File No . 33-25941

811-5718

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM N-1A

REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933   [X]

  Pre-Effective Amendment No.     [__]

  Post-Effective Amendment No. 39     [X]

and/or

REGISTRATION STATEMENT UNDER THE INVESTMENT COMPANY ACT OF 1940   [X]

  Amendment No. 39     [X]

(Check appropriate box or boxes.)

Dreyfus Treasury Prime Cash Management

(Exact Name of Registrant as Specified in Charter)

c/o The Dreyfus Corporation

200 Park Avenue, New York, New York 10166

(Address of Principal Executive Offices) (Zip Code)

  Registrant's Telephone Number, including Area Code: (212) 922-6000

Janette Farragher, Esq.

200 Park Avenue

New York, New York 10166

(Name and Address of Agent for Service)

It is proposed that this filing will become effective (check appropriate box)

 

  X __ immediately upon filing pursuant to paragraph (b)

  _____   on (date) pursuant to paragraph (b)

  _____ (days) days after filing pursuant to paragraph (a)(1)

  _____   on (date) pursuant to paragraph (a)(1)

  _____ (days) days after filing pursuant to paragraph (a)(2)

  _____   on (date) pursuant to paragraph (a)(2) of Rule 485

If appropriate, check the following box:

  _____   this post-effective amendment designates a new effective date for a previously filed post-effective amendment.

 

SIGNATURES

  Pursuant to the requirements of the Securities Act of 1933, the Registrant, Dreyfus Treasury Prime Cash Management, certifies that it meets all of the requirements for effectiveness of this Amendment to the Registration Statement pursuant to Rule 485(b) under the Securities Act of 1933 and has duly caused this Amendment to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of New York, and State of New York on the 20th day of June 2012.

Dreyfus Treasury Prime Cash Management

   

BY:

/s/ Bradley J. Skapyak*

 

Bradley J. Skapyak, PRESIDENT

  Pursuant to the requirements of the Securities Act of 1933, this Amendment to the Registration Statement has been signed below by the following persons in the capacities and on the date indicated.

         

Signatures

 

Title

 

Date

         

/s/ Bradley J. Skapyak*

 

President (Principal Executive Officer)

 

06/20/2012

Bradley J. Skapyak

       

/s/ James Windels*

 

Treasurer (Principal Financial
and Accounting Officer)

 

06/20/2012

James Windels

       

/s/ Joseph S. DiMartino*

 

Chairman of the Board

 

06/20/2012

Joseph S. DiMartino

       

/s/ David W. Burke*

 

Board Member

 

06/20/2012

David W. Burke

       

/s/ Isabel P. Dunst*

 

Board Member

 

06/20/2012

Isabel P. Dunst

       

/s/ Robin A. Melvin*

 

Board Member

 

06/20/2012

Robin A. Melvin

       

/s/ Philip L. Toia*

 

Board Member

 

06/20/2012

Philip L. Toia

       

/s/ Roslyn M. Watson*

 

Board Member

 

06/20/2012

Roslyn M. Watson

       

/s/ Benaree P. Wiley*

 

Board Member

 

06/20/2012

Benaree P. Wiley

       

 

 

   

*BY:

/s/ John B. Hammalian

 

John B. Hammalian
Attorney-in-Fact

 

INDEX OF EXHIBITS

_________________________

Exhibits

EX-101.INS – Instance Document.

EX-101.SCH – Taxonomy.

EX-101.CAL – Calculation Linkbase.

EX-101.DEF – Definition Linkbase.

EX-101.LAB – Labels Linkbase.

EX-101.PRE – Presentation Linkbase.

 

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