| 2026-05-13 | Mr. Kevin F. McLaughlinIndependent Director | -7,00k | 174,90k | Derivative Exercise and Sale | 2,63 - 32,83 | 18,30k | - |
| 2026-05-11 | Dr. Paul Kevin WottonIndependent Director | -10,00k | 327,43k | Vendita | 32,64 - 33,05 | 18,80k | -34,72% |
| 2026-05-07 | Mr. Joseph Anthony MaraCFO & Treasurer | -5,00k | 202,50k | Automatic Disposition | 40,50 | 21,01k | -19,22% |
| 2026-05-06 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | -4,86k | 188,05k | Automatic Disposition | 38,00 - 40,50 | 1,12k | -81,28% |
| 2026-04-29 | Ms. Lisa WrightIndependent Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 15,85k | 25,29% |
| 2026-04-29 | Dr. Paul Kevin WottonIndependent Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 28,80k | 12,50% |
| 2026-04-29 | Mr. Alan L. RubinoIndependent Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 64,19k | 5,25% |
| 2026-04-29 | Dr. Robert L. ZerbeIndependent Chairman & Lead Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 33,00k | 10,74% |
| 2026-04-29 | Ms. Heidi M. HagenIndependent Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 35,05k | 10,05% |
| 2026-04-29 | Mr. Kevin F. McLaughlinIndependent Director | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 18,30k | 21,19% |
| 2026-04-02 | Dr. Jonathan M. HopperChief Medical Officer | -3,47k | 83,50k | Derivative Exercise and Sale | 10,95 - 35,00 | 75,56k | - |
| 2026-03-25 | Mr. Alan L. RubinoIndependent Director | 15,00k | 41,40k | Derivative Exercise and Retained Stock | 2,76 | 60,99k | 32,61% |
| 2026-03-23 | Ms. Heidi M. HagenIndependent Director | -15,00k | 444,75k | Derivative Exercise and Sale | 2,76 - 32,41 | 31,85k | - |
| 2026-03-02 | Mr. Sean C. FlynnChief Legal Officer | -15,00k | 286,65k | Derivative Exercise and Sale | 16,25 - 35,36 | 1,26k | - |
| 2026-03-02 | Mr. Sean C. FlynnChief Legal Officer | -6,42k | 223,13k | Automatic Disposition | 34,75 | 1,26k | -83,57% |
| 2026-03-02 | Mr. Michael HalpinCOO | -10,31k | 363,77k | Automatic Disposition | 35,30 | 16,08k | -39,06% |
| 2026-02-24 | Mr. Sean C. FlynnChief Legal Officer | 3,62k | 0,00 | Derivative Exercise and Retained Stock | - | 7,68k | 88,91% |
| 2026-02-24 | Mr. Sean C. FlynnChief Legal Officer | -2,88k | 110,06k | Derivative Exercise and Sale | 38,09 - 38,25 | 7,68k | - |
| 2026-02-24 | Mr. Michael HalpinCOO | 5,53k | 0,00 | Derivative Exercise and Retained Stock | - | 26,39k | 26,50% |
| 2026-02-24 | Mr. Michael HalpinCOO | -4,97k | 189,78k | Derivative Exercise and Sale | 38,09 - 38,25 | 26,39k | - |
| 2026-02-24 | Dr. Jonathan M. HopperChief Medical Officer | 4,53k | 0,00 | Derivative Exercise and Retained Stock | - | 75,56k | 6,38% |
| 2026-02-24 | Dr. Jonathan M. HopperChief Medical Officer | -1,97k | 75,18k | Derivative Exercise and Sale | 38,09 - 38,25 | 75,56k | - |
| 2026-02-24 | Mr. Dominick C. ColangeloCEO, President & Director | 27,68k | 0,00 | Derivative Exercise and Retained Stock | - | 312,45k | 9,72% |
| 2026-02-24 | Mr. Dominick C. ColangeloCEO, President & Director | -8,82k | 336,11k | Derivative Exercise and Sale | 38,09 | 312,45k | - |
| 2026-02-24 | Mr. Joseph Anthony MaraCFO & Treasurer | 6,53k | 0,00 | Derivative Exercise and Retained Stock | - | 25,90k | 33,73% |
| 2026-02-24 | Mr. Joseph Anthony MaraCFO & Treasurer | -2,72k | 103,67k | Derivative Exercise and Sale | 38,09 - 38,25 | 25,90k | - |
| 2026-02-24 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | 2,05k | 0,00 | Derivative Exercise and Retained Stock | - | 5,85k | 53,99% |
| 2026-02-24 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | -1,37k | 52,11k | Derivative Exercise and Sale | 38,09 - 38,25 | 5,85k | - |
| 2026-02-18 | Mr. Joseph Anthony MaraCFO & Treasurer | 5,07k | 0,00 | Derivative Exercise and Retained Stock | - | 19,37k | 35,42% |
| 2026-02-18 | Mr. Joseph Anthony MaraCFO & Treasurer | -2,31k | 85,68k | Derivative Exercise and Sale | 36,82 - 37,41 | 19,37k | - |
| 2026-02-18 | Mr. Michael HalpinCOO | 4,78k | 0,00 | Derivative Exercise and Retained Stock | - | 20,86k | 29,71% |
| 2026-02-18 | Mr. Michael HalpinCOO | -4,30k | 159,32k | Derivative Exercise and Sale | 36,82 - 37,41 | 20,86k | - |
| 2026-02-18 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | 1,62k | 0,00 | Derivative Exercise and Retained Stock | - | 3,80k | 74,01% |
| 2026-02-18 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | -1,31k | 48,16k | Derivative Exercise and Sale | 36,82 - 37,41 | 3,80k | - |
| 2026-02-18 | Dr. Jonathan M. HopperChief Medical Officer | 4,34k | 0,00 | Derivative Exercise and Retained Stock | - | 71,03k | 6,51% |
| 2026-02-18 | Dr. Jonathan M. HopperChief Medical Officer | -982,00 | 36,74k | Derivative Exercise and Sale | 37,41 | 71,03k | - |
| 2026-02-18 | Mr. Sean C. FlynnChief Legal Officer | 2,81k | 0,00 | Derivative Exercise and Retained Stock | - | 4,07k | 222,27% |
| 2026-02-18 | Mr. Sean C. FlynnChief Legal Officer | -2,52k | 93,39k | Derivative Exercise and Sale | 36,82 - 37,41 | 4,07k | - |
| 2026-02-18 | Mr. Dominick C. ColangeloCEO, President & Director | 24,29k | 0,00 | Derivative Exercise and Retained Stock | - | 284,77k | 9,33% |
| 2026-02-18 | Mr. Dominick C. ColangeloCEO, President & Director | -5,66k | 211,63k | Derivative Exercise and Sale | 37,41 | 284,77k | - |
| 2026-02-11 | Mr. Kevin F. McLaughlinIndependent Director | -7,00k | 224,21k | Derivative Exercise and Sale | 2,63 - 34,66 | 15,10k | - |
| 2026-01-07 | Mr. Michael HalpinCOO | -10,00k | 238,20k | Derivative Exercise and Sale | 16,66 - 40,48 | 16,08k | - |
| 2025-07-22 | Ms. Karen MahoneyChief HR Officer | 1,85k | 0,00 | Derivative Exercise and Retained Stock | - | 1,85k | - |
| 2025-07-22 | Ms. Karen MahoneyChief HR Officer | -771,00 | 29,28k | Derivative Exercise and Sale | 37,98 | 1,85k | - |
| 2025-12-02 | Dr. Jonathan M. HopperChief Medical Officer | -1,65k | 34,92k | Derivative Exercise and Sale | 18,00 - 39,14 | 66,56k | - |
| 2025-12-02 | Dr. Paul Kevin WottonIndependent Director | -5,00k | 189,50k | Vendita | 37,83 - 37,97 | 25,60k | -16,34% |
| 2025-11-11 | Mr. Michael HalpinCOO | -2,64k | 62,75k | Derivative Exercise and Sale | 16,66 - 40,41 | 15,93k | - |
| 2025-11-10 | Mr. Kevin F. McLaughlinIndependent Director | -7,00k | 251,72k | Derivative Exercise and Sale | 2,63 - 38,59 | 15,10k | - |
| 2025-11-06 | Mr. Michael HalpinCOO | -7,36k | 175,19k | Derivative Exercise and Sale | 16,66 - 40,47 | 15,93k | - |
| 2025-09-30 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | 568,00 | 0,00 | Derivative Exercise and Retained Stock | - | 2,07k | 37,82% |
| 2025-09-30 | Mr. Jonathan D. SiegalPrincipal Accounting Officer, VP & Corporate Controller | -370,00 | 11,64k | Derivative Exercise and Sale | 31,47 | 2,07k | - |
| 2025-09-02 | Dr. Jonathan M. HopperChief Medical Officer | -10,00k | 177,70k | Derivative Exercise and Sale | 18,00 - 35,77 | 66,36k | - |
| 2025-08-06 | Mr. Kevin F. McLaughlinIndependent Director | -7,00k | 232,12k | Derivative Exercise and Sale | 2,76 - 35,92 | 15,10k | - |