Form SC 13G/A - Statement of acquisition of beneficial ownership by individuals: [Amend]
14 Febbraio 2024 - 4:33PM
Edgar (US Regulatory)
UNITED
STATES
SECURITIES
AND EXCHANGE COMMISSION
WASHINGTON,
DC 20549
SCHEDULE
13G
Under the Securities
Exchange Act of 1934
(Amendment No. 2)*
Karyopharm
Therapeutics Inc. |
(Name
of Issuer) |
Common
Stock, $0.0001 par value |
(Title
of Class of Securities) |
December
31, 2023 |
(Date
of Event Which Requires Filing of this Statement) |
Check the appropriate
box to designate the rule pursuant to which this Schedule is filed:
[_] Rule 13d-1(b)
[X] Rule 13d-1(c)
[_] Rule 13d-1(d)
__________
*The remainder
of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities,
and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.
The
information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of
the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be
subject to all other provisions of the Act (however, see the Notes).
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Avidity Partners Management LP |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
Delaware |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IA, PN |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Avidity Partners Management (GP) LLC |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
Delaware |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Avidity Capital Partners Fund (GP) LP |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
Delaware |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO, PN |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Avidity Capital Partners (GP) LLC |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
Delaware |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Avidity Master Fund LP |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
Cayman Islands |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
8,164,070 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
8,164,070 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
8,164,070 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
7.0% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
OO, PN |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
David Witzke |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
United States of America |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN |
|
1. |
NAME OF REPORTING PERSONS |
|
|
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES
ONLY) |
|
|
|
|
|
Michael Gregory |
|
|
|
|
2. |
CHECK THE APPROPRIATE BOX IF A MEMBER
OF A GROUP (SEE INSTRUCTIONS) |
|
|
(a) [_] |
|
|
(b) [X] |
|
|
|
3. |
SEC USE ONLY |
|
|
|
|
|
|
|
|
|
|
4. |
CITIZENSHIP OR PLACE OF ORGANIZATION |
|
|
|
|
|
United States of America |
|
|
|
|
NUMBER OF SHARES BENEFICIALLY OWNED
BY EACH REPORTING PERSON WITH |
|
|
|
5. |
SOLE VOTING POWER |
|
|
|
|
|
0 |
|
|
|
|
6. |
SHARED VOTING POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
7. |
SOLE DISPOSITIVE POWER |
|
|
|
|
|
0 |
|
|
|
|
8. |
SHARED DISPOSITIVE POWER |
|
|
|
|
|
11,188,743 |
|
|
|
|
9. |
AGGREGATE AMOUNT BENEFICIALLY OWNED
BY EACH REPORTING PERSON |
|
|
|
|
11,188,743 |
|
|
|
|
10. |
CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9)
EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) |
|
|
|
[_] |
|
|
|
|
|
|
11. |
PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW
(9) |
|
|
|
|
|
9.5% |
|
|
|
|
12. |
TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)
IN |
|
Item 1. |
(a). |
Name of Issuer: |
|
|
|
|
|
|
|
Karyopharm Therapeutics
Inc. |
|
|
(b). |
Address of issuer's principal executive
offices: |
|
|
|
|
|
|
|
85 Wells Avenue, 2nd Floor
Newton,
Massachusetts 02459 |
|
Item 2. |
(a). |
Name of person filing: |
|
|
|
|
|
|
|
Avidity Partners Management
LP
Avidity Partners Management
(GP) LLC
Avidity Capital Partners Fund
(GP) LP
Avidity Capital Partners (GP)
LLC
Avidity Master Fund LP
David Witzke
Michael Gregory |
|
|
(b). |
Address or principal business office
or, if none, residence: |
|
|
|
|
|
|
|
Avidity Partners Management
LP
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
Avidity Partners Management
(GP) LLC
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
Avidity Capital Partners Fund
(GP) LP
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
Avidity Capital Partners (GP)
LLC
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
Avidity Master Fund LP
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
David Witzke
c/o Avidity Partners Management
LP
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America
Michael Gregory
c/o Avidity Partners Management
LP
2828 N Harwood Street, Suite
1220
Dallas, Texas 75201
United States of America |
|
|
(c). |
Citizenship: |
|
|
|
|
|
|
|
Avidity Partners Management
LP– Delaware
Avidity Partners Management
(GP) LLC – Delaware
Avidity Capital Partners Fund
(GP) LP – Delaware
Avidity Capital Partners (GP) LLC –
Delaware
Avidity Master Fund LP – Cayman
Islands
David Witzke – United States of
America
Michael Gregory – United States
of America |
|
|
(d). |
Title of class of securities: |
|
|
|
|
|
|
|
Common Stock,
$0.0001 par value |
|
|
(e). |
CUSIP No.: |
|
|
|
|
|
|
|
48576U106 |
|
Item 3. |
|
If This Statement
is filed pursuant to §§.240.13d-1(b) or 240.13d-2(b), or (c), check whether the person filing is a |
|
(a) |
[_] |
Broker or dealer registered under
section 15 of the Act (15 U.S.C. 78o). |
|
(b) |
[_] |
Bank as defined in section 3(a)(6)
of the Act (15 U.S.C. 78c). |
|
(c) |
[_] |
Insurance company as defined in section
3(a)(19) of the Act (15 U.S.C. 78c). |
|
(d) |
[_] |
Investment company
registered under section 8 of the Investment Company Act of 1940 (15 U.S.C. 80a-8). |
|
(e) |
[_] |
An investment
adviser in accordance with § 240.13d-1(b)(1)(ii)(E); |
|
(f) |
[_] |
An employee
benefit plan or endowment fund in accordance with § 240.13d-1(b)(1)(ii)(F); |
|
(g) |
[_] |
A parent holding
company or control person in accordance with §240.13d-1(b)(1)(ii)(G); |
|
(h) |
[_] |
A savings association
as defined in Section 3(b) of the Federal Deposit Insurance Act (12 U.S.C.1813); |
|
(i) |
[_] |
A church plan
that is excluded from the definition of an investment company under section 3(c)(14) of the Investment Company Act of 1940 (15 U.S.C.
80a-3); |
|
(j) |
[_] |
A non-U.S. institution
in accordance with §240.13d-1(b)(1)(ii)(J); |
|
(k) |
[_] |
Group, in accordance
with §240.13d-1(b)(1)(ii)(K). If filing as a non-U.S. institution in accordance with §240.13d-1(b)(1)(ii)(J),
please specify the type of institution: |
|
Provide
the following information regarding the aggregate number and percentage of the class of securities of the issuer identified in Item
1. |
|
(a) |
Amount beneficially owned: |
|
|
|
|
|
Avidity Partners Management
LP: 11,188,743
Avidity Partners Management
(GP) LLC: 11,188,743
Avidity Capital Partners Fund (GP) LP:
11,188,743
Avidity Capital Partners (GP) LLC: 11,188,743
Avidity Master Fund LP: 8,164,070
David Witzke: 11,188,743
Michael Gregory: 11,188,743 |
|
(b) |
Percent of class: |
|
|
|
|
|
Avidity Partners Management
LP: 9.5%
Avidity Partners Management
(GP) LLC: 9.5%
Avidity Capital Partners Fund
(GP) LP: 9.5%
Avidity Capital Partners (GP) LLC: 9.5%
Avidity Master Fund LP: 7.0%
David Witzke: 9.5%
Michael Gregory: 9.5% |
|
(c) |
Number of shares as to which the
person has: |
|
|
|
|
|
(i) |
Sole power to vote or to direct the
vote |
Avidity Partners Management
LP: 0
Avidity Partners Management
(GP) LLC: 0
Avidity Capital Partners Fund
(GP) LP: 0
Avidity Capital Partners (GP) LLC: 0
Avidity Master Fund LP: 0
David Witzke: 0
Michael Gregory: 0 |
|
|
|
|
|
|
|
|
(ii) |
Shared power to vote or to direct the vote |
Avidity Partners Management
LP: 11,188,743
Avidity Partners Management
(GP) LLC: 11,188,743
Avidity Capital Partners Fund
(GP) LP: 11,188,743
Avidity Capital Partners (GP) LLC: 11,188,743
Avidity Master Fund LP: 8,164,070
David Witzke: 11,188,743
Michael Gregory: 11,188,743 |
|
|
|
|
|
|
|
|
(iii) |
Sole power to dispose or to direct the disposition
of |
Avidity Partners Management
LP: 0
Avidity Partners Management
(GP) LLC: 0
Avidity Capital Partners Fund
(GP) LP: 0
Avidity Capital Partners (GP) LLC: 0
Avidity Master Fund LP: 0
David Witzke: 0
Michael Gregory: 0 |
|
|
|
|
|
|
|
|
(iv) |
Shared power to dispose or to direct the disposition
of |
Avidity Partners Management
LP: 11,188,743
Avidity Partners Management
(GP) LLC: 11,188,743
Avidity Capital Partners Fund
(GP) LP: 11,188,743
Avidity Capital Partners (GP) LLC: 11,188,743
Avidity Master Fund LP: 8,164,070
David Witzke: 11,188,743
Michael Gregory: 11,188,743 |
|
|
|
|
|
|
Item
5. |
Ownership
of Five Percent or Less of a Class. |
|
If this statement
is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than
five percent of the class of securities, check the following [__]. |
|
|
N/A |
|
|
Item 6. |
Ownership of More Than Five Percent
on Behalf of Another Person. |
|
If any other person
is known to have the right to receive or the power to direct the receipt of dividends from, or the proceeds from the sale of, such
securities, a statement to that effect should be included in response to this item and, if such interest relates to more than 5 percent
of the class, such person should be identified. A listing of the shareholders of an investment company registered under the Investment
Company Act of 1940 or the beneficiaries of employee benefit plan, pension fund or endowment fund is not required.
|
|
N/A |
|
|
Item 7. |
Identification
and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company or Control Person. |
|
If a parent holding
company or control person has filed this schedule, pursuant to Rule 13d-1(b)(1)(ii)(G), so indicate under Item 3(g) and attach an
exhibit stating the identity and the Item 3 classification of the relevant subsidiary. If a parent holding company or control person
has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d), attach an exhibit stating the identification of the relevant
subsidiary.
|
|
N/A |
|
|
Item 8. |
Identification and Classification
of Members of the Group. |
|
If a group has
filed this schedule pursuant to §240.13d-1(b)(1)(ii)(J), so indicate under Item 3(j) and attach an exhibit stating the identity
and Item 3 classification of each member of the group. If a group has filed this schedule pursuant to Rule 13d-1(c) or Rule 13d-1(d),
attach an exhibit stating the identity of each member of the group.
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N/A |
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Item 9. |
Notice of Dissolution of Group. |
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Notice of dissolution
of a group may be furnished as an exhibit stating the date of the dissolution and that all further filings with respect to transactions
in the security reported on will be filed, if required, by members of the group, in their individual capacity. See Item 5.
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N/A |
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By signing below
I certify that, to the best of my knowledge and belief, the securities referred to above acquired and are held in the ordinary course
of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of
the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having
that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. |
SIGNATURE
After reasonable inquiry and to the best
of my knowledge and belief, the undersigned certify that the information set forth in this statement is true, complete and correct.
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February 14, 2024 |
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(Date) |
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David Witzke
Avidity Partners Management LP
Avidity Partners Management (GP) LLC
Avidity Capital Partners Fund (GP) LP
Avidity Capital Partners (GP) LLC
Avidity Master Fund LP
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By: /s/ David
Witzke |
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David Witzke, for himself and as Managing Member
of Avidity Partners Management (GP) LLC (for itself and as general partner of Avidity Partners Management LP) and Avidity Capital
Partners (GP) LLC (for itself and as general partner of Avidity Capital Partners Fund (GP) LP (for itself and as general partner
of Avidity Master Fund LP)) |
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Michael Gregory
Avidity Partners Management LP
Avidity Partners Management (GP) LLC
Avidity Capital Partners Fund (GP) LP
Avidity Capital Partners (GP) LLC
Avidity Master Fund LP
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By: /s/Michael
Gregory |
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Michael Gregory, for himself and as Managing
Member of Avidity Partners Management (GP) LLC (for itself and as general partner of Avidity Partners Management LP) and Avidity
Capital Partners (GP) LLC (for itself and as general partner of Avidity Capital Partners Fund (GP) LP (for itself and as general
partner of Avidity Master Fund LP)) |
The original
statement shall be signed by each person on whose behalf the statement is filed or his authorized representative. If the statement is
signed on behalf of a person by his authorized representative other than an executive officer or general partner of the filing person,
evidence of the representative's authority to sign on behalf of such person shall be filed with the statement, provided, however, that
a power of attorney for this purpose which is already on file with the Commission may be incorporated by reference. The name and any
title of each person who signs the statement shall be typed or printed beneath his signature.
Note. Schedules
filed in paper format shall include a signed original and five copies of the schedule, including all exhibits. See s.240.13d-7 for other
parties for whom copies are to be sent.
Attention. Intentional
misstatements or omissions of fact constitute Federal criminal violations (see 18 U.S.C. 1001).
Exhibit 1
JOINT FILING
AGREEMENT
In
accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended, the persons named below agree to the joint filing
on behalf of each of them of a Statement on Schedule 13G (including amendments thereto) with respect to the Common Stock, $0.0001 par
value of Karyopharm Therapeutics Inc., and further agree that this Joint Filing Agreement be included as an Exhibit to such joint filing
The
undersigned further agree that each party hereto is responsible for the timely filing of such Statement on Schedule 13G and any amendments
thereto, and for the accuracy and completeness of the information concerning such party contained therein; provided, however, that no
party is responsible for the accuracy or completeness of the information concerning any other party, unless such party knows or has reason
to believe that such information is inaccurate.
IN
WITNESS WHEREOF, the undersigned hereby execute this Agreement as of February 14, 2024.
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|
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David Witzke
Avidity Partners Management LP
Avidity Partners Management (GP) LLC
Avidity Capital Partners Fund (GP) LP
Avidity Capital Partners (GP) LLC
Avidity Master Fund LP
/s/ David Witzke |
|
|
David Witzke, for himself and as Managing Member of Avidity Partners Management (GP)
LLC (for itself and as general partner of Avidity Partners Management LP) and Avidity Capital Partners (GP) LLC (for itself and as
general partner of Avidity Capital Partners Fund (GP) LP (for itself and as general partner of Avidity Master Fund LP)) |
|
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Michael Gregory |
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Avidity Partners Management LP |
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Avidity Partners Management (GP) LLC |
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Avidity Capital Partners Fund (GP) LP |
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Avidity Capital Partners (GP) LLC
Avidity Master Fund LP |
|
|
|
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By: |
/s/ Michael Gregory |
|
|
Michael Gregory, for himself and as Managing Member of Avidity Partners Management
(GP) LLC (for itself and as general partner of Avidity Partners Management LP) and Avidity Capital Partners (GP) LLC (for itself
and as general partner of Avidity Capital Partners Fund (GP) LP (for itself and as general partner of Avidity Master Fund LP)) |
Grafico Azioni Karyopharm Therapeutics (NASDAQ:KPTI)
Storico
Da Ago 2024 a Set 2024
Grafico Azioni Karyopharm Therapeutics (NASDAQ:KPTI)
Storico
Da Set 2023 a Set 2024