Motif Bio PLC Potent Efficacy of Iclaprim Confirmed (8137W)
24 Agosto 2015 - 8:00AM
UK Regulatory
TIDMMTFB
RNS Number : 8137W
Motif Bio PLC
24 August 2015
24 August 2015
Motif Bio plc
("Motif" or the "Company")
Potent Efficacy of Iclaprim Confirmed in Independent Laboratory
Study
Motif (LSE: MTFB), the clinical stage biopharmaceutical company
specialising in developing novel antibiotics, today announced the
topline results of an independent report from microbiology
specialists, JMI Laboratories. The report shows that iclaprim is
effective in vitro against a range of Gram-positive bacteria,
including Staphylococcus aureus, one of the key causes of acute
bacterial skin and skin structure infection (ABSSSI) and
hospital-acquired bacterial pneumonia (HABP).
The recently completed laboratory study tested iclaprim against
more than 2,000 bacterial strains, including 1,178 strains of
Staphylococcus aureus collected in 2014 from patients in the
U.S.A., Europe, Asia Pacific, and Latin America. Iclaprim was found
to be 16-fold more potent than trimethoprim, the only other
antibacterial dihydrofolate reductase inhibitor (DHFRi)
administered alone in today's market.
Reported minimum inhibitory concentrations (MICs) demonstrated
that iclaprim is active against Staphylococcus aureus at very low
concentrations. The MIC50, the minimum concentration of iclaprim
required to kill 50% of tested bacteria, was 0.06 mcg/ml and the
MIC90, the minimum concentration of iclaprim required to kill 90%
of tested bacteria, was 0.12 mcg/ml. Comparing this to data for
other antibiotics against the same 1,178 strains of Staphylococcus
aureus, 1 mcg/ml of vancomycin and 1 mcg/ml of linezolid was
required to meet the MIC50 and MIC90 levels. Against
methicillin-resistant Staphylococcus aureus (MRSA), iclaprim was
also highly active: the MIC50 was 0.06 mcg/ml and the MIC90 was 0.5
mcg/ml.
The tests were conducted according to Clinical and Laboratory
Standards Institute (CLSI) methods. CLSI develops clinical
laboratory testing standards based on input from and consensus
among industry, government, and health care professionals around
the world.
Dr. David Huang, Chief Medical Officer at Motif, commented:
"These encouraging new results confirm the Board's confidence in
developing iclaprim to treat ABSSSI and HABP. We believe that
iclaprim will prove to be an important option for treating these
life threatening infections where currently available treatments
are not fully effective due to resistance or side effects."
Enquiries:
Motif Bio plc. info@motifbio.com
Graham Lumsden (Chief Executive
Officer)
Robert Bertoldi (Chief Financial
Officer)
www.motifbio.com
+49 (0) 89
MC Services AG (TRADE PR) 210 2280
Raimund Gabriel +44 (0) 207
Shaun Brown 148 5998
Zeus Capital Partners Limited +44 (0) 20
(BROKER and NOMAD) 3709 0142
Phil Walker/ John Treacy
Dominic Wilson
Northland Capital Partners Limited +44 (0) 20
(BROKER) 7382 1100
Patrick Claridge/ David Hignell
John Howes/ Mark Treharne (Broking)
Plumtree Capital Limited (FINANCIAL +44 (0) 207
ADVISOR) 183 2493
Stephen Austin
Yellow Jersey PR Limited (FINANCIAL
PR)
Dominic Barretto
Philip Ranger +44 (0) 7768
Charles Goodwin 537 739
Notes to Editors:
Motif is a clinical stage biopharmaceutical company, which
specialises in developing novel antibiotics designed to be
effective against serious and life-threatening infections caused by
multi-drug resistant bacteria.
Iclaprim is being developed for the treatment of the most common
and serious bacterial infections such as acute bacterial skin and
skin structure infections (ABSSSI) and hospital acquired bacterial
pneumonia (HABP), including those caused by resistant strains such
as MRSA (methicillin-resistant Staphylococcus aureus) and MDRSP
(multi-drug resistant Streptococcus pneumoniae) that have become
prevalent in patients in both the community and hospital
settings.
The Company is in discussions with pharmaceutical companies and
universities to build a pipeline of innovative antibiotics
targeting Gram-positive and Gram-negative bacteria.
This information is provided by RNS
The company news service from the London Stock Exchange
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