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| Data | Nome del titolare | Azioni transazionate | Intervallo di valore ($) | Tipo di transazione | Intervallo di prezzo ($) | Azioni a fine dichiarazione | % di variazione |
|---|---|---|---|---|---|---|---|
| 2026-04-02 | Mr. James William BurnsChief Legal Officer | 5,22k | 0,00 | Derivative Exercise and Retained Stock | - | 49,31k | 11,84% |
| 2026-04-02 | Mr. James William BurnsChief Legal Officer | -3,28k | 113,85k | Derivative Exercise and Sale | 34,71 | 49,31k | - |
| 2026-04-02 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -2,94k | 102,05k | Derivative Exercise and Sale | 34,71 | 80,28k | - |
| 2026-04-02 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | 5,56k | 0,00 | Derivative Exercise and Retained Stock | - | 80,28k | 7,44% |
| 2026-04-02 | Ms. Cecilia JonesCFO | -3,14k | 109,02k | Derivative Exercise and Sale | 34,71 | 55,00k | - |
| 2026-04-02 | Ms. Cecilia JonesCFO | 5,36k | 0,00 | Derivative Exercise and Retained Stock | - | 55,00k | 10,80% |
| 2026-04-02 | Ms. Tsveta MilanovaChief Commercial Officer | -3,26k | 113,22k | Derivative Exercise and Sale | 34,71 | 46,83k | - |
| 2026-04-02 | Ms. Tsveta MilanovaChief Commercial Officer | 5,24k | 0,00 | Derivative Exercise and Retained Stock | - | 46,83k | 12,59% |
| 2026-04-02 | Dr. Krishnan ViswanadhanChief Strategy & Operations Officer | -2,96k | 102,71k | Derivative Exercise and Sale | 34,71 | 10,28k | - |
| 2026-04-02 | Dr. Krishnan ViswanadhanChief Strategy & Operations Officer | 5,14k | 0,00 | Derivative Exercise and Retained Stock | - | 10,28k | 100,00% |
| 2026-04-02 | Mr. Brian M. GoffCEO & Director | -19,07k | 661,85k | Derivative Exercise and Sale | 34,71 | 184,51k | - |
| 2026-04-02 | Mr. Brian M. GoffCEO & Director | 19,96k | 0,00 | Derivative Exercise and Retained Stock | - | 184,51k | 12,13% |
| 2026-03-05 | Dr. Krishnan ViswanadhanChief Strategy & Operations Officer | 5,14k | 0,00 | Derivative Exercise and Retained Stock | - | 5,14k | - |
| 2026-03-05 | Dr. Krishnan ViswanadhanChief Strategy & Operations Officer | -2,96k | 82,26k | Derivative Exercise and Sale | 27,80 | 5,14k | - |
| 2026-03-03 | Mr. T. J. WashburnVP, Controller & Principal Accounting Officer | -5,27k | 152,26k | Vendita | 28,88 | 868,00 | -85,86% |
| 2026-03-02 | Mr. Brian M. GoffCEO & Director | 21,45k | 0,00 | Derivative Exercise and Retained Stock | - | 164,55k | 14,99% |
| 2026-03-02 | Mr. Brian M. GoffCEO & Director | -18,06k | 522,87k | Derivative Exercise and Sale | 28,96 | 164,55k | - |
| 2026-03-02 | Mr. James William BurnsChief Legal Officer | 12,37k | 0,00 | Derivative Exercise and Retained Stock | - | 44,09k | 38,99% |
| 2026-03-02 | Mr. James William BurnsChief Legal Officer | -5,22k | 151,11k | Derivative Exercise and Sale | 28,96 | 44,09k | - |
| 2026-03-02 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | 9,61k | 0,00 | Derivative Exercise and Retained Stock | - | 74,41k | 14,83% |
| 2026-03-02 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -4,06k | 117,43k | Derivative Exercise and Sale | 28,96 | 74,41k | - |
| 2026-03-02 | Ms. Cecilia JonesCFO | 11,93k | 0,00 | Derivative Exercise and Retained Stock | - | 49,33k | 31,91% |
| 2026-03-02 | Ms. Cecilia JonesCFO | -5,04k | 145,81k | Derivative Exercise and Sale | 28,96 | 49,33k | - |
| 2026-03-02 | Ms. Tsveta MilanovaChief Commercial Officer | 6,80k | 0,00 | Derivative Exercise and Retained Stock | - | 41,59k | 19,54% |
| 2026-03-02 | Ms. Tsveta MilanovaChief Commercial Officer | -2,87k | 83,06k | Derivative Exercise and Sale | 28,96 | 41,59k | - |
| 2026-03-02 | Mr. T. J. WashburnVP, Controller & Principal Accounting Officer | 5,27k | 0,00 | Derivative Exercise and Retained Stock | - | 6,14k | 607,37% |
| 2026-03-02 | Mr. T. J. WashburnVP, Controller & Principal Accounting Officer | -2,22k | 64,38k | Derivative Exercise and Sale | 28,96 | 6,14k | - |
| 2026-01-05 | Ms. Tsveta MilanovaChief Commercial Officer | 5,60k | 0,00 | Derivative Exercise and Retained Stock | - | 34,79k | 19,19% |
| 2026-01-05 | Ms. Tsveta MilanovaChief Commercial Officer | -2,87k | 77,60k | Derivative Exercise and Sale | 27,02 | 34,79k | - |
| 2025-12-30 | Mr. James William BurnsChief Legal Officer | 3,07k | 0,00 | Derivative Exercise and Retained Stock | - | 31,72k | 10,71% |
| 2025-12-30 | Mr. James William BurnsChief Legal Officer | -2,93k | 79,43k | Derivative Exercise and Sale | 27,09 | 31,72k | - |
| 2025-12-30 | Mr. Brian M. GoffCEO & Director | 19,58k | 0,00 | Derivative Exercise and Retained Stock | - | 143,10k | 15,85% |
| 2025-12-30 | Mr. Brian M. GoffCEO & Director | -18,70k | 506,66k | Derivative Exercise and Sale | 27,09 | 143,10k | - |
| 2025-12-30 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | 3,07k | 0,00 | Derivative Exercise and Retained Stock | - | 64,80k | 4,97% |
| 2025-12-30 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -2,93k | 79,43k | Derivative Exercise and Sale | 27,09 | 64,80k | - |
| 2025-12-30 | Ms. Tsveta MilanovaChief Commercial Officer | 3,07k | 0,00 | Derivative Exercise and Retained Stock | - | 29,19k | 11,74% |
| 2025-12-30 | Ms. Tsveta MilanovaChief Commercial Officer | -2,93k | 79,43k | Derivative Exercise and Sale | 27,09 | 29,19k | - |
| 2025-12-30 | Ms. Cecilia JonesCFO | 3,07k | 0,00 | Derivative Exercise and Retained Stock | - | 37,39k | 8,94% |
| 2025-12-30 | Ms. Cecilia JonesCFO | -2,93k | 79,43k | Derivative Exercise and Sale | 27,09 | 37,39k | - |
| 2025-11-12 | Dr. David T. ScaddenIndependent Director | -200,00 | 5,15k | Derivative Exercise and Sale | 18,09 - 43,84 | 17,60k | - |
| 2025-11-11 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -2,45k | 46,06k | Derivative Exercise and Sale | 25,01 - 43,78 | 61,73k | - |
| 2025-10-30 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -200,00 | 3,76k | Derivative Exercise and Sale | 25,01 - 43,81 | 61,73k | - |
| 2025-10-27 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -3,30k | 62,44k | Derivative Exercise and Sale | 25,01 - 43,92 | 61,73k | - |
| 2025-10-08 | Dr. David T. ScaddenIndependent Director | -200,00 | 4,58k | Derivative Exercise and Sale | 18,09 - 41,00 | 17,60k | - |
| 2025-09-30 | Dr. David T. ScaddenIndependent Director | -200,00 | 4,38k | Derivative Exercise and Sale | 18,09 - 40,00 | 17,60k | - |
| 2025-09-26 | Ms. Cecilia JonesCFO | 3,82k | 0,00 | Derivative Exercise and Retained Stock | - | 33,87k | 12,72% |
| 2025-09-26 | Ms. Cecilia JonesCFO | -3,65k | 134,25k | Derivative Exercise and Sale | 36,77 | 33,87k | - |
| 2025-09-05 | Mr. T. J. WashburnVP, Controller & Principal Accounting Officer | -8,55k | 315,09k | Vendita | 36,87 | 868,00 | -90,78% |
| 2025-08-27 | Dr. David T. ScaddenIndependent Director | -200,00 | 4,38k | Derivative Exercise and Sale | 18,09 - 40,00 | 17,60k | - |
| 2025-08-11 | Dr. Rahul D. BallalIndependent Director | 2,30k | 0,00 | Derivative Exercise and Retained Stock | - | 12,41k | 22,77% |
| 2025-08-11 | Ms. Cynthia SmithIndependent Director | 2,30k | 0,00 | Derivative Exercise and Retained Stock | - | 12,41k | 22,77% |
| 2025-08-08 | Mr. Brian M. GoffCEO & Director | 11,61k | 0,00 | Derivative Exercise and Retained Stock | - | 123,53k | 10,37% |
| 2025-08-08 | Mr. Brian M. GoffCEO & Director | -11,09k | 406,49k | Derivative Exercise and Sale | 36,67 | 123,53k | - |
| 2025-07-10 | Dr. David T. ScaddenIndependent Director | -1,40k | 30,67k | Derivative Exercise and Sale | 18,09 - 40,00 | 17,60k | - |
| 2025-07-09 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -11,91k | 154,63k | Derivative Exercise and Sale | 25,01 - 38,76 | 61,27k | - |
| 2025-07-01 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | 4,28k | 0,00 | Derivative Exercise and Retained Stock | - | 61,27k | 7,52% |
| 2025-07-01 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -4,09k | 139,79k | Derivative Exercise and Sale | 34,17 | 61,27k | - |
| 2025-06-24 | Mr. James William BurnsChief Legal Officer | 3,20k | 0,00 | Derivative Exercise and Retained Stock | - | 28,65k | 12,58% |
| 2025-06-24 | Mr. James William BurnsChief Legal Officer | -2,80k | 93,88k | Derivative Exercise and Sale | 33,54 | 28,65k | - |
| 2025-06-24 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | 3,09k | 0,00 | Derivative Exercise and Retained Stock | - | 56,99k | 5,74% |
| 2025-06-24 | Dr. Sarah GheuensChief Medical Officer and Head of Research & Development | -2,91k | 97,57k | Derivative Exercise and Sale | 33,54 | 56,99k | - |
| 2025-06-24 | Ms. Cecilia JonesCFO | 4,22k | 0,00 | Derivative Exercise and Retained Stock | - | 30,05k | 16,34% |
| 2025-06-24 | Ms. Cecilia JonesCFO | -1,78k | 59,70k | Derivative Exercise and Sale | 33,54 | 30,05k | - |
| 2025-06-24 | Ms. Tsveta MilanovaChief Commercial Officer | 3,23k | 0,00 | Derivative Exercise and Retained Stock | - | 26,12k | 14,11% |
| 2025-06-24 | Ms. Tsveta MilanovaChief Commercial Officer | -2,77k | 92,91k | Derivative Exercise and Sale | 33,54 | 26,12k | - |
| 2025-06-24 | Mr. Brian M. GoffCEO & Director | 19,58k | 0,00 | Derivative Exercise and Retained Stock | - | 111,92k | 21,20% |
| 2025-06-24 | Mr. Brian M. GoffCEO & Director | -18,70k | 627,20k | Derivative Exercise and Sale | 33,54 | 111,92k | - |
| 2025-06-20 | Dr. Rahul D. BallalIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 10,11k | 26,53% |
| 2025-06-20 | Mr. Jeffrey D. CapelloIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 6,07k | 53,63% |
| 2025-06-20 | Ms. Kaye I. Foster-CheekLead Independent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 7,47k | 39,64% |
| 2025-06-20 | Dr. Jacqualyn A. FouseChair of the Board of Directors | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 151,34k | 1,42% |
| 2025-06-20 | Dr. Maykin HoIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 17,03k | 14,22% |
| 2025-06-20 | Ms. Catherine E. Owen AdamsIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 6,07k | 53,63% |
| 2025-06-20 | Dr. David T. ScaddenIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 17,60k | 13,69% |
| 2025-06-20 | Ms. Cynthia SmithIndependent Director | 2,12k | 0,00 | Derivative Exercise and Retained Stock | - | 10,11k | 26,53% |
| 2025-06-13 | Mr. Jeffrey D. CapelloIndependent Director | 1,98k | 0,00 | Derivative Exercise and Retained Stock | - | 3,95k | 100,05% |
| 2025-06-13 | Ms. Catherine E. Owen AdamsIndependent Director | 1,98k | 0,00 | Derivative Exercise and Retained Stock | - | 3,95k | 100,05% |
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