| 2026-05-18 | Mr. Hunter C. SmithCFO & Treasurer | 3,00k | 53,61k | Derivative Exercise and Retained Stock | 17,87 | 119,61k | 2,57% |
| 2026-05-15 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -201,00 | 18,53k | Vendita | 92,21 | 0,00 | -100,00% |
| 2026-05-15 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -4,44k | 222,28k | Derivative Exercise and Sale | 17,97 - 92,21 | 0,00 | - |
| 2026-04-01 | Mr. Yann MazabraudExec. VP & Head of International | 12,88k | 0,00 | Derivative Exercise and Retained Stock | - | 66,03k | 24,22% |
| 2026-03-04 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -4,11k | 368,45k | Vendita | 89,56 | 160,00 | -96,26% |
| 2026-03-04 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -1,50k | 107,39k | Derivative Exercise and Sale | 17,97 - 89,56 | 160,00 | - |
| 2026-03-01 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | 820,00 | 0,00 | Derivative Exercise and Retained Stock | - | 4,25k | 23,89% |
| 2026-03-01 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -342,00 | 32,47k | Derivative Exercise and Sale | 94,94 | 4,25k | - |
| 2026-03-02 | Mr. Hunter C. SmithCFO & Treasurer | 6,10k | 41,47k | Derivative Exercise and Retained Stock | 6,80 | 116,61k | 5,52% |
| 2026-02-17 | Mr. Hunter C. SmithCFO & Treasurer | -7,95k | 805,81k | Automatic Disposition | 99,42 - 103,84 | 110,51k | -6,71% |
| 2026-02-14 | Mr. Yann MazabraudExec. VP & Head of International | 10,00k | 0,00 | Derivative Exercise and Retained Stock | - | 53,16k | 23,17% |
| 2026-02-10 | Mr. Hunter C. SmithCFO & Treasurer | -7,07k | 708,58k | Automatic Disposition | 96,26 - 104,76 | 118,47k | -5,63% |
| 2026-02-04 | Mr. Hunter C. SmithCFO & Treasurer | -6,63k | 702,74k | Automatic Disposition | 104,74 - 107,67 | 125,54k | -5,01% |
| 2026-02-01 | Mr. Yann MazabraudExec. VP & Head of International | 5,50k | 0,00 | Derivative Exercise and Retained Stock | - | 43,16k | 14,61% |
| 2026-02-01 | Mr. Hunter C. SmithCFO & Treasurer | 15,25k | 0,00 | Derivative Exercise and Retained Stock | - | 132,17k | 13,04% |
| 2026-02-01 | Mr. Hunter C. SmithCFO & Treasurer | -10,75k | 1,17M | Derivative Exercise and Sale | 108,99 | 132,17k | - |
| 2026-02-01 | Dr. David P. MeekerChairman, President & CEO | 37,19k | 0,00 | Derivative Exercise and Retained Stock | - | 239,02k | 18,43% |
| 2026-02-01 | Dr. David P. MeekerChairman, President & CEO | -31,52k | 3,44M | Derivative Exercise and Sale | 108,99 | 239,02k | - |
| 2026-02-01 | Mr. Joseph ShulmanChief Technical Officer | 10,46k | 0,00 | Derivative Exercise and Retained Stock | - | 18,97k | 122,94% |
| 2026-02-01 | Mr. Joseph ShulmanChief Technical Officer | -6,51k | 709,20k | Derivative Exercise and Sale | 108,99 | 18,97k | - |
| 2026-02-01 | Ms. Jennifer LeeExec. VP & Head of North America | 13,38k | 0,00 | Derivative Exercise and Retained Stock | - | 19,23k | 228,32% |
| 2026-02-01 | Ms. Jennifer LeeExec. VP & Head of North America | -9,24k | 1,01M | Derivative Exercise and Sale | 108,99 | 19,23k | - |
| 2026-02-01 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | 2,48k | 0,00 | Derivative Exercise and Retained Stock | - | 3,43k | 258,35% |
| 2026-02-01 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -1,14k | 124,03k | Derivative Exercise and Sale | 108,99 | 3,43k | - |
| 2026-02-01 | Dr. Alastair GarfieldChief Scientific Officer | 4,64k | 0,00 | Derivative Exercise and Retained Stock | - | 7,76k | 148,34% |
| 2026-02-01 | Dr. Alastair GarfieldChief Scientific Officer | -2,03k | 220,81k | Derivative Exercise and Sale | 108,99 | 7,76k | - |
| 2026-02-01 | Ms. Pamela J. CramerChief HR Officer | 8,56k | 0,00 | Derivative Exercise and Retained Stock | - | 29,38k | 41,14% |
| 2026-02-01 | Ms. Pamela J. CramerChief HR Officer | -4,73k | 515,63k | Derivative Exercise and Sale | 108,99 | 29,38k | - |
| 2025-12-11 | Ms. Pamela J. CramerChief HR Officer | -3,35k | 280,23k | Derivative Exercise and Sale | 27,35 - 111,00 | 20,81k | - |
| 2025-11-20 | Ms. Pamela J. CramerChief HR Officer | -3,35k | 260,13k | Derivative Exercise and Sale | 27,35 - 105,00 | 20,81k | - |
| 2025-11-07 | Ms. Pamela J. CramerChief HR Officer | -22,87k | 2,00M | Derivative Exercise and Sale | 6,80 - 100,00 | 20,81k | - |
| 2025-10-30 | Mr. Joseph ShulmanChief Technical Officer | -9,75k | 824,52k | Derivative Exercise and Sale | 30,66 - 115,24 | 8,51k | - |
| 2025-10-28 | Mr. Joseph ShulmanChief Technical Officer | -2,82k | 244,37k | Derivative Exercise and Sale | 27,35 - 115,01 | 8,51k | - |
| 2025-10-16 | Mr. Joseph ShulmanChief Technical Officer | -14,44k | 1,18M | Derivative Exercise and Sale | 27,35 - 112,81 | 8,51k | - |
| 2025-09-02 | Mr. Joseph ShulmanChief Technical Officer | -16,78k | 1,26M | Derivative Exercise and Sale | 27,35 - 105,30 | 8,51k | - |
| 2025-08-21 | Mr. Joseph ShulmanChief Technical Officer | -4,19k | 304,55k | Derivative Exercise and Sale | 27,35 - 100,07 | 8,51k | - |
| 2025-08-12 | Mr. Hunter C. SmithCFO & Treasurer | -28,09k | 2,51M | Derivative Exercise and Sale | 6,88 - 96,33 | 116,92k | - |
| 2025-08-12 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -1,50k | 99,92k | Derivative Exercise and Sale | 17,97 - 95,00 | 922,00 | - |
| 2025-08-11 | Mr. Joseph ShulmanChief Technical Officer | -3,98k | 331,80k | Derivative Exercise and Sale | 6,80 - 90,08 | 8,51k | - |
| 2025-07-26 | Ms. Pamela J. CramerChief HR Officer | 1,61k | 0,00 | Derivative Exercise and Retained Stock | - | 20,81k | 8,36% |
| 2025-07-26 | Ms. Pamela J. CramerChief HR Officer | -1,52k | 130,61k | Derivative Exercise and Sale | 85,93 | 20,81k | - |
| 2025-07-09 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -2,85k | 148,24k | Derivative Exercise and Sale | 17,97 - 85,00 | 922,00 | - |
| 2025-07-09 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -967,00 | 82,20k | Automatic Disposition | 85,00 | 922,00 | -51,19% |
| 2025-07-09 | Mr. Joseph ShulmanChief Technical Officer | -7,97k | 565,66k | Derivative Exercise and Sale | 6,80 - 80,00 | 8,51k | - |
| 2025-07-09 | Mr. Hunter C. SmithCFO & Treasurer | -42,12k | 3,10M | Derivative Exercise and Sale | 6,88 - 84,50 | 116,92k | - |
| 2025-07-09 | Ms. Pamela J. CramerChief HR Officer | -15,57k | 991,91k | Derivative Exercise and Sale | 6,80 - 80,00 | 19,21k | - |
| 2025-07-07 | Mr. Hunter C. SmithCFO & Treasurer | 6,99k | 48,06k | Derivative Exercise and Retained Stock | 6,88 | 116,92k | 6,36% |
| 2025-07-01 | Dr. Alastair GarfieldChief Scientific Officer | 3,13k | 0,00 | Derivative Exercise and Retained Stock | - | 3,13k | - |
| 2025-07-01 | Dr. Alastair GarfieldChief Scientific Officer | -1,32k | 85,48k | Derivative Exercise and Sale | 64,60 - 64,81 | 3,13k | - |
| 2025-06-18 | Mr. Edward T. MathersInsider | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 12,77k | 45,60% |
| 2025-06-18 | Mr. Christophe R. JeanIndependent Director | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-18 | Ms. Jennifer L. GoodIndependent Director | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-18 | Dr. Camille L. BedrosianInsider | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-18 | Mr. Stuart A. ArbuckleIndependent Director | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-18 | Mr. David W. J. McGirrIndependent Director | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-18 | Ms. Lynn A. TetraultIndependent Lead Director | 4,00k | 0,00 | Derivative Exercise and Retained Stock | - | 7,00k | 133,33% |
| 2025-06-10 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -1,07k | 52,62k | Derivative Exercise and Sale | 17,97 - 67,19 | 1,89k | - |
| 2025-06-10 | Mr. Christopher P. GermanCorporate Controller & Principal Accounting Officer | -1.000,00 | 67,19k | Automatic Disposition | 67,19 | 1,89k | -34,61% |
| 2025-06-06 | Ms. Pamela J. CramerChief HR Officer | -7,03k | 430,62k | Derivative Exercise and Sale | 6,80 - 68,05 | 19,21k | - |