PTI Protherics

    RNS Number : 6146I
  Protherics PLC
  20 November 2008
   

    Protherics PLC

    Notification of Major Interest in Shares


    London, UK; Brentwood, TN, US; 20 November 2008 - Protherics PLC ("Protherics" or the "Company"), the international biopharmaceutical
company focused on critical care and cancer, announces that, on 19 November 2008, the following notification of interest in the ordinary
share capital of the Company was received from Aviva plc.


 1. Reason for the notification     (please tick the
 appropriate box or boxes)
 A disposal voting rights                                  X 
 An acquisition or disposal of financial instruments
 which may result in the acquisition of shares
 already issued to which voting rights are attached
 An event changing the breakdown of voting rights

 Other (please specify): 
 2. Full name of person(s)            Aviva plc & its subsidiaries   
 subject to the notification
 obligation:
 3. Full name of shareholder(s)  Registered Holder:
 (if different from 2.):

                                 BNY Norwich Union Nominees Limited     
                                  5,959,368*


                                 Chase GA Group Nominees Limited
                                 19,321,240*


                                 Chase Nominees Limited
                                 879,543*


                                 CUIM Nominee Limited
                                 4,366,418*


                                 Vidacos Nominees Limited
                                 65,125*




                                 *denotes direct interest  
                                  
                                 BNP Paribas - London
                                 636,429


                                 Chase Nominees Limited 
                                 3,065,451


                                 State Street Nominees Limited  
                                 9,428,137


                                 Vidacos Nominees Limited 
                                 1,603,080   

 4. Date of the transaction      18 November 2008
 (and date on which the
 threshold is crossed or
 reached if different):
 5. Date on which issuer         19 November 2008
 notified:
 6. Threshold(s) that is/are     13% to 12% Change at Combined Interest
 crossed or reached:             level   

 7. Notified details:


 A: Voting rights attached to shares
 Class/type of shares            Situation previous to the Triggering        Resulting situation after the triggering transaction
 if possible using the ISIN      transaction 
 CODE
                                 Number of Shares      Number of Voting      Number of shares   Number of voting rights  % of voting
                                                       Rights                                                            rights
                                                                             Direct             Direct       Indirect    Direct  Indirect
                                                                                                                                    
 Ordinary Shares                                                 45,971,166                                                       


 GB0007029209                    45,971,166                                                     30,591,694               8.73%   4.20%
                                                                             30,591,694                      14,733,097








 B: Financial Instruments
 Resulting situation after the triggering transaction 
 Type of financial instrument   Expiration date   Exercise/ Conversion  Number of voting      % of voting rights
                                                  Period/ Date          rights that may be
                                                                        acquired if the
                                                                        instrument is
                                                                        exercised/
                                                                        converted. 



                                                       N/A











 Total (A+B)
 Number of voting rights  % of voting rights
                             
 45,324,791               12.93%


 8. Chain of controlled undertakings through which the voting rights and/or
 the financial instruments are effectively held, if applicable :

 The voting rights are managed and controlled by Aviva Investors Global
 Services Limited, with the following chain of controlled undertakings:-


 Aviva Investors Global Services Limited:
 * Aviva plc (Parent Company)
 * Aviva Group Holdings Limited (wholly owned subsidiary of Aviva plc)
 * Aviva Investors Holdings Limited (wholly owned subsidiary of Aviva Group
 Holdings Limited)
 * Aviva Investors Global Services Limited (wholly owned subsidiary of Aviva
 Investors Holdings Limited)


 Proxy Voting:
 9. Name of the proxy holder:                                    See Section 3
 10. Number of voting rights proxy holder will cease to          
 hold:
 11. Date on which proxy holder will cease to hold voting              
 rights:

 12. Additional information:  Figures are based on a revised total number of
                              voting rights of 350,427,481



    | Ends |


    For further information please contact:

 Protherics 
 Nick Staples, Director of Corporate Affairs  +44 (0) 7919 480510  
 Julie Vickers, Company Secretary             +44 (0)1928 518010

 Financial Dynamics - press enquiries
 London: Ben Atwell, Lara Mott                +44 (0) 20 7831 3113 
 New York: John Capodanno                     +1 212 850 5600

    Or visit  www.protherics.com

This information is provided by RNS
The company news service from the London Stock Exchange
 
  END 
 
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