AMED Amedeo Res

RNS No 4246k
CHIROSCIENCE GROUP PLC

                    DEALINGS BY SUBSTANTIAL SHAREHOLDERS

1)  NAME OF COMPANY

CHIROSCIENCE GROUP PLC

2)  NAME OF SHAREHOLDER HAVING A MAJOR INTEREST

GENERAL ACCIDENT

3)  Please state whether notification indicates that it is in respect of holding
    of the Shareholder named in 2 above or in respect of a non-beneficial
    interest or in the case of an individual holder if it is a holding of that
    person's spouse or children under the age of 18

AS 2 ABOVE

4)  Name of the registered holder(s) and, if more than one holder, the number of
    shares held by each of them.

GAFLAC NOMINEES LTD                               950,000
PROVIDENT MUTUAL (NOMINEES) LTD                 4,806,911

5)  Number of shares/amount of stock acquired.

800,000

6)  (0.75%) of issued Class

7)  Number of shares/amount of stock disposed

N/A

8)  ( N/A %) of issued Class

9)  Class of security

ORDINARY

10) Date of transaction

23-9-97

11) Date company informed

25-9-97

12) Total holding following this notification

5,756,911

13) Total percentage holding of issued class following this notification

5.38%

14) Any additional information

N/A

15) Name of contact and telephone number for queries

MRM JENNER
01223 420430

16) Name and signature of authorised company official responsible for making
    this notification

    Date of Notification.......26-9-97..........


END


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