TIDMMTFB

RNS Number : 2268X

Motif Bio PLC

27 August 2015

Motif Bio plc

("Motif" or the "Company")

Interims Results for the 6 months to 30 June 2015

27 August 2015 - Motif Bio plc (AIM: MTFB), the clinical stage biopharmaceutical company specialising in developing novel antibiotics, announced today its maiden interim financial results as an AIM-listed Company.

Corporate/operational highlights:

-- On 2 April 2015, the Company completed an AIM listing raising GBP2.8 million at 20 pence per share;

   --     The U.S. Food and Drug Administration (FDA) agreed to Phase III trials of iclaprim; and 
   --     Motif partnered with a global leading CRO for Phase III clinical trials of iclaprim. 

Financial Highlights:

   --     Cash and cash equivalents as at 30 June 2015 of $2.8 million (31 December 2014: nil) 

Since Period End:

   --     QIDP designation granted by the FDA for iclaprim in ABSSSI and HABP; 
   --     Successful placing on 22 July 2015 raising GBP22 million at 50 pence per share; 

-- Independent tests by JMI Laboratories showed iclaprim to be effective in vitro against a range of Gram-positive bacteria and 16 times more potent than trimethoprim; and

-- Appointment on 15 July of Dr. Thomas M. File, and the appointments today of Dr. Matthew Dryden, and Dr. Antoni Torres to the Scientific Advisory Board.

Graham Lumsden, CEO of Motif Bio plc said:

"This has been a truly transformational period for Motif. In April, the Company completed its IPO and listing on AIM raising GBP2.8 million, which was followed by FDA approval to enter Phase III with iclaprim and a further successful share placing in July, which raised GBP22 million from institutional investors, enabling Motif to proceed with its plans to conduct Phase III trials with iclaprim. Iclaprim is a broad-spectrum antibiotic designed to be effective against multi-drug resistant bacteria.

"Since the period end, Motif has achieved some important milestones. In July, we received QIDP (Qualified Infectious Disease Product) designation for iclaprim for two indications, ABSSSI (Acute Bacterial Skin and Skin Structure Infections) and HABP (Hospital Acquired Bacterial Pneumonia). In addition, as reported on 24 August, JMI Laboratories' independent report showed iclaprim to be effective in vitro against a broad range of Gram-positive bacteria. The results showed iclaprim to be 16 times more potent than trimethoprim, which is the only other antibacterial dihydrofolate reductase inhibitor administered alone in today's market.

"We continue to build value for our shareholders and are making excellent progress with the preparations for commencing the Phase III trials."

Chairman's Statement

I am pleased to report to shareholders today on the Company's maiden interim financial results as an AIM-listed Company, which covers the period of the 6 months to 30 June 2015.

Progress to Date

On 2 April 2015, Motif Bio plc successfully completed its AIM listing raising GBP2.8 million at 20 pence per share. We were delighted to announce on 23 June 2015, a conditional placing of 44 million new ordinary shares at a placing price of 50 pence per ordinary share with institutional investors to raise GBP22 million. On 22 July 2015, the FDA designated iclaprim as a Qualified Infectious Diseases Product (QIDP) for hospital acquired bacterial pneumonia (HABP). This satisfied the final condition of the placing, with admission of the 44 million new ordinary shares occurring on 27 July 2015.

Further on 22 July 2015, the Company reported that the FDA had also designated iclaprim as QIDP for acute bacterial skin and skin structure infections (ABSSSI), the second of two serious and life threatening infections for which we applied for QIDP status. With QIDP designation, iclaprim is now eligible for a total of 10 years of market exclusivity, thus making this development an important step in continuing to build the value of iclaprim for Motif and our investors. The Board believes that iclaprim is the first and only dihydrofolate reductase inhibitor to receive QIDP designation. With the support of our investors we look forward to commencing the Phase III trials for iclaprim and further advancing the Company's portfolio.

Most recently, on 24 August 2015, the Company updated shareholders on the results of an independent report from microbiology specialists, JMI Laboratories. The report showed that iclaprim is effective in vitro against a range of Gram-positive bacteria, including Staphylococcus aureus, one of the key causes of ABSSSI and HABP. The recently completed laboratory study tested iclaprim against more than 2,000 bacterial strains, including 1,178 strains of Staphylococcus aureus collected in 2014 from patients in the U.S.A., Europe, Asia Pacific, and Latin America. Iclaprim was found to be 16 times more potent than trimethoprim, the only other antibacterial dihydrofolate reductase inhibitor (DHFRi) administered alone in today's market. The tests were conducted according to Clinical and Laboratory Standards Institute (CLSI) methods. CLSI develops clinical laboratory testing standards based on input from and consensus among industry, government, and health care professionals around the world.

After the reporting period, Motif further strengthened its Scientific Advisory Board with the appointment of three new advisors. As previously reported, Motif appointed Dr. Thomas File, an internationally recognised expert in infectious diseases including skin structure infections (SSSIs) and pneumonia. We are pleased to announce today the additional appointments of Dr. Matthew Dryden and Dr. Antoni Torres. Dr. Dryden is an Infectious Diseases Specialists who serves as the Director of Infection, Hampshire Hospitals, Winchester and University of Southampton, United Kingdom. Dr. Dryden's research interests have been in staphylococcal infection, the development of new antibiotics, the management of MRSA infections, and Lyme disease in the UK. Dr. Torres is a Pulmonologist and he currently serves as the Head of the Respiratory Intensive Care Unit in the Department of Pneumology and Respiratory Allergy, Clinical Institute of the Thorax, Hospital Clinic of Barcelona. He is Professor of Medicine at the University of Barcelona.

Addressing a Global Crisis

Resistance to antibiotics is a major global health threat. So-called "superbugs" are developing resistance to currently available antibiotics faster than new, effective antibiotics are being developed. In June 2013, Dr. Margaret Chan, Director-General of the World Health Organisation stated that, "a post-antibiotic era means, in effect, an end to modern medicine as we know it. Things as common as strep throat or a child's scratched knee could once again kill. Some sophisticated interventions, like hip replacements, organ transplants, cancer chemotherapy, and care of preterm infants, would become far more difficult or even too dangerous to undertake."

Outlook

Iclaprim is being designed to be administered in hospitals as an intravenous infusion. The directors believe the most urgent need for novel antibiotics effective against multi-drug resistant bacteria is in the hospital setting where patients often succumb to serious, life-threatening infections that require immediate treatment with the best available antibiotic. In the case of HABP, mortality rates for infected patients are currently between 20 per cent. and 50 per cent. The directors believe that commercialisation of hospital products can be done with fewer resources than commercialisation in the community because there are fewer hospital healthcare professionals to communicate with, compared to launching and educating the larger number of primary care and general practitioners in most countries.

This has been a truly transformational period for Motif. We continue to build value for our shareholders and are making excellent progress with the preparations for commencing the Phase III trials.

Richard C.E. Morgan

Chairman

27 August 2015

Enquiries

 
 Motif Bio plc                          info@motifbio.com 
  Graham Lumsden (Chief Executive 
  Officer) 
  Robert Bertoldi (Chief Financial 
  Officer) 
  www.motifbio.com 
 
 Zeus Capital Limited (Nominated        +44 (0) 207 
  Advisor and Broker)                    533 7727 
 Phil Walker / John Treacy 
  Dominic Wilson 
 Northland Capital Partners Limited     +44 (0) 20 
  (Broker)                               7382 1100 
 Patrick Claridge/David Hignell 
  John Howes/Mark Treharne (Broking) 
 Plumtree Capital Limited (Financial 
  Advisor)                              +44 (0) 207 
  Stephen Austin                         183 2493 
 
 
                                          +49 (0) 89 
   MC Services AG (Public Relations)      210 2280 
   Raimund Gabriel                        +44 (0) 207 
   Shaun Brown                            148 5998 
 Yellow Jersey PR Limited (Investor 
  Relations)                            +44 (0) 7768 
  Dominic Barretto/Charles Goodwin       537 739 
 

Notes to Editors:

Motif is a clinical stage biopharmaceutical company, which specialises in developing novel antibiotics designed to be effective against serious and life-threatening infections caused by multi-drug resistant bacteria

Iclaprim is being developed for the treatment of the most common and serious bacterial infections such as acute bacterial skin and skin structure infections (ABSSSI) and hospital acquired bacterial pneumonia (HABP), including those caused by resistant strains such as MRSA (methicillin-resistant Staphylococcus aureus) and MDRSP (multi-drug resistant Streptococcus pneumoniae) that have become prevalent in patients in both the community and hospital settings.

(MORE TO FOLLOW) Dow Jones Newswires

August 27, 2015 02:03 ET (06:03 GMT)

The Company is in discussions with pharmaceutical companies and universities to build a pipeline of innovative antibiotics targeting Gram positive and Gram negative bacteria.

 
 Motif Bio plc 
 Condensed consolidated statement 
  of comprehensive income 
 For the six months 
  ended 30 June 2015 
 
 
                                                                 Pro-forma 
                                               Unaudited           Audited          Pro-forma 
                                Notes         Six months        Six months            Audited 
                                                   ended             ended         Year ended 
                                                 30 June           30 June        31 December 
                                                    2015              2014               2014 
                                            ------------       -----------       ------------ 
 Continuing operations                              US $              US $               US $ 
 
 Revenue                                               -                 -                  - 
 Cost of revenue                                       -                 -                  - 
                                            ------------       -----------       ------------ 
 Gross margin                                          -                 -                  - 
 
 General and administrative 
  expenses                                   (1,083,085)         (325,025)        (1,096,116) 
 Research and development                      (639,101)                 -                  - 
  expenses 
                                            ------------       -----------       ------------ 
 
 Operating loss                              (1,722,186)         (325,025)        (1,096,116) 
 
 Interest income                                     260                 -                 78 
 Interest expense, 
  net                                          (141,177)         (221,092)          (449,036) 
 Other income                                      5,995                 -            360,060 
                                            ------------       -----------       ------------ 
 
 Loss before income 
  taxes                                      (1,857,108)         (546,117)        (1,185,014) 
 
 Income tax                                            -                 -              (876) 
                                            ------------       -----------       ------------ 
 
 Net loss for the 
  period                                     (1,857,108)         (546,117)        (1,185,890) 
                                            ------------       -----------       ------------ 
 
 
 
 Total comprehensive 
  loss for the period                        (1,857,108)         (546,117)        (1,185,890) 
                                            ============       ===========       ============ 
 
 
 
 
 Loss per share 
 
 Basic and diluted 
  *                             4       US      $ (0.05)   US     $ (0.05)   US      $ (0.10) 
                                            ============       ===========       ============ 
 
 
   * In accordance with IAS33 "Earnings per share", where 
   the entity has reported a loss for the period, the shares 
   are not diluted. 
 
 
 Motif Bio plc 
 Condensed consolidated statement 
  of financial position 
 At 30 June 2015 
 
 
 
 
                                                         Pro-forma             Pro-forma 
                                         Unaudited         Audited               Audited 
                                           30 June         30 June           31 December 
                             Notes            2015            2014                  2014 
                                    --------------  --------------  -------------------- 
                                              US $            US $                  US $ 
 
 Non-current assets 
 Intangible assets               9       6,195,748               -                     - 
                                         6,195,748               -                     - 
                                    --------------  --------------  -------------------- 
 
 Current assets 
 Notes receivable                           12,000               -                12,000 
 Prepaid expenses and 
  other receivables                         47,300               -               210,661 
 Cash                                    2,783,034              99                 3,281 
                                         2,842,334              99               225,942 
                                    --------------  --------------  -------------------- 
 
 Total assets                            9,038,082              99               225,942 
                                    ==============  ==============  ==================== 
 
 Current liabilities 
 Trade and other payables                1,827,982       3,872,628             4,162,946 
 Other interest-bearing 
  loans and borrowings           5               -       6,892,064             6,981,454 
                                         1,827,982      10,764,692            11,144,400 
                                    --------------  --------------  -------------------- 
 
 Non-current liabilities 
 Other interest-bearing 
  loans and borrowings           5       3,550,786               -                     - 
                                         3,550,786               -                     - 
                                    --------------  --------------  -------------------- 
 
 Total liabilities                       5,378,768      10,764,692            11,144,400 
                                    ==============  ==============  ==================== 
 
 Net assets                              3,659,314    (10,764,593)          (10,918,458) 
                                    ==============  ==============  ==================== 
 
 Equity 
 Share capital                   7         953,575             844                 1,110 
 Share premium                           6,769,256       3,692,207    3,964,455 
 Group reorganization 
  reserve                        7       9,938,362               -                     - 
 Retained deficit                     (14,001,879)    (14,457,644)          (14,884,023) 
 
 Total stockholders' 
  equity/(deficit)                       3,659,314    (10,764,593)          (10,918,458) 
                                    ==============  ==============  ==================== 
 
 
 
 Motif Bio plc 
 Condensed consolidated statement 
  of changes in equity 
 For the six 
 months 
 ended 30 June 
 2015 
 
 Unaudited 
 
                                                                Group 
                            Share             Share    reorganization            Retained 
                          capital           Premium           reserve             deficit               Total 
                   --------------  ----------------  ----------------  ------------------  ------------------ 
                             US $              US $              US $                US $                US $ 
 
 Balance at 1 
  January 
  2014                        844         3,692,207                 -        (13,969,350)        (10,276,299) 
 
 Loss for the 
  period                        -                 -                 -           (546,117)           (546,117) 
 
 Total 
  comprehensive 
  loss for the 
  period                        -                 -                 -           (546,117)           (546,117) 
                   --------------  ----------------  ----------------  ------------------  ------------------ 
 
 Stock based 
  payments                      -                 -                 -              57,823              57,823 
 
 Balance at 30 
  June 
  2014                        844         3,692,207                 -        (14,457,644)        (10,764,593) 
 
 Loss for the 
  period                        -                 -                 -           (639,773)           (639,773) 
 
 Total 
  comprehensive 
  loss for the 
  period                        -                 -                 -           (639,773)           (639,773) 
                   --------------  ----------------  ----------------  ------------------  ------------------ 
 
 Issue of share 
  capital                     211           210,373                                                   210,584 
 
 Exercise of 
  share 
  options                      55            61,875                 -            (28,930)              33,000 
 
 Stock based 
  payments                      -                 -                 -             242,324             242,324 
 
 Balance at 31 
  December 
  2014                      1,110         3,964,455                 -        (14,884,023)        (10,918,458) 
                   ==============  ================  ================  ==================  ================== 
 
 Balance at 1 
  January 
  2015                      1,110         3,964,455                 -        (14,884,023)        (10,918,458) 
 
 Loss for the 
  period                        -                 -                -     (1,857,108)         (1,857,108) 
 
 Total 
  comprehensive 
  loss for the 
  period                        -                 -                -     (1,857,108)         (1,857,108) 
                   --------------  ----------------  ----------------  ------------------  ------------------ 
 
 Transfer                 (1,110)   (3,964,455)             3,965,565                   -                   - 
 
 Issue of share 
  capital                   3,706            70,407                 -                   -              74,113 
 
 Group 
  reorganisation          544,378                 -         5,972,797                   -           6,517,175 
 
 Issue of share 
  capital 
  net of issue 
  costs                   405,491         6,698,849                                     -           7,104,340 
 

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August 27, 2015 02:03 ET (06:03 GMT)

 Issue of 
  warrants 
  issued to 
  acquire 
  assets                        -                 -                 -           2,340,372           2,340,372 
 
 Share-based 
  payments                      -                 -                 -             398,880             398,880 
 
 Balance at 30 
  June 
  2015                    953,575         6,769,256         9,938,362        (14,001,879)           3,659,314 
                   ==============  ================  ================  ==================  ================== 
 
 
 
 Motif Bio plc 
 Condensed consolidated statement 
  of cash flows 
 For the six months ended 30 
  June 2015 
 
                                                                          Pro-forma 
                                                   Unaudited                Audited              Pro-forma 
                                                  Six months             Six months                Audited 
                                                       ended                  ended             Year ended 
                                                     30 June                30 June            31 December 
                                                        2015                   2014                   2014 
                                           -----------------  ---------------------  --------------------- 
                                                        US $                   US $                   US $ 
 
 Operating activities 
 
 Operating loss for the period                   (1,722,186)              (325,025)            (1,096,116) 
 
 Adjustments to reconcile net 
  loss to net cash used in activities: 
   Stock-based payments                              398,880                 57,823                300,147 
   Interest expense                                (141,177)              (221,092)              (449,036) 
   Interest income                                       260                      -                     78 
   Other income                                        5,995                      -                360,060 
   Changes in operating assets 
    and liabilities: 
      Prepaid expenses, notes receivable 
       and accounts receivable                      (47,222)                      -              (222,661) 
      Accounts payable and other 
       accrued liabilities                           213,582                367,375                657,693 
 
 Net cash used in operating activities         (1,291,868)             (120,919)                 (449,835) 
                                           -----------------  ---------------------  --------------------- 
 
 Taxation paid                                             -                      -                  (876) 
 
 Financing activities 
 
 Proceeds from issuance of promissory 
  notes                                              704,210                120,974                210,364 
 Proceeds from issue of share 
  capital, net                                     3,367,411                      -                210,584 
 Proceeds from exercise of options                         -                      -                 33,000 
 
 Net cash provided by financing 
  activities                                       4,071,621                120,974                453,948 
                                           -----------------  ---------------------  --------------------- 
 
 Net change in cash                                2,779,753                     55                  3,237 
 
 Cash, beginning of the period                         3,281                     44                     44 
 
 Cash, end of the period                           2,783,034                     99                  3,281 
                                           =================  =====================  ===================== 
 

Motif Bio plc

Notes to the condensed consolidated financial statement (Unaudited)

For the six months ended 30 June 2015

   1.   General information 

Motif Bio Limited was incorporated in England and Wales on 20 November 2014 as a private company limited by shares. On 1 April 2015 the Company was re-registered as a public company limited by shares and changed its name to Motif Bio plc. On 1 April 2015 it became the holding company for Motif BioSciences, Inc. by way of a group reorganisation by plan of merger (see note 10).

The condensed consolidated interim financial statements for the six months ended 30 June 2015 are unaudited and do not constitute statutory accounts as defined in section 434 of the Companies Act 2006.

2. Accounting policies

Basis of preparation

The condensed set of financial statements included in this half-yearly financial report has been prepared in accordance with the recognition and measurement requirements of International Financial Reporting Standards (IFRS), as adopted by the European Union.

The interim financial information has been drawn up using accounting policies and presentations expected to be adopted in the Group's full financial statements for the year ending 31 December 2015 and consistent with those set out in Part IV of the AIM admission document published by Motif Bio plc on 27 March 2015. The audited pro-forma comparative information for the year ended 31 December 2014 has been extracted from the audited non-statutory financial statements of Motif BioSciences, Inc. for the year then ended. The auditors' report on these financial statements was unqualified.

The interim financial information set out herein was approved and authorised for issue by the Board of Directors of Motif Bio plc on 26 August 2015. Copies of this financial information will be available on the Company's website.

The condensed consolidated interim financial statements include the accounts of Motif Bio plc and its one wholly owned subsidiary, Motif BioSciences Inc. (the "Group"). On 1 April 2015 Motif BioSciences Inc. became a wholly owned subsidiary of Motif Bio plc by way of a group reorganisation effected by a plan of merger between Motif BioSciences Inc. and Motif Acquisition Sub, Inc., a special purpose merger subsidiary of Motif Bio plc. The comparative financial information for the six months ended 30 June 2014 and 31 December 2014 is that of Motif BioSciences Inc. only and is therefore pro-forma.

Research and development expenditure

Capitalisation of expenditure on drug development commences from the point at which technical feasibility and commercial viability of the product can be demonstrated and the Group is satisfied that it is probable that future economic benefits will result from the product once completed. No such costs have been capitalised to date.

Expenditure on research and development activities that do not meet the above criteria is charged to the Statement of Comprehensive income as incurred.

Intangible assets

Intangible assets are stated at cost, net of any amortisation and any provision for impairment. Where a finite useful life of the acquired intangible asset cannot be determined, the asset is not subject to amortisation but is tested for impairment annually or more frequently whenever events or changes in circumstances indicate that the carrying amount may not be recoverable. No amortisation or impairment has been charged to date as the assets are not yet available for commercial use.

3. Segment reporting

The chief operating decision-maker is considered to be the Board of Directors of Motif Bio plc. The chief operating decision-maker allocates resources and assesses performance of the business and other activities at the operating segment level.

The chief operating decision maker has determined that Motif has one operating segment, the development and commercialisation of pharmaceutical formulations. All activities take place in the USA.

4. Loss per share

Basic loss per share is calculated by dividing the loss attributable to equity holders by the weighted average number of shares in issue during the period. For comparative purposes, the weighted average number of shares in issue in the six months ended 30 June 2014 and the year ended 31 December 2014 have been adjusted to reflect the reverse stock split in the capital of Motif BioSciences, Inc. on 13 March 2015.

In accordance with IAS 33, where the Group has reported a loss for the period, the shares are not diluted.

 
                                 Six months           Six months 
                                      ended                ended               Year ended 
                                    30 June              30 June                   31 Dec 
                                       2015                 2014                     2014 
                                        US$                  US$                      US$ 
                          -----------------  -------------------  ----------------------- 
 Loss after taxation            (1,857,108)            (546,117)              (1,185,890) 
 Basic weighted average 
  shares in issue                40,809,623          11,751,343             12,453,312 
 Basic and diluted loss 
  per share                          (0.05)               (0.05)                   (0.10) 
                          -----------------  -------------------  ----------------------- 
 

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August 27, 2015 02:03 ET (06:03 GMT)

5. Other interest bearing loans and borrowings

 
 Other interest bearing loans 
  and borrowings 
 
                                        Six months                  Six months 
                                             ended                       ended                            Year ended 
                                           30 June                     30 June                           31 December 
                                              2015                        2014                                  2014 
                                               US$                         US$                                   US$ 
                          ------------------------  --------------------------  ------------------------------------ 
 Amounts due within 
  one year 
 
 Convertible promissory 
  notes                                         -               200,000                               200,000 
 Notes payable to 
  affiliates                                    -            6,692,064                             6,781,454 
                       -                                     6,892,064                             6,981,454 
 -------------------------------------------------  --------------------------  ------------------------------------ 
 
 Amounts due longer 
  than one year 
 
 Notes payable to 
  affiliates                     3,550,786                                   -                                     - 
        3,550,786                                                            -                                     - 
 -------------------------------------------------  --------------------------  ------------------------------------ 
 

On 20 January 2015, the convertible promissory noteholders exercised the option, conditional upon Motif Bio plc's admission on AIM, to convert the $200,000 of convertible promissory notes and accrued interest of $78,787 into shares of Motif BioSciences Inc.

On 1 April 2015, Amphion Innovations plc converted US $6,000,000 of notes and accrued interest into shares of Motif BioSciences Inc. Convertible promissory notes were issued for Amphion Innovations plc's remaining balance of $1,471,700 and Amphion Innovations US Inc.'s balance of US $2,079,086 that include unpaid accrued interest and advisory and consultancy fees. The new notes which accrue interest at the rate of 7% per annum, mature on 31 December 2016 and can be converted into ordinary shares of Motif Bio plc at the rate of US $0.1758 per share.

In January 2015, Motif BioSciences Inc. entered into four convertible promissory notes totaling US $704,210 as part of a pre-Admission fundraising. Upon admission, the notes were converted into 2,612,766 shares of Motif Bio plc. Motif Bio plc issued 499,570 warrants to the noteholders with an exercise price of 20 pence per share. The expiration date for 176,246 of the warrants is 31 December 2015 and 31 December 2016 for 323,324 of the warrants.

6. Stock based payments

As part of the merger between Motif Acquisition Sub, Inc. and Motif BioSciences, Inc., described at note 10, each outstanding share option granted by Motif BioSciences, Inc. was assumed and converted by Motif Bio plc into options to subscribe for ordinary shares in Motif Bio plc.

Motif Bio plc adopted a Share Option Plan on 1 April 2015 that is limited to employees of the Group. In 2015, 100,000 options were issued under the Plan with an exercise price of GBP0.4775 per share, expire in ten years and vest over three years.

Motif Bio plc issued 642,384 warrants to its nominated advisor, 642,384 warrants to its broker, and 82,321 warrants to a fundraising advisor in part consideration for their participation in the admission. The warrants have an exercise price of 20 pence per share and expire on the fifth anniversary of admission.

7. Share capital and reserves

 
 
 Allotted, called up and 
  full paid:                                  Number                   US $ 
 
 In issue at 31 December 
  2014                                           100                      - 
 
 Issued: 
  Ordinary shares of 1p each              36,726,242                544,378 
  Ordinary shares of 1p each               9,805,400                145,342 
  Ordinary shares of 1p each                 657,894                  9,752 
  Ordinary shares of 1p each               2,612,766                 38,728 
  Ordinary shares of 1p each              14,436,140                215,375 
 In issue at 30 June 2015                 64,238,442                953,575 
                               ---------------------  --------------------- 
 

Motif Bio plc was incorporated on 20 November 2014 with 100 ordinary shares of 1 pence each, which was subscribed for unpaid. The shares were transferred upon capitalisation.

On 2 April 2015, Motif Bio plc issued 36,726,242 ordinary shares to the Motif BioSciences Inc. shareholders as consideration for the transfer of the entire issued common stock of Motif BioSciences Inc. to the Company.

On 2 April 2015, Motif Bio plc issued 9,805,400 ordinary shares to the former Nuprim shareholders as consideration for the merger of Motif BioSciences, Inc. and Nuprim.

On 2 April 2015, Motif Bio plc issued 657,894 ordinary shares to a creditor of Motif BioSciences Inc. in payment of the balance due.

On 2 April 2015, Motif Bio plc issued 2,612,766 shares to the pre-admission note holders upon conversion of the convertible promissory notes.

On 2 April 2015, Motif Bio plc issued 14,436,140 ordinary shares upon its admission on AIM at the price of 20 pence per share.

Share premium represents the excess over nominal value of the fair value consideration received for equity shares net of expenses of the share issue.

Retained deficit represents accumulated losses.

The group re-organisation reserve arose when Motif Bio plc became the parent of the Group. The plan of merger, falling as it does outside the scope of IFRS 3, has been accounted for as a group re-organisation and not a business combination on a merger or pooling of interest basis as if both entities have always been combined, using book values, with no fair value adjustments made nor good will recognised. The group re-organisation reserve represents the difference between the nominal value of the shares in Motif Bio plc issued to the former shareholders in Motif BioSciences, Inc. to effect the plan of merger and the share capital and share premium reserve of Motif BioSciences, Inc. at the date of the merger.

8. Issue costs

Motif Bio plc incurred costs of US $942,164 relating to the issue of shares in an IPO on the Alternative Investment Market. The costs were primarily for fundraising commissions and professional advisory fees in relation to the issue of shares. These equity transaction costs were deducted from equity in accordance with IAS 32, Financial Instruments Disclosure and Presentation.

9. Acquisition of asset

Motif BioSciences Inc., as the result of the merger agreement with Nuprim, Inc. acquired the exclusive rights to Nuprim's iclaprim assets and the rights to acquire 600 kilograms of iclaprim API over a period ending 31 December 2017. As part of the transaction Motif BioSciences Inc. is responsible for costs and expenses related to or arising from the transfer prices of the iclaprim assets, including storage and delivery costs of the physical drug supply and inventory which are due and payable after 17 October 2014 and Motif BioSciences Inc. must assume and accept the terms and obligations arising under the Acino-LSMG agreement, including payment obligations. Motif BioSciences Inc. is also responsible for any third-party legal or administrative costs incurred by Nuprim in connection with the transaction and any obligations arising under a sale and purchase agreement between F. Hoffmann-La Roche Ltd, Hoffmann-La Roche Inc and Arpida Ltd., dated 1 June 2001. Motif BioSciences Inc. issued 1,513,040 (post reverse stock split) shares of common stock to the shareholders of Nuprim that were held in escrow until the closing of the

reorganisation. These shares of common stock in Motif BioSciences Inc. were converted into ordinary shares in Motif Bio plc on admission.

On 31 December 2014, Motif BioSciences finalised the merger agreement. On admission, 9,805,400 ordinary shares of Motif Bio plc and 9,432,033 warrants were issued to the former Nuprim shareholders. The warrants have an exercise price of 20 pence and expire on the date ten years from the closing date of the transaction. In the event that Motif BioSciences Inc. fails to advance the development of iclaprim by commencing clinical development by 15 February 2017, the former Nuprim shareholders have the right to acquire the iclaprim assets for a purchase price of US $10,000.

The directors believe that the merger between Motif BioSciences Inc. and Nuprim Inc. is unlikely to meet the definition of an acquisition of a business as set out in IFRS 3 and is therefore accounted for as the acquisition of an asset or a group of assets that does not constitute a business. IFRS 3 requires that in such cases the acquirer shall identify and recognise the individual identifiable assets acquired (including those assets that meet the definition of, and recognition criteria for, intangible assets in IAS 38, Intangible Assets) and to allocate the cost of the individual identifiable assets and liabilities on the basis of their relative fair values at the date of purchase. Such a transaction or event does not give rise to good will.

The fair value of the assets acquired under the merger arrangement represent the aggregate estimated value of:

   --     11,318,439 ordinary shares in Motif Bio plc at the placing price of 20 pence per share; 
   --     9,432,033 non-assignable warrants at the placing price of 20 pence per ordinary share; and 

-- a milestone payment of US $500,000 expected to be paid by Motif BioSciences Inc. to Acino upon completion of the first Phase III trial.

(MORE TO FOLLOW) Dow Jones Newswires

August 27, 2015 02:03 ET (06:03 GMT)

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