TIDMKING 
 
IGRAINE PLC 
 
                                  AQSE: KING 
 
                         ("Igraine" or the "Company") 
 
                   Audited Final Results to 31 December 2020 
 
STRATEGIC REPORT 
 
PRINCIPAL ACTIVITIES 
 
The Company's principal activity is that of an investment company listed on the 
Access Segment of the AQSE Growth Market (formerly the NEX Exchange Growth 
Market) with trading symbol AQSE:KING 
 
Since June 2017, the Company's investment strategy has been focused on the 
service and technology sectors, including products related to social or life 
enhancement. 
 
Following the restructuring process concluded in September 2020 and the 
appointment of Brian Jones as Non-Executive Chairman, the Company has continued 
to support its existing investments, focused on the service and technology 
sectors (including products related to social or life enhancement), with a view 
to achieving exits where opportunities arise. The Company will narrow the focus 
of its investment strategy going forward, to target businesses and companies 
where the opportunity exists to develop complementary services that support the 
NHS in delivering high quality, patient focused, integrated care. 
 
It is intended that the Company will, invest through a number of financial 
instruments including but not limited to; secured convertible loan notes, 
equity and to acquire shareholdings in UK based or overseas companies whose 
managements are proposing to seek a stock market quotation in the short/medium 
term, although the acquisition of minority interests in companies already 
admitted to the AIM Market of the London Stock Exchange or the AQSE Growth 
Market will not necessarily be precluded. The Directors will also consider 
investment opportunities where the natural exit strategy will be through a 
trade sale. 
 
In April 2021, the Company began to conduct a recapitalisation and restructure 
welcoming new Directors, investment and adopting a revised investment policy, 
focusing on the med-tech industry. Please refer to the Directors Post Year End 
Review for full detail. 
 
REVIEW OF BUSINESS 
 
During the year to 31 December 2020 the Company made a loss before amortisation 
of preference shares of £560,573 (31 December 2019: loss of £2,798,129). 
Following Meetings of both classes of Shareholders the Company's preference 
shares were converted into ordinary shares on 26 September 2020. This resulted 
in a write back to reserves of £4,548,821. During the year there was a charge 
of £278,980 (31 December 2019: £557,959) in respect of amortisation of the 
preference shares which was required up to date of conversion. In addition, 
there was a charge of £418,087 crystallised on the conversion of the shares. 
 
As at 31 December 2020, the Company had net liabilities per share totalling 
0.01p (2019: 0.55p) 
 
Wallet Ads 
 
On 2 January 2019 the Company announced that £150,000 of secured convertible 
loan notes ("Loan Notes") had been converted into equity representing 20% of 
the ordinary share capital of Wallet Ads. 
 
Wallet Ads owns and operates a mobile engagement platform that combines mobile 
wallet passes (Apple Wallet / Google Pay), HTML5 web and social media 
(Facebook, Twitter, WhatsApp) technologies to enable brands to deliver digital 
vouchers or passes direct to consumers' smartphones. Wallet Ads became revenue 
generating in the latter half of 2019, although progress was mostly linked to 
test campaigns. 
 
Further development of the platform stalled in 2020 due to the limited working 
capital available to Wallet Ads with it requiring further investment. The 
Company will not be providing further investment to Wallet Ads and The 
Directors continue to monitor this investment, consider it non-core and will 
seek to materialise value from the investment position. 
 
 
Rapid Nutrition 
 
In early January 2020 the Company received the final repayment of the loan 
monies previously advanced to Rapid Nutrition Plc ("Rapid"), a natural 
healthcare company focused on the research, development and production of a 
range of life science products. Rapid is presently listed on the SIX Swiss 
Exchange, Zurich, and has also applied for the dual admission of its existing 
issued shares to the OTCQB listing segment of the OTC Market. 
 
As part of negotiations in recovering the loan in full the Company agreed to 
forgo any remaining costs and interest due on the loan in exchange for 232,010 
fully paid shares, in addition to 250,000 fully paid ordinary shares previously 
accepted in lieu of interest due on the loan. 
 
The Company's shareholding in Rapid represents a 0.8% holding. Rapid's share 
price was USD 0.138 at 31 December 2020 with the movement in the share price 
leading to a fair value loss of £3,132 in the year. 
 
XMG 
 
We reported in 2017 that we had provided a loan facility, to X Markets Group 
Limited ("XMG"). XMG seeks to provide non-bank liquidity offering executable 
prices for a variety of mainly spot products which includes CFDs, FX, futures 
and equities. It streams prices to its clients who are forex and CFD brokers as 
well as tier-1 & tier-2 banks, brokers and other financial institutions (and 
exchanges) for their own clients' order execution. 
 
The Company continues to work with the director of XMG, who previously reported 
ongoing delays in securing funding needed to commence trading. This has 
continued to be the case in 2020. 
 
The balance of the loan to XMG at 31 December 2020 was £178,776 of which £ 
100,000 is secured by way of a personal guarantee provided by the director of 
XMG. Having reviewed this investment and in light of the developments during 
2020 The Directors consider the full provision made against this loan in 2019 
to continue to be appropriate although the Company will continue to seek to 
recover this balance. 
 
 
One Media 
 
In 2013 the Company invested in One Media (OME). Following numerous attempts to 
support the officers of OME in their efforts to stabilise the business, 
ultimately OME was unable to secure additional funding to re-energise that 
business. In late 2019 the SEC suspended trading in OME and since that time the 
Directors have sought to refinance the business. In December 2020 they advised 
that their efforts had proved fruitless, partially affected by the difficulties 
caused by the COVID-19 crisis, and they had collectively stepped down. OME is 
now in the hands of the SEC who are likely to dissolve it in due course. Any 
monies due from this investment were fully written off as at 31 December 2020. 
 
 
Just Bee Drinks 
 
On the 10 April 2019 the Directors of Igraine PLC announced that the Company 
had agreed to subscribe £150,000 for 1,840,000 Ordinary A shares in Just Bee 
Drinks Limited ("Just Bee"). This investment, which formed part of a total 
equity fund raise of £292,000, represented an equity stake of 9.14% in Just Bee 
following completion of this funding round. In addition, Igraine PLC  agreed to 
provide a working capital loan to Just Bee supported by a first ranking fixed 
and floating debenture over the assets of Just Bee Drinks Ltd. To date this 
facility has not been called upon. 
 
At the time of the investment, Just Bee produced a 100% natural juicy water 
drink, sweetened with a drop of honey. The brand was developed by beekeepers 
and also has a social and ethical mission to protect bees, helping to plant 
bee-friendly wildflower patches across the UK, with 5 million flowers planted 
to date. 
 
 
During 2020, the Covid-19 crisis saw a significant impact on sales as key 
customers streamlined their product lines. After significant Board discussions 
it was decided that the company was to close down its drinks production and 
that they were to be replaced by a new range of vitamin honey products. Since 
this change in strategic direction, early sales show indications of promise but 
the change in operational direction from point of original investment has 
altered the company's ability to materialise value from this investment and the 
company are not considering future investment by way of equity or debt. The 
Board have reviewed this investment and in light of these developments in 
conjunction with the latest accounts and are of the view that this investment 
should be written down to £15,113 at 31 December 2020. 
 
ASSIF 
 
The Directors of Igraine announced in May 2019 that the Company agreed to 
subscribe for up to £150,000 0% fixed rate secured convertible loan notes 
("Notes") issued by ASSIF Limited ("ASSIF"), a company that is developing a 
digital product related to employees' mental health. The loan was to be 
provided in two equal sums, the second due when certain conditions were met and 
are supported by a first ranking legal charge over the assets of ASSIF. 
 
The conversion will be for a maximum of 35% of the ordinary equity share 
capital of ASSIF, which will be reduced by 5% of the ordinary equity share 
capital in respect of a number of key milestones achieved prior to conversion 
to a minimum of 15%. 
 
ASSIF is a mental health and wellness platform. It will primarily be a 
community for peer to peer support for people worried about mental health. 
Within the platform will be tools to help individuals with their mental health, 
including gamification and breathing videos. ASSIF is using cutting edge 
technology to deliver said tools and will have a consumer application and a 
business to business platform. 
 
COVID - 19 has caused a number of inevitable delays to the early development of 
the platform although discussions with key major institutions, targeted as 
early adopters of the platform, continue to be constructive. In addition, the 
delay in executing the previous plan for the platform and continuing 
discussions with potential early adopters have seen the platform change 
significantly from what was originally planned. During the year ASSIF 
identified the need for substantial further pre revenue investment and stated 
their intention to repay the loan plus interest and costs. Discussions are 
continuing at this time. 
 
The Board have therefore reviewed this financial asset and have estimated that 
its fair value at 31 December 2020 was equal to cost. The primary justification 
for this is the fact that nothing has been noted to suggest that the fair value 
has fallen to below cost since the convertible loan notes were purchased and 
the business has continued to progress with its aims for the year. 
 
CAPITAL REORGANISATION 
 
On 18 June 2020, the Company entered into a framework agreement with Brian 
Jones under which he provided £30,000 of funding in the form of convertible 
loan notes and, subject to the conversion of the preference shares then in 
issue to ordinary shares, was to provide a further £20,000 of funding which 
would result in him holding 29.90% of the ordinary shares capital of the 
Company following the conversion of both the loan notes and the preference 
shares. This was completed on 29 September 2020. 
 
POST-YEAR REVIEW 
 
Due to a late filing of the Company's final results for the Year Ending, 30 
December 2019, the Company's shares were suspended in 2020. 
 
On 26 April 2021, the Company completed a recapitalisation and Board change, 
introducing new Directors, Mr Simon Grant-Rennick and Mr Burns Singh 
Tennent-Bhohi. After the Company's Annual General Meeting held on 26 April 
2021, Mr Brian Jones & Mr Kenneth Hillen resigned from the Board of Directors. 
 
The injection of new capital and Directors enabled the Company to review its 
existing financial position, its underlying assets and consider how best to 
progress and create value for shareholders of the Company. I am pleased to 
report that on 11 June 2021, the Company announced and posted a Circular to 
convene a General Meeting to approve proposals and resolutions to create a 
premier MedTech and biotech investment company that includes a conditional 
brokered financing for gross proceeds of, £2,000,500. 
 
As at date of this report the Company confirms that the resolutions and 
proposals put to the shareholders of the Company were duly passed. 
 
On 28 July 2021 the Company changed its name to Igraine PLC. 
 
The Financing 
 
£2,000,500 (gross proceeds) through the issue of, 77,519,230 new ordinary 
shares at a subscription price of, £0.025807 which is considered to have put 
the Company in a robust financial position. 
 
Change of Corporate Advisor 
 
The company appointed Peterhouse Capital Limited as the company's Corporate 
Advisor & Corporate Broker 
 
BOARD ADDITIONS 
 
Sir Professor Christopher Evans (aged 63) - Executive Chairman 
 
Professor Sir Christopher Evans is the founder and Chairman of Excalibur Group 
and a renowned scientist and highly successful entrepreneur with numerous 
prestigious awards and medals for his work over the last 30 years during which 
time he has built more than 50 medical companies from start-up and floated 20 
new medical businesses on stock markets in six different countries. He has 
created 11 successful academic spin-outs and companies worth over $2.4 billion, 
and has raised $2.6 billion from disposals. He directed the raising of 
approximately $450 million for Merlin Biosciences Funds and $2.6 billion from 
disposals including the sale of BioVex Group, Inc. to Amgen Inc. and Piramed 
Limited to Roche Group. Through Merlin Ventures Limited, he co-founded and 
advised Biotech Growth Trust plc. Arakis Limited, one of the companies 
developed by him was sold to Sosei Co. Ltd for $187 million. He has founded 
notable companies such as Chiroscience, Celsis, ReNeuron, Vectura, Biovex and 
Merlin Biosciences Ltd. Appointed an OBE in 1995 for services to medical 
bioscience he was knighted in 2001 for services to bioscience and enterprise. 
Latterly he was founder of Arix Bioscience plc (LSE:ARX), of the oncology 
specialist Ellipses Pharma Limited and of Excalibur Healthcare Services Ltd. 
 
Stephen "Steve" David Winfield (aged 28) - Executive Director 
 
Stephen Winfield is currently the commercial director and a board director of 
Excalibur Healthcare Services Ltd.  He has a track record of building, 
financing and selling various businesses from the ground up.  His experience 
spans 9 years in building and managing teams across the technology, food and 
beverage and healthcare sectors, primarily alongside Professor Sir Christopher 
Evans OBE. 
 
He has managed over £170m of transactions acting as a director of various 
companies and helped raise in excess of £20m to date for private businesses 
in the UK. More recently Stephen has been advising Scoffs Group (UK's largest 
Costa Coffee franchisee). 
 
Martin Walton (aged 57) - Executive Director 
 
Martin Walton is currently Chairman and CEO, Bradshaw Consulting Ltd, a 
Strategic Advisory group assisting companies and shareholders in creating, 
generating and realising value from investments in life sciences and tech 
sectors. In 2020 he set up and now manages Excalibur Medicines Ltd to develop 
the AZD1656. He is a director of Interrad Medical, a Minneapolis-based MedTech 
company. 
 
Previously he was Vice Chairman of Simbec-Orion Group a specialist CRO which he 
sold to private equity for a 3x return. He has been Executive Chairman of Iota 
Sciences Ltd, a spin-out from Oxford University with revolutionary technology 
in microfluidics. With Professor Sir Chris Evans he assisted in founding Arix 
Bioscience in 2016 and listed it on the LSE in 2017. He was co-founder and CEO 
of Arthurian Life Sciences Ltd, the manager of the top-decile Wales Life 
Sciences Investment Fund, an innovative hybrid of private and public equity. He 
was CEO of Excalibur Group 2010 - 2016, and CEO of both Excalibur Fund Managers 
(Life Sciences VC / PE fund manager) and Excalibur Healthcare Services 
(provision of healthcare services and facilities).  Prior to this he had a 
highly successful 25 year career in investment banking and investment 
management. 
 
Burns Singh Tennent-Bhohi (aged 28) - Non-Executive Director 
 
Burns Singh Tennent-Bhohi is the founder & CEO of The Glenpani Group, an 
international private venture capital business based in London/UK. Glenpani's 
principal activity is the evaluation and augmentation of distressed-asset 
opportunities and private-transaction/investment origination. Glenpani Group 
cornerstone-invest, originate transactions and provide corporate consultancy to 
international companies both private and public including; AQSE, AIM, TSX-V, 
CSE & ASX. 
 
Burns assumes a number of directorships of both private and public companies 
and his current appointments in public interest companies include: Chairman of 
Oscillate plc (AQSE: MUSH), CEO and a Director of, Evrima plc (AQSE: EVA), 
Director of Igraine plc (AQSE: KING) and Director of Globe Capital Ltd (AQSE; 
GCAP) and have included: Forum Energy Metals Corp. (TSX-V: FMC), in 2019 FMC 
executed a $30,000,000 project earn-in agreement with Rio Tinto on its Janice 
Lake sedimentary copper project and a $6,000,000 project earn-in with Orano & 
the CEO and a Director of IamFire plc (AQSE: FIRE) 
 
Active in North American capital markets, Burns is also the founder of LC, a 
specialised private investment vehicle that syndicates and connects global 
capital investment for private transaction origination & pre-IPO opportunities. 
Glenpani Group maintains an extensive international network that includes 
corporate brokers/financiers, investment bankers, merchant banks, UHNWIs, 
project financiers, asset-banks and technical teams. Burns graduated from the 
University of Glasgow with a degree in Economics/Social Sciences. 
 
Simon Grant-Renncik (aged 64)- Non-Executive Director 
 
Simon graduated from the Camborne School of Mines (BSc Mining Engineering 
[Hons], ACSM) and has been actively involved in the mining and metal trading 
industry for over 30-years. During this time Simon has served Board & 
Management roles for both private and public (LSE, ASX, AQSE) entities 
globally. 
 
Simon has extensive experiences in the industrial and non-ferrous metal 
industry which includes a successfully operating Falconbridge Internationals 
non-ferrous trading arm. 
 
Simon maintains a number of Board & Management Roles across industries 
including; agriculture, property, technology & the mining sector, including; 
All Active Asset Capital Ltd (AIM: AAA), U.K. Spac plc (AIM: SPC), Evrima plc 
(AQSE: EVA), Globe Capital (AQSE: GCAP) and was most recently the Executive 
Chairman of Quetzal Capital plc (AQSE: QTZ). 
 
Adoption of New Investment Policy 
 
The Company's business strategy will be to source and develop breakthrough 
innovative technologies and commercially attractive discoveries in the 
healthcare and life science sector worldwide. The proposed Co-Investment 
Agreement will give the Company privileged access to attractive opportunities 
which have been sourced, selected and subjected to due diligence by sector 
experts. 
 
Its objective will be to develop and commercialise these opportunities to 
provide attractive returns to its investors. The Company will do this through 
the sourcing and identification of promising technologies, the arrangement of 
appropriate financing for those technologies and experienced management 
oversight of the structured development of the technologies and, ultimately, 
their commercialisation. 
 
The Company will execute its strategy by sourcing world class innovation from a 
rich pipeline of opportunities. The pipeline of opportunities will be derived 
from four key sources: 
 
? personal and professional networks - the newly appointed Directors and senior 
leadership team bring high quality and extensive networks of personal, 
professional and industry contacts (including an extensive network of 
scientists and key opinion leaders in medicine both inside and outside 
pharmaceutical corporates). In particular, such extensive networks provide 
opportunities to pursue relationships with pharmaceutical companies which are 
both a potential source of innovative opportunities and as potential acquirers; 
 
? academia - contacts developed over many years with leading universities and 
other academic and research institutions globally provide direct access to 
innovative technologies, ahead of third parties; 
 
? the professional adviser market - links with Peterhouse Capital and others 
ensure we will see opportunities before the broader investor market will; and 
 
? fund managers - the newly appointed Directors maintain close relationships 
with fund managers who can provide a source of innovative opportunities. 
 
The new Executive Team will make such opportunities subject to a rigorous 
evaluation process. Initially there will be a high level assessment where the 
following criteria are considered: 
 
 a. does the technology have a potential market; 
 b. are there any competing technologies known to be under development; 
 c. at what stage of development is the technology; 
 d. basic assessment of intellectual property rights; and 
 e. vetting of the team or the business owning and managing the technology. 
 
 
More detailed assessment will follow, typically after having entered a 
confidentiality agreement to review more substantial information in relation to 
proprietary technology. This would involve a direct consultation with the 
inventor(s), and technical and scientific validation by the Company's proposed 
consultants.to ascertain the following: 
 
 a. whether the technology has breakthrough quality; 
 b. if the scientific base of the proposal is sound; 
 c. ownership of intellectual property rights in relation to the technology 
    (including patentability, "freedom to operate" and identifying if any third 
    party intellectual property rights are necessary for the further 
    development and ultimate commercialisation of the innovation); 
 d. assessment of the suitability of the development of the technology from a 
    regulatory perspective (in particular whether there are any potential 
    reasons for refusing the licensing of a product candidate); and 
 e. to identify the requirements and approximate timing of achieving 
    commercialisation. 
 
If these pass muster then a final stage of due diligence would be undertaken to 
ascertain the available options to acquire an interest in the opportunity. 
Should an opportunity be available then a final stage is completed as follows: 
 
 a. legal due diligence as to intellectual property rights, including 
    ownership, restrictions to operations and licence arrangement, corporate 
    governance and existing financing arrangements; 
 b. clinical due diligence as to robustness and fitness for purpose of the 
    clinical trials and the suitability of the CRO; any ethical and regulatory 
    issues, requirements for permits and consents; - feasibility of key 
    milestone achievement (such as a product candidate approval by relevant 
    regulatory agencies) within pre-defined time frames and appropriateness of 
    the proposed endpoints; and targeted disease indication; 
 c. commercialisation potential as to availability or achievability of CMC for 
    Investigational New Drug applications (INDs) and New Drug Applications 
    (NDAs); projected cost and location of product manufacturing; access to 
    market and size of potential market; product pricing and projected time and 
    rate of return on development costs; availability of one or more highly 
    innovative product candidates, products or proprietary technologies 
    targeting a significant medical and/or commercial need; and - presence of 
    foreseeable sustainable competitive advantages; 
 d. financing arrangements as to adequacy of existing finance; assessment of 
    financial strength of investors; and availability of funding 
 e. quality of the scientific and management credentials of the team 
 f. examination and possible adaptation of appropriate development plan and 
    business plan. 
 
Igraine completed Co-Investment Rights with Excalibur Healthcare 
 
On 28 June 2021, following the resolutions being passed at the company's AGM, 
Excalibur Healthcare Services granted the Company rights to co-invest in all 
healthcare and life-science investment opportunities sourced or invested into 
by Excalibur Healthcare Services. As consideration for the granting to the 
Company of these co-investment rights, and the purchase of the 2% stake in 
Excalibur Medicines Ltd ("EML"), the Company has agreed to pay the vendors the 
following consideration; 
 
  * £600,000 in cash, plus 
  * £500,000 of new Deferred Shares in the Company at an issue price of 5p per 
    share (approximately 2x the placing price). These Deferred Shares will not 
    be admitted to trading on Aquis, will be non-transferable, and will have no 
    rights attached. They will be cancelled on the 6-month anniversary of issue 
    unless, within 30 calendar days of the publication of the results of the 
    trial of the AZD1656 drug, the Board of Igraine PLC, at its sole 
    discretion, unanimously agree that the trial has been a success and thus 
    consent to the immediate conversion of all Deferred Shares into the 
    equivalent number of new ordinary shares in the Company. 
 
ABOUT EML INVESTMENT 
 
EML has secured exclusive rights to and owns the patents on a drug, AZD1656, 
which is being developed as a potential therapeutic for diabetics suffering 
from COVID-19. As there are very few new therapeutics in development for 
COVID-19 and associated virally transmitted diseases (most research is in 
combining existing treatments) this has the potential to be highly attractive 
to big pharma and biotech buyers. Further, if the trials are successful, it is 
likely the drug will be effective for the general population in Covid -19 and 
in other respiratory diseases. The results of the Phase 2 trials of the drug - 
the ARCADIA trial - to assess the safety and efficacy of AZD1656 in 150 
patients with either Type 1 or Type 2 diabetes who have been hospitalised with 
COVID-19, were released on the 9 September 2021: 
 
Results from ARCADIA Phase II Clinical Trial of a Potential Therapy for 
COVID-19 
 
St George Street Capital, a UK-based biomedical charity, and Excalibur 
Medicines Ltd., a biotechnology investment company, are pleased to announce the 
receipt of the final data from the ARCADIA Phase ll clinical trial which was 
conducted to assess a therapy that could treat diabetic patients suffering from 
COVID-19. 
 
In light of the encouraging trial results, St George Street Capital and 
Excalibur will immediately start to undertake commercial discussions with 
potential licensees and/or fundraise for further clinical trials to investigate 
AZD1656 in a larger study. Further analysis to determine the precise nature of 
the biological effects of AZD1656 that explain the observed clinical outcomes 
will also be conducted. 
 
The trial data has shown the following: 
 
Efficacy: 
 
A strong trend towards reduced mortality in patients receiving AZD1656. This 
was noted in both mortality on treatment and all-cause mortality, which were 
lower in the AZD1656 group compared to the placebo group. The strong trend to 
improved mortality for patients on AZD1656 was observed on top of patients 
receiving other medication, including dexamethasone, as part of standard of 
care. Certain clinically and biochemically defined subsets of patients appeared 
to benefit most from treatment with AZD1656. The data from ARCADIA supports 
continued investigation of AZD1656 for the treatment of patients with COVID-19, 
with or without diabetes, in future clinical trials. 
 
Safety and Tolerability: 
 
AZD1656 was shown to be well-tolerated in this patient population with no 
serious adverse reactions (SARs) occurring. The degree of glycaemic control, as 
measured by the need to increase baseline medication requirements or the need 
to add additional diabetic medications, was no different between the AZD1656 
group and the placebo group. The proportion of Serious Adverse Events (SAEs) 
was numerically lower in the AZD1656 group compared with the placebo group. The 
proportion of Treatment Emergent Adverse Events (TEAE) was also no different 
between the groups. Overall no safety concerns were identified regarding the 
use of AZD1656 in this patient population. 
 
Diabetes, whether type 1 or 2, has been the leading single cause of 
co-morbidity during the pandemic and one in three of all deaths with COVID-19 
in hospital in England have been associated with diabetes. 
 
About the ARCADIA Trial 
 
AZD1656 was identified by St George Street Capital as a potential treatment for 
people with diabetes infected with COVID-19. 
 
The objectives of the ARCADIA clinical trial were to assess the safety and 
tolerability of a glucose kinase activator, AZD1656, and to determine the 
effect of the therapy on clinical improvement and mortality in people with 
diabetes hospitalised with COVID-19. The trial also explored whether AZD1656 
benefits COVID-19 patients via its effects on immune function. 
 
ARCADIA was a randomised, double-blind, placebo-controlled Phase II clinical 
trial involving 153 patients. The clinical trial was arranged and structured by 
Professor Sir Chris Evans, Chairman and CEO of Excalibur Healthcare Services, 
through its subsidiary, Excalibur Medicines Ltd. Sir Chris worked closely with 
Professor John Martin and his team at St George Street, a UK-based biomedical 
research charity, which secured the initial project and permission to run the 
trial from AstraZeneca. 
 
As at date of this report, the Company has a well capitalised treasury, newly 
constructed investment policy and has welcomed Directors that have been at the 
forefront of innovation and value creation in the MedTech, life sciences and 
biotech industries. 
 
Dividends 
 
The Directors do not propose a dividend in respect of the year ended 31 
December 2020 (2019: nil). See note 19 for commentary on the dividends payable 
in respect of the preference shares issued in previous years by the Company. 
 
The Directors of the Company accept responsibility for the contents of this 
announcement. 
 
On behalf of the Board 
 
Simon Grant Rennick 
Non-Executive Director 
On Behalf of the Board 
21 December 2021 
 
 
 
Enquiries 
 
Company: 
 
Martin Walton (Executive Director) 
Steve Winfield (Executive Director) 
 
AQSE Growth Market Corporate Adviser 
 
Peterhouse Capital Limited 
Guy Miller / Mark Anwyl 
Tel: +44 (0) 207 469 0930 
 
Media inquiries: 
 
Ramsay Smith, Media House International 
ramsay@mediahouse.co.uk: +44 (0) 7788414856 
 
 
 
STATEMENT OF COMPREHENSIVE INCOME 
 
 
                                                                        2020          2019 
                                                                           £             £ 
 
Revenue                                                                    -             - 
 
Cost of sales                                                              -             - 
 
Gross profit/(loss)                                                        -             - 
 
Other operating income                                                61,556        47,000 
 
Administrative expenses                                            (294,084)     (229,160) 
 
Loss before investment activities                                  (232,528)     (182,160) 
 
Fair value decrease in investments                                 (147,033)     (923,365) 
 
                                                                           -      (11,095) 
Foreign exchange gain/loss 
 
                                                                    (41,229)   (1,626,367) 
Impairment of loans and trade receivables 
 
                                                                      23,657       271,759 
Interest income 
 
                                                                   (163,450)     (326,900) 
Interest payable at 7.1% on preference shares 
 
                                                                   (560,583)   (2,798,129) 
Loss before amortisation of preference shares 
 
 
Conversion of Preference shares to Ordinary                        4,548,821             - 
shares 
 
                                                                   (697,067)     (557,959) 
Amortisation of preference shares 
 
                                                                   3,291,171   (3,356,088) 
Profit/(Loss) before taxation 
 
Taxation                                                                   -             - 
 
                                                                   3,291,171   (3,356,088) 
Profit/(Loss) for the period 
 
Other comprehensive income                                                 -             - 
 
Total comprehensive income attributable to equity                  3,291,171   (3,356,088) 
holders of the company 
 
Earnings per share for profit attributable to the 
equity shareholders 
 
Basic earnings per ordinary share (p)                                  0.109       (0.123) 
 
Diluted earnings per ordinary share (p)                                0.107       (0.123) 
 
 
There are no recognised gains and losses other than those passing through the 
income statement. 
 
 
 
STATEMENT OF FINANCIAL POSITION 
 
                                                                    2020        2019 
                                                                       £           £ 
 
Assets 
 
Non-current assets 
 
Property, plant and equipment                                      1,048         913 
 
Investments at FVTPL                                              15,113     154,014 
 
 
                                                                  16,161     154,927 
 
Current assets 
 
Short term investments at FVTPL                                   48,201      28,553 
 
Trade and other receivables falling due within one               115,784     208,881 
year 
 
Cash and cash equivalents                                          7,812          56 
 
 
                                                                 171,797     237,490 
 
 
Total assets                                                     187,958     392,417 
 
Equity and liabilities 
 
Equity 
 
Issued share capital                                             554,616      71,008 
 
Share premium                                                     26,818           - 
 
Retained earnings                                              (678,711) (3,969,882) 
 
 
                                                                (97,277) (3,898,874) 
 
 
Non-current liabilities 
Loans and borrowings                                              50,000   3,907,208 
 
Current liabilities 
 
Trade and other payables                                         235,235     384,083 
 
 
Total liabilities                                                285,235   4,291,291 
 
 
Total equity and liabilities                                     187,958     392,417 
 
 
Approved by the Board for issue on 21 December 2021 
 
Mr Simon Grant-Rennick 
 
Non-Executive Director 
 
 
 
STATEMENT OF CHANGES IN EQUITY 
 
                                           Share        Share     Retained 
                                         Capital      Premium     Earnings        Total 
                                               £            £            £            £ 
 
Balance at 31 December 2018               71,008            -    (613,794)    (542,786) 
 
Loss for period                                -            -  (3,356,088)  (3,356,088) 
 
Other comprehensive income for the             -            -            -            - 
year 
 
Total comprehensive income for the             -            -  (3,356,088)  (3,356,088) 
year 
 
Balance at 31 December 2019               71,008            -  (3,969,882)  (3,898,874) 
 
Profit for period                              -            -    3,291,171    3,291,171 
 
Other comprehensive income for the             -            -            -            - 
year 
 
Total comprehensive income for the             -            -    3,291,171    3,291,177 
year 
 
Issue of Ordinary Shares                   6,525       26,818            -       33,343 
 
Issue of A Deferred Shares                56,807            -            -       56,807 
 
Issue of B Deferred Shares               420,276            -            -      420,276 
 
Balance at 31 December 2020              554,616       26,818    (678,711)     (97,277) 
 
 
 
STATEMENT OF CASH FLOWS 
 
 
                                                                     2020        2019 
                                                                        £           £ 
 
Cash flow from operating activities 
 
Net cash outflow from operating activities                A     (140,468)   (181,338) 
 
Cash flows from investing activities 
 
Purchase of plant, property and equipment                           (591)       (913) 
 
Purchase of non-current investments                                     -   (243,415) 
 
Increase in loan payable                                           50,000           - 
 
Increase in short term investments                                      -           - 
 
Decrease in loan receivables                                       48,815   (902,711) 
 
Net cash outflow from investing activities                         98,224 (1,147,099) 
 
Cash flow from financing activities 
 
Preference dividends                                                    -   (155,743) 
paid 
 
Proceeds from issue of shares                                      50,000           - 
 
Net cash inflow from financing activities                          50,000   (155,743) 
 
Net increase/(decrease) in cash in the year                         7,756 (1,484,180) 
 
Cash and cash equivalents at the beginning of the year                 56   1,484,236 
 
Cash and cash equivalents at the end of the year                    7,812          56 
 
 
 
 
END 
 
 

(END) Dow Jones Newswires

December 22, 2021 10:17 ET (15:17 GMT)

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