 2025-12-12 | Ms. Molly HarperLead Independent Director | -6,75k | 155,56k | Vendita | 23,06 | 2,36k | -74,08% |
| 2025-12-08 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | 5,55k | 0,00 | Derivative Exercise and Retained Stock | - | 9,51k | 140,01% |
| 2025-12-08 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | -2,49k | 0,00 | Derivative Exercise and Sale | - | 9,51k | - |
| 2025-12-08 | Mr. Donald A. DenkhausIndependent Director | 1,41k | 0,00 | Derivative Exercise and Retained Stock | - | 497,44k | 0,28% |
| 2025-12-08 | Ms. Molly HarperLead Independent Director | 1,41k | 0,00 | Derivative Exercise and Retained Stock | - | 9,11k | 18,37% |
| 2025-12-08 | Mr. Brian ElsberndCCO & Chief Legal Officer | 4,29k | 0,00 | Derivative Exercise and Retained Stock | - | 238,46k | 1,83% |
| 2025-12-08 | Mr. Brian ElsberndCCO & Chief Legal Officer | -2,78k | 0,00 | Derivative Exercise and Sale | - | 238,46k | - |
| 2025-12-08 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | 3,53k | 0,00 | Derivative Exercise and Retained Stock | - | 4,15M | 0,09% |
| 2025-12-08 | Dr. Preethi SundaramChief Strategy Officer | 5,19k | 0,00 | Derivative Exercise and Retained Stock | - | 50,51k | 11,44% |
| 2025-12-08 | Dr. Preethi SundaramChief Strategy Officer | -1,67k | 0,00 | Derivative Exercise and Sale | - | 50,51k | - |
| 2025-12-08 | Ms. Tamar ThompsonIndependent Director | 1,41k | 0,00 | Derivative Exercise and Retained Stock | - | 3,77k | 59,87% |
| 2025-12-08 | Dr. Steven R. MillerExec. VP, COO & Chief Scientific Officer | 11,87k | 0,00 | Derivative Exercise and Retained Stock | - | 1,08M | 1,11% |
| 2025-12-08 | Dr. David S. TierneyIndependent Director | 1,41k | 0,00 | Derivative Exercise and Retained Stock | - | 381,98k | 0,37% |
| 2025-12-01 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | -135,00k | 0,00 | Other Disposition | - | 4,15M | -3,15% |
| 2025-11-26 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | -10,98k | 210,01k | Derivative Exercise and Sale | 4,21 - 23,33 | 3,96k | - |
| 2025-11-21 | Mr. Michael W. KalbExec. VP, Treasurer & CFO | 4,41k | 0,00 | Derivative Exercise and Retained Stock | - | 8,61k | 105,05% |
| 2025-11-21 | Mr. Michael W. KalbExec. VP, Treasurer & CFO | -2,49k | 0,00 | Derivative Exercise and Sale | - | 8,61k | - |
| 2025-11-21 | Ms. Tamar ThompsonIndependent Director | 947,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,36k | 67,02% |
| 2025-11-21 | Dr. David S. TierneyIndependent Director | 947,00 | 0,00 | Derivative Exercise and Retained Stock | - | 380,57k | 0,25% |
| 2025-11-21 | Dr. Preethi SundaramChief Strategy Officer | 4,24k | 0,00 | Derivative Exercise and Retained Stock | - | 45,32k | 10,32% |
| 2025-11-21 | Dr. Preethi SundaramChief Strategy Officer | -1,36k | 0,00 | Derivative Exercise and Sale | - | 45,32k | - |
| 2025-11-21 | Dr. Steven R. MillerExec. VP, COO & Chief Scientific Officer | 8,27k | 0,00 | Derivative Exercise and Retained Stock | - | 1,07M | 0,78% |
| 2025-11-21 | Mr. Richard John DalyPresident, CEO & Director | 12,13k | 0,00 | Derivative Exercise and Retained Stock | - | 238,93k | 5,35% |
| 2025-11-21 | Mr. Richard John DalyPresident, CEO & Director | -7,87k | 0,00 | Derivative Exercise and Sale | - | 238,93k | - |
| 2025-11-21 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | 3,96k | 0,00 | Derivative Exercise and Retained Stock | - | 3,96k | - |
| 2025-11-21 | Mr. Jeffrey Del CarmenExec. VP & Chief Commercial Officer | -1,64k | 0,00 | Derivative Exercise and Sale | - | 3,96k | - |
| 2025-11-21 | Mr. Donald A. DenkhausIndependent Director | 947,00 | 0,00 | Derivative Exercise and Retained Stock | - | 496,03k | 0,19% |
| 2025-11-21 | Mr. Brian ElsberndCCO & Chief Legal Officer | 3,13k | 0,00 | Derivative Exercise and Retained Stock | - | 234,17k | 1,36% |
| 2025-11-21 | Mr. Brian ElsberndCCO & Chief Legal Officer | -2,03k | 0,00 | Derivative Exercise and Sale | - | 234,17k | - |
| 2025-11-21 | Ms. Molly HarperLead Independent Director | 947,00 | 0,00 | Derivative Exercise and Retained Stock | - | 7,69k | 14,04% |
| 2025-11-21 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | 1,78k | 0,00 | Derivative Exercise and Retained Stock | - | 4,28M | 0,04% |
| 2025-11-12 | Mr. Brian ElsberndCCO & Chief Legal Officer | -40,00k | 908,00k | Vendita | 22,70 | 231,04k | -14,76% |
| 2025-09-08 | Mr. Brian ElsberndCCO & Chief Legal Officer | 82,48k | 184,74k | Derivative Exercise and Retained Stock | 2,24 | 271,04k | 43,74% |
| 2025-09-08 | Mr. Brian ElsberndCCO & Chief Legal Officer | -30,00k | 541,80k | Derivative Exercise and Sale | 2,24 - 20,30 | 271,04k | - |
| 2025-09-03 | Mr. Brian ElsberndCCO & Chief Legal Officer | -50,00k | 875,20k | Derivative Exercise and Sale | 2,24 - 20,08 | 188,56k | - |
| 2025-08-27 | Dr. David S. TierneyIndependent Director | 24,00k | 53,76k | Derivative Exercise and Retained Stock | 2,24 | 379,62k | 6,75% |
| 2025-08-27 | Dr. David S. TierneyIndependent Director | -26,00k | 466,96k | Derivative Exercise and Sale | 2,24 - 20,20 | 379,62k | - |
| 2025-08-26 | Mr. Richard John DalyPresident, CEO & Director | 27,03k | 60,55k | Derivative Exercise and Retained Stock | 2,24 | 226,79k | 13,53% |
| 2025-08-26 | Mr. Richard John DalyPresident, CEO & Director | -22,97k | 422,19k | Derivative Exercise and Sale | 2,24 - 20,62 | 226,79k | - |
| 2025-08-27 | Dr. Steven R. MillerExec. VP, COO & Chief Scientific Officer | 110,00k | 246,40k | Derivative Exercise and Retained Stock | 2,24 | 1,06M | 11,58% |
| 2025-08-26 | Dr. Steven R. MillerExec. VP, COO & Chief Scientific Officer | -115,00k | 2,07M | Derivative Exercise and Sale | 2,24 - 20,28 | 1,06M | - |
| 2025-06-10 | Dr. Preethi SundaramChief Strategy Officer | -3,92k | 103,65k | Vendita | 26,41 - 26,42 | 41,08k | -8,72% |
| 2025-06-06 | Mr. Patrick J. McEnanyCo-Founder & Non-Executive Chairman | -200,00k | 5,22M | Vendita | 25,95 - 26,11 | 4,28M | -4,46% |