RNS No 2074w
CHIROSCIENCE GROUP PLC


                                       Date of Disclosure 29-JUL-99.............

               DISCLOSURE UNDER RULES 8.1(a), 8.1(b)(i) and 8.3
                 OF THE CITY CODE ON TAKE-OVERS AND MERGERS

Date of dealing 28-JUL-99.....................

Dealing in....CHIROSCIENCE GROUP PLC.......................(name of company)

(1)  Class of securities (eg ordinary shares)....ORDINARY SHARES 5P........

(2)  Amount bought                  Amount sold             Price per unit

     3,300                                                  3.0300

(3)  Resultant total owned or controlled of ordinary shares
(and percentage of class)....7,434,639............................. (6.57%)

(4)  Party making disclosure..PRUDENTIAL PORTFOLIO MANAGERS LTD..............

(5)  EITHER (a) Name of purchaser/vendor (Note 1)..............................

     OR     (b) if dealing for discretionary client(s), name of fund management
                organisation
...................PRUDENTIAL PORTFOLIO MANAGERS LTD...........................

(6)  Reason for disclosure (Note 2)  
     (a) associate of (i)  offeror (Note 3)                             YES
                      (ii) offeree company                              YES

Specify which category or categories of associate (1-8 overleaf)...6...........

If category (8), explain........................................................

................................................................................
     (b) Rule 8.3 (ie disclosure because of ownership or control of 1% or more
         of the class of relevant securities dealt in)                  YES

Signed, for and on behalf of the party named in (4) above.....N/A...............

(Also print name of signatory).. MARK FOULKES .....COLIN HOUGHTON.............

Telephone and extension number...0171 548 3302 ....0171 548 3801..............

Note 1.   Specify owner, not nominee or vehicle company.  If relevant, also
          identify controller of owner, eg where an owner normally acts on
          instructions of a controller.

Note 2.   Disclosure might be made for more than one reason; if so, state all
          reasons.

Note 3.   Specify which offeror if there is more than one.

Note 4.   When an arrangement exists with any offeror, with the offeree company
          or with an associate of any offeror or of the offeree company in
          relation to relevant securities, details of such arrangement must be
          disclosed, as required by Note 6 on Rule 8...........................
          .....................................................................
          ......................................................................

Note 5.   It may be necessary, particularly when disclosing derivative
          transactions, to append a sheet to this disclosure form so that
          relevant information can be given.

Note 6.   In the case of an average price bargain, each underlying trade should
          be disclosed.

For full details of disclosure requirements, see Rule 8 of the Code.  If in
doubt, contact the Panel on Take-overs and Mergers, Tel. No: 0171-382 9026.


END

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