As filed with the Securities and Exchange
Commission on January 6, 2025
Registration No. 333-283306
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
PRE-EFFECTIVE
AMENDMENT NO. 2
TO
FORM S-3
REGISTRATION STATEMENT
UNDER THE
SECURITIES ACT OF 1933
Neuphoria Therapeutics Inc.
(Exact name of Registrant as specified in its
charter)
Not Applicable
(Translation of Registrant’s name into
English)
Delaware |
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99-3845449 |
(State or other jurisdiction of
incorporation or organization) |
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(IRS Employer
Identification No.) |
100 Summit Dr
Burlington, Massachusetts 01803
+1 781 439 5551
(Address and telephone number of Registrant’s
principal executive offices)
Spyridon “Spyros” Papapetropoulos
President, Chief Executive Officer and Director
100 Summit Dr
Burlington, Massachusetts 01803
+1 781 439 5551
(Name, address, and telephone number of agent
for service)
With copies to:
Theodore Ghorra, Esq.
Rimon P.C.
400 Madison Ave
New York, NY 10017
(212) 515-9979
Approximate date of commencement of proposed
sale to the public: From time to time after the effective date of this Registration Statement.
If the only securities being registered on this
Form are being offered pursuant to dividend or interest reinvestment plans, please check the following box. ☐
If any of the securities being registered on this
Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, other than securities offered
only in connection with dividend or interest reinvestment plans, check the following box. ☒
If this Form is filed to register additional securities
for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration
statement number of the earlier effective registration statement for the same offering. ☐
If this Form is a post-effective amendment filed
pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of
the earlier effective registration statement for the same offering. ☐
If this Form is a registration statement pursuant
to General Instruction I.D. or a post-effective amendment thereto that shall become effective upon filing with the Commission pursuant
to Rule 462(e) under the Securities Act, check the following box. ☐
If this Form is a post-effective amendment to
a registration statement filed pursuant to General Instruction I.D. filed to register additional securities or additional classes of securities
pursuant to Rule 413(b) under the Securities Act, check the following box. ☐
Indicate by check mark whether the registrant
is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company.
See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,”
and “emerging growth company” in Rule 12b-2 of the Exchange Act.
Large accelerated filer |
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Accelerated filer |
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Non-accelerated filer |
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Smaller reporting company |
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Emerging growth company |
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If an emerging growth company, indicate by check
mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting
standards† provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☐
The term “new or revised financial accounting
standard” refers to any update issued by the Financial Accounting Standards Board to its Accounting Standards Codification after
April 5, 2012.
We hereby amend this Registration Statement
on such date or dates as may be necessary to delay its effective date until we file a further amendment which will specifically state
that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act, or until
the Registration Statement shall become effective on such date as the Securities and Exchange Commission, acting pursuant to said Section 8(a),
may determine.
EXPLANATORY NOTE
This registration statement contains:
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A base prospectus, which covers the offering, issuance
and sales by us of up to $100,000,000 in the aggregate of our common stock, par value $0.00001 per share (“common stock”),
from time to time in one or more offerings; and |
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An ATM offering sales agreement prospectus covering
the offering, issuance and sale by us of up to a maximum aggregate offering price of $2,000,000 of our common stock that may be issued
and sold from time to time under an ATM Offering Agreement (the “Sales Agreement”), with H.C. Wainwright & Co., LLC
(“HCW”), as sales agent. |
This Pre-Effective Amendment No. 2 to the
registration statement is being filed for the purpose of reflecting the redomiciliation of Bionomics Limited, an Australian
corporation (“Bionomics”), which was implemented under Australian law in accordance with a Scheme Implementation
Agreement (as amended) between Bionomics and the registrant, a Delaware corporation. As a result of the redomiciliation, Bionomics
became a wholly-owned subsidiary of the registrant.
The base prospectus immediately follows this
explanatory note. The specific terms of any securities to be offered pursuant to the base prospectus will be specified in a prospectus
supplement to the base prospectus. The Sales Agreement prospectus immediately follows the base prospectus. The $2,000,000 of common stock
that may be offered, issued and sold under the Sales Agreement prospectus is included in the $100,000,000 of securities that may be offered,
issued and sold by us under the base prospectus. Upon termination of the Sales Agreement, any portion of the $2,000,000 included in the
Sales Agreement prospectus that is not sold pursuant to the Sales Agreement will be available for sale in other offerings pursuant to
the base prospectus, and if no common stock is sold under the Sales Agreement, the full $2,000,000 of securities may be sold in other
offerings pursuant to the base prospectus.
The information in this prospectus is
not complete and may be changed. These securities may not be sold until the registration statement filed with the Securities and Exchange
Commission is declared effective. This prospectus is not an offer to sell the securities and it is not soliciting an offer to buy these
securities in any jurisdiction where the offer or sale is not permitted.
Subject to Completion,
dated January 6, 2025
PROSPECTUS
Up to $100,000,000
Common Stock
Debt Securities
Warrants
We may offer and sell up to $100,000,000 in the
aggregate of the securities identified above from time to time in one or more offerings. This prospectus provides you with a general description
of the securities.
Each time we offer and sell securities, we will
provide a supplement to this prospectus that contains specific information about the offering and the amounts, prices and terms of the
securities, if required. The supplement may also add, update or change information contained in this prospectus with respect to that offering.
You should carefully read this prospectus and the applicable prospectus supplement before you invest in any of our securities.
We may offer and sell the securities described
in this prospectus and any prospectus supplement to or through one or more underwriters, dealers and agents, or directly to purchasers,
or through a combination of these methods. If any underwriters, dealers or agents are involved in the sale of any of the securities, their
names and any applicable purchase price, fee, commission or discount arrangement between or among them will be set forth, or will be calculable
from the information set forth, in the applicable prospectus supplement. See the sections of this prospectus entitled “About
this Prospectus” and “Plan of Distribution” for more information. No securities may be sold without delivery
of this prospectus and the applicable prospectus supplement describing the method and terms of the offering of such securities.
INVESTING IN OUR SECURITIES INVOLVES RISKS.
SEE THE “RISK FACTORS” ON PAGE 8 OF THIS PROSPECTUS AND ANY SIMILAR SECTION CONTAINED IN THE APPLICABLE PROSPECTUS
SUPPLEMENT CONCERNING FACTORS YOU SHOULD CONSIDER BEFORE INVESTING IN OUR SECURITIES.
Our common stock is listed on the Nasdaq Global
Market (“Nasdaq”) under the symbol “NEUP.” On January 3, 2025, the last reported sale price of our common stock,
as reported on Nasdaq, was $3.40 per share.
As of January 3, 2025, the aggregate market
value of our common stock held by non-affiliates, or public float, was approximately $10,773,823 based on 1,628,659 shares of common
stock outstanding (less any insider holdings), based on a closing price of $6.63 per share on December 24, 2024, which was the highest
closing sale price of our common stock on the Nasdaq Global Market, the principal market for our common equity, within 60 days of the
filing date of this registration statement. In the past 12 calendar months, we have offered and sold pursuant to General Instruction
I.B.5 of Form F-3 (which the Company was previously subject to as a foreign private issuer) an aggregate of 1,200,578 American Depositary
Shares (“ADSs”) for gross proceeds of approximately $1,483,706. Pursuant to General Instruction I.B.6 of Form S-3 (which
the Company is now subject to as a domestic U.S. reporting company), in no event will we sell securities registered on this registration
statement in a public primary offering with a value exceeding more than one-third of our public float in any 12-month period so long
as our public float remains below $75.0 million
Neither the Securities and Exchange Commission,
any state securities commission, nor any other foreign securities commission has approved or disapproved of these securities or passed
upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.
This prospectus is dated January 6, 2025.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This prospectus is part of a registration
statement that we filed with the Securities and Exchange Commission (the “SEC”), using a “shelf” registration
process. By using a shelf registration statement, we may, from time to time, offer and sell, in one or more offerings as described in
this prospectus, our common stock, par value $0.00001 per share, debt securities and/or warrants, with a total aggregate offering price
of up to $100,000,000.
This prospectus provides you with a general description
of the securities that we may offer. Each time we sell our securities, we will provide a prospectus supplement to this prospectus that
contains specific information about the securities being offered and sold and the specific terms of that offering, if required. We may
also authorize one or more free writing prospectuses to be provided to you that may contain material information relating to these offerings.
The prospectus supplement or free writing prospectus may also add, update or change information contained in this prospectus with respect
to that offering or in the documents that we have incorporated by reference into this prospectus with respect to that offering. If there
is any inconsistency between the information in this prospectus and the applicable prospectus supplement or free writing prospectus, you
should rely on the prospectus supplement or free writing prospectus, as applicable. Before purchasing any of our securities, you should
carefully read both this prospectus and the applicable prospectus supplement (and any applicable free writing prospectuses), together
with additional information incorporated by reference herein and described under the headings “Where You Can Find More Information”
and “Incorporation by Reference.”
The registration statement containing this prospectus,
including exhibits to the registration statement, provides additional information about us and the securities offered under this prospectus.
The registration statement can be read on the SEC website or at the SEC office mentioned under the heading “Where You Can Find More
Information.”
When acquiring any securities described in this
prospectus, you should rely only on the information provided in this prospectus and in any applicable prospectus supplement, including
the information incorporated by reference. Neither we nor any underwriter, dealer or agent have authorized anyone to provide you with
different information. If anyone provides you with different or inconsistent information, you should not rely on it. We are not offering
our securities in any jurisdiction where the offer or sale is prohibited. You should not assume that the information in this prospectus,
any prospectus supplement or any document incorporated by reference is truthful or complete at any date other than the date mentioned
on the cover page of any such document.
We may sell our securities to underwriters who
will sell the securities to the public at a fixed offering price or at varying prices determined at the time of sale. The applicable prospectus
supplement will contain the names of the underwriters, dealers or agents, if any, together with the terms of offering, the compensation
of those underwriters, dealers or agents and the net proceeds to us. Any underwriters, dealers or agents participating in the offering
may be deemed “underwriters” within the meaning of the Securities Act of 1933, as amended (the “Securities Act”).
The terms “we,” “our,”
“us” and the “Company” in this prospectus refer to Neuphoria Therapeutics Inc. and its consolidated subsidiaries
after December 23, 2024 and Bionomics and its consolidated subsidiaries on and prior to December 23, 2024, unless otherwise specified.
When we refer to “you,” we mean the potential holders of the applicable series of securities.
We use our registered and unregistered trademarks,
including Neuphoria™ and Bionomics™, in this prospectus. This prospectus also includes trademarks,
tradenames and service marks that are the property of other organizations. Solely for convenience, trademarks and tradenames referred
to in this prospectus appear without the ® and ™ symbols, but those references are
not intended to indicate in any way that we will not assert, to the fullest extent under applicable law, our rights or that the applicable
owner will not assert its rights, to these trademarks and tradenames.
Unless otherwise indicated, all amounts presented
in this prospectus are presented in U.S. Dollars (“$”). Our fiscal year end is June 30. References to a particular “fiscal
year” are to our fiscal year ended June 30 of that calendar year.
For investors outside the United States: We
have not done anything that would permit the offering or possession or distribution of this prospectus in any jurisdiction where action
for that purpose is required, other than in the United States. Persons outside the United States who come into possession of this prospectus
must inform themselves about, and observe any restrictions relating to, the offering of the securities described herein and the distribution
of this prospectus outside the United States.
PROSPECTUS SUMMARY
This summary does not contain all of the information
that may be important to you in making your investment decision. In addition to this summary, you should carefully read the entire prospectus,
the applicable prospectus supplement and any related free writing prospectus, including the risks of investing in our securities discussed
under the heading “Risk Factors” contained herein and in the applicable prospectus supplement and any related free writing
prospectus, and under similar headings in the other documents that are incorporated by reference into this prospectus before deciding
whether to invest in our securities. You should also carefully read the information incorporated by reference into this prospectus, including
our financial statements, and the exhibits to the registration statement of which this prospectus is a part.
Overview
We are a clinical-stage biotechnology company
dedicated to developing therapies that address the complex needs of individuals affected by neuropsychiatric disorders. Neuphoria is
advancing its lead drug candidate, BNC210, an oral, proprietary, selective negative allosteric modulator of the α7 nicotinic acetylcholine
receptor, for the acute, “as needed” treatment of social anxiety disorder (“SAD”) and for chronic treatment of
post-traumatic stress disorder (“PTSD”). BNC210 is a first-of-its-kind, well-tolerated, broad spectrum anti-anxiety experimental
therapeutic, designed to restore neurotransmitter balance in relevant brain areas, providing rapid relief from stress and anxiety symptoms
without the common pitfalls of sedation, cognitive impairment, or addiction. In addition, Neuphoria has a strategic partnership with
Merck & Co., Inc. (known as MSD outside the United States and Canada) with two drugs in early-stage clinical trials for the treatment
of cognitive deficits in Alzheimer’s disease and other central nervous system conditions. Neuphoria's pipeline also includes the
α7 nicotinic acetylcholine receptor next generation and the Kv3.1/3.2 preclinical programs, both in the lead optimization development
stage.
We are advancing our lead product candidate,
BNC210, an oral, proprietary, selective negative allosteric modulators of the α7 nicotinic acetylcholine (“ACh”) receptor
(“α7 receptor”), for the chronic treatment of PTSD and the acute treatment of Social Anxiety Disorder. There remains
a significant unmet medical need for the over 27 million patients in the United States alone suffering from SAD and PTSD.
Current pharmacological treatments include certain
antidepressants and benzodiazepines, and there have been no new FDA approved therapies in these indications in nearly two decades. These
existing treatments have multiple shortcomings, such as a slow onset of action of antidepressants, and significant side effects of both
classes of drugs, including abuse liability, addiction potential and withdrawal symptoms. BNC210 has been observed in our clinical trials
to have a fast onset of action and clinical activity without the limiting side effects seen with the current standard of care.
In September 2023, we announced the results of
the Phase 2b ATTUNE study, which was a double-blind, placebo-controlled trial conducted in a total of 34 sites in the United States and
the United Kingdom, with 212 enrolled patients, randomized 1:1 to receive either twice daily 900 mg BNC210 as a monotherapy (n=106) or
placebo (n=106) for 12 weeks. The trial met its primary endpoint of change in Clinician-Administered PTSD Scale for DSM-5 (“CAPS-5”)
total symptom severity score from baseline to Week 12 (p=0.048). A statistically significant change in CAPS-5 score was also observed
at Week 4 (p=0.016) and at Week 8 (p=0.015). Treatment with BNC210 also showed statistically significant improvement both in clinician-administered
and patient self-reporting in two of the secondary endpoints of the trial. Specifically, BNC210 led to significant improvements at Week
12 in depressive symptoms (p=0.041) and sleep (p=0.039) as measured by Montgomery-Åsberg Depression Rating Scale (“MADRS”)
and Insomnia Severity Index (ISI), respectively. BNC210 also showed signals and trends across visits in the other secondary endpoints
including the clinician and patient global impression - symptom severity (“CGI-S”, “PGI-S”, respectively) and
the Sheehan Disability Scale (“SDS”). In July 2024, we announced a positive outcome of an End-of-Phase 2 meeting with FDA
that provides a potential path to New Drug Application (“NDA”) submission for BNC210 for PTSD that alongside the positive
Phase 2b ATTUNE trial includes a single additional Phase 3 trial. This Phase 3 trial will evaluate two dose levels of BNC210 in a 12-week
randomized, double-blind, placebo-controlled trial with a 52-week open-label extension. Start-up activities for a planned Phase 3 trial
of BNC210 in PTSD are underway. We plan to initiate the Phase 3 trial in PTSD in the second half of 2025, contingent upon having sufficient
capital on hand. Although the FDA has denied our initial Breakthrough Therapy designation application, we are considering a rebuttal in
the future. The approval process for the BNC210 PTSD program is not expected to be impeded, as we have already received Fast-Track designation
for both the PTSD and SAD programs.
We have completed our Phase 2 PREVAIL trial for
BNC210 for the acute treatment of SAD. While PREVAIL narrowly missed its primary endpoint, as measured by the change from baseline to
the average of the Subjective Units of Distress Scale (“SUDS”) scores during a 5-minute Public Speaking Challenge in the BNC210-treated
patients when compared to placebo, the December 2022 topline data readout revealed encouraging trends in the prespecified endpoints. The
findings did indicate a consistent trend toward improvements across primary and secondary endpoints and a favorable safety and tolerability
profile consistent with previously reported results. These results supported a post-hoc in-depth analysis of the full dataset to better
understand the potential of the drug and guide late-stage trial design. In October 2023, we announced a positive outcome of an End-of-Phase
2 meeting with FDA that enables advancement of BNC210 into Phase 3 studies in SAD. Start-up activities for a planned Phase 3 trial of
BNC210 in SAD are underway. In July 2024, we announced the initiation of patient screening for the Phase 3 AFFIRM-1 trial evaluating the
safety and efficacy of BNC210 for the acute, as-needed treatment of SAD. AFFIRM-1 targets enrollment of 330 adult patients with SAD at
clinical sites in the United States. It is a multi-center, double-blind, two-arm, parallel group, placebo-controlled trial. Participants
will be randomized 1:1 to receive a single dose of 225 mg BNC210 or matched placebo about one hour before speaking in public. The primary
endpoint will compare BNC210 to placebo using the SUDS to measure self-reported anxiety levels during a public speaking task. Secondary
efficacy endpoints include the Clinical and Patient Global Impression (“CGI” and “PGI”, respectively) scales and
the State-Trait Anxiety Inventory (“STAI”). Topline results from the AFFIRM-1 trial are expected in the third quarter of 2025.
The Company’s expertise in ion channels
and approach to developing allosteric modulators have been validated through its strategic partnership with MSD for our α7 receptor
positive allosteric modulator program, which targets a receptor that has garnered significant attention for treating cognitive deficits.
This partnership enables us to maximize the value of its ion channel and chemistry platforms and develop transformative medicines for
patients suffering from cognitive disorders such as Alzheimer’s disease.
The above-stated overview is a summary, and
not a complete statement on our Company, business, pipeline products or clinical trials. For a complete description of the Company and
its business and product pipelines, as well as clinical trials and more, please read our annual report on form 10-K, filed with the SEC
on September 30, 2024, as well as any quarterly and current reports we have filed and will subsequently file with the SEC, which provides
further updates on our company, the business, risk factors, financial performance and more, each of which is incorporated by reference
in this registration statement.
Summary Risks Factors
Investing in our securities involves a high degree
of risk. Below is a summary of certain factors that make an investment in our securities speculative or risky. Importantly, this summary
does not address all of the risks that we face. Additional discussion of the risks summarized below, as well as other risks that we face,
can be found under the heading “Risk Factors” contained in the applicable prospectus supplement and in any free writing prospectuses
we have authorized for use in connection with a specific offering, and under similar headings in the documents that are incorporated
by reference into this prospectus.
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We are a clinical-stage biopharmaceutical company with no approved products. We have incurred significant operating losses since our inception and expect to incur significant losses for the foreseeable future. We may never generate any revenue or become profitable or, if we achieve profitability, we may not be able to sustain it. |
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We will require substantial additional financing to achieve our goals, and a failure to obtain this necessary capital when needed on acceptable terms, or at all, could force us to delay, limit, reduce or terminate our product development programs, commercialization efforts or other operations. |
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Preclinical and clinical drug development is a lengthy and expensive process, with an uncertain outcome. Our preclinical and clinical programs may experience delays or may never advance, which would adversely affect our ability to obtain regulatory approvals or commercialize our product candidates on a timely basis or at all, which could have an adverse effect on our business. |
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If we experience delays or difficulties in the initiation,
enrollment and/or retention of patients in clinical trials, our regulatory submissions or receipt of necessary regulatory approvals
could be delayed or prevented. |
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The trading price of our
common stock has been and may remain volatile, and you may not be able to resell your common stock at or above the price you paid. |
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An active trading market for our common stock may
not be maintained or be liquid enough for you to sell your common stock quickly or at market price. |
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Your right as a holder of our common stock to participate
in any future preferential subscription rights offering or to elect to receive dividends in shares of our common stock may be limited,
which may cause dilution to your holdings. |
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Our current or future product candidates may cause adverse or other undesirable side effects that could delay or prevent their regulatory approval, limit the commercial profile of an approved label or result in significant negative consequences following marketing approval, if any. |
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We may have difficulties in attracting and retaining key personnel, and if we fail to do so our business may suffer. |
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We depend on collaboration partners to develop and commercialize our collaboration product candidates, including Merck and Carina Biotech. If our collaboration partners fail to perform as expected, fail to advance our collaboration product candidates or are unable to obtain the required regulatory approvals for our collaboration product candidates, the potential for us to generate future revenue from such product candidates would be significantly reduced and our business would be significantly harmed. |
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We currently rely, and expect to continue to rely, on third parties to conduct some or all aspects of our product manufacturing, research and preclinical and clinical testing, and these third parties may not perform satisfactorily. |
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We may not be able to protect our intellectual property rights throughout the world. |
Corporate Information
We are a Delaware company listed on the Nasdaq
Global Market. Our registered office is located at 100 Summit Dr, Burlington, Massachusetts 01803, and our telephone number is +1 781
439 5551. Our website address is www.neuphoriatx.com. The information contained in, or accessible through, our website
does not constitute part of this prospectus.
As previously disclosed in a current report
on Form 8-K, which was filed with the SEC on October 2, 2024, we and Bionomics entered into a Scheme Implementation Agreement to re-domicile
from Australia to the U.S. State of Delaware pursuant to a Scheme of Arrangement under Australian law. Subsequently, as further disclosed
in another current report on Form 8-K filed on November 8, 2024, we and Bionomics entered into an amendment to the Scheme Implementation
Agreement to amend the exchange ratio of securities outstanding. On December 23, 2024, as disclosed in another current report on Form
8-K filed on the same day, the redomiciliation of Bionomics was implemented under Australian law in accordance with the Scheme Implementation
Agreement, as amended. As a result of the redomiciliation, (i) Bionomics became our wholly-owned subsidiary; (ii) holders of ordinary
shares of Bionomics received one share of our common stock for every 2,160 ordinary shares of Bionomics held on the Scheme record date;
(iii) holders of Bionomics’ ADSs, with each ADS representing 180 ordinary shares of Bionomics, received one share of our common
stock for every 12 ADSs held on the Scheme record date; and (iv) we became the successor issuer to Bionomics. Bionomics was previously
listed on the ASX between November 26, 1999 and August 28, 2023.
As disclosed in a Form 8-K filed on July
16, 2024, Bionomics received a letter from the Listing Qualifications Department of the Nasdaq Stock Market (“Nasdaq”)
indicating that, based upon the closing bid price of the company’s ADSs for the 30 consecutive business days between May 28,
2024 and July 10, 2024, Bionomics did not meet the minimum bid price of $1.00 per share required for continued listing on The Nasdaq
Global Market pursuant to Nasdaq Listing Rule 5450(a)(1). The letter also indicated that Bionomics will be provided with a
compliance period of 180 calendar days, or until January 7, 2025, in which to regain compliance. Following completion of the Scheme,
we have regained compliance with Nasdaq’s minimum bid price requirement. Each of the form 8-Ks noted above, along with other
annual, quarterly and current reports previously and subsequently filed with the SEC are incorporated by reference into this
registration statement. See the “Incorporation by Reference” heading on page 27 for more information on the SEC filings
that are incorporated by reference into this registration statement.
Since July 1, 2024, we have been reporting
as a domestic U.S. issuer on SEC Forms 10-K, 10-Q and 8-K.
Implications of Being an Emerging Growth Company
As a company with less than $1.235 billion
in revenue during our last fiscal year, we qualify as an “emerging growth company” as defined in the Jumpstart Our Business
Startups Act (the “JOBS Act”), enacted in April 2012. An emerging growth company may take advantage of reduced reporting
requirements that are otherwise applicable to public companies. These provisions include, but are not limited to:
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not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley Act”); |
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reduced disclosure obligations regarding executive compensation in our periodic reports (if any), proxy statements (if any) and registration statements; and |
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exemptions from the requirements of holding a nonbinding
advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved. |
We may take advantage of these provisions
until the last day of our fiscal year following the fifth anniversary of our initial public offering. However, if certain events occur
prior to the end of such five-year period, including if we become a “large accelerated filer,” our annual gross revenues
exceed $1.235 billion or we issue more than $1.0 billion of non-convertible debt in any three-year period, we will
cease to be an emerging growth company prior to the end of such five-year period.
We have elected to take advantage of certain of
the reduced disclosure obligations in this prospectus and in the registration statement of which this prospectus is a part and may elect
to take advantage of other reduced reporting requirements in future filings. As a result, the information in this prospectus and that
we provide to our stockholders in the future may be different than what you might receive from other public reporting companies in which
you hold equity interests.
The Securities We May Offer
Under this prospectus, we may offer common
stock, various series of debt securities or warrants to purchase any of such securities, either individually or in units, with a total
aggregate offering price of up to $100,000,000, from time to time at prices and on terms to be determined by market conditions at the
time of the offering. This prospectus provides you with a general description of the securities we may offer. Each time we offer a type
or series of securities under this prospectus, we will provide a prospectus supplement that will describe the specific amounts, prices
and other important terms of the securities, including, to the extent applicable:
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designation or classification; |
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aggregate principal amount or aggregate offering price; |
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maturity, if applicable; |
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rates and times of payment of interest or dividends, if any; |
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redemption, conversion or sinking fund terms, if any; |
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voting or other rights, if any; and |
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conversion or exercise prices, if any. |
The prospectus supplement, and any related free
writing prospectus that we may authorize to be provided to you, also may add, update or change information contained in this prospectus
or in documents we have incorporated by reference into this prospectus.
We may sell the securities directly to investors
or to or through agents, underwriters or dealers. We, and our agents or underwriters, reserve the right to accept or reject all or part
of any proposed purchase of securities. If we offer securities through agents or underwriters, we will include in the applicable prospectus
supplement:
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the names of those agents or underwriters; |
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applicable fees, discounts and commissions to be paid to them; |
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details regarding over-allotment options, if any; and |
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the net proceeds to us. |
This prospectus may not be used to consummate
a sale of any securities unless it is accompanied by a prospectus supplement.
CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING
STATEMENTS
This prospectus, the documents incorporated by
reference herein and any accompanying prospectus supplement may contain or incorporate forward-looking statements that are based on our
management’s belief and assumptions and on information currently available to our management. Although we believe that the expectations
reflected in these forward-looking statements are reasonable, these statements relate to future events or our future financial performance,
and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance
or achievements to be materially different from any future results, levels of activity, performance or achievements stated in or implied
by these forward-looking statements.
All statements other than statements of historical
facts are forward-looking statements. These forward-looking statements are made under the “safe harbor” provision under Section 27A
of the Securities Act and 21E of the Securities Exchange Act of 1934 (as amended, the “Exchange Act”), and as defined in
the Private Securities Litigation Reform Act of 1995. In some cases, you can identify forward-looking statements by terms such as “anticipate,”
“believe,” “contemplate,” “continue,” “could,” “estimate,” “expect,”
“intend,” “may,” “plan,” “potential,” “predict,” “project,” “should,”
“target,” “will,” or “would” or the negative of these terms or other similar expressions, although
not all forward-looking statements contain these words. These statements are only predictions. You should not place undue reliance on
forward-looking statements because they involve known and unknown risks, uncertainties and other factors, which are, in some cases, beyond
our control and which could materially affect results. You should refer to the “Risk Factors” section of this
prospectus, any accompanying prospectus supplement, and our annual reports on Form 10-K and quarterly reports on Form 10-Q filed
with the SEC for specific risks that could cause actual results to be significantly different from those stated in or implied by these
forward-looking statements. If one or more of these risks or uncertainties occur, or if our underlying assumptions prove to be incorrect,
actual events or results may vary significantly from those implied or projected by the forward-looking statements. No forward-looking
statement is a guarantee of future performance. Forward-looking statements speak only as of the date made and we undertake no obligation
to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. You
should read this prospectus, any accompanying prospectus supplement and the documents that we reference in this prospectus and have filed
with the SEC as exhibits to the registration statement, of which this prospectus is a part, completely and with the understanding that
our actual future results may be materially different from any future results stated in or implied by these forward-looking statements.
Forward-looking statements in this prospectus
include, but are not limited to, statements about:
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the ability of our clinical trials to demonstrate safety and efficacy of our product candidates, and other positive results; |
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the timing and focus of our ongoing and future clinical trials and preclinical studies, and the reporting and interpretation of data from those trials and studies; |
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our plans relating to commercializing our product candidates, if approved, including the geographic areas of focus and sales strategy; |
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the market opportunity and competitive landscape for our product candidates, including our estimates of the number of patients who suffer from the conditions we are targeting; |
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the success of competing therapies that are or may become available; |
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our estimates of the number of patients that we will enroll in our clinical trials; |
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the beneficial characteristics, safety, efficacy and therapeutic effects of our product candidates; |
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the timing of initiation and completion, and the progress of our drug discovery and research programs; |
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the timing or likelihood of regulatory filings and approvals for our product candidates for various diseases; |
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our ability to obtain and maintain regulatory approval of our product candidates; |
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our plans relating to the further development of our product candidates, including additional indications we may pursue; |
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existing regulations
and regulatory developments in the United States, Europe and other jurisdictions; |
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risks associated with the COVID-19 pandemic, which has and may continue to materially and adversely impact our business, preclinical studies and clinical trials; |
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our plans and ability to obtain, maintain, protect and enforce our intellectual property rights and our proprietary technologies, including extensions of existing patent terms where available; |
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our continued reliance on third parties to conduct additional clinical trials of our product candidates, and for the manufacture of our product candidates for preclinical studies and clinical trials; |
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our plans regarding, and our ability to enter into, and negotiate favorable terms of, any collaboration, licensing or other arrangements that may be necessary or desirable to develop, manufacture or commercialize our product candidates; |
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the need to hire additional personnel and our ability to attract and retain such personnel; |
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our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; |
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our financial performance; |
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the period over which we estimate our existing cash and cash equivalents will be sufficient to fund our future operating expenses and capital expenditure requirements; |
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our anticipated use of our existing resources; and |
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cyber security risks and any failure to maintain the confidentiality, integrity and availability of our computer hardware, software and internet applications and related tools and functions; and |
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our expectations regarding the period during which we will qualify as an emerging growth company under the JOBS Act. |
The “Risk Factors” section of
this prospectus, any accompanying prospectus supplement, our annual reports on Form 10-K and our quarterly reports on Form 10-Q filed
with the SEC references the principal contingencies and uncertainties to which we believe we are subject, which should be considered
in evaluating any forward-looking statements contained or incorporated by reference in this prospectus or in any prospectus supplement.
RISK FACTORS
Before purchasing any of the securities, you should
carefully consider the risk factors incorporated by reference in this prospectus from our most recent Annual Report on Form 10-K and any
subsequent updates described in our Quarterly Reports on Form 10-Q and Current Reports on Form 8-K, as well as the risks, uncertainties
and additional information set forth in our SEC reports on Forms 10-K, 10-Q and 8-K and in the other documents incorporated by reference
in this prospectus. For a description of these reports and documents, and information about where you can find them, see “Incorporation
of Certain Information By Reference.” Additional risks not presently known or that we presently consider to be immaterial could
subsequently materially and adversely affect our financial condition, results of operations, business and prospects.
The occurrence of any of these risks might cause
you to lose all or part of your investment in the offered securities. There may be other unknown or unpredictable economic, business,
competitive, regulatory or other factors that could have material adverse effects on our future results. Past financial performance may
not be a reliable indicator of future performance, and historical trends should not be used to anticipate results or trends in future
periods. If any of these risks actually occurs, our business, financial condition, results of operations or cash flow could be seriously
harmed. This could cause the trading price of our securities to decline, resulting in a loss of all or part of your investment. Please
also carefully read the section entitled “Cautionary Statement Regarding Forward-Looking Statements” included in our most
recent Annual Report on Form 10-K.
USE OF PROCEEDS
Our management will have broad discretion over
the use of the net proceeds from the sale of our securities pursuant to this prospectus, both in terms of the purposes for which they
will be used and the amounts that will be allocated for each purpose. We intend to use the net proceeds from the sale of any securities
offered under this prospectus for funding our research and development, pre-commercialization activities and for general corporate
purposes, unless otherwise indicated in the applicable prospectus supplement or free writing prospectus. General corporate purposes may
include, but are not limited to, the acquisition of companies or businesses, repayment and refinancing of debt, working capital, clinical
trial expenditures, commercial expenditures and capital expenditures. We will set forth in the applicable prospectus supplement or free
writing prospectus our intended use for the net proceeds received from the sale of any securities sold pursuant to the prospectus supplement
or free writing prospectus.
CAPITALIZATION
Our capitalization will be set forth in a prospectus
supplement to this prospectus subsequently furnished to the SEC and specifically incorporated herein by reference.
DESCRIPTION OF CAPITAL
STOCK
General
The following description of our capital stock
is only a summary. This summary is subject to the General Corporation Law of the State of Delaware (the “DGCL”) and the complete
text of our amended and restated certificate of incorporation (the “Certificate of Incorporation”) and bylaws (the “Bylaws”),
which are included as exhibits to the registration statement of which this prospectus forms a part.
Under our Certificate of Incorporation, Neuphoria
is authorized to issue up to 30,000,000 shares of common stock and 3,000,000 shares of preferred stock, par value $0.00001 per share.
Since we are not a foreign private issuer,
we are subject to all of the applicable rules of the Nasdaq Stock Market, and the rules and regulations governing publicly reporting
companies by the United States Securities and Exchange Commission. Our corporate affairs are principally governed by our Certificate
of Incorporation, Bylaws and the DGCL. Our common stock trades on the Nasdaq Global Market.
Subject to restrictions on the issue of securities
in our Certificate of Incorporation, the Securities Act of 1933, as amended, and the Nasdaq Stock Market listing rules and any other
applicable law, we may at any time issue shares and grant options or warrants on any terms, with the rights and restrictions and for
the consideration that our board of directors determine.
A general summary of some of the rights and
restrictions attaching to our common stock are summarized below. Each stockholder is entitled to receive notice of, and to be present,
vote and speak at, general meetings. As of December 31, 2024, we had (i) 1,628,659 fully paid shares of common stock issued, (ii) 50,536
shares of common stock issuable upon exercise of outstanding options at a weighted average exercise price of $158.19 per share, of which
options to purchase 37,166 shares of common stock were vested at a weighted average exercise price of $129.60 per share, and (iii) 1,054,381
shares of common stock issuable upon exercise of outstanding warrants at a weighted average exercise price of $11.88.
Common Stock
Dividend Rights
Subject to the rights of the holders of any
outstanding series of preferred stock, the holders of common stock are entitled to receive any dividends to the extent permitted by law
when, as and if declared by our directors.
Voting Rights
The holders of our common stock are entitled
to one vote per share on all matters on which stockholders are generally entitled to vote; provided, however, that, except as otherwise
required by law, holders of common stock, as such, are not entitled to vote on any amendment to the Certificate of Incorporation that
relates solely to the terms of one or more outstanding series of preferred stock if the holders of such affected series are entitled,
either separately or together with the holders of one or more other such series, to vote thereon pursuant to the Certificate of Incorporation.
Holders of our common stock do not have cumulative voting rights in the election of directors. Accordingly, the holders of a majority
of the combined voting power of our common stock could, if they so choose, elect all the directors.
Liquidation, Dissolution and Winding Up
Upon our dissolution, liquidation or winding
up of Neuphoria, subject to the rights of the holders of any outstanding series of preferred stock, the holders of shares of common stock
are entitled to receive the assets of Neuphoria available for distribution to its stockholders ratably in proportion to the number of
shares held by them.
Preemptive or Other Rights
The Certificate of Incorporation does not
entitle holders of our common stock to preemptive or conversion rights or other subscription rights. There are no redemption or sinking
fund provisions applicable to our common stock. The common stock may be subdivided or combined in any manner unless the other class is
subdivided or combined in the same proportion. All outstanding shares of our common stock are fully paid and non-assessable.
Authorized but Unissued Preferred Stock
Unless required by law or by any stock exchange
on which our common stock may be listed, the authorized shares of preferred stock will be available for issuance without further action
by our stockholders. Delaware law does not require stockholder approval for any issuance of authorized shares. However, the listing requirements
of Nasdaq, which apply as long as our common stock is listed on Nasdaq, require stockholder approval of certain issuances equal to or
exceeding 20% of the combined voting power of our common stock. These additional shares may be used for a variety of corporate purposes,
including future public offerings to raise additional capital, acquisitions and employee benefit plans.
Our Certificate of Incorporation authorizes
our board of directors to establish from time to time the number of shares to be included in each series of preferred stock, and to fix
the designation, powers, preferences, and relative, participating, optional or other rights, if any, and the qualifications, limitations
or restrictions, if any, of the shares of each series of preferred stock. Our board of directors is also able to increase or decrease
the number of authorized shares of any series of preferred stock (but not below the number of shares of that series of preferred stock
then outstanding) without any further vote or action by the stockholders.
The existence of unissued and unreserved common
stock or preferred stock may enable our board of directors to issue shares to persons friendly to current management, which could render
more difficult or discourage an attempt to obtain control of Neuphoria by means of a merger, tender offer, proxy contest or otherwise,
and could thereby protect the continuity of our management and possibly deprive stockholders of opportunities to sell their shares of
common stock at prices higher than prevailing market prices.
Meetings of Stockholders
Except as otherwise provided for or fixed
with respect to actions required or permitted to be taken solely by holders of preferred stock pursuant to the provisions of our Certificate
of Incorporation, no action that is required or permitted to be taken by our stockholders may be effected by consent of stockholders
in lieu of a meeting of stockholders. Except as otherwise required by law, and except as otherwise provided for or fixed pursuant to
our Certificate of Incorporation, a special meeting of stockholders may be called at any time only by our board of directors. Only such
business shall be conducted at a special meeting of stockholders as shall have been brought before the meeting by or at the direction
of our board of directors.
Quorum
At any meeting of stockholders, one-third
of the voting power of the stock outstanding and entitled to vote at the meeting, present in person or represented by proxy, shall constitute
a quorum for the transaction of business; provided, however, that where a separate vote by a class or series or classes or series is
required, a majority of the voting power of the stock of such class or series or classes or series outstanding and entitled to vote on
that matter, present in person or represented by proxy, constitutes a quorum entitled to take action with respect to such matter.
Exclusive Jurisdiction of Certain Actions
Our Certificate of Incorporation provides
that, unless we, in writing, select or consent to the selection of an alternative forum: (a) the sole and exclusive forum for any complaint
asserting any internal corporate claims (as defined in our Certificate of Incorporation), to the fullest extent permitted by law, and
subject to applicable jurisdictional requirements, will be the Court of Chancery of the State of Delaware (or, if the Court of Chancery
does not have, or declines to accept, jurisdiction, another state court or a federal court located within the State of Delaware); and
(b) the sole and exclusive forum for any complaint asserting a cause of action arising under the Securities Act, to the fullest extent
permitted by law, will be the federal district courts of the United States of America. Notwithstanding anything herein to the contrary,
this exclusive forum provision will not apply to suits brought to enforce a duty or liability created by the Exchange Act.
Anti-Takeover Effects of Delaware Law, the Certificate of Incorporation
and the Bylaws
Certain provisions of Delaware law, the Certificate
of Incorporation and the Bylaws could make the acquisition of Neuphoria more difficult and could delay, defer or prevent a tender offer
or other takeover attempt that a stockholder might consider to be in its best interest, including takeover attempts that might result
in the payment of a premium to stockholders over the market price for their shares. These provisions also may promote the continuity
of our management by making it more difficult for a person to remove or change the incumbent members of our board of directors.
Authorized but Unissued Shares; Undesignated
Preferred Stock. The authorized but unissued shares of our common stock are available for future issuance without stockholder approval
except as required by law or by any stock exchange on which our common stock may be listed. These additional shares may be utilized for
a variety of corporate purposes, including future public offerings to raise additional capital, acquisitions and employee benefit plans.
In addition, our board of directors may authorize, without stockholder approval, the issuance of undesignated preferred stock with voting
rights or other rights or preferences designated from time to time by our board of directors. The existence of authorized but unissued
shares of common stock or preferred stock may enable our board of directors to render more difficult or to discourage an attempt to obtain
control of us by means of a merger, tender offer, proxy contest or otherwise.
Board Classification. The Certificate
of Incorporation provides that our board of directors is divided into three classes of directors, with the directors serving three-year
terms. As a result, approximately one-third of our board of directors is elected each year. The classification of directors has the effect
of making it more difficult for stockholders to change the composition of our board of directors. The Certificate of Incorporation and
the Bylaws provide that, subject to any rights of holders of preferred stock to elect additional directors under specified circumstances,
the number of directors may be fixed from time to time exclusively pursuant to a resolution adopted by our board of directors.
No Cumulative Voting. Holders of our
common stock do not have cumulative voting rights in the election of directors.
Special Meetings of Stockholders. The
Certificate of Incorporation and the Bylaws provide that special meetings of our stockholders may be called only by our board of directors.
Only such business shall be conducted at a special meeting of stockholders as shall have been brought before the meeting by or at the
direction of our board of directors.
Stockholder Action by Written Consent.
Pursuant to Section 228 of the DGCL, any action required to be taken at any annual or special meeting of the stockholders may be taken
without a meeting, without prior notice and without a vote if a consent or consents in writing, setting forth the action so taken, is
signed by the holders of outstanding stock having not less than the minimum number of votes that would be necessary to authorize or take
such action at a meeting at which all shares of our stock entitled to vote thereon were present and voted, unless our certificate of
incorporation provides otherwise. The Certificate of Incorporation precludes stockholder action by written consent.
Advance Notice Requirements for Stockholder
Proposals and Nomination of Directors. The Bylaws require stockholders seeking to bring business before an annual meeting of stockholders,
or to nominate individuals for election as directors at an annual or special meeting of stockholders, to provide timely notice in writing.
To be timely, a stockholder’s notice must be delivered to the secretary at our principal executive offices not later than the close
of business on the 90th day nor earlier than the close of business on the 120th day, prior to the anniversary of the preceding year’s
annual meeting. However, in the event that the date of the annual meeting is more than 30 days before or more than 60 days after such
anniversary date, such notice will be timely only if delivered not earlier than the close of business on the 120th day prior to such
annual meeting and not later than the close of business on the later of the 90th day prior to such annual meeting or the tenth day following
the date on which a public announcement of the date of such annual meeting is first made by us. The Bylaws also specify requirements
as to the form and content of a stockholder’s notice. These provisions may preclude our stockholders from bringing matters before
our annual meeting of stockholders or from making nominations for directors at our meetings of stockholders. These provisions may also
discourage or deter a potential acquiror from conducting a solicitation of proxies to elect the potential acquiror’s own slate
of directors or otherwise attempting to obtain control of Neuphoria.
Removal of Directors; Vacancies. Under
the DGCL, unless otherwise provided in the Certificate of Incorporation, directors serving on a classified board may be removed by the
stockholders only for cause. The Certificate of Incorporation provides that directors may only be removed for cause and only by the affirmative
vote of holders of at least 66 2/3% in the voting power of the stock outstanding and entitled to vote thereon. In addition, the Certificate
of Incorporation also provides that, subject to the rights of the holders of any outstanding series of preferred stock and unless otherwise
required by law, any newly created directorship on our board of directors resulting from any increase in the authorized number of directors
and any vacancies in our board of directors may be filled solely by the affirmative vote of a majority of the remaining directors then
in office, even though less than a quorum, or by the sole remaining director (and not by the stockholders).
Supermajority Provisions. The Certificate
of Incorporation and the Bylaws provide that our board of directors is expressly authorized to adopt, amend or repeal the Bylaws without
a stockholder vote. Any adoption, amendment or repeal of the Bylaws by our stockholders requires the affirmative vote of the holders
of at least 66 2/3% of the voting power of the stock outstanding and entitled to vote thereon, voting together as a single class.
The DGCL provides generally that the affirmative
vote of a majority of the outstanding shares entitled to vote thereon, voting together as a single class, is required to amend a corporation’s
certificate of incorporation, unless the certificate of incorporation requires a greater percentage. The Certificate of Incorporation
provides that the affirmative vote of at least 66 2/3% of the voting power of the stock outstanding and entitled to vote thereon, voting
together as a single class, is required to amend or repeal, or adopt any provision inconsistent with, the following provisions in the
Certificate of Incorporation, among others:
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the provisions providing
for a classified board of directors (the election and term of our directors); |
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the provisions regarding
removal of directors; |
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the provisions regarding
filling vacancies on our board of directors and newly created directorships; |
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the provisions precluding
stockholder action by written consent; |
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the provisions regarding
calling special meetings of stockholders; |
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the provision requiring
a 66 2/3% supermajority vote for stockholders to amend the Bylaws; |
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the provisions eliminating
monetary damages for breaches of fiduciary duty by a director; and |
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the amendment provision
requiring that the above provisions be amended only with a 66 2/3% supermajority vote. |
Section 203 of the Delaware General Corporation
Law. The Certificate of Incorporation provides that we are not governed by, or otherwise subject to, Section 203 of the
DGCL.
Ownership Threshold
Since July 1, 2024, as a U.S. reporting public
company, our stockholders are subject to disclosure requirements under U.S. securities laws, including Schedule 13 and Section 16 of
the Securities Act. Stockholders who acquire more than 5% of the outstanding shares of our common stock must file beneficial owner reports
on Schedule 13D or 13G until their holdings drop below 5%. These filings contain background information about the stockholders who file
them as well as their investment intentions, providing investors and the company with information about accumulations of securities that
may potentially change or influence company management and policies.
Additionally, Section 16 of the Exchange Act
applies to an SEC reporting company’s directors and officers, as well as stockholders who own more than 10% of a class of the company’s
equity securities registered under the Exchange Act. The rules under Section 16 require these “insiders” to report most of
their transactions involving the company’s equity securities to the SEC within two business days on Forms 3, 4 or 5. Section 16
also establishes mechanisms for a company to recover “short swing” profits, or profits an insider realizes from a purchase
and sale of the company’s security that occur within a six-month period. In addition, Section 16 prohibits short selling by insiders
of any class of the company’s securities, whether or not that class is registered under the Exchange Act.
Stockholder Approval of Offering
Under applicable Nasdaq Listing Rules, a company
must not, subject to specified exceptions, without the approval of its stockholders, issue or agree to issue, any equity securities,
or other securities with rights to convert into equity at a price that is less than the Minimum Price (as defined in Nasdaq Rule 5636(d)(1))
if the number of those securities exceeds 19.99% of the number of shares issued and outstanding at the commencement of such offering.
Certain Nasdaq Corporate Governance Rules
In connection with applicable Nasdaq Listing and
Corporate Governance rules, since July 1, 2024 (at which time we no longer qualified as a foreign private issuer), we are required to
comply with corporate governance standards, laws, rules, regulations or generally accepted business practices in the United States. These
include, but are not limited to, items described below:
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The Nasdaq Listing Rules require us to have a majority of independent directors. Our board is currently composed of five directors, three are “independent” as defined under applicable Nasdaq rules. |
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Nasdaq Listing Rules require that an issuer provide
for a quorum as specified in its Bylaws for any meeting of the holders of common stock, which quorum may not be less than 33-1/3% of
the outstanding shares of an issuer’s voting common stock. |
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Under applicable Nasdaq Listing Rules, an issuer
must obtain stockholder approval prior to the issuance of any equity securities, or other securities with rights to convert into
equity at a price that is less than the Minimum Price (as defined in Nasdaq Rule 5636(d)(1)) if the number of those securities exceeds
19.99% of the number of shares issued and outstanding at the commencement of certain acquisitions, private placements of securities,
or the establishment or amendment of certain equity option, purchase or other compensation plans. |
Transfer Agent and Registrar
The transfer agent and registrar for Neuphoria’s
common stock is Computershare Trust Company, N.A. The transfer agent and registrar’s address is 250 Royall St., Canton, Massachusetts
02021.
Listing
Our common stock is listed on the Nasdaq Global
Market under the symbol “NEUP.”
DESCRIPTION OF DEBT SECURITIES
The following description, together with the additional
information we include in any applicable prospectus supplement or free writing prospectus, summarizes certain general terms and provisions
of the debt securities that we may offer under this prospectus. When we offer to sell a particular series of debt securities, we will
describe the specific terms of the series in a supplement to this prospectus. We will also indicate in the supplement to what extent the
general terms and provisions described in this prospectus apply to a particular series of debt securities.
We may issue debt securities either separately,
or together with, or upon the conversion or exercise of or in exchange for, other securities described in this prospectus. Debt securities
may be our senior, senior subordinated or subordinated obligations and, unless otherwise specified in a supplement to this prospectus,
the debt securities will be our direct, unsecured obligations and may be issued in one or more series.
The debt securities will be issued under an indenture
between us and a third party to be identified therein, as trustee. We have summarized select portions of the indenture below. The summary
is not complete. The form of the indenture has been filed as an exhibit to the registration statement and you should read the indenture
for provisions that may be important to you. In the summary below, we have included references to the section numbers of the indenture
so that you can easily locate these provisions. Capitalized terms used in the summary and not defined herein have the meanings specified
in the indenture.
As used in this section only, “Neuphoria,”
“we,” “our” or “us” refer to Neuphoria Therapeutics Inc. excluding our subsidiaries, unless expressly
stated or the context otherwise requires.
General
The terms of each series of debt securities will
be established by or pursuant to a resolution of our board of directors and set forth or determined in the manner provided in a resolution
of our board of directors, in an officer’s certificate or by a supplemental indenture. The particular terms of each series of debt
securities will be described in a prospectus supplement relating to such series (including any pricing supplement or term sheet).
We can issue an unlimited amount of debt securities
under the indenture that may be in one or more series with the same or various maturities, at par, at a premium, or at a discount. We
will set forth in a prospectus supplement (including any pricing supplement or term sheet) relating to any series of debt securities being
offered, the aggregate principal amount and the following terms of the debt securities, if applicable:
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the title and ranking of the debt securities (including the terms of any subordination provisions); |
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the price or prices (expressed as a percentage of the principal amount) at which we will sell the debt securities; |
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any limit on the aggregate principal amount of the debt securities; |
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the date or dates on which the principal of the securities of the series is payable; |
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the rate or rates (which may be fixed or variable) per annum or the method used to determine the rate or rates (including any commodity, commodity index, stock exchange index or financial index) at which the debt securities will bear interest, the date or dates from which interest will accrue, the date or dates on which interest will commence and be payable and any regular record date for the interest payable on any interest payment date; |
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the place or places where principal of, and interest, if any, on the debt securities will be payable (and the method of such payment), where the securities of such series may be surrendered for registration of transfer or exchange, and where notices and demands to us in respect of the debt securities may be delivered; |
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the period or periods within which, the price or prices at which and the terms and conditions upon which we may redeem the debt securities; |
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any obligation we have to redeem or purchase the debt securities pursuant to any sinking fund or analogous provisions or at the option of a holder of debt securities and the period or periods within which, the price or prices at which and in the terms and conditions upon which securities of the series shall be redeemed or purchased, in whole or in part, pursuant to such obligation; |
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the dates on which and the price or prices at which we will repurchase debt securities at the option of the holders of debt securities and other detailed terms and provisions of these repurchase obligations; |
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the denominations in which the debt securities will be issued, if other than denominations of $1,000 and any integral multiple thereof; |
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whether the debt securities will be issued in the form of certificated debt securities or global debt securities; |
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the portion of principal amount of the debt securities payable upon declaration of acceleration of the maturity date, if other than the principal amount; |
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the currency of denomination of the debt securities, which may be United States Dollars or any foreign currency, and if such currency of denomination is a composite currency, the agency or organization, if any, responsible for overseeing such composite currency; |
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the designation of the currency, currencies or currency units in which payment of principal of, premium and interest on the debt securities will be made; |
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if payments of principal of, premium or interest on the debt securities will be made in one or more currencies or currency units other than that or those in which the debt securities are denominated, the manner in which the exchange rate with respect to these payments will be determined; |
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the manner in which the amounts of payment of principal of, premium, if any, or interest on the debt securities will be determined, if these amounts may be determined by reference to an index based on a currency or currencies or by reference to a commodity, commodity index, stock exchange index or financial index; |
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any provisions relating to any security provided for the debt securities; |
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any addition to, deletion of or change in the Events of Default described in this prospectus or in the indenture with respect to the debt securities and any change in the acceleration provisions described in this prospectus or in the indenture with respect to the debt securities; |
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any addition to, deletion of or change in the covenants described in this prospectus or in the indenture with respect to the debt securities; |
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any depositaries, interest rate calculation agents, exchange rate calculation agents or other agents with respect to the debt securities; |
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the provisions, if any, relating to conversion or exchange of any debt securities of such series, including if applicable, the conversion or exchange price and period, provisions as to whether conversion or exchange will be mandatory, the events requiring an adjustment of the conversion or exchange price and provisions affecting conversion or exchange; |
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any other terms of the debt securities, which may supplement, modify or delete any provision of the indenture as it applies to that series, including any terms that may be required under applicable law or regulations or advisable in connection with the marketing of the securities; and |
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whether any of our direct or indirect subsidiaries will guarantee the debt securities of that series, including the terms of subordination, if any, of such guarantees. |
We may issue debt securities that provide for
an amount less than their stated principal amount to be due and payable upon declaration of acceleration of their maturity pursuant to
the terms of the indenture. We will provide you with information on the federal income tax considerations and other special considerations
applicable to any of these debt securities in the applicable prospectus supplement.
If we denominate the purchase price of any of
the debt securities in a foreign currency or currencies or a foreign currency unit or units, or if the principal of and any premium and
interest on any series of debt securities is payable in a foreign currency or currencies or a foreign currency unit or units, we will
provide you with information on the restrictions, elections, general tax considerations, specific terms and other information with respect
to that issue of debt securities and such foreign currency or currencies or foreign currency unit or units in the applicable prospectus
supplement.
Transfer and Exchange
Each debt security will be represented by either
one or more global securities registered in the name of The Depository Trust Company, or DTC, or a nominee of DTC (we will refer to any
debt security represented by a global debt security as a “book-entry debt security”), or a certificate issued in definitive
registered form (we will refer to any debt security represented by a certificated security as a “certificated debt security”)
as set forth in the applicable prospectus supplement. Except as set forth under the heading “Global Debt Securities and Book-Entry
System” below, book-entry debt securities will not be issuable in certificated form.
Certificated Debt Securities. You may transfer
or exchange certificated debt securities at any office we maintain for this purpose in accordance with the terms of the indenture. (Section
2.4) No service charge will be made for any transfer or exchange of certificated debt securities, but we may require payment of a sum
sufficient to cover any tax or other governmental charge payable in connection with a transfer or exchange. (Section 2.7)
You may effect the transfer of certificated debt
securities and the right to receive the principal of, premium and interest on certificated debt securities only by surrendering the certificate
representing those certificated debt securities and either reissuance by us or the trustee of the certificate to the new holder or the
issuance by us or the trustee of a new certificate to the new holder.
Global Debt Securities and Book-Entry System.
Each global debt security representing book-entry debt securities will be deposited with, or on behalf of, DTC, and registered in the
name of DTC or a nominee of DTC. Please see “Global Securities.”
Covenants
We will set forth in the applicable prospectus
supplement any restrictive covenants applicable to any issue of debt securities. (Article IV)
No Protection in the Event of a Change of Control
Unless we state otherwise in the applicable prospectus
supplement, the debt securities will not contain any provisions which may afford holders of the debt securities protection in the event
we have a change in control or in the event of a highly leveraged transaction (whether or not such transaction results in a change in
control) which could adversely affect holders of debt securities.
Consolidation, Merger and Sale of Assets
We may not consolidate with or merge with or into,
or convey, transfer or lease all or substantially all of our properties and assets to any person (a “successor person”) unless:
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we are the surviving entity or the successor person
(if other than Neuphoria) is a corporation, partnership, trust or other entity organized and validly existing under the laws of any
U.S. domestic jurisdiction, Australia, Canada, the Cayman Islands or the United Kingdom and expressly assumes our obligations on
the debt securities and under the indenture; and |
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immediately after giving effect to the transaction, no Default or Event of Default, shall have occurred and be continuing. |
Notwithstanding the above, any of our subsidiaries
may consolidate with, merge into or transfer all or part of its properties to us. (Section 5.1)
Events of Default
“Event of Default” means with respect
to any series of debt securities, any of the following:
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default in the payment of any interest upon any debt
security of that series when it becomes due and payable, and continuance of such default for a period of 30 days (unless the entire
amount of the payment is deposited by us with the trustee or with a paying agent prior to the expiration of the 30-day period); |
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default in the payment of principal of any security of that series at its maturity; |
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default in the performance or breach of any other
covenant or warranty by us in the indenture (other than a covenant or warranty that has been included in the indenture solely for
the benefit of a series of debt securities other than that series), which default continues uncured for a period of 60 days after
we receive written notice from the trustee or Neuphoria and the trustee receive written notice from the holders of not less than
25% in principal amount of the outstanding debt securities of that series as provided in the indenture; |
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certain voluntary or involuntary events of bankruptcy,
insolvency or reorganization of Neuphoria; |
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any other Event of Default provided with respect to debt securities of that series that is described in the applicable prospectus supplement. (Section 6.1) |
No Event of Default with respect to a particular
series of debt securities (except as to certain events of bankruptcy, insolvency or reorganization) necessarily constitutes an Event of
Default with respect to any other series of debt securities. (Section 6.1) The occurrence of certain Events of Default or an acceleration
under the indenture may constitute an event of default under certain indebtedness of ours or our subsidiaries outstanding from time to
time.
We will provide the trustee written notice of
any Default or Event of Default within 30 days of becoming aware of the occurrence of such Default or Event of Default, which notice will
describe in reasonable detail the status of such Default or Event of Default and what action we are taking or propose to take in respect
thereof. (Section 6.1)
If an Event of Default with respect to debt securities
of any series at the time outstanding occurs and is continuing, then the trustee or the holders of not less than 25% in principal amount
of the outstanding debt securities of that series may, by a notice in writing to us (and to the trustee if given by the holders), declare
to be due and payable immediately the principal of (or, if the debt securities of that series are discount securities, that portion of
the principal amount as may be specified in the terms of that series) and accrued and unpaid interest, if any, on all debt securities
of that series. In the case of an Event of Default resulting from certain events of bankruptcy, insolvency or reorganization, the principal
(or such specified amount) of and accrued and unpaid interest, if any, on all outstanding debt securities will become and be immediately
due and payable without any declaration or other act on the part of the trustee or any holder of outstanding debt securities. At any time
after a declaration of acceleration with respect to debt securities of any series has been made, but before a judgment or decree for payment
of the money due has been obtained by the trustee, the holders of a majority in principal amount of the outstanding debt securities of
that series may rescind and annul the acceleration if all Events of Default, other than the non-payment of accelerated principal
and interest, if any, with respect to debt securities of that series, have been cured or waived as provided in the indenture. (Section
6.2) We refer you to the prospectus supplement relating to any series of debt securities that are discount securities for the particular
provisions relating to acceleration of a portion of the principal amount of such discount securities upon the occurrence of an Event of
Default.
The indenture provides that the trustee may refuse
to perform any duty or exercise any of its rights or powers under the indenture unless the trustee receives indemnity satisfactory to
it against any cost, liability or expense which might be incurred by it in performing such duty or exercising such right or power. (Section
7.1(e)) Subject to certain rights of the trustee, the holders of a majority in principal amount of the outstanding debt securities of
any series will have the right to direct the time, method and place of conducting any proceeding for any remedy available to the trustee
or exercising any trust or power conferred on the trustee with respect to the debt securities of that series. (Section 6.12)
No holder of any debt security of any series will
have any right to institute any proceeding, judicial or otherwise, with respect to the indenture or for the appointment of a receiver
or trustee, or for any remedy under the indenture, unless:
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that holder has previously given to the trustee written notice of a continuing Event of Default with respect to debt securities of that series; and |
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the holders of not less than 25% in principal amount of the outstanding debt securities of that series have made written request, and offered indemnity or security satisfactory to the trustee, to the trustee to institute the proceeding as trustee, and the trustee has not received from the holders of not less than a majority in principal amount of the outstanding debt securities of that series a direction inconsistent with that request and has failed to institute the proceeding within 60 days. (Section 6.7) |
Notwithstanding any other provision in the indenture,
the holder of any debt security will have an absolute and unconditional right to receive payment of the principal of, premium and any
interest on that debt security on or after the due dates expressed in that debt security and to institute suit for the enforcement of
payment. (Section 6.8)
The indenture requires us, within 120 days after
the end of our fiscal year, to furnish to the trustee a statement as to compliance with the indenture. (Section 4.3) If a Default or Event
of Default occurs and is continuing with respect to the securities of any series and if it is known to a responsible officer of the trustee,
the trustee shall mail to each Securityholder of the securities of that series notice of a Default or Event of Default within 90 days
after it occurs or, if later, after a responsible officer of the trustee has knowledge of such Default or Event of Default. The indenture
provides that the trustee may withhold notice to the holders of debt securities of any series of any Default or Event of Default (except
in payment on any debt securities of that series) with respect to debt securities of that series if the trustee determines in good faith
that withholding notice is in the interest of the holders of those debt securities. (Section 7.5)
Modification and Waiver
We and the trustee may modify, amend or supplement
the indenture or the debt securities of any series without the consent of any holder of any debt security:
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to cure any ambiguity, defect or inconsistency; |
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to comply with covenants in the indenture described above under the heading “Consolidation, Merger and Sale of Assets”; |
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to provide for uncertificated securities in addition to or in place of certificated securities; |
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to add guarantees with respect to debt securities of any series or secure debt securities of any series; |
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to surrender any of our rights or powers under the indenture; |
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to add covenants or events of default for the benefit of the holders of debt securities of any series; |
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to make any change that does not adversely affect the rights of any holder of debt securities; |
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to provide for the issuance of and establish the form and terms and conditions of debt securities of any series as permitted by the indenture; |
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to effect the appointment of a successor trustee with respect to the debt securities of any series and to add to or change any of the provisions of the indenture to provide for or facilitate administration by more than one trustee; or |
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to comply with requirements of the SEC in order to effect or maintain the qualification of the indenture under the Trust Indenture Act. (Section 9.1) |
We may also modify and amend the indenture with
the consent of the holders of at least a majority in principal amount of the outstanding debt securities of each series affected by the
modifications or amendments. We may not make any modification or amendment without the consent of the holders of each affected debt security
then outstanding if that amendment will:
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reduce the amount of debt securities whose holders must consent to an amendment, supplement or waiver; |
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reduce the rate of or extend the time for payment of interest (including default interest) on any debt security; |
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reduce the principal of or premium on or change the fixed maturity of any debt security or reduce the amount of, or postpone the date fixed for, the payment of any sinking fund or analogous obligation with respect to any series of debt securities; |
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reduce the principal amount of discount securities payable upon acceleration of maturity; |
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waive a default in the payment of the principal of, premium or interest on any debt security (except a rescission of acceleration of the debt securities of any series by the holders of at least a majority in aggregate principal amount of the then outstanding debt securities of that series and a waiver of the payment default that resulted from such acceleration); |
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make the principal of or premium or interest on any debt security payable in currency other than that stated in the debt security; |
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make any change to certain provisions of the indenture relating to, among other things, the right of holders of debt securities to receive payment of the principal of, premium and interest on those debt securities and to institute suit for the enforcement of any such payment and to waivers or amendments; or |
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waive a redemption payment with respect to any debt security. (Section 9.3) |
Except for certain specified provisions, the holders
of at least a majority in principal amount of the outstanding debt securities of any series may on behalf of the holders of all debt securities
of that series waive our compliance with provisions of the indenture. (Section 9.2) The holders of a majority in principal amount of the
outstanding debt securities of any series may on behalf of the holders of all the debt securities of such series waive any past default
under the indenture with respect to that series and its consequences, except a default in the payment of the principal of, premium or
any interest on any debt security of that series; provided, however, that the holders of a majority in principal amount of the outstanding
debt securities of any series may rescind an acceleration and its consequences, including any related payment default that resulted from
the acceleration. (Section 6.13)
Defeasance of Debt Securities and Certain Covenants in Certain Circumstances
Legal Defeasance. The indenture provides
that, unless otherwise provided by the terms of the applicable series of debt securities, we may be discharged from any and all obligations
in respect of the debt securities of any series (subject to certain exceptions). We will be so discharged upon the irrevocable deposit
with the trustee, in trust, of money and/or U.S. government obligations or, in the case of debt securities denominated in a single currency
other than U.S. Dollars, government obligations of the government that issued or caused to be issued such currency, that, through the
payment of interest and principal in accordance with their terms, will provide money or U.S. government obligations in an amount sufficient
in the opinion of a nationally recognized firm of independent public accountants or investment bank to pay and discharge each installment
of principal, premium and interest on and any mandatory sinking fund payments in respect of the debt securities of that series on the
stated maturity of those payments in accordance with the terms of the indenture and those debt securities.
This discharge may occur only if, among other
things, we have delivered to the trustee an opinion of counsel stating that we have received from, or there has been published by, the
United States Internal Revenue Service a ruling or, since the date of execution of the indenture, there has been a change in the applicable
United States federal income tax law, in either case to the effect that, and based thereon such opinion shall confirm that, the holders
of the debt securities of that series will not recognize income, gain or loss for United States federal income tax purposes as a result
of the deposit, defeasance and discharge and will be subject to United States federal income tax on the same amounts and in the same manner
and at the same times as would have been the case if the deposit, defeasance and discharge had not occurred. (Section 8.3)
Defeasance of Certain Covenants. The indenture
provides that, unless otherwise provided by the terms of the applicable series of debt securities, upon compliance with certain conditions:
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we may omit to comply with the covenant described under the heading “Consolidation, Merger and Sale of Assets” and certain other covenants set forth in the indenture, as well as any additional covenants which may be set forth in the applicable prospectus supplement; and |
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any omission to comply with those covenants will not constitute a Default or an Event of Default with respect to the debt securities of that series (“covenant defeasance”). |
The conditions include:
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depositing with the trustee money and/or U.S. government obligations or, in the case of debt securities denominated in a single currency other than U.S. Dollars, government obligations of the government that issued or caused to be issued such currency, that, through the payment of interest and principal in accordance with their terms, will provide money in an amount sufficient in the opinion of a nationally recognized firm of independent public accountants or investment bank to pay and discharge each installment of principal of, premium and interest on and any mandatory sinking fund payments in respect of the debt securities of that series on the stated maturity of those payments in accordance with the terms of the indenture and those debt securities; and |
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delivering to the trustee an opinion of counsel to the effect that the holders of the debt securities of that series will not recognize income, gain or loss for United States federal income tax purposes as a result of the deposit and related covenant defeasance and will be subject to United States federal income tax on the same amounts and in the same manner and at the same times as would have been the case if the deposit and related covenant defeasance had not occurred. (Section 8.4) |
No Personal Liability of Directors, Officers, Employees or Securityholders
None of our past, present or future directors,
officers, employees or securityholders, as such, will have any liability for any of our obligations under the debt securities or the indenture
or for any claim based on, or in respect or by reason of, such obligations or their creation. By accepting a debt security, each holder
waives and releases all such liability. This waiver and release is part of the consideration for the issue of the debt securities. However,
this waiver and release may not be effective to waive liabilities under U.S. federal securities laws, and it is the view of the SEC that
such a waiver is against public policy.
Governing Law
The indenture and the debt securities, including
any claim or controversy arising out of or relating to the indenture or the securities, will be governed by the laws of the State of New
York.
The indenture will provide that we, the trustee
and the holders of the debt securities (by their acceptance of the debt securities) irrevocably waive, to the fullest extent permitted
by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to the indenture, the debt securities
or the transactions contemplated thereby.
The indenture will provide that any legal suit,
action or proceeding arising out of or based upon the indenture or the transactions contemplated thereby may be instituted in the federal
courts of the United States of America located in the City of New York or the courts of the State of New York in each case located in
the City of New York, and we, the trustee and the holder of the debt securities (by their acceptance of the debt securities) irrevocably
submit to the non-exclusive jurisdiction of such courts in any such suit, action or proceeding. The indenture will further provide
that service of any process, summons, notice or document by mail (to the extent allowed under any applicable statute or rule of court)
to such party’s address set forth in the indenture will be effective service of process for any suit, action or other proceeding
brought in any such court. The indenture will further provide that we, the trustee and the holders of the debt securities (by their acceptance
of the debt securities) irrevocably and unconditionally waive any objection to the laying of venue of any suit, action or other proceeding
in the courts specified above and irrevocably and unconditionally waive and agree not to plead or claim any such suit, action or other
proceeding has been brought in an inconvenient forum. (Section 10.10)
DESCRIPTION OF WARRANTS
We may issue warrants for the purchase of
our common stock and/or debt securities. We may issue warrants independently or together with other securities, and the warrants may
be attached to or separate from any offered securities. Each series of warrants will be issued under a separate warrant agreement to
be entered into between us and the investors or a warrant agent. The following summary of material provisions of the warrants and warrant
agreements are subject to, and qualified in their entirety by reference to, all the provisions of the warrant agreement and warrant certificate
applicable to a particular series of warrants. The terms of any warrants offered under a prospectus supplement may differ from the terms
described below. We urge you to read the applicable prospectus supplement and any related free writing prospectus, as well as the complete
warrant agreements and warrant certificates that contain the terms of the warrants.
The particular terms of any issue of warrants
will be described in the prospectus supplement relating to the issue. Those terms may include:
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the number of shares of our common stock purchasable
upon the exercise of warrants to purchase such shares and the price at which such number of shares may be purchased upon such exercise; |
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the principal amount of debt securities that may be purchased upon exercise of a debt warrant and the exercise price for the warrants, which may be payable in cash, securities or other property; |
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the date, if any, on and after which the warrants
and the related debt securities or common stock will be separately transferable; |
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the terms of any rights to redeem or call the warrants; |
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the date on which the right to exercise the warrants will commence and the date on which the right will expire; |
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United States Federal income tax consequences applicable to the warrants; and |
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any additional terms of the warrants, including terms, procedures, and limitations relating to the exchange, exercise and settlement of the warrants. |
Holders of equity warrants will not be entitled:
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to vote, consent or receive dividends; |
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receive notice as stockholders with respect to any
meeting of stockholders for the election of our directors or any other matter; or |
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exercise any rights as stockholders of Neuphoria. |
Each warrant will entitle its holder to purchase
the principal amount of debt securities or the number of shares of our common stock at the exercise price set forth in, or calculable
as set forth in, the applicable prospectus supplement. Unless we otherwise specify in the applicable prospectus supplement, holders of
the warrants may exercise the warrants at any time up to the specified time on the expiration date that we set forth in the applicable
prospectus supplement. After the close of business on the expiration date, unexercised warrants will become void.
A holder of warrant certificates may exchange
them for new warrant certificates of different denominations, present them for registration of transfer and exercise them at the corporate
trust office of the warrant agent or any other office indicated in the applicable prospectus supplement. Until any warrants to purchase
debt securities are exercised, the holder of the warrants will not have any rights of holders of the debt securities that can be purchased
upon exercise, including any rights to receive payments of principal, premium or interest on the underlying debt securities or to enforce
covenants in the applicable indenture. Until any warrants to purchase common stock are exercised, the holders of the warrants will not
have any rights of holders of the underlying common stock, including any rights to receive dividends or payments upon any liquidation,
dissolution or winding up on the common stock, if any.
PLAN OF DISTRIBUTION
We may sell or distribute our securities from
time to time in one or more public or private transactions:
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directly to one or more purchasers; |
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in “at the market” offerings, within the meaning of Rule 415(a)(4) of the Securities Act, to or through a market maker or into an existing trading market on an exchange or otherwise; |
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through a combination of any of the above; and |
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any other method permitted pursuant to applicable law. |
Any sale or distribution may be effected by us:
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at market prices prevailing at the time of sale; |
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at varying prices determined at the time of sale; or |
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at negotiated or fixed prices. |
At any time a particular offer of the securities
is made, a prospectus supplement, if required, will be distributed and set forth the terms of each specific offering, including the name
or names of any underwriters or agents, the purchase price of the securities and the proceeds to us from such sales or distribution, any
delayed delivery arrangements, any underwriting discounts and other items constituting underwriters’ compensation, any public offering
price and any discounts or concessions allowed or re-allowed or paid to dealers. Any public offering price and any discounts
or concessions allowed or re-allowed or paid to dealers may be changed from time to time.
In addition, we may distribute the securities
as a dividend or in a rights offering to our existing security holders. In some cases, we or dealers acting for us or on behalf of us
may also repurchase the securities and reoffer them to the public by one or more of the methods described above.
Through Underwriters
If underwriters are used in a sale or distribution,
the securities will be acquired by the underwriters for their own account and may be resold from time to time in one or more transactions,
including negotiated transactions, at a fixed public offering price or at varying prices determined at the time of sale. The securities
may be offered to the public either through underwriting syndicates represented by one or more managing underwriters or directly by one
or more firms acting as underwriters. The underwriter or underwriters with respect to a particular underwritten offering and, if an underwriting
syndicate is used, the managing underwriter or underwriters will be set forth on the cover of such prospectus supplement. Unless otherwise
set forth in the prospectus supplement, the underwriters will be obligated to purchase all the securities if any are purchased.
During and after an offering through underwriters,
the underwriters may purchase and sell or distribute the securities in the open market. These transactions may include overallotment and
stabilizing transactions and purchases to cover syndicate short positions created in connection with the offering. The underwriters also
may impose a penalty bid, under which selling concessions allowed to syndicate members or other broker-dealers for the securities they
sell or distribute for their account may be reclaimed by the syndicate if the syndicate repurchases the securities in stabilizing or covering
transactions. These activities may stabilize, maintain or otherwise affect the market price of the securities, which may be higher than
the price that might otherwise prevail in the open market, and, if commenced, may be discontinued at any time.
Through Agents or to Dealers
We may sell or distribute the securities directly
or through agents we designate from time to time. Unless otherwise indicated in a prospectus supplement, any such agent will be acting
on a best efforts basis for the period of its appointment.
If dealers are used in any of the sales or distribution
of the securities covered by this prospectus, we will sell those securities to dealers as principals. The dealers may then resell the
securities to the public at varying prices the dealers determine at the time of resale.
Direct Sales
We may sell or distribute the securities directly
to institutional investors or others who may be deemed to be underwriters within the meaning of the Securities Act with respect to any
sale thereof.
Delayed Delivery
If so indicated in a prospectus supplement, we
may authorize agents, underwriters or dealers to solicit offers from certain types of institutions to purchase the securities from us
at the public offering price set forth in the prospectus supplement pursuant to delayed delivery contracts providing for payment and delivery
on a specified date in the future. These contracts will be subject only to those conditions set forth in the prospectus supplement, and
the prospectus supplement will set forth the commission payable for solicitation of such contracts.
Derivative Transactions and Hedging
We and the underwriters may engage in derivative
transactions involving the securities. These derivatives may consist of short sale transactions and other hedging activities. The underwriters
may acquire a long or short position in the securities, hold or resell the securities acquired and purchase options or futures on the
securities and other derivative instruments with returns linked to or related to changes in the price of the securities. In order to facilitate
these derivative transactions, we may enter into security lending or repurchase agreements with the underwriters. The underwriters may
carry out the derivative transactions through sales or distributions of the securities to the public, including short sales, or by lending
the securities in order to facilitate short sale transactions by others. The underwriters may also use the securities purchased or borrowed
from us or others (or, in the case of derivatives, securities received from us in settlement of those derivatives) to directly or indirectly
settle sales of the securities or close out any related open borrowings of the securities.
Loans of Securities
We may loan or pledge the securities to a financial
institution or other third party that in turn may sell the securities using this prospectus and an applicable prospectus supplement.
General
Agents, dealers and direct purchasers that participate
in the distribution of the offered securities may be underwriters as defined in the Securities Act and any discounts or commissions they
receive from us and any profit on the resale of the offered securities by them may be treated as underwriting discounts and commissions
under the Securities Act. Agents, dealers and underwriters may be entitled under agreements entered into with us to indemnification by
us against certain civil liabilities, including liabilities under the Securities Act, or to contribution with respect to payments which
such agents, dealers or underwriters may be required to make in respect thereof. Agents, dealers and underwriters may be customers of,
engage in transactions with, or perform services on our behalf.
WHERE YOU CAN FIND MORE INFORMATION
We file reports and other information with the
SEC. The SEC maintains a web site that contains reports, proxy and information statements and other information about issuers, such as
us, who file electronically with the SEC. The address of that website is http://www.sec.gov.
Our web site address is http:// www.neuphoriatx.com.
The information on our web site, however, is not, and should not be deemed to be, a part of this prospectus.
This prospectus and any prospectus supplement
are part of a registration statement that we filed with the SEC and do not contain all of the information in the registration statement.
The full registration statement may be obtained from the SEC or us, as provided below. Other documents establishing the terms of the offered
securities are or may be filed as exhibits to the registration statement or documents incorporated by reference in the registration statement.
Statements in this prospectus or any prospectus supplement about these documents are summaries and each statement is qualified in all
respects by reference to the document to which it refers. You should refer to the actual documents for a more complete description of
the relevant matters. You may inspect a copy of the registration statement through the SEC’s website, as provided above.
INCORPORATION BY REFERENCE
The SEC’s rules allow us to “incorporate
by reference” information into this prospectus, which means that we can disclose important information to you by referring you to
another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus, and
subsequent information that we file with the SEC will automatically update and supersede that information. Any statement contained in
this prospectus or a previously filed document incorporated by reference will be deemed to be modified or superseded for purposes of this
prospectus to the extent that a statement contained in this prospectus or a subsequently filed document incorporated by reference modifies
or replaces that statement.
We incorporate by reference the documents listed
below, all filings filed by us pursuant to the Exchange Act after the date of the registration statement of which this prospectus forms
a part, and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the time that
all securities covered by this prospectus have been sold; provided, however, that we are not incorporating any information furnished under
either Item 2.02 or Item 7.01 of any current report on Form 8-K:
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Bionomics’ Annual Report on Form
10-K for the fiscal year ended June 30, 2024, filed with the SEC on September 30, 2024; |
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Bionomics’
Current Report on Form 8-K filed with the SEC on November 21, 2024; |
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Bionomics’ Quarterly Report
on Form 10-Q
for the quarter ended September 30, 2024, filed with the SEC on November 14, 2024; and |
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Neuphoria’s Current
Report on Form 8-K filed with the SEC on December
23, 2024. |
Any statements made in a document incorporated
by reference in this prospectus are deemed to be modified or superseded for purposes of this prospectus to the extent that a statement
in this prospectus or in any other subsequently filed document, which is also incorporated by reference, modifies or supersedes the statement.
Any statement made in this prospectus supplement is deemed to be modified or superseded to the extent a statement in any subsequently
filed document, which is incorporated by reference in this prospectus, modifies or supersedes such statement. Any statement so modified
or superseded will not be deemed, except as so modified or superseded, to constitute a part of this prospectus.
The information relating to us contained in this
prospectus should be read together with the information in the documents incorporated by reference. In addition, certain information,
including financial information, contained in this prospectus or incorporated by reference in this prospectus should be read in conjunction
with documents we have filed with the SEC.
You may request a free copy of any of the documents
incorporated by reference in this prospectus by writing or telephoning us at the following address:
100 Summit Dr
Burlington, Massachusetts 01803
Tel: +1 781 439 5551
Exhibits to the filings will not be sent, however,
unless those exhibits have specifically been incorporated by reference in this prospectus or any accompanying prospectus supplement.
ENFORCEMENT OF CIVIL LIABILITIES
A majority of our directors and executive
officers are non-residents of the United States, and all or substantially all of the assets of such persons are located outside
the United States. As a result, it may not be possible for you to:
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effect service of process within the United States upon our non-U.S. resident directors and executive officers or on us; |
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enforce in U.S. courts judgments obtained against our non-U.S. resident directors and executive officers or us in U.S. courts in any action, including actions under the civil liability provisions of U.S. securities laws; |
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enforce in U.S. courts judgments obtained against any of our non-U.S. resident directors and executive officers or us in courts of jurisdictions outside the United States in any action, including actions under the civil liability provisions of U.S. securities laws; or |
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bring an original action in a foreign court to enforce
liabilities against any of our non-U.S. resident directors and executive officers or us based solely upon U.S. securities
laws. |
You may also have difficulties enforcing in courts
outside the United States judgments obtained in U.S. courts against any of our non-U.S. resident directors and executive officers
or us, including actions under the civil liability provisions of U.S. securities laws.
LEGAL MATTERS
The validity of the securities and certain
other matters under U.S. law will be passed upon for us by Rimon P.C. Additional legal matters may be passed upon for any underwriters,
dealers or agents by counsel that we will name in the applicable prospectus supplement.
EXPERTS
Wolf & Company, P.C., an independent registered
public accounting firm, has audited our consolidated financial statements included in Bionomic Limited’s Annual Report on Form 10-K for the
year ended June 30, 2024, as set forth in their report, which is incorporated by reference in this prospectus and elsewhere in this registration
statement. Bionomics Limited’s financial statements are incorporated by reference in reliance on Wolf & Company, P.C.’s
report, given on their authority as experts in accounting and auditing.
Change in Accountants
Our independent registered public accounting firm
is Wolf & Company, P.C., which has served as our independent auditor for fiscal years 2024 and 2023, with respect to our financial
statements prepared in accordance with U.S. GAAP. Ernst & Young served as our independent registered public accounting firm for fiscal
year 2023 and for part of fiscal year 2024 with respect to our financial statements prepared in accordance with International Financial
Reporting Standards (“IFRS”), as we were a foreign private issuer until June 30, 2024 and reported our financial statements
under IFRS. During the auditor transition period from Ernst & Young to Wolf & Company, P.C. for the period ended June 30, 2024,
there were no reportable events (as defined in Regulation S-K Item 304(a)(1)(v)).
OFFERING EXPENSES
The following is an estimate of the expenses that
we may incur in connection with a possible offering of securities registered under this registration statement.
SEC registration fee |
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$ |
0 |
** |
FINRA filing fee |
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$ |
0 |
*** |
Printing expenses |
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|
* |
Legal fees and expenses |
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|
|
* |
Accounting fees and expenses |
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* |
Transfer agent and trustee fees and expenses |
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* |
Miscellaneous |
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* |
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|
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Total |
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$ |
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* |
* |
These fees are calculated based on the securities offered and the number of issuances and accordingly cannot be estimated at this time. |
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** |
Pursuant to Rule 415(a)(6) under the Securities
Act, this registration statement includes $100,000,000 of securities that were previously registered, but were not sold, pursuant
to the Company’s registration statement on Form F-3 (File No. 333-271696) filed with the SEC on May 5, 2023 (the “Prior
Registration Statement”). The registration fee with respect to such securities, totaling $19,836, was previously paid when
the prospectus supplement relating to such securities was filed with the SEC pursuant to Rule 424(b)(5) and such registration fee
will continue to be applied to the unsold securities. In accordance with Rule 415(a)(6), the offering of securities registered under
the Prior Registration Statement will be terminated as of the date of effectiveness of this registration statement. |
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*** |
The Company paid FINRA filing fees of $27,500 upon the filing and registration of it Form F-3 registration statement, on May 5, 2023, and therefore, the unused portion is being carried forward to this registration statement on Form S-3. |
The information in this prospectus is
not complete and may be changed. We may not sell these securities until the Registration Statement filed with the Securities and Exchange
Commission, of which this prospectus is a part, is effective. This prospectus is not an offer to sell these securities and it is not
soliciting an offer to buy these securities in any state where the offer or sale is not permitted.
Subject to completion,
dated January , 2025
PROSPECTUS SUPPLEMENT
(To Prospectus dated January 6, 2025)
Up to $2,000,000
Common Stock
We have entered into an At The Market Offering
Agreement, or the sales agreement, with H.C. Wainwright & Co., LLC, or Wainwright, dated November 18, 2024, as amended on January
6, 2025. Under this prospectus, we may offer and sell common stock having an aggregate offering price of up to $2.0 million from
time to time through Wainwright, acting as sales agent, in accordance with the Sales Agreement.
Sales of the common stock, if any, under this
prospectus may be made by any method permitted that is deemed an “at the market” offering as defined in Rule 415(a)(4) promulgated
under the Securities Act of 1933, as amended, or the Securities Act. Wainwright may sell our common stock by any method permitted by
law deemed to be an at-the-market offering as defined in Rule 415(a)(4) promulgated under the Securities Act. Wainwright is
not required to sell any specific number or dollar amount of securities but will act as our sales agent using commercially reasonable
efforts consistent with their normal trading and sales practices and applicable state and federal laws, rules and regulations and the
rules of the Nasdaq, on mutually agreed terms between the Wainwright and us. There are no minimum sale requirements, and there is no
arrangement for funds to be received in any escrow, trust or similar arrangement.
As of January 3, 2025, the aggregate market
value of our common stock held by non-affiliates, or public float, was approximately $10,773,823 based on 1,628,659 shares of common
stock outstanding (less any insider holdings), based on a closing price of $6.63 per share on December 24, 2024, which was the highest
closing sale price of our common stock on the Nasdaq Global Market, the principal market for our common equity, within 60 days of the
filing date of this registration statement. In the past 12 calendar months, we have offered and sold pursuant to General Instruction
I.B.5 of Form F-3 (which the Company was previously subject to as a foreign private issuer) an aggregate of 1,200,578 American Depositary
Shares (“ADSs”) for gross proceeds of approximately $1,483,706. Pursuant to General Instruction I.B.6 of Form S-3 (which
the Company is now subject to as a domestic U.S. reporting company), in no event will we sell securities registered on this registration
statement in a public primary offering with a value exceeding more than one-third of our public float in any 12-month period so long
as our public float remains below $75.0 million.
Wainwright will be entitled to a commission
of 3.0% of the gross sales price per share sold under the Sales Agreement. See “Plan of Distribution” beginning on
page S-11 for additional information regarding the compensation to be paid to Wainwright. In connection with the sale of the common
stock on our behalf, Wainwright will be deemed to be an “underwriter” within the meaning of the Securities Act, and the compensation
paid to Wainwright will be deemed to be underwriting compensation. We have also agreed in the Sales Agreement to provide indemnification
and contribution to Wainwright with respect to certain liabilities, including liabilities under the Securities Act.
Our common stock is listed on the Nasdaq under
the symbol “NEUP.” On January 3, 2025, the last reported sale price of our common stock on the Nasdaq was $3.40 per share.
INVESTING IN OUR COMMON STOCK INVOLVES
A HIGH DEGREE OF RISK. BEFORE MAKING AN INVESTMENT DECISION, PLEASE READ THE INFORMATION UNDER THE HEADING “RISK FACTORS”
BEGINNING ON PAGE S-6 OF THIS PROSPECTUS SUPPLEMENT, AND IN THE DOCUMENTS INCORPORATED BY REFERENCE INTO THIS PROSPECTUS
SUPPLEMENT.
Neither the Securities and Exchange Commission,
any state securities commission, nor any other foreign securities commission has approved or disapproved of these securities or passed
upon the adequacy or accuracy of this prospectus supplement. Any representation to the contrary is a criminal offense.
H.C. Wainwright & Co.
This prospectus supplement is dated ,
2025.
TABLE OF CONTENTS
ABOUT THIS PROSPECTUS
This prospectus is part of a registration
statement that we filed on Form S-3 with the SEC, under the Securities Act of 1933, as amended, or the Securities Act, using
a “shelf” registration process. Under this prospectus supplement, we may offer and sell up to $2,000,000 of shares of our
common stock from time to time through H.C. Wainwright & Co., LLC or Wainwright, acting as our sales agent at prices and on terms
to be determined by market conditions at the time of the offering.
This prospectus relates to the offering of
our common stock. Before buying any of the common stock that we are offering, we urge you to carefully read this prospectus, together
with the information incorporated by reference as described under the heading “Incorporation by Reference.” These documents
contain important information that you should consider when making your investment decision.
This prospectus describes the specific details
regarding this offering and also adds to and updates information contained in the documents incorporated by reference into this prospectus.
If any statement in one of these documents is inconsistent with a statement in another document having a later date—for example,
a document incorporated by reference into this prospectus—the statement in the document having the later date modifies or supersedes
the earlier statement.
We have not, and Wainwright has not, authorized
anyone to provide any information other than that contained in or incorporated by reference in this prospectus, any applicable prospectus
supplement and any free writing prospectus prepared by or on behalf of us or to which we have referred you. Neither we nor Wainwright,
take responsibility for, and can provide no assurance as to the reliability of, any other information that others may give you. We are
not, and Wainwright is not, making an offer to sell or soliciting an offer to buy our securities in any jurisdiction where an offer or
solicitation is not authorized or in which the person making that offer or solicitation is not qualified to do so or to anyone to whom
it is unlawful to make an offer or solicitation. You should assume that the information appearing in this prospectus, any applicable prospectus
supplement, the documents incorporated by reference herein or therein, and in any free writing prospectus that we may authorize for use
in connection with this offering, is accurate only as of the date of those respective documents. Our business, financial condition, results
of operations and prospects may have changed since those dates. You should read this prospectus, the documents incorporated by reference
into this prospectus, any applicable prospectus supplement and any free writing prospectus that we may authorize for use in connection
with this offering, in their entirety before making an investment decision.
The terms “we,” “our,”
“us” and the “Company” in this prospectus refer to Neuphoria Therapeutics Inc. and its consolidated subsidiaries
after December 23, 2024 and Bionomics and its consolidated subsidiaries on and prior to December 23, 2024, unless otherwise specified.
When we refer to “you,” we mean the potential holders of the applicable series of securities.
We use our registered and unregistered trademarks,
including Neuphoria™ and Bionomics™, in this prospectus. This prospectus also includes trademarks,
tradenames and service marks that are the property of other organizations. Solely for convenience, trademarks and tradenames referred
to in this prospectus appear without the ® and ™ symbols, but those references are
not intended to indicate in any way that we will not assert, to the fullest extent under applicable law, our rights or that the applicable
owner will not assert its rights, to these trademarks and tradenames.
Unless otherwise indicated, all amounts presented
in this prospectus are presented in U.S. Dollars (“$”).
Our fiscal year end is June 30. References to
a particular “fiscal year” are to our fiscal year ended June 30 of that calendar year.
For investors outside the United States: We
have not done anything that would permit the offering or possession or distribution of this prospectus supplement in any jurisdiction
where action for that purpose is required, other than in the United States. Persons outside the United States who come into possession
of this prospectus supplement must inform themselves about, and observe any restrictions relating to, the offering of the securities described
herein and the distribution of this prospectus supplement outside the United States.
Since July 1, 2024, we have been required
and began to file periodic reports and financial statements with the SEC as a U.S. domestic registrants whose securities are registered
under the U.S. Securities Exchange Act of 1934, as amended (the “Exchange Act”).
CAUTIONARY STATEMENT REGARDING FORWARD-LOOKING
STATEMENTS
This prospectus, the documents incorporated by
reference herein and any accompanying prospectus supplement may contain or incorporate forward-looking statements that are based on our
management’s belief and assumptions and on information currently available to our management. Although we believe that the expectations
reflected in these forward-looking statements are reasonable, these statements relate to future events or our future financial performance,
and involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance
or achievements to be materially different from any future results, levels of activity, performance or achievements stated in or implied
by these forward-looking statements.
All statements other than statements of historical
facts are forward-looking statements. These forward-looking statements are made under the “safe harbor” provision under Section 27A
of the Securities Act and 21E of the Exchange Act and as defined in the Private Securities Litigation Reform Act of 1995. In some cases,
you can identify forward-looking statements by terms such as “anticipate,” “believe,” “contemplate,”
“continue,” “could,” “estimate,” “expect,” “intend,” “may,” “plan,”
“potential,” “predict,” “project,” “should,” “target,” “will,”
or “would” or the negative of these terms or other similar expressions, although not all forward-looking statements contain
these words. These statements are only predictions. You should not place undue reliance on forward-looking statements because they involve
known and unknown risks, uncertainties and other factors, which are, in some cases, beyond our control and which could materially affect
results.
You should refer to the “Risk Factors”
section of this prospectus, any accompanying prospectus supplement, and our annual reports on Form 10-K, quarterly reports on
Form 10-Q and current reports on Form 8-K filed with the SEC for specific risks that could cause actual results to be significantly
different from those stated in or implied by these forward-looking statements. If one or more of these risks or uncertainties occur, or
if our underlying assumptions prove to be incorrect, actual events or results may vary significantly from those implied or projected by
the forward-looking statements. No forward-looking statement is a guarantee of future performance. Forward-looking statements speak only
as of the date made and we undertake no obligation to publicly update or revise any forward-looking statements, whether as a result of
new information, future events or otherwise. You should read this prospectus, any accompanying prospectus supplement and the documents
that we reference in this prospectus and have filed with the SEC as exhibits to the registration statement, of which this prospectus is
a part, completely and with the understanding that our actual future results may be materially different from any future results stated
in or implied by these forward-looking statements.
Forward-looking statements in this prospectus
include, but are not limited to, statements about:
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the ability of our clinical trials to demonstrate safety and efficacy of our product candidates, and other positive results; |
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the timing and focus of our ongoing and future clinical trials and preclinical studies, and the reporting and interpretation of data from those trials and studies; |
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our plans relating to commercializing our product candidates, if approved, including the geographic areas of focus and sales strategy; |
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the market opportunity and competitive landscape for our product candidates, including our estimates of the number of patients who suffer from the conditions we are targeting; |
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the success of competing therapies that are or may become available; |
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our estimates of the number of patients that we will enroll in our clinical trials; |
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the beneficial characteristics, safety, efficacy and therapeutic effects of our product candidates; |
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the timing of initiation and completion, and the progress of our drug discovery and research programs; |
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the timing or likelihood of regulatory filings and approvals for our product candidates for various diseases; |
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our ability to obtain and maintain regulatory approval of our product candidates; |
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our plans relating to the further development of our product candidates, including additional indications we may pursue; |
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existing regulations and regulatory developments
in the United States, Europe and other jurisdictions; |
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risks associated with the COVID-19 pandemic, which has and may continue to materially and adversely impact our business, preclinical studies and clinical trials; |
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our plans and ability to obtain, maintain, protect and enforce our intellectual property rights and our proprietary technologies, including extensions of existing patent terms where available; |
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our continued reliance on third parties to conduct additional clinical trials of our product candidates, and for the manufacture of our product candidates for preclinical studies and clinical trials; |
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our plans regarding, and our ability to enter into, and negotiate favorable terms of, any collaboration, licensing or other arrangements that may be necessary or desirable to develop, manufacture or commercialize our product candidates; |
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the need to hire additional personnel and our ability to attract and retain such personnel; |
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our estimates regarding expenses, future revenue, capital requirements and needs for additional financing; |
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our financial performance; |
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the period over which we estimate our existing cash and cash equivalents will be sufficient to fund our future operating expenses and capital expenditure requirements; |
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our anticipated use of our existing resources; |
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our anticipated use of proceeds from this offering, if any; |
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cyber security risks and any failure to maintain the confidentiality, integrity and availability of our computer hardware, software and internet applications and related tools and functions; and |
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our expectations regarding the period during which we will qualify as an emerging growth company under the JOBS Act. |
The “Risk Factors” section of
this prospectus, any accompanying prospectus supplement, and our annual reports on Form 10-K, quarterly reports on Form 10-Q and
current reports on Form 8-K filed with the SEC references the principal contingencies and uncertainties to which we believe
we are subject, which should be considered in evaluating any forward-looking statements contained or incorporated by reference in this
prospectus or in any prospectus supplement.
PROSPECTUS SUMMARY
This summary does not contain all of the information
that may be important to you in making your investment decision. In addition to this summary, you should carefully read the entire prospectus,
the applicable prospectus supplement and any related free writing prospectus, including the risks of investing in our securities discussed
under the heading “Risk Factors” contained herein and in the applicable prospectus supplement and any related free writing
prospectus, and under similar headings in the other documents that are incorporated by reference into this prospectus before deciding
whether to invest in our securities. You should also carefully read the information incorporated by reference into this prospectus, including
our financial statements, and the exhibits to the registration statement of which this prospectus is a part.
Overview
We are a clinical-stage biotechnology company
dedicated to developing therapies that address the complex needs of individuals affected by neuropsychiatric disorders. Neuphoria is
advancing its lead drug candidate, BNC210, an oral, proprietary, selective negative allosteric modulator of the α7 nicotinic acetylcholine
receptor, for the acute, “as needed” treatment of social anxiety disorder (“SAD”) and for chronic treatment of
post-traumatic stress disorder (“PTSD”). BNC210 is a first-of-its-kind, well-tolerated, broad spectrum anti-anxiety experimental
therapeutic, designed to restore neurotransmitter balance in relevant brain areas, providing rapid relief from stress and anxiety symptoms
without the common pitfalls of sedation, cognitive impairment, or addiction. In addition, Neuphoria has a strategic partnership with
Merck & Co., Inc. (known as MSD outside the United States and Canada) with two drugs in early-stage clinical trials for the treatment
of cognitive deficits in Alzheimer’s disease and other central nervous system conditions. Neuphoria's pipeline also includes the
α7 nicotinic acetylcholine receptor next generation and the Kv3.1/3.2 preclinical programs, both in the lead optimization development
stage.
We are advancing our lead product candidate,
BNC210, an oral, proprietary, selective negative allosteric modulators of the α7 nicotinic acetylcholine (“ACh”) receptor
(“α7 receptor”), for the chronic treatment of PTSD and the acute treatment of Social Anxiety Disorder. There remains
a significant unmet medical need for the over 27 million patients in the United States alone suffering from SAD and PTSD.
Current pharmacological treatments include certain
antidepressants and benzodiazepines, and there have been no new FDA approved therapies in these indications in nearly two decades. These
existing treatments have multiple shortcomings, such as a slow onset of action of antidepressants, and significant side effects of both
classes of drugs, including abuse liability, addiction potential and withdrawal symptoms. BNC210 has been observed in our clinical trials
to have a fast onset of action and clinical activity without the limiting side effects seen with the current standard of care.
In September 2023, we announced the results of
the Phase 2b ATTUNE study, which was a double-blind, placebo-controlled trial conducted in a total of 34 sites in the United States and
the United Kingdom, with 212 enrolled patients, randomized 1:1 to receive either twice daily 900 mg BNC210 as a monotherapy (n=106) or
placebo (n=106) for 12 weeks. The trial met its primary endpoint of change in Clinician-Administered PTSD Scale for DSM-5 (“CAPS-5”)
total symptom severity score from baseline to Week 12 (p=0.048). A statistically significant change in CAPS-5 score was also observed
at Week 4 (p=0.016) and at Week 8 (p=0.015). Treatment with BNC210 also showed statistically significant improvement both in clinician-administered
and patient self-reporting in two of the secondary endpoints of the trial. Specifically, BNC210 led to significant improvements at Week
12 in depressive symptoms (p=0.041) and sleep (p=0.039) as measured by Montgomery-Åsberg Depression Rating Scale (“MADRS”)
and Insomnia Severity Index (ISI), respectively. BNC210 also showed signals and trends across visits in the other secondary endpoints
including the clinician and patient global impression - symptom severity (“CGI-S”, “PGI-S”, respectively) and
the Sheehan Disability Scale (“SDS”). In July 2024, we announced a positive outcome of an End-of-Phase 2 meeting with FDA
that provides a potential path to New Drug Application (“NDA”) submission for BNC210 for PTSD that alongside the positive
Phase 2b ATTUNE trial includes a single additional Phase 3 trial. This Phase 3 trial will evaluate two dose levels of BNC210 in a 12-week
randomized, double-blind, placebo-controlled trial with a 52-week open-label extension. Start-up activities for a planned Phase 3 trial
of BNC210 in PTSD are underway. We plan to initiate the Phase 3 trial in PTSD in the second half of 2025, contingent upon having sufficient
capital on hand. Although the FDA has denied our initial Breakthrough Therapy designation application, we are considering a rebuttal in
the future. The approval process for the BNC210 PTSD program is not expected to be impeded, as we have already received Fast-Track designation
for both the PTSD and SAD programs.
We have completed our Phase 2 PREVAIL trial for
BNC210 for the acute treatment of SAD. While PREVAIL narrowly missed its primary endpoint, as measured by the change from baseline to
the average of the Subjective Units of Distress Scale (“SUDS”) scores during a 5-minute Public Speaking Challenge in the BNC210-treated
patients when compared to placebo, the December 2022 topline data readout revealed encouraging trends in the prespecified endpoints. The
findings did indicate a consistent trend toward improvements across primary and secondary endpoints and a favorable safety and tolerability
profile consistent with previously reported results. These results supported a post-hoc in-depth analysis of the full dataset to better
understand the potential of the drug and guide late-stage trial design. In October 2023, we announced a positive outcome of an End-of-Phase
2 meeting with FDA that enables advancement of BNC210 into Phase 3 studies in SAD. Start-up activities for a planned Phase 3 trial of
BNC210 in SAD are underway. In July 2024, we announced the initiation of patient screening for the Phase 3 AFFIRM-1 trial evaluating the
safety and efficacy of BNC210 for the acute, as-needed treatment of SAD. AFFIRM-1 targets enrollment of 330 adult patients with SAD at
clinical sites in the United States. It is a multi-center, double-blind, two-arm, parallel group, placebo-controlled trial. Participants
will be randomized 1:1 to receive a single dose of 225 mg BNC210 or matched placebo about one hour before speaking in public. The primary
endpoint will compare BNC210 to placebo using the SUDS to measure self-reported anxiety levels during a public speaking task. Secondary
efficacy endpoints include the Clinical and Patient Global Impression (“CGI” and “PGI”, respectively) scales and
the State-Trait Anxiety Inventory (“STAI”). Topline results from the AFFIRM-1 trial are expected in the third quarter of 2025.
The Company’s expertise in ion channels
and approach to developing allosteric modulators have been validated through its strategic partnership with MSD for our α7 receptor
positive allosteric modulators program, which targets a receptor that has garnered significant attention for treating cognitive deficits.
This partnership enables us to maximize the value of its ion channel and chemistry platforms and develop transformative medicines for
patients suffering from cognitive disorders such as Alzheimer’s disease.
The above-stated overview is a summary, and not
a complete statement on our Company, business, pipeline products or clinical trials. For a complete description of the Company and its
business and product pipelines, as well as clinical trials and more, please read our annual report on form 10-K, filed with the Securities
and Exchange Commission (the “SEC”) on September 30, 2024, as well as any quarterly and current reports we have filed and
will subsequently file with the SEC, which provides further updates on our company, the business, risk factors, financial performance
and more, each of which is incorporated by reference in this registration statement.
Summary Risks Factors
Investing in our securities involves a high degree
of risk. Below is a summary of certain factors that make an investment in our securities speculative or risky. Importantly, this summary
does not address all of the risks that we face. Additional discussion of the risks summarized below, as well as other risks that we face,
can be found under the heading “Risk Factors” contained in the prospectus supplement and in any free writing prospectuses
we have authorized for use in connection with a specific offering, and under similar headings in the documents that are incorporated by
reference into this prospectus.
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We are a clinical-stage biopharmaceutical company with no approved products. We have incurred significant operating losses since our inception and expect to incur significant losses for the foreseeable future. We may never generate any revenue or become profitable or, if we achieve profitability, we may not be able to sustain it. |
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We will require substantial additional financing to achieve our goals, and a failure to obtain this necessary capital when needed on acceptable terms, or at all, could force us to delay, limit, reduce or terminate our product development programs, commercialization efforts or other operations. |
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Preclinical and clinical drug development is a lengthy and expensive process, with an uncertain outcome. Our preclinical and clinical programs may experience delays or may never advance, which would adversely affect our ability to obtain regulatory approvals or commercialize our product candidates on a timely basis or at all, which could have an adverse effect on our business. |
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If we experience delays or difficulties in the initiation, enrollment and/or retention of patients in clinical trials, our regulatory submissions or receipt of necessary regulatory approvals could be delayed or prevented. |
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The trading price of our common stock has been and may remain volatile, and you may not be able to resell your common stock
at or above the price you paid. |
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An active trading market for our common stock may
not be maintained or be liquid enough for you to sell your common stock quickly or at market price. |
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Your right as a holder of our common stock to participate
in any future preferential subscription rights offering or to elect to receive dividends in our common stock may be limited, which
may cause dilution to your holdings. |
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Our current or future product candidates may cause adverse or other undesirable side effects that could delay or prevent their regulatory approval, limit the commercial profile of an approved label or result in significant negative consequences following marketing approval, if any. |
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We may have difficulties in attracting and retaining key personnel, and if we fail to do so our business may suffer. |
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We depend on collaboration partners to develop and commercialize our collaboration product candidates, including Merck and Carina Biotech. If our collaboration partners fail to perform as expected, fail to advance our collaboration product candidates or are unable to obtain the required regulatory approvals for our collaboration product candidates, the potential for us to generate future revenue from such product candidates would be significantly reduced and our business would be significantly harmed. |
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We currently rely, and expect to continue to rely, on third parties to conduct some or all aspects of our product manufacturing, research and preclinical and clinical testing, and these third parties may not perform satisfactorily. |
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We may not be able to protect our intellectual property rights throughout the world. |
Corporate Information
We are a Delaware company listed on the Nasdaq
Global Market. Our registered office is located at 100 Summit Dr, Burlington, Massachusetts 01803, and our telephone number is +1 781
439 5551. Our website address is www.neuphoriatx.com. The information contained in, or accessible through, our website
does not constitute part of this prospectus.
As previously disclosed in a current report
on Form 8-K, which was filed with the SEC on October 2, 2024, we and Bionomics entered into a Scheme Implementation Agreement to re-domicile
from Australia to the U.S. State of Delaware pursuant to a Scheme of Arrangement under Australian law. Subsequently, as further disclosed
in another current report on Form 8-K filed on November 8, 2024, we and Bionomics entered into an amendment to the Scheme Implementation
Agreement to amend the exchange ratio of securities outstanding. On December 23, 2024, as disclosed in another current report on Form
8-K filed on the same day, the redomiciliation of Bionomics was implemented under Australian law in accordance with the Scheme Implementation
Agreement, as amended. As a result of the redomiciliation, (i) Bionomics became our wholly-owned subsidiary; (ii) holders of ordinary
shares of Bionomics received one share of our common stock for every 2,160 ordinary shares of Bionomics held on the Scheme record date;
(iii) holders of Bionomics ADSs, with each ADS representing 180 ordinary shares of Bionomics, received one share of our common stock
for every 12 ADSs held on the Scheme record date; and (iv) we became the successor issuer to Bionomics. Bionomics was previously listed
on the ASX between November 26, 1999 and August 28, 2023.
As disclosed in a Form 8-K filed on July 16,
2024, Bionomics received a letter from the Listing Qualifications Department of the Nasdaq Stock Market (“Nasdaq”) indicating
that, based upon the closing bid price of the company’s ADSs for the 30 consecutive business days between May 28, 2024 and July
10, 2024, Bionomics did not meet the minimum bid price of $1.00 per share required for continued listing on The Nasdaq Global Market
pursuant to Nasdaq Listing Rule 5450(a)(1). The letter also indicated that Bionomics will be provided with a compliance period of 180
calendar days, or until January 7, 2025, in which to regain compliance. Following completion of the Scheme of Arrangement, we have regained
compliance with Nasdaq’s minimum bid price requirement. Each of the form 8-Ks noted above, along with other annual, quarterly and
current reports previously and subsequently filed with the SEC are incorporated by reference into this registration statement. See the
“Incorporation by Reference” heading on page S-13 for more information on the SEC filings that are incorporated by reference
into this prospectus supplement.
Since July 1, 2024, we have been reporting
as a domestic U.S. issuer on SEC Forms 10-K, 10-Q and 8-K.
Implications of Being an Emerging Growth Company
As a company with less than $1.235 billion
in revenue during our last fiscal year, we qualify as an “emerging growth company” as defined in the Jumpstart Our Business
Startups Act (the “JOBS Act”), enacted in April 2012. An emerging growth company may take advantage of reduced reporting requirements
that are otherwise applicable to public companies. These provisions include, but are not limited to:
|
● |
not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, as amended (the “Sarbanes-Oxley Act”); |
|
● |
reduced disclosure obligations regarding executive compensation in our periodic reports (if any), proxy statements (if any) and registration statements; and |
|
● |
exemptions from the requirements of holding a nonbinding
advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved. |
We may take advantage of these provisions
until the last day of our fiscal year following the fifth anniversary of our initial public offering. However, if certain events occur
prior to the end of such five-year period, including if we become a “large accelerated filer,” our annual gross revenues
exceed $1.235 billion or we issue more than $1.0 billion of non-convertible debt in any three-year period, we will
cease to be an emerging growth company prior to the end of such five-year period.
We have elected to take advantage of certain of
the reduced disclosure obligations in this prospectus and in the registration statement of which this prospectus is a part and may elect
to take advantage of other reduced reporting requirements in future filings. As a result, the information in this prospectus and that
we provide to our stockholders in the future may be different than what you might receive from other public reporting companies in which
you hold equity interests.
THE OFFERING
Common Stock offered by us |
|
Shares of our common stock having an aggregate offering price of up
to $2,000,000, or up to 588,235 shares, assuming sales at a price of $3.40 per share, which was the closing price of our common stock
on the Nasdaq on January 3, 2024. The actual number of shares issued will vary depending on the sales price under this offering. |
|
|
|
Manner
of offering |
|
“At the market offering” that may be made from time to time through our sales agent, H.C. Wainwright
& Co., LLC. See “Plan of Distribution” contained in this prospectus supplement. |
Use of proceeds |
|
We intend to use the net proceeds from this offering, if any, together with our existing cash and cash equivalents, to fund our pipeline development, to maintain our working capital, and for general corporate purposes. |
Risk
factors |
|
You should read the “Risk
Factors” section of this prospectus supplement and the other information in this prospectus supplement, and as also incorporated
by reference herein, for a discussion of factors to consider carefully before deciding to invest in our common stock. |
Listing |
|
Our common stock is listed on
the Nasdaq Global Market under the symbol “NEUP.” |
RISK FACTORS
An investment in our securities involves
a high degree of risk. Before deciding whether to invest in our securities, you should consider carefully the risks described below and
discussed under the section captioned “Risk Factors” in our most recent Annual Report on Form 10-K and any subsequent Quarterly
Reports on Form 10-Q, which are each incorporated by reference in their entirety in this prospectus supplement and the accompanying prospectus,
as well as any amendment or update to our risk factors reflected in subsequent filings with the SEC, together with other information
in this prospectus supplement, and the information and documents incorporated by reference that we have authorized for use in connection
with this offering. If any of these risks actually occur, our business, financial condition, results of operations or cash flows could
be seriously harmed. This could cause the trading price of our common stock to decline, resulting in a loss of all or part of your investment.
The risks and uncertainties summarized and described below are not intended to be exhaustive and are not the only ones we face. Additional
risks and uncertainties not presently known to us or that we currently deem immaterial may also impair our business, prospects, financial
condition and results of operations. Certain statements in this prospectus supplement, and the accompany prospectus, are forward-looking
statements. Please also see the section entitled “Disclosure Regarding Forward-Looking Statements.”
Risks Related to this Offering
You may experience immediate and substantial dilution in
the book value per share of the common stock you purchase.
The offering price per share of our common
stock in this offering may exceed the net tangible book value per share of the common stock outstanding prior to this offering. If holders
of outstanding options exercise those options at prices below the price you pay, you would experience further dilution. Because the sales
of our common stock offered hereby will be made directly into the market, the prices at which we sell our common stock will vary and
these variations may be significant. Purchasers of the common stock we sell, as well as holders of our existing common stock, will experience
significant dilution if we sell common stock at prices significantly below the price at which they invested.
You may experience future dilution as a result of future equity
offerings.
To raise additional capital, we may in the
future offer additional common stock or other securities convertible into or exchangeable for our common stock at prices that may not
be the same as the price per share of our common stock in this offering. We may sell common stock or other securities in any other offering
at a price that is less than the price paid by investors in this offering, and investors purchasing our common stock or other securities
in the future could have rights superior to the rights of common stock holders. After this offering of up to $2,000,000 in common stock
is completed, our effective Registration Statement on Form S-3 will remain available to cover the future public offering and
sale of up to $98,000,000 of our securities registered thereon, and, if no common stock is sold in this offering, the full $2,000,000
of our common stock may be sold in other offerings pursuant to the base prospectus. The price at which we sell our common stock, or securities
convertible or exchangeable into common stock, in future transactions may be higher or lower than the price per share of our common stock
paid by investors in this offering.
Future sales or issuances of our securities
in the public markets, or the perception of such sales, could depress the trading price of our common stock.
The sale of a substantial number of shares
of our common stock or other equity-related securities in the public markets, or the perception that such sales could occur, could depress
the market price of our common stock and impair our ability to raise capital through the sale of additional equity securities. We may
sell large quantities of our common stock at any time pursuant to this prospectus supplement or in one or more separate offerings. We
cannot predict the effect that future sales of common stock or other equity-related securities would have on the market price of our
common stock.
Sales of common stock issuable upon exercise of warrants
and other derivative securities could cause the market price of our common stock to decline.
If we issue warrants, then such warrants will
entitle the holder to receive additional securities from us, diluting your ownership interest. For example, in the private placement
offering we consummated on June 3, 2024, the warrants issued in the first tranche of that offering entitles the investor to purchase
up to 18,932,477 ADSs (equivalent to 1,577,706 shares of our common stock). As of January 3, 2025, 1,054,381 shares of our common stock
remain exercisable under the accompanying cash exercise warrant issued in June 2024 private placement as of the date of this prospectus
supplement. The sale of additional common stock, or the perception that such sales could occur, could cause the market price of our common
stock to decline or become more volatile.
We will have broad discretion in how to use the net proceeds
of this offering, and we may not use these proceeds in a manner desired by our investors.
We will have broad discretion as to the use of
the net proceeds from this offering and could use them for purposes other than those contemplated at the time of this offering. Accordingly,
you will be relying on the judgment of our management with regard to the use of these net proceeds, and you will not have the opportunity
as part of your investment decision to assess whether the proceeds are being used appropriately. Our needs may change as the business
and the industry that we address evolves. As a result, the proceeds to be received in this offering may be used in a manner significantly
different from our current expectations. It is possible that the proceeds will be invested in a way that does not yield a favorable, or
any, return. The failure of our management to use such funds effectively could have a material adverse effect on our business, financial
condition, operating results and cash flow.
SEC regulations may limit the number of shares we may sell under
this prospectus.
Under current SEC regulations, because our
public float is currently less than $75 million, and for so long as our public float remains less than $75 million, the amount
we can raise through primary public offerings of securities in any twelve-month period using shelf registration statements, including
sales under this prospectus, is limited to an aggregate of one-third of our public float, which is referred to as the baby
shelf rules.
As of January 3, 2025, the aggregate market
value of our common stock held by non-affiliates, or public float, was approximately $10,773,823 based on 1,628,659 shares of common
stock outstanding (less any insider holdings), based on a closing price of $6.63 per share on December 24, 2024, which was the highest
closing sale price of our common stock on the Nasdaq Global Market, the principal market for our common equity, within 60 days of the
filing date of this registration statement. In the past 12 calendar months, we have offered and sold pursuant to General Instruction
I.B.5 of Form F-3 (which the Company was previously subject to as a foreign private issuer) an aggregate of 1,200,578 American Depositary
Shares (“ADSs”) for gross proceeds of approximately $1,483,706. If our public float decreases, the amount of securities we
may sell under our Form S-3 shelf registration statement, including this prospectus supplement, will also decrease. Conversely,
if our public float increases sufficiently, the amount of securities we may sell under our Form S-3, including this prospectus supplement,
will also increase, and we may amend this prospectus supplement to reflect such possible increase in shares of common stock hereunder.
It is not possible to predict the number of shares of our
common stock sold under the Sales Agreement.
Subject to certain limitations in the Sales
Agreement and compliance with applicable law, we have the discretion to deliver a placement notice to Wainwright at any time throughout
the term of the Sales Agreement. The number of shares of our common stock that are sold through Wainwright after our delivery of a placement
notice will fluctuate based on a number of factors, including the market price of our common stock during the sales period, any limits
we may set with Wainwright in any applicable placement notice and the demand for our common stock. If the market price of our common
stock during the sales period declines, we would be able to potentially sell a higher number of shares of common stock than the number
based on the current market price of our common stock and, in any event, we may choose to sell a lower number of shares of common stock
than the $2.0 million of our common stock set forth on the cover of this prospectus supplement.
The common stock offered hereby will be sold in “at-the-market offerings”
and investors who buy common stock at different times will likely pay different prices.
Investors who purchase our common stock in
this offering at different times likely will pay different prices, and accordingly may experience different levels of dilution and different
outcomes in their investment results. We will have discretion, subject to market demand, to vary the timing, prices and number of our
common stock sold in this offering. In addition, subject to the final determination by our board of directors or any restrictions we
may place in any applicable placement notice, there is no minimum or maximum sales price for our common stock to be sold in this offering.
Investors may experience a decline in the value of our common stock they purchase in this offering as a result of sales made at prices
lower than the prices they paid.
Shares of common stock representing a substantial percentage
of our outstanding shares of common stock may be sold in this offering and such shares will be freely tradable, which could cause the
price of our common stock to decline.
A substantial number of shares of our common
stock may be sold in the public market in this offering, and all of the common stock sold in the offering will be freely tradable without
restriction or further registration under the Securities Act. These sales, and any future sales of a substantial number of shares of
our common stock in the public market, or the perception that such sales may occur, may cause the market price of our common stock to
decline. This could make it more difficult for you to sell your common stock at a time and price that you deem appropriate and could
impair our ability to raise capital through the sale of additional equity securities.
USE OF PROCEEDS
We may sell common stock from time to time
having gross aggregate sales proceeds of up to $2.0 million. Because there is no minimum offering amount required as a condition
of this offering, the actual total public offering amount, estimated commissions and proceeds to us, if any, are not determinable at
this time. There can be no assurance that we will be able to sell any common stock under or fully utilize the Sales Agreement with Wainwright
as a source of financing.
We intend to use the net proceeds from this offering,
if any, together with our existing cash and cash equivalents, to fund our pipeline development, to maintain our working capital, and for
general corporate purposes.
The amounts and timing of our actual expenditures
will depend upon numerous factors, including the progress of our development and commercialization efforts, the status of and results
from our clinical, non-clinical or pre-clinical trials, whether or not we enter into strategic collaborations or partnerships,
and our operating costs and expenditures. Accordingly, our management will have significant flexibility in applying the net proceeds of
this offering. In addition, while we have not entered into any outstanding binding agreements or commitments relating to any significant
transaction as of the date of this prospectus, we may use a portion of the net proceeds to pursue acquisitions, joint ventures, and other
strategic transactions.
CAPITALIZATION
The following table sets forth our cash and
cash equivalents and our capitalization as of September 30, 2024, presented in U.S. Dollars:
|
● |
on an actual basis; and |
|
● |
on
an as-adjusted basis to give further effect to the sale of 588,235 shares of common stock in this offering at an assumed
offering price of $3.40 per share, which was the closing price of our common stock on the Nasdaq Global Market on January 3, 2025,
after deducting the estimated sales commissions and estimated offering expenses payable by us. |
| |
As of September 30, 2024 | |
| |
Actual | | |
As Adjusted | |
| |
| | |
(in thousands) | |
Cash and cash equivalents | |
$ | 8,082,410 | | |
| 9,822,410 | |
| |
| | | |
| | |
Equity: | |
| | | |
| | |
Capital | |
$ | 198,280,436 | | |
$ | 200,020,436 | |
Share-based payments reserve | |
$ | | | |
| | |
Foreign currency translation reserve | |
$ | (2,428,214 | ) | |
| (2,428,214 | ) |
Accumulated losses | |
$ | (178,781,858 | ) | |
| (178,781,858 | ) |
Total equity | |
$ | 17,070,364 | | |
| 18,910,364 | |
| |
| | | |
| | |
Total capitalization | |
$ | 25,152,774 | | |
| 28,732,774 | |
The number of shares of our common stock in
the table above is based on 1,628,659 shares of common stock outstanding as of December 31, 2024 on an as converted basis to reflect
the redomiciliation effective December 23, 2024 and excludes:
|
● |
50,536
shares of common stock issuable upon exercise of options outstanding as of December 31, 2024 at a weighted average exercise price
of $158.19 per share, of which options to purchase 37,166 shares of common stock were vested at a weighted average exercise price
of $129.60 per share; and |
|
● |
1,054,381 shares of
common stock issuable upon exercise of warrants outstanding as of December 31, 2024 at a weighted average exercise price of
$11.88 per share, of which all were fully vested. |
In addition, the number of shares of our common
stock in the table above excludes shares issuable pursuant to future awards granted to our employees under the Neuphoria Therapeutics
Inc. 2024 Equity Incentive Plan (the “2024 Equity Incentive Plan”) or that might be granted to our directors.
DILUTION
If you invest in our common stock in this
offering, your ownership interest will be immediately diluted to the extent of the difference between the public offering price per share
and the as adjusted net tangible book value per share after this offering. As of September 30, 2024, our net tangible book value was
$2.9 million, or $1.76 per share. Net tangible book value per share represents our total tangible assets (excluding deferred issuance
costs) less our total liabilities, divided by the number of shares of common stock outstanding as of December 31, 2024 on an as converted
basis to reflect the redomiciliation effective December 23, 2024.
Net tangible book value dilution per share
to investors participating in this offering represents the difference between the amount per share paid by purchasers of our common stock
in this offering and the as adjusted net tangible book value per share immediately after this offering. After giving effect to the sale
of 588,235 shares of common stock in this offering at an assumed offering price of $3.40 per share, the last reported sale price of our
common stock on The Nasdaq Capital Market on January 3, 2025, and after deducting commissions and estimated aggregate offering expenses
payable by us, our as adjusted net tangible book value as of September 30, 2024 would have been approximately $4.6 million, or approximately
$2.83 per share. This represents an immediate increase in as adjusted net tangible book value of $1.07 per share to our existing stockholders
and an immediate dilution in net tangible book value of $0.57 per share to investors participating in this offering at the assumed public
offering price.
Assumed public offering price per share | |
| | | |
$ | 3.40 | |
Historical net tangible book value per share as of September 30, 2024 | |
$ | 1.76 | | |
| | |
Increase in net tangible per share attributable to this
offering | |
$ | 1.07 | | |
| | |
As adjusted net tangible book value
per share as of September 30, 2024 after giving effect to this offering | |
| | | |
$ | 2.83 | |
Dilution in net tangible book value per share to investors participating in
this offering | |
| | | |
$ | 0.57 | |
The table above assumes for illustrative purposes
that an aggregate of $2 million in common stock is sold at a price of $3.40 per share, the last reported sale price of our share on The
Nasdaq Capital Market on January 3, 2025. The common stock sold in this offering, if any, will be sold from time to time at various prices.
An increase of $.25 per share in the price at which the common stock is sold from the assumed public offering price of $3.40 per share
shown in the table above, assuming all of our common stock in the aggregate amount of $2 million is sold at that price, would increase
our as adjusted net tangible book value per share after the offering to $2.92 per share and would increase the dilution in net tangible
book value per share to investors participating in this offering to $.73 per share, after deducting commissions and estimated aggregate
offering expenses payable by us. A decrease of $.25 per share in the price at which the common stock is sold from the assumed public
offering price of $3.40 per share shown in the table above, assuming all of our common stock in the aggregate amount of $2 million is
sold at that price, would decrease our as adjusted net tangible book value per share after the offering to $2.74 per share and would
decrease the dilution in net tangible book value per share to investors participating in this offering to $.41 per share, after deducting
commissions and estimated aggregate offering expenses payable by us.
The information discussed above is illustrative
only and will adjust based on the actual public offering price and other terms of this offering determined at pricing.
The above discussion and table is based on
1,628,659 shares of common stock outstanding as of December 31, 2024 on an as converted basis to reflect the redomiciliation effective
December 23, 2024 and excludes as of that date:
|
● |
50,536
shares of common stock issuable upon exercise of outstanding stock options; and |
|
● |
1,054,381 shares of
common stock issuable upon exercise of warrants at a weighted average exercise price of $11.88 per share. |
To the extent that stock options or warrants
are exercised, we issue new stock options under our equity incentive plan, or we issue additional common stock in the future, there will
be further dilution to investors. In addition, if we raise additional capital through the sale of equity or convertible debt securities,
the issuance of these securities could result in further dilution to our stockholders.
PLAN OF DISTRIBUTION
We have entered into a sales agreement with
Wainwright, pursuant to which we may issue and sell from time to time shares of our common stock having an aggregate offering price of
not more than $2,000,000 through Wainwright as our sales agent. Sales of common stock, if any, will be made by any method permitted by
law deemed to be an “at the market offering” as defined in Rule 415(a)(4) promulgated under the Securities Act.
Wainwright will offer our common stock at
prevailing market prices subject to the terms and conditions of the sales agreement as agreed upon by us and Wainwright. We will designate
the number of shares of our common stock which we desire to sell, the time period during which sales are requested to be made, any limitation
on the number of shares of our common stock that may be sold in one day and any minimum price below which sales may not be made. Subject
to the terms and conditions of the sales agreement, Wainwright will use its commercially reasonable efforts consistent with its normal
trading and sales practices to sell on our behalf all of the common stock requested to be sold by us. We or Wainwright may suspend the
offering of our common stock being made through Wainwright under the sales agreement upon proper notice to the other party.
Settlement for sales of our common stock will occur on the first trading
day or such shorter settlement cycle as may be in effect under Exchange Act Rule 15c6-1 from time to time, following the date on which
any sales are made, or on some other date that is agreed upon by us and Wainwright in connection with a particular transaction, in return
for payment of the net proceeds to us. Sales of our common stock as contemplated in this prospectus supplement and the accompanying prospectus
will be settled through the facilities of The Depository Trust Company or by such other means as we and Wainwright may agree upon. There
is no arrangement for funds to be received in an escrow, trust or similar arrangement.
We will pay Wainwright in cash, upon each
sale of our common stock pursuant to the sales agreement, a commission of 3.0% of the gross proceeds from each sale of our common stock.
Because there is no minimum offering amount required as a condition to this offering, the actual total public offering amount, commissions
and proceeds to us, if any, are not determinable at this time.
Pursuant to the terms of the sales agreement,
we agreed to reimburse Wainwright for the documented fees and costs of its legal counsel reasonably incurred in connection with entering
into the transactions contemplated by the sales agreement in an amount not to exceed $50,000 in the aggregate, in addition to up to $2,500
per due diligence update session for Wainwright’s counsel’s fees. We will report at least quarterly the number of shares
of our common stock sold through Wainwright under the sales agreement, the net proceeds to us and the compensation paid by us to Wainwright
in connection with the sales of our common stock.
In connection with the sales of our common
stock on our behalf, Wainwright will be deemed to be an “underwriter” within the meaning of the Securities Act, and the compensation
paid to Wainwright will be deemed to be underwriting commissions or discounts. We have agreed in the sales agreement to provide indemnification
and contribution to Wainwright against certain liabilities, including liabilities under the Securities Act.
The offering of our common stock pursuant
to the sales agreement will terminate upon the termination of the sales agreement as permitted therein.
To the extent required by Regulation M, Wainwright
will not engage in any market making activities involving our common stock while the offering is ongoing under this prospectus supplement.
Wainwright and its affiliates may in the future
provide various investment banking and other financial services for us and our affiliates, for which services they may in the future receive
customary fees.
This prospectus supplement and the accompanying
prospectus may be made available in electronic format on a website maintained by Wainwright, and Wainwright may distribute this prospectus
and the accompanying prospectus electronically. A copy of the sales agreement is filed with the SEC as an exhibit to the registration
statement of which this prospectus is a part.
WHERE YOU CAN FIND MORE INFORMATION
We are subject to the informational requirements
of the Exchange Act and in accordance therewith file annual, quarterly and current reports, proxy statements and other information with
the SEC. The SEC maintains a website that contains reports, proxy and information statements and other information regarding registrants
that file electronically with the SEC. The address of the SEC’s website is www.sec.gov.
We make available free of charge on or through
our website our Annual Reports on Form 10-K, Quarterly Reports on Form 10-Q, Current Reports on Form 8-K and amendments to those reports
filed or furnished pursuant to Section 13(a) or 15(d) of the Exchange Act as soon as reasonably practicable after we electronically file
such material with or otherwise furnish it to the SEC.
Our web site address is http://www.neuphoriatx.com.
The information on our web site, however, is not, and should not be deemed to be, a part of this prospectus supplement or the accompanying
prospectus.
This prospectus supplement and the accompanying
prospectus are part of a registration statement that we filed with the SEC and do not contain all of the information in the registration
statement. The full registration statement may be obtained from the SEC or us, as provided below. Other documents establishing the terms
of the offered securities are or may be filed as exhibits to the registration statement or documents incorporated by reference in the
registration statement. Statements in this prospectus supplement or the accompanying prospectus about these documents are summaries and
each statement is qualified in all respects by reference to the document to which it refers. You should refer to the actual documents
for a more complete description of the relevant matters. You may inspect a copy of the registration statement and the documents incorporated
by reference therein through the SEC’s website set forth above.
INCORPORATION BY REFERENCE
The SEC’s rules allow us to “incorporate
by reference” information into this prospectus supplement, which means that we can disclose important information to you by referring
you to another document filed separately with the SEC. The information incorporated by reference is deemed to be part of this prospectus
supplement, and subsequent information that we file with the SEC will automatically update and supersede that information. Any statement
contained in this prospectus supplement, the accompanying prospectus or a previously filed document incorporated by reference will be
deemed to be modified or superseded for purposes of this prospectus supplement to the extent that a statement contained in this prospectus
supplement or a subsequently filed document incorporated by reference modifies or replaces that statement.
We incorporate by reference the documents listed
below, all filings filed by us pursuant to the Exchange Act after the date of the registration statement of which this prospectus supplement
forms a part, and any future filings we make with the SEC under Sections 13(a), 13(c), 14 or 15(d) of the Exchange Act prior to the time
that all securities covered by this prospectus have been sold; provided, however, that we are not incorporating any information furnished
under either Item 2.02 or Item 7.01 of any current report on Form 8-K:
|
● |
Bionomics’ Annual
Report on Form 10-K
for the fiscal year ended June 30, 2024, filed with the SEC on September 30, 2024; |
|
● |
Bionomics’
Current Report on Form 8-K
filed with the SEC on November 21, 2024; |
|
● |
Bionomics’ Quarterly Report
on Form 10-Q for the quarter ended September 30, 2024, filed with the SEC on November 14, 2024; and |
|
|
|
|
● |
Neuphoria’s Current
Report on Form 8-K filed with the SEC on December
23, 2024. |
The SEC maintains a website that contains
reports, proxy and information statements and other information regarding registrants that file electronically with the SEC. The address
of the SEC’s website is www.sec.gov. You may access and view for free any of our incorporated filings and exhibits related thereto
made by us with the SEC. Alternatively, you may also request a free copy of any of the documents incorporated by reference in this prospectus
supplement by writing or telephoning us at the following address:
100 Summit Dr
Burlington, Massachusetts 01803
Tel: +1 781 439 5551
Exhibits to the filings will not be sent, however,
unless those exhibits have specifically been incorporated by reference in this prospectus or any accompanying prospectus supplement.
LEGAL MATTERS
The validity of the securities and certain
other matters under U.S. law will be passed upon for us by Rimon P.C. Ellenoff Grossman & Schole LLP, New York, New York, is counsel
for Wainwright in connection with this offering with respect to United States federal securities law.
EXPERTS
Wolf & Company, P.C., an independent registered
public accounting firm, has audited our consolidated financial statements included in Bionomics Limited’s Annual Report on Form
10-K for the year ended June 30, 2024, as set forth in their report, which is incorporated by reference in this prospectus and elsewhere
in this registration statement. Bionomics Limited’s financial statements are incorporated by reference in reliance on Wolf &
Company, P.C.’s report, given on their authority as experts in accounting and auditing.
Change in Accountants
Our independent registered public accounting firm
is Wolf & Company, P.C., which has served as our independent auditor for fiscal years 2024 and 2023, with respect to our financial
statements prepared in accordance with U.S. GAAP. Ernst & Young served as our independent registered public accounting firm for
fiscal year 2023 and for part of fiscal year 2024 with respect to our financial statements prepared in accordance with International Financial
Reporting Standards (“IFRS”), as we were a foreign private issuer until June 30, 2024 and reported our financial statements
under IFRS. During the auditor transition period from Ernst & Young to Wolf & Company, P.C. for the period ended June 30, 2024,
there were no reportable events (as defined in Regulation S-K Item 304(a)(1)(v)).
$2,000,000
COMMON STOCK
PROSPECTUS SUPPLEMENT
H.C. Wainwright & Co.
,
2025
Item 9. Exhibits
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Incorporation
by Reference |
Exhibit
No. |
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Description |
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Form |
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File
No. |
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Exhibit
No. |
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Filing
Date |
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1.1** |
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Form of Underwriting Agreement |
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1.2* |
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At The Market Offering Agreement, by and between the Registrant and H.C. Wainwright & Co., LLC, as amended |
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3.1 |
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Amended
and Restated Certificate of Incorporation of the Registrant |
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8-K |
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001-41157 |
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3.1 |
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12/23/2024 |
3.2 |
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Bylaws
of the Registrant |
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8-K |
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001-41157 |
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3.2 |
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12/23/2024 |
4.4+ |
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Form
of Indenture |
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5.1* |
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Opinion of Rimon P.C. |
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10.1* |
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Common Stock Purchase Warrant, dated December 24, 2024, issued by Neuphoria Therapeutics Inc. to Armistice Capital Master Fund Ltd |
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10.2 |
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Scheme
Implementation Agreement, dated October 1, 2024, between Bionomics Limited and Neuphoria Therapeutics Inc. (incorporated by reference
to Exhibit 2.1 to Neuphoria Therapeutics Inc.’s Current Report on Form 8-K filed on December 23, 2024) |
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8-K |
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001-41157 |
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2.1 |
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12/23/2024 |
23.1* |
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Consent of Wolf & Company, P.C., an independent registered public accounting firm. |
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23.2* |
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Consent of Rimon P.C. (included in Exhibit 5.1) |
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24.1* |
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Powers of Attorney (included on signature page to the registration statement) |
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25.1*** |
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Statement of Eligibility on Form T-1 under
the Trust Indenture Act of 1939, as amended, of the Trustee under the Indenture |
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107* |
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Filing Fee
Table |
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** |
If applicable, to be filed as an exhibit to a post-effective
amendment to this Registration Statement or as an exhibit to a current report on Form 8-K and incorporated herein by reference. |
*** |
Where applicable, to be incorporated by reference to
a subsequent filing in accordance with Section 305(b)(2) of the Trust Indenture Act of 1939, as amended. |
Item 10. Undertakings
(a) The undersigned registrant hereby undertakes:
(i) To file, during any period in which
offers or sales are being made, a post-effective amendment to this Registration Statement:
(1) to include any prospectus required
by Section 10(a)(3) of the Securities Act of 1933;
(2) to reflect in the prospectus any
facts or events arising after the effective date of the Registration Statement (or the most recent post-effective amendment thereof) which,
individually or in the aggregate, represent a fundamental change in the information set forth in the Registration Statement. Notwithstanding
the foregoing, any increase or any decrease in volume of securities offered (if the total dollar value of securities offered would not
exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected
in the form of prospectus filed with the SEC pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no
more than a 20% change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in
the effective registration statement; and
(3) to include any material information
with respect to the plan of distribution not previously disclosed in the Registration Statement or any material change to such information
in the Registration Statement;
provided, however, that paragraphs
(a)(i)(1), (a)(i)(2) and (a)(i)(3) of this section do not apply if the information required to be included in a post-effective amendment
by those paragraphs is contained in reports filed with or furnished to the SEC by the registrant pursuant to Section 13 or Section 15(d)
of the Securities Exchange Act of 1934 that are incorporated by reference in the Registration Statement, or is contained in a form of
prospectus filed pursuant to Rule 424(b) that is part of the Registration Statement.
(ii) That, for the purpose of determining
any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement
relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide
offering thereof.
(iii) To remove from registration by
means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
(iv) To file a post-effective amendment
to the Registration Statement to include any financial statements required by Item 8.A of Form 10-K at the start of any delayed
offering or throughout a continuous offering. Financial statements and information otherwise required by Section 10(a)(3) of the
Securities Act of 1933 need not be furnished, provided, that the registrant includes in the prospectus, by means of a post-effective amendment,
financial statements required pursuant to this paragraph (a)(4) and other information necessary to ensure that all other information in
the prospectus is at least as current as the date of those financial statements. Notwithstanding the foregoing, a post-effective amendment
need not be filed to include financial statements and information required by Section 10(a)(3) of the Securities Act of 1933 or Rule 3-19 of
Regulation S-X if such financial statements and information are contained in periodic reports filed with or furnished to the
SEC by the registrant pursuant to Section 13 or Section 15(d) of the Securities Exchange Act of 1934 that are incorporated by
reference in this Form S-3.
(v) That, for the purpose of determining
liability under the Securities Act of 1933 to any purchaser:
(1) each prospectus filed by the registrant
pursuant to Rule 424(b)(3) shall be deemed to be part of the Registration Statement as of the date the filed prospectus was deemed part
of and included in the Registration Statement; and
(2) each prospectus required to be
filed pursuant to Rule 424(b)(2), (b)(5) or (b)(7) as part of a registration statement in reliance on Rule 430B relating to an offering
made pursuant to Rule 415(a)(1)(i), (vii) or (x) for the purpose of providing the information required by section 10(a) of the
Securities Act of 1933 shall be deemed to be part of and included in the registration statement as of the earlier of the date such form
of prospectus is first used after effectiveness or the date of the first contract of sale of securities in the offering described in the
prospectus. As provided in Rule 430B, for liability purposes of the issuer and any person that is at that date an underwriter, such date
shall be deemed to be a new effective date of the registration statement relating to the securities in the registration statement to which
that prospectus relates, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.
Provided, however, that no statement made in a registration statement or prospectus that is part of the registration statement or made
in a document incorporated or deemed incorporated by reference into the registration statement or prospectus that is part of the registration
statement will, as to a purchaser with a time of contract of sale prior to such effective date, supersede or modify any statement that
was made in the registration statement or prospectus that was part of the registration statement or made in any such document immediately
prior to such effective date.
(vi) That, for the purpose of determining
liability of the undersigned registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities
of the undersigned registrant, the undersigned registrant undertakes that in a primary offering of its securities pursuant to this Registration
Statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to
such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will
be considered to offer or sell such securities to such purchaser:
(1) any preliminary prospectus or prospectus
of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;
(2) any free writing prospectus relating
to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;
(3) the portion of any other free writing
prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or
on behalf of the undersigned registrant; and
(4) any other communication that is
an offer in the offering made by the undersigned registrant to the purchaser.
(b) The undersigned registrant hereby undertakes
that, for purposes of determining any liability under the Securities Act of 1933, each filing of the registrant’s annual report
pursuant to Section 13(a) or Section 15(d) of the Securities Exchange Act of 1934 that is incorporated by reference in the Registration
Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities
at that time shall be deemed to be the initial bona fide offering thereof.
(c) Insofar as indemnification for liabilities
arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to
the foregoing provisions, or otherwise the registrant has been advised that in the opinion of the SEC such indemnification is against
public policy as expressed in the Securities Act of 1933 and is, therefore, unenforceable. In the event that a claim for indemnification
against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling
person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling
person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been
settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against
public policy as expressed in the Securities Act of 1933 and will be governed by the final adjudication of such issue.
(d) The undersigned registrant hereby undertakes
to file an application for the purpose of determining the eligibility of the trustee to act under subsection (a) of section 310 of
the Trust Indenture Act (“Act”) in accordance with the rules and regulations prescribed by the Commission under section 305(b)(2)
of the Act.
SIGNATURES
Pursuant to the requirements of the
Securities Act, the registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing
on Form S-3 and has duly caused this Pre-Effective Amendment No. 2 to the registration statement to be signed on its
behalf by the undersigned, thereto duly authorized in Weston, Massachusetts, on January 6, 2025.
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Neuphoria Therapeutics Inc. |
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By: |
/s/ Spyridon “Spyros”
Papapetropoulos, M.D. |
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Spyridon “Spyros”
Papapetropoulos, M.D. |
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President, Chief
Executive Officer and Director |
KNOW ALL PERSONS BY THESE PRESENTS, that each
person whose signature appears below hereby constitutes and appoints Spyridon “Spyros” Papapetropoulos, M.D. and Tim Cunningham
and each of them, individually, as his true and lawful attorneys-in-fact and agents, with full power of substitution and resubstitution,
for him and in his name, place and stead in any and all capacities, in connection with this registration statement, including to sign
in the name and on behalf of the undersigned, this registration statement and any and all amendments thereto, including post-effective
amendments and registrations filed pursuant to Rule 462 under the Securities Act of 1933, as amended, and to file the same, with all exhibits
thereto, and other documents in connection therewith, with the U.S. Securities and Exchange Commission, granting unto such attorneys-in-fact and
agents full power and authority to do and perform each and every act and thing requisite and necessary to be done in and about the premises,
as fully to all intents and purposes as he might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and
agents, or his substitute, may lawfully do or cause to be done by virtue hereof.
Pursuant to the requirements of the
Securities Act of 1933, this Pre-Effective Amendment No. 2 to the registration statement has been signed by the following persons in
the capacities held on the dates indicated.
Signature |
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Title |
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Date |
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/s/
Spyridon “Spyros” Papapetropoulos |
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President, Chief Executive
Officer and Director |
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January
6, 2025 |
Spyridon “Spyros” Papapetropoulos,
M.D. |
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(principal executive
officer) |
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/s/
Tim Cunningham |
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Chief Financial Officer |
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January
6, 2025 |
Tim Cunningham |
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(principal financial
and accounting officer) |
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/s/
Alan Fisher |
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Director |
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January
6, 2025 |
Alan Fisher |
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/s/
Jane Ryan |
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Director |
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January
6, 2025 |
Jane Ryan, Ph.D. |
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/s/
Miles Davies |
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Director |
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January
6, 2025 |
Miles Davies |
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/s/
David Wilson |
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Director |
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January
6, 2025 |
David Wilson |
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Exhibit 1.2
AT THE MARKET OFFERING AGREEMENT
January 6, 2025
H.C. Wainwright & Co., LLC
430 Park Avenue
New York, New York 10022
Ladies and
Gentlemen:
Neuphoria Therapeutics Inc.,
a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”)
with H.C. Wainwright & Co., LLC (the “Manager”) as follows (for purposes of clarity, this Agreement amends the
At The Market Offering Agreement dated November 18, 2024, by and between the Company and the Manager, solely to update the Company’s
name and status as a domestic U.S. issuer following it’s Redomiciliation, effective December 24, 2024):
1. Definitions.
The terms that follow, when used in this Agreement and any Terms Agreement, shall have the meanings indicated.
“Accountants” shall
have the meaning ascribed to such term in Section 4(m).
“Act”
shall mean the Securities Act of 1933, as amended, and the rules and regulations of the Commission promulgated thereunder.
“Action”
means any action, suit, inquiry, notice of violation, proceeding or investigation pending or, to the knowledge of the Company, threatened
against or affecting the Company, any Subsidiary or any of their respective properties before or by any court, arbitrator, governmental
or administrative agency or regulatory authority (federal, state, county, local or foreign).
“Affiliate”
means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control
with a Person, as such terms are used in and construed under Rule 144 under the Act.
“Applicable
Time” shall mean, with respect to any Shares, the time of sale of such Shares pursuant to this Agreement or any relevant Terms
Agreement.
“Base Prospectus”
shall mean the base prospectus contained in the Registration Statement at the Effective Time.
“Board”
shall have the meaning ascribed to such term in Section 2(b)(iii).
“Broker
Fee” shall have the meaning ascribed to such term in Section 2(b)(v).
“Business
Day” shall mean any day other than Saturday, Sunday or other day on which commercial banks in The City of New York are authorized
or required by law to remain closed; provided, however, that, for purposes of clarity, commercial banks shall not be deemed
to be authorized or required by law to remain closed due to “stay at home”, “shelter-in-place”, “non-essential
employee” or any other similar orders or restrictions or the closure of any physical branch locations at the direction of
any governmental authority so long as the electronic funds transfer systems (including for wire transfers) of commercial banks in The
City of New York generally are open for use by customers on such day.
“Commission”
shall mean the United States Securities and Exchange Commission.
“Common
Stock” shall have the meaning ascribed to such term in Section 2.
“Common
Stock Equivalents” shall have the meaning ascribed to such term in Section 4(h).
“Company
Counsel” shall have the meaning ascribed to such term in Section 4(l).
“DTC”
shall have the meaning ascribed to such term in Section 2(b)(vii).
“Effective
Date” shall mean each date and time that the Registration Statement and any post-effective amendment or amendments thereto became
or becomes effective.
“Effective
Time” shall mean the first date and time that the Registration Statement becomes effective.
“Exchange
Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations of the Commission promulgated
thereunder.
“Execution
Time” shall mean the date and time that this Agreement is executed and delivered by the parties hereto.
“Free Writing
Prospectus” shall mean a free writing prospectus, as defined in Rule 405.
“GAAP”
shall have the meaning ascribed to such term in Section 3(f).
“Incorporated
Documents” shall mean the documents or portions thereof filed with the Commission on or prior to the Effective Date that are
incorporated by reference in the Registration Statement or the Prospectus and any documents or portions thereof filed with the Commission
after the Effective Date that are deemed to be incorporated by reference in the Registration Statement or the Prospectus.
“Intellectual
Property Rights” shall have the meaning ascribed to such term in Section 3(u).
“Issuer
Free Writing Prospectus” shall mean an issuer free writing prospectus, as defined in Rule 433.
“Losses”
shall have the meaning ascribed to such term in Section 7(d).
“Material
Adverse Effect” shall have the meaning ascribed to such term in Section 3(g).
“Net Proceeds”
shall have the meaning ascribed to such term in Section 2(b)(v).
“Permitted
Free Writing Prospectus” shall have the meaning ascribed to such term in Section 4(g).
“Placement”
shall have the meaning ascribed to such term in Section 2(c).
“Proceeding”
means any Action, claim, suit, investigation or proceeding (including, without limitation, an informal investigation or partial proceeding,
such as a deposition), whether commenced or, to the Company’s knowledge, threatened.
“Prospectus”
shall mean the Base Prospectus, as supplemented by the Prospectus Supplement included in the Registration Statement at the Effective Time
and any subsequently filed Prospectus Supplement.
“Prospectus
Supplement” shall mean each prospectus supplement relating to the Shares included in the Registration Statement at the Effective
Time and any other prospectus supplement relating to the Shares prepared and filed pursuant to Rule 424(b) from time to time.
“Registration
Statement” shall mean the shelf registration statement on Form S-3 registering $100,000,000 of securities of the Company
to be filed on or about the Execution Time, including exhibits and financial statements and any prospectus supplement relating to the
Shares that is filed with the Commission pursuant to Rule 424(b) and deemed part of such registration statement pursuant to Rule 430B,
as amended on each Effective Date and, in the event any post-effective amendment thereto becomes effective, shall also mean such registration
statement as so amended.
“Representation
Date” shall have the meaning ascribed to such term in Section 4(k).
“Rule 158”,
“Rule 164”, “Rule 172”, “Rule 173”, “Rule 405”,
“Rule 415”, “Rule 424”, “Rule 430B” and “Rule 433”
refer to such rules under the Act.
“Sales
Notice” shall have the meaning ascribed to such term in Section 2(b)(i).
“SEC Reports”
shall have the meaning ascribed to such term in Section 3(a).
“Settlement
Date” shall have the meaning ascribed to such term in Section 2(b)(vii).
“Subsidiary”
shall have the meaning ascribed to such term in Section 3(i).
“Terms
Agreement” shall have the meaning ascribed to such term in Section 2(a).
“Time of
Delivery” shall have the meaning ascribed to such term in Section 2(c).
“Trading
Day” means a day on which the Trading Market is open for trading.
“Trading
Market” means the Nasdaq Global Market.
2. Sale
and Delivery of Shares. The Company proposes to issue and sell through or to the Manager, as sales agent and/or principal, from time
to time during the term of this Agreement and on the terms set forth herein, up to such number of shares (the “Shares”)
of the Company’s common stock, $0.00001 par value per share (“Common Stock”) that does not exceed (a) the
number or dollar amount of Shares included in the Prospectus Supplement to the Registration Statement, pursuant to which the offering
is being made, (b) the maximum number of Shares authorized for issuance hereunder or (c) the number or dollar amount of Shares representing
the maximum number of securities that would cause the Company or the offering of the Shares to not satisfy the eligibility and transaction
requirements for use of Form S-3, including, if applicable, General Instruction I.B.6 of Registration Statement on Form S-3 (the lesser
of (a), (b) and (c), the “Maximum Amount”). Notwithstanding anything to the contrary contained herein, the parties
hereto agree that compliance with the limitations set forth in this Section 2 on the number and aggregate sales price of Shares issued
and sold under this Agreement shall be the sole responsibility of the Company and that the Manager shall have no obligation in connection
with such compliance.
(a) Appointment
of Manager as Selling Agent; Terms Agreement. For purposes of selling the Shares through the Manager, the Company hereby
appoints the Manager as exclusive agent of the Company for the purpose of selling the Shares pursuant to this Agreement and the
Manager agrees to use its commercially reasonable efforts to sell the Shares on the terms and subject to the conditions stated
herein. The Company agrees that, whenever it determines to sell the Shares directly to the Manager as principal, it will enter into
a separate agreement (each, a “Terms Agreement”) in substantially the form of Annex I hereto, relating to
such sale in accordance with Section 2 of this Agreement.
(b) Agent
Sales. Subject to the terms and conditions and in reliance upon the representations and warranties herein set forth, following the
effectiveness of the Registration Statement, the Company will issue and agrees to sell Shares from time to time through the Manager, acting
as sales agent, and the Manager agrees to use its commercially reasonable efforts to sell, as sales agent for the Company, on the following
terms:
(i) The
Shares are to be sold on a daily basis or otherwise as shall be agreed to by the Company and the Manager on any day that (A) is a
Trading Day, (B) the Company has instructed the Manager by telephone (confirmed promptly by electronic mail) to make such sales (“Sales
Notice”) and (C) the Company has satisfied its obligations under Section 6 of this Agreement. The Company will designate the
maximum amount of the Shares to be sold by the Manager daily (subject to the limitations set forth in Section 2(d)) and the minimum price
per Share at which such Shares may be sold. Subject to the terms and conditions hereof, the Manager shall use its commercially reasonable
efforts to sell on a particular day all of the Shares designated for the sale by the Company on such day. The gross sales price of the
Shares sold under this Section 2(b) shall be the market price for the shares of Common Stock sold by the Manager under this Section 2(b)
on the Trading Market at the time of sale of such Shares.
(ii) The
Company acknowledges and agrees that (A) there can be no assurance that the Manager will be successful in selling the Shares, (B) the
Manager will incur no liability or obligation to the Company or any other person or entity if it does not sell the Shares for any reason
other than a failure by the Manager to use its commercially reasonable efforts consistent with its normal trading and sales practices
and applicable law and regulations to sell such Shares as required under this Agreement, and (C) the Manager shall be under no obligation
to purchase Shares on a principal basis pursuant to this Agreement, except as otherwise specifically agreed by the Manager and the Company
pursuant to a Terms Agreement.
(iii) The
Company shall not authorize the issuance and sale of, and the Manager shall not be obligated to use its commercially reasonable
efforts to sell, any Shares at a price lower than the minimum price therefor designated from time to time by the Company’s
Board of Directors (the “Board”), or a duly authorized committee thereof, or such duly authorized officers of the
Company, and notified to the Manager in writing. The Company or the Manager may, upon notice to the other party hereto by telephone
(confirmed promptly by electronic mail), suspend the offering of the Shares for any reason and at any time; provided, however,
that such suspension or termination shall not affect or impair the parties’ respective obligations with respect to the Shares
sold hereunder prior to the giving of such notice.
(iv) The
Manager may sell Shares by any method permitted by law deemed to be an “at the market offering” as defined in Rule 415
under the Act, including without limitation sales made directly on the Trading Market, on any other existing trading market for the Common
Stock or to or through a market maker. The Manager may also sell Shares in privately negotiated transactions, provided that the Manager
receives the Company’s prior written approval for any sales in privately negotiated transactions and if so provided in the “Plan
of Distribution” section of the Prospectus Supplement or a supplement to the Prospectus Supplement or a new Prospectus Supplement
disclosing the terms of such privately negotiated transaction.
(v) The
compensation to the Manager for sales of the Shares under this Section 2(b) shall be a placement fee of 3.0% of the gross sales price
of the Shares sold pursuant to this Section 2(b) (“Broker Fee”). The foregoing rate of compensation shall not apply
when the Manager acts as principal, in which case the Company may sell Shares to the Manager as principal at a price agreed upon at the
relevant Applicable Time pursuant to a Terms Agreement. The remaining proceeds, after deduction of the Broker Fee and deduction of any
transaction fees imposed by any clearing firm, execution broker, or governmental or self-regulatory organization in respect of such sales,
shall constitute the net proceeds to the Company for such Shares (the “Net Proceeds”).
(vi) The
Manager shall provide written confirmation (which may be by electronic mail) to the Company following the close of trading on the Trading
Market each day in which the Shares are sold under this Section 2(b) setting forth the number of the Shares sold on such day, the aggregate
gross sales proceeds and the Net Proceeds to the Company, and the compensation payable by the Company to the Manager with respect to such
sales.
(vii) Unless
otherwise agreed between the Company and the Manager, settlement for sales of the Shares will occur at 10:00 a.m. (New York City
time) on the first (1st) Trading Day (or any such shorter settlement cycle
as may be in effect pursuant to Rule 15c6-1 under the Exchange Act from time to time) following the date on which such sales
are made (each, a “Settlement Date”). On or before the Trading Day prior to each Settlement Date, the Company
will, or will cause its transfer agent to, electronically transfer the Shares being sold by crediting the Manager’s or its
designee’s account (provided that the Manager shall have given the Company written notice of such designee at least one
Trading Day prior to the Settlement Date) at The Depository Trust Company (“DTC”) through its Deposit and
Withdrawal at Custodian System or by such other means of delivery as may be mutually agreed upon by the parties hereto which Shares
in all cases shall be freely tradable, transferable, registered shares in good deliverable form. On each Settlement Date, the
Manager will deliver the related Net Proceeds in same day funds to an account designated by the Company. The Company agrees that, if
the Company, or its transfer agent (if applicable), defaults in its obligation to deliver duly authorized Shares on a Settlement
Date, in addition to and in no way limiting the rights and obligations set forth in Section 7 hereto, the Company will (i) hold the
Manager harmless against any loss, claim, damage, or reasonable, documented expense (including reasonable and documented legal fees
and expenses), as incurred, arising out of or in connection with such default by the Company, and (ii) pay to the Manager any
commission, discount or other compensation to which the Manager would otherwise have been entitled absent such default.
(viii) At
each Applicable Time, Settlement Date, and Representation Date, the Company shall be deemed to have affirmed each representation and warranty
contained in this Agreement as if such representation and warranty were made as of such date, modified as necessary to relate to the Registration
Statement and the Prospectus as amended as of such date. Any obligation of the Manager to use its commercially reasonable efforts to sell
the Shares on behalf of the Company shall be subject to the continuing accuracy of the representations and warranties of the Company herein,
to the performance by the Company of its obligations hereunder and to the continuing satisfaction of the additional conditions specified
in Section 6 of this Agreement.
(ix) If
the Company shall declare or make any dividend or other distribution of its assets (or rights to acquire its assets) to holders of shares
of Common Stock, by way of return of capital or otherwise (including, without limitation, any distribution of cash, stock or other securities,
property or options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme of arrangement or other similar
transaction) (a “Distribution” and the record date for the determination of stockholders entitled to receive the Distribution,
the “Record Date”), the Company hereby covenants that, in connection with any sales of Shares pursuant to a Sales Notice
on the Record Date, the Company shall issue and deliver such Shares to the Manager on the Record Date and the Record Date shall be the
Settlement Date and the Company shall cover any additional costs of the Manager in connection with the delivery of Shares on the Record
Date.
(c) Term
Sales. If the Company wishes to sell the Shares pursuant to this Agreement in a manner other than as set forth in Section 2(b)
of this Agreement (each, a “Placement”), the Company will notify the Manager of the proposed terms of such
Placement. If the Manager, acting as principal, wishes to accept such proposed terms (which it may decline to do for any reason in
its sole discretion) or, following discussions with the Company wishes to accept amended terms, the Manager and the Company will
enter into a Terms Agreement setting forth the terms of such Placement. The terms set forth in a Terms Agreement will not be binding
on the Company or the Manager unless and until the Company and the Manager have each executed such Terms Agreement accepting all of
the terms of such Terms Agreement. In the event of a conflict between the terms of this Agreement and the terms of a Terms
Agreement, the terms of such Terms Agreement will control. A Terms Agreement may also specify certain provisions relating to the
reoffering of such Shares by the Manager. The commitment of the Manager to purchase the Shares pursuant to any Terms Agreement shall
be deemed to have been made on the basis of the representations and warranties of the Company herein contained and shall be subject
to the terms and conditions herein set forth. Each Terms Agreement shall specify the number of the Shares to be purchased by the
Manager pursuant thereto, the price to be paid to the Company for such Shares, any provisions relating to rights of, and default by,
underwriters acting together with the Manager in the reoffering of the Shares, and the time and date (each such time and date being
referred to herein as a “Time of Delivery”) and place of delivery of and payment for such Shares. Such Terms
Agreement shall also specify any requirements for opinions of counsel, accountants’ letters and officers’ certificates
pursuant to Section 6 of this Agreement and any other information or documents required by the Manager.
(d) Maximum
Number of Shares. Under no circumstances shall the Company cause or request the offer or sale of any Shares if, after giving effect
to the sale of such Shares, the aggregate amount of Shares sold pursuant to this Agreement would exceed the lesser of (A) together with
all sales of Shares under this Agreement, the Maximum Amount, (B) the amount available for offer and sale under the currently effective
Registration Statement and (C) the amount authorized from time to time to be issued and sold under this Agreement by the Board, a duly
authorized committee thereof or a duly authorized executive committee, and notified to the Manager in writing. Under no circumstances
shall the Company cause or request the offer or sale of any Shares pursuant to this Agreement at a price lower than the minimum price
authorized from time to time by the Board, a duly authorized committee thereof or a duly authorized executive officer, and notified to
the Manager in writing. Further, under no circumstances shall the Company cause or permit the aggregate offering amount of Shares sold
pursuant to this Agreement to exceed the Maximum Amount.
(e) Regulation
M Notice. Unless the exceptive provisions set forth in Rule 101(c)(1) of Regulation M under the Exchange Act are satisfied
with respect to the Shares, the Company shall give the Manager at least one (1) Business Day’s prior notice of its intent to sell
any Shares in order to allow the Manager time to comply with Regulation M.
3. Representations
and Warranties. The Company represents and warrants to, and agrees with, the Manager at the Execution Time and the Effective Time
and on each such time that the following representations and warranties are repeated or deemed to be made pursuant to this Agreement,
as set forth below, except as set forth in the Registration Statement, the Prospectus or the Incorporated Documents.
(a) Registration
Statement and Prospectuses. The Company and the transactions contemplated by this Agreement meet the requirements for and comply with
the applicable conditions set forth in Form S-3 under the Act. The Registration Statement will be filed with the Commission and will be
declared effective by the Commission under the Act prior to the issuance of any Sales Notices by the Company. The Prospectus Supplement
will name the Manager as the agent in the section entitled “Plan of Distribution.” The Company has not received, and has no
notice of, any order of the Commission preventing or suspending the use of the Registration Statement, or threatening or instituting proceedings
for that purpose. The Registration Statement and the offer and sale of Shares as contemplated hereby meet the requirements of Rule 415
under the Act and comply in all material respects with said Rule. Any statutes, regulations, contracts or other documents that are required
to be described in the Registration Statement or the Prospectus or to be filed as exhibits to the Registration Statement have been so
described or filed or incorporated by reference therein. Copies of the Registration Statement, the Prospectus, and any such amendments
or supplements and all documents incorporated by reference therein that were filed with the Commission on or prior to the date of this
Agreement have been delivered, or are available through the Commissions Electronic Data Gathering Analysis and Retrieval system, to Manager
and its counsel. The Company has not distributed and, prior to the later to occur of each Settlement Date and completion of the distribution
of the Shares, will not distribute any offering material in connection with the offering or sale of the Shares other than the Registration
Statement and the Prospectus and any Issuer Free Writing Prospectus to which the Manager has consented any such consent not to be unreasonable
withheld, conditioned, or delayed. The Common Stock is registered pursuant to Section 12(b) of the Exchange Act and are currently listed
on the Trading Market under the trading symbol “NEUP.” The Company has taken no action designed to, or likely to have the effect
of, terminating the registration of the Common Stock under the Exchange Act, delisting the Common Stock from the Trading Market, nor has
the Company received any notification that the Commission or the Trading Market is contemplating terminating such registration or listing.
Except as disclosed in the Company’s SEC Reports, to the Company’s knowledge, it is in compliance with all applicable listing requirements
of the Trading Market. As used herein, “SEC Reports” means all reports, schedules, forms, statements and other documents
required to be filed by the Company under the Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the
two years preceding the date hereof (or such shorter period as the Company was required by law or regulation to file such material), including
the exhibits thereto and documents incorporated by reference therein, together with the Prospectus and the Prospectus Supplement.
(b) No
Misstatement or Omission. The Registration Statement, when such registration statement became or becomes effective, and the Prospectus,
and any amendment or supplement thereto, on the date of such Prospectus or amendment or supplement, conformed and will conform in all
material respects with the requirements of the Act and Exchange Act, as applicable. At each Settlement Date, the Registration Statement
and the Prospectus, as of such date, will conform in all material respects with the requirements of the Act and Exchange Act, as applicable.
Each of the Registration Statement, when such registration statement became or becomes effective, did not, and will not, contain an untrue
statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein
not misleading. The Prospectus and any amendment and supplement thereto, on the date thereof and at each Applicable Time, did not or will
not include an untrue statement of a material fact or omit to state a material fact necessary to make the statements therein, in light
of the circumstances under which they were made, not misleading. The documents incorporated by reference in the Prospectus or any Prospectus
Supplement did not, and any further documents filed and incorporated by reference therein will not, when filed with the Commission, contain
an untrue statement of a material fact or omit to state a material fact required to be stated in such document or necessary to make the
statements in such document, in light of the circumstances under which they were made, not misleading. The foregoing shall not apply to
statements in, or omissions from, any such document made in reliance upon, and in conformity with, information furnished to the Company
by Manager specifically for use in the preparation thereof.
(c) Company
Not Ineligible Issuer. At the time of filing the Registration Statement and any post-effective amendment thereto, at the earliest
time thereafter that the Company or another offering participant made a bona fide offer (within the meaning of Rule 164(h)(2) of
the Act) of the Shares and at the date hereof, the Company was not and is not an “ineligible issuer,” as defined in Rule 405,
without taking account of any determination by the Commission pursuant to Rule 405 that it is not necessary that the Company be considered
an ineligible issuer.
(d) Emerging
Growth Company Status. From the time of the filing of the Registration Statement with the Commission through the date hereof, the
Company has been and is an “emerging growth company,” as defined in Section 2(a) of the Act (an “Emerging Growth Company”).
(e) Independent
Accountants. The accountants who certified the financial statements and supporting schedules included in the Registration Statement
and the Prospectus are independent public accountants as required by the Act and the Public Company Accounting Oversight Board.
(f) Financial
Statements. The financial statements included in the Registration Statement and the Prospectus, together with the related
schedules and notes, present fairly, in all material respects, the financial position of the Company and its consolidated
subsidiaries at the dates indicated and the statement of operations, shareholders’ equity and cash flows of the Company and its
consolidated subsidiaries for the periods specified; said financial statements have been prepared in conformity with United States
generally accepted accounting principles (“GAAP”) applied on a consistent basis throughout the periods involved.
The supporting schedules, if any, present fairly, in all material respects, in accordance with GAAP the information required to be
stated therein. The selected financial data and the summary financial information included in the Registration Statement and the
Prospectus present fairly, in all material respects, the information shown therein and have been compiled on a basis consistent with
that of the audited financial statements included therein. Except as included therein, no historical or pro forma financial
statements or supporting schedules are required to be included or incorporated by reference in the Registration Statement or the
Prospectus under the Act.
(g) No
Material Adverse Change in Business. Except as otherwise stated therein, since the respective dates as of which information is given
in the Registration Statement or the Prospectus, (i) there has been no material adverse change in the condition, financial or otherwise,
or in the earnings, business affairs or business prospects of the Company and its subsidiaries considered as one enterprise, whether or
not arising in the ordinary course of business (a “Material Adverse Effect”), (ii) there have been no transactions entered
into by the Company or any of its subsidiaries, other than those in the ordinary course of business, which are material with respect to
the Company and its subsidiaries considered as one enterprise, and (iii) except as disclosed in the Registration Statement and the Prospectus,
there has been no dividend or distribution of any kind declared, paid or made by the Company on any class of its shares.
(h) Organization
and Existence of the Company. The Company has been duly organized, registered and is validly existing as a corporation under the laws
of Delaware and has corporate power and authority to own, lease and operate its properties and to conduct its business as described in
the Registration Statement and the Prospectus and to enter into and perform its obligations under this Agreement; and the Company is duly
qualified as a foreign corporation to transact business and is in good standing in each other jurisdiction in which such qualification
is required (or such equivalent concept to the extent it exists under the laws of such jurisdiction), whether by reason of the ownership
or leasing of property or the conduct of business, except where the failure to qualify or to be in good standing would not result in a
Material Adverse Effect.
(i) Good
Standing of Subsidiaries. Each “significant subsidiary” of the Company (as such term is defined in Rule 1-02 of
Regulation S-X) (each, a “Subsidiary” and, collectively, the “Subsidiaries”) has been duly
organized and is validly existing in good standing (if applicable) under the laws of the jurisdiction of its incorporation or
organization (or such equivalent concept to the extent it exists under the laws of such jurisdiction), has corporate or similar
power and authority to own, lease and operate its properties and to conduct its business as described in the Registration Statement
and the Prospectus and is duly qualified to transact business and is in good standing in each jurisdiction in which such
qualification is required (or such equivalent concept to the extent it exists under the laws of such jurisdiction), whether by
reason of the ownership or leasing of property or the conduct of business, except where the failure to so qualify or to be in good
standing would not result in a Material Adverse Effect. Except as otherwise disclosed in the Registration Statement and the
Prospectus, all of the issued and outstanding capital stock of each Subsidiary has been duly authorized and validly issued, is fully
paid and non-assessable and is owned by the Company, directly or through subsidiaries, free and clear of any security interest,
mortgage, pledge, lien, encumbrance, claim or equity. None of the outstanding shares of capital stock of any Subsidiary were issued
in violation of the preemptive or similar rights of any securityholder of such Subsidiary. The only subsidiaries of the Company are
(A) the subsidiaries listed on Exhibit 21.1 to the Company’s Form 10-K and (B) certain other subsidiaries which, considered in the
aggregate as a single subsidiary, do not constitute a “significant subsidiary” as defined in Rule 1-02 of Regulation
S-X.
(j) Capitalization.
The authorized, issued and outstanding shares of capital stock of the Company are as set forth in the Registration Statement and the Prospectus
(except for subsequent issuances, if any, pursuant to this Agreement, pursuant to reservations, agreements or employee benefit plans referred
to in the Registration Statement and the Prospectus or pursuant to the exercise of convertible securities or options referred to in the
Registration Statement and the Prospectus). The outstanding shares of capital stock of the Company have been duly authorized and validly
issued and are fully paid and non-assessable. None of the outstanding shares of capital stock of the Company were issued in violation
of the preemptive or other similar rights of any securityholder of the Company.
(k) Authorization
of Agreement. The Company has full legal right, power and authority to enter into this Agreement and perform the transactions contemplated
hereby. This Agreement has been duly authorized, executed and delivered by the Company and is a legal, valid and binding agreement of
the Company enforceable in accordance with its terms, except to the extent that enforceability may be limited by bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting creditors’ rights generally and by general equitable principles.
(l) Authorization
and Description of Shares. The Shares, when issued and delivered pursuant to the terms approved by the board of directors of the
Company or a duly authorized committee thereof, or a duly authorized executive committee, against payment therefor as provided
herein, will be duly and validly authorized and issued and fully paid and nonassessable, free and clear of any pledge, lien,
encumbrance, security interest or other claim, including any statutory or contractual preemptive rights, resale rights, rights of
first refusal or other similar rights, and will be registered pursuant to Section 12 of the Exchange Act. The Shares and Common
Stock conform in all material respects to all statements relating thereto contained in the Registration Statement and the Prospectus
and such description conforms in all material respects to the rights set forth in the instruments defining the same. No holder of
Common Stock will be subject to personal liability solely by reason of being such a holder.
(m) Registration
Rights. There are no persons with registration rights or other similar rights to have any securities registered for sale pursuant
to the Registration Statement or otherwise registered for sale or sold by the Company under the Act pursuant to this Agreement, other
than those rights that have been disclosed in the Registration Statement and the Prospectus and have been waived as of the date of this
Agreement.
(n) Absence
of Violations, Defaults and Conflicts. Neither the Company nor any of its subsidiaries is (i) in violation of its certificate of
incorporation (or similar charter documents) (ii) in default in the performance or observance of any obligation, agreement, covenant
or condition contained in any contract, indenture, mortgage, deed of trust, loan or credit agreement, note, lease or other agreement
or instrument to which the Company or any of its subsidiaries is a party or by which it or any of them may be bound or to which any
of the properties or assets of the Company or any subsidiary is subject (collectively, “Agreements and
Instruments”), except for such defaults that would not, singly or in the aggregate, reasonably be expected to result in a
Material Adverse Effect, or (iii) in violation of any law, statute, rule, regulation, judgment, order, writ or decree of any
arbitrator, court, governmental body, regulatory body, administrative agency or other authority, body or agency having jurisdiction
over the Company or any of its subsidiaries or any of their respective properties, assets or operations (each, a
“Governmental Entity”), except for such violations that would not, singly or in the aggregate, reasonably be
expected to result in a Material Adverse Effect. The execution, delivery and performance of this Agreement and the consummation of
the transactions contemplated herein and in the Registration Statement and the Prospectus (including the issuance and sale of the
Shares and the use of the proceeds from the sale of the Shares as described therein under the caption “Use of Proceeds”)
and compliance by the Company with its obligations hereunder have been duly authorized by all necessary corporate action and do not
and will not, whether with or without the giving of notice or passage of time or both, conflict with or constitute a breach of, or
default or Repayment Event (as defined below) under, or result in the creation or imposition of any lien, charge or encumbrance upon
any properties or assets of the Company or any subsidiary pursuant to, the Agreements and Instruments (except for such conflicts,
breaches, defaults or Repayment Events or liens, charges or encumbrances that would not, singly or in the aggregate, result in a
Material Adverse Effect), nor will such action result in any violation of the provisions of the constitution of the Company or any
of its subsidiaries or any law, statute, rule, regulation, judgment, order, writ or decree of any Governmental Entity, except for
such violation that would not, singly or in the aggregate, result in a Material Adverse Effect. As used herein, a “Repayment
Event” means any event or condition which gives the holder of any note, debenture or other evidence of indebtedness (or any
person acting on such holder’s behalf) the right to require the repurchase, redemption or repayment of all or a portion of such
indebtedness by the Company or any of its subsidiaries.
(o) Absence
of Labor Dispute. No labor dispute with the employees of the Company or any of its subsidiaries exists or, to the knowledge of the
Company, is imminent, and the Company is not aware of any existing or imminent labor disturbance by the employees of any of its or any
subsidiary’s principal suppliers, manufacturers, customers or contractors, which, in either case, would result in a Material Adverse Effect.
(p) Absence
of Proceedings. Except as disclosed in the Registration Statement and the Prospectus, there is no action, suit, proceeding, inquiry
or investigation before or brought by any Governmental Entity now pending or, to the knowledge of the Company, threatened, against or
affecting the Company or any of its subsidiaries, which would reasonably be expected to result in a Material Adverse Effect, or which
would reasonably be expected to materially and adversely affect their respective properties or assets or the consummation of the transactions
contemplated in this Agreement or the performance by the Company of its obligations hereunder; and the aggregate of all pending legal
or governmental proceedings to which the Company or any such subsidiary is a party or of which any of their respective properties or assets
is the subject which are not described in the Registration Statement and the Prospectus, including ordinary routine litigation incidental
to the business, would not reasonably be expected to result in a Material Adverse Effect.
(q) Accuracy
of Exhibits. There are no contracts or documents which are required to be described in the Registration Statement or the Prospectus
or to be filed as exhibits to the Registration Statement which have not been so described and filed as required.
(r) Absence
of Further Requirements. No filing with, or authorization, approval, consent, license, order, registration, qualification or decree
of, any Governmental Entity is necessary or required for the performance by the Company of its obligations hereunder, in connection with
the offering, issuance or sale of the Shares hereunder or the consummation of the transactions contemplated by this Agreement, except
such as have been already obtained or as may be required under the Act, the rules of the Trading Market, or state securities laws.
(s) Possession
of Licenses and Permits. The Company and its subsidiaries possess such permits, licenses, approvals, consents and other
authorizations (collectively, “Governmental Licenses”) issued by the appropriate Governmental Entities necessary to
conduct the business now operated by them, except where the failure so to possess would not, singly or in the aggregate, result in a
Material Adverse Effect. The Company and its subsidiaries are in compliance with the terms and conditions of all Governmental
Licenses, except where the failure so to comply would not, singly or in the aggregate, result in a Material Adverse Effect. All of
the Governmental Licenses are valid and in full force and effect, except when the invalidity of such Governmental Licenses or the
failure of such Governmental Licenses to be in full force and effect would not, singly or in the aggregate, result in a Material
Adverse Effect. Neither the Company nor any of its subsidiaries has received any notice of proceedings relating to the revocation or
modification of any Governmental Licenses which, singly or in the aggregate, if the subject of an unfavorable decision, ruling or
finding, would result in a Material Adverse Effect.
(t) Title
to Property. The Company and its subsidiaries have good and marketable title to all real property owned by them and good title to
all other properties owned by them (excluding, for the purposes of this Section 3(t), Intellectual Property Rights as defined below),
in each case, free and clear of all mortgages, pledges, liens, security interests, claims, restrictions or encumbrances of any kind except
such as (i) are described in the Registration Statement and the Prospectus or (ii) do not, singly or in the aggregate, materially affect
the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company or
any of its subsidiaries; and all of the leases and subleases material to the business of the Company and its subsidiaries, considered
as one enterprise, and under which the Company or any of its subsidiaries holds properties described in the Registration Statement or
the Prospectus, are in full force and effect, and neither the Company nor any such subsidiary has any notice of any material claim of
any sort that has been asserted by anyone adverse to the rights of the Company or any subsidiary under any of the leases or subleases
mentioned above, or affecting or questioning the rights of the Company or such subsidiary to the continued possession of the leased or
subleased premises under any such lease or sublease, except to the extent that any claim or adverse effect on the Company’s rights thereto
would not reasonably be expected to result in a Material Adverse Effect.
(u) Possession
of Intellectual Property. The Company and its subsidiaries own or possess, have license to, or can acquire rights to (whether by
ownership or license) on reasonable terms, adequate patents, patent applications, inventions, copyrights, know-how (including trade
secrets and other unpatented and/or unpatentable proprietary or confidential information, systems or procedures), trademarks,
service marks, trade names or other intellectual property (collectively, “Intellectual Property Rights”) necessary
or material to carry on the business now operated by them, or, to the knowledge of the Company, as proposed to be conducted as
disclosed in the Registration Statement and the Prospectus. To the knowledge of the Company, the conduct of its and its
subsidiaries’ respective businesses as currently conducted and as proposed to be conducted does not and will not infringe,
misappropriate or otherwise violate any valid Intellectual Property Rights of others in any material respect. Except as would not
reasonably be expected, singly or in the aggregate, to have a Material Adverse Effect on the Company and its subsidiaries, taken as
a whole, neither the Company nor any of its subsidiaries has received any written notice of any claim of infringement,
misappropriation or other violation of any Intellectual Property Rights of any third party by the Company or any of its
Subsidiaries, or any claim challenging the validity, scope, or enforceability of any Intellectual Property Rights owned by the
Company or any of its subsidiaries or the Company’s or any of its subsidiaries’ rights therein. To the knowledge of the Company,
there is no material infringement, misappropriation, breach, default or other violation, or the occurrence of any event that with
notice or the passage of time would constitute any of the foregoing, by any third party of any of the Intellectual Property Rights
of the Company or any of its subsidiaries. To the knowledge of the Company, and except as would not reasonably be expected, singly
or in the aggregate, to have a Material Adverse Effect on the Company and its subsidiaries, taken as a whole, (i) each patent
application owned by the Company or its subsidiaries is being diligently prosecuted, (ii) each issued patent owned by the Company or
its subsidiaries is being diligently maintained, (iii) all Intellectual Property Rights owned or purported to be owned by the
Company are owned free and clear of all material liens, encumbrances, or defects, and (iv) all such issued or granted patents are
valid and enforceable. All Intellectual Property Rights described in the Registration Statement as owned solely by the Company or
its subsidiaries are owned solely by the Company or its subsidiaries. The Company and its subsidiaries are not subject to any
judgment, order, writ, injunction or decree of any court or any federal, state, local, foreign or other governmental department,
commission, board, bureau, agency or instrumentality, domestic or foreign, or any arbitrator, nor has it entered into or is it a
party to any agreement made in settlement of any pending or threatened litigation, which restricts or impairs their respective use
of any Intellectual Property Rights, except as would not reasonably be expected, singly or in the aggregate, to have a material
adverse effect on the Company and its subsidiaries, taken as a whole. The Company and its subsidiaries have taken reasonable actions
to protect their rights in confidential information and trade secrets. The product candidates described in the Registration
Statement and the Prospectus as under development by the Company or any subsidiary fall within the scope of the claims of one or
more patents or patent applications owned by, or licensed to, the Company or any subsidiary.
(v) Regulatory
Compliance. Except as would not, singly or in the aggregate, result in a Material Adverse Effect, the Company and its
subsidiaries (i) are, and have been, in compliance with all applicable Health Care Laws (defined herein), including, but not limited
to, the rules and regulations of the Food and Drug Administration (“FDA”), the U.S. Department of Health and Human
Services Office of Inspector General, the Centers for Medicare & Medicaid Services, the Office for Civil Rights, the Department
of Justice and any other governmental agency or body having jurisdiction over the Company or any of its properties, and (ii) have
not engaged in any activities which are, as applicable, cause for false claims liability, civil penalties, or mandatory or
permissive exclusion from Medicare, Medicaid, or any other local, state or federal healthcare program. For purposes of this
Agreement, “Health Care Laws” shall mean the federal Anti-kickback Statute (42 U.S.C. § 1320a-7b(b)), the
Physician Payments Sunshine Act (42 U.S.C. § 1320a-7h), the civil False Claims Act (31 U.S.C. §§ 3729 et seq.), the
criminal False Claims Act (42 U.S.C. § 1320a-7b(a)), all criminal laws relating to health care fraud and abuse, including but
not limited to 18 U.S.C. Sections 286, 287, 1347 and 1349, and the health care fraud criminal provisions under the Health Insurance
Portability and Accountability Act of 1996 (42 U.S.C. §§ 1320d et seq.) (“HIPAA”), the exclusion laws (42 U.S.C.
§ 1320a-7), the civil monetary penalties law (42 U.S.C. § 1320a-7a), the Stark Law (42 U.S.C. § 1395nn), HIPAA, as
amended by the Health Information Technology for Economic and Clinical Health Act (42 U.S.C. §§ 17921 et seq.), the
Federal Food, Drug, and Cosmetic Act, as amended (21 U.S.C. §§ 301 et seq.), Medicare (Title XVIII of the Social Security
Act), Medicaid (Title XIX of the Social Security Act), the regulations promulgated pursuant to such laws and all other laws, rules
and regulations of any other national, federal, state or local governmental or regulatory body or authority related to the
regulation of the ownership, testing, development, manufacture, packaging, processing, use, distribution, marketing, advertising,
labeling, promotion, sale, offer for sale, storage, import, export or disposal of any product manufactured or distributed by or for
the Company. Except as would not, singly or in the aggregate, result in a Material Adverse Effect, the Company and its subsidiaries
have filed, maintained or submitted all reports, documents, forms, notices, applications, records, claims, submissions and
supplements or amendments as required by any Health Care Laws, and all such reports, documents, forms, notices, applications,
records, claims, submissions and supplements or amendments were complete and accurate on the date filed in all material respects (or
were corrected or supplemented by a subsequent submission). Neither the Company nor any of its subsidiaries is a party to or has any
ongoing reporting obligations pursuant to any corporate integrity agreement, deferred prosecution agreement, monitoring agreement,
consent decree, settlement order, plan of correction or similar agreement imposed by any governmental authority.
(w) Certain
Communications and Authorizations. Except as would not, singly or in the aggregate, result in a Material Adverse Effect, the
Company and its subsidiaries (i) have not received any Form FDA 483, notice of adverse finding, warning letter, untitled letter or
other correspondence or notice from the FDA or any other similar federal, state, local or foreign governmental or regulatory
authority alleging or asserting material noncompliance with any Health Care Laws or any licenses, certificates, approvals,
clearances, authorizations, registrations, certifications, exemptions, permits and supplements or amendments thereto required by any
Health Care Laws to conduct the Company’s business as described in the Prospectus (“Authorizations”); (ii) possess
all applicable Authorizations and such Authorizations are valid and in full force and effect and neither the Company nor its
subsidiaries is in violation of any such Authorizations except where such violation would not, singly or in the aggregate, have a
Material Adverse Effect; (iii) have not received written notice of any pending or threatened claim, action, suit, proceeding,
hearing, enforcement, investigation, arbitration or other action from the FDA or any other federal, state, local or foreign
governmental or regulatory authority or third party alleging that any product candidate, operation, or activity is in material
violation of any Health Care Laws or Authorizations and the Company has no knowledge that the FDA or any other federal, state, local
or foreign governmental or regulatory authority or third party is considering any such claim, action, suit, proceeding, hearing,
enforcement, investigation, arbitration or other action; (iv) have not received written notice that the FDA or any other federal,
state, local or foreign governmental or regulatory authority has taken, is taking or intends to take action to limit, suspend,
materially modify or revoke any Authorizations and has no knowledge that the FDA or any other federal, state, local or foreign
governmental or regulatory authority is considering such action; and (v) have filed, obtained, maintained or submitted all material
reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments as required by any
Health Care Laws or Authorizations and all such reports, documents, forms, notices, applications, records, claims, submissions and
supplements or amendments were materially true, complete and correct on the date filed (or were corrected or supplemented by a
subsequent submission).
(x) Pre-Clinical
Studies and Clinical Trials. The preclinical studies and clinical trials conducted by or on behalf of the Company or its subsidiaries
that are described in the Registration Statement and the Prospectus were and, if still pending, are being, conducted in all material respects
in accordance with the protocols submitted to the FDA or any foreign governmental body exercising comparable authority, procedures and
controls pursuant to, where applicable, accepted professional and scientific standards, and all applicable laws and regulations, including
the Federal Food, Drug, and Cosmetic Act and its applicable implementing regulations and comparable drug regulatory agencies outside of
the United States to which such preclinical studies and clinical trials are subject, and current Good Clinical Practices and Good Laboratory
Practices; the descriptions of the preclinical studies and clinical trials, if any, conducted by or, to the Company’s knowledge, on behalf
of the Company or its subsidiaries, and the results thereof, contained in the Registration Statement and the Prospectus are accurate and
complete in all material respects and fairly present the data derived from such preclinical studies and clinical trials, if any; the Company
is not aware of any other preclinical studies or clinical trials, the results of which reasonably call into question the results described
in the Registration Statement and the Prospectus; and neither the Company nor any of its subsidiaries have received any notices or correspondence
from the FDA, any foreign, state or local governmental body exercising comparable authority or any Institutional Review Board requiring
the termination, suspension, material modification or clinical hold of any pre-clinical studies or clinical trials conducted by or on
behalf of the Company or its subsidiaries.
(y) Governmental
Inquiries. Neither the Company nor its subsidiaries, nor any of its or their respective officers, employees or directors, nor to
the knowledge of the Company any of its or their respective agents or clinical investigators, has been excluded, suspended,
disqualified or debarred from participation in any U.S. federal health care program or human clinical research or, to the knowledge
of the Company, is subject to a governmental inquiry, investigation, proceeding, or other similar action that would reasonably be
expected to result in debarment, disqualification, suspension, or exclusion, or convicted of any crime or engaged in any conduct
that would reasonably be expected to result in debarment under 21 U.S.C. § 335a or comparable foreign law. The Company and its
subsidiaries are not nor have they ever been subject to FDA’s policy respecting “Fraud, Untrue Statements of Material Facts,
Bribery, and Illegal Gratuities,” set forth in 56 Fed. Reg. 46191 (September 10, 1991) and any amendments thereto, or any
comparable policy of another governmental body.
(z) Environmental
Laws. Except as described in the Registration Statement and the Prospectus, or incorporated by reference therein, or would not, singly
or in the aggregate, reasonably be expected to result in a Material Adverse Effect, (i) neither the Company nor any of its subsidiaries
is in violation of any applicable federal, state, local or foreign statute, law, rule, regulation, ordinance, code, policy or rule of
common law or any judicial or administrative interpretation thereof, including any judicial or administrative order, consent, decree or
judgment, relating to pollution or protection of human health, the environment (including, without limitation, ambient air, surface water,
groundwater, land surface or subsurface strata) or wildlife, including, without limitation, laws and regulations relating to the release
or threatened release of chemicals, pollutants, contaminants, wastes, toxic substances, hazardous substances, petroleum or petroleum products,
asbestos-containing materials or mold (collectively, “Hazardous Materials”) or to the manufacture, processing, distribution,
use, treatment, storage, disposal, transport or handling of Hazardous Materials (collectively, “Environmental Laws”),
(ii) the Company and its subsidiaries have all permits, authorizations and approvals required under any applicable Environmental Laws
and are each in compliance with their requirements, (iii) there are no pending or, to the knowledge of the Company, threatened administrative,
regulatory or judicial actions, suits, demands, demand letters, claims, liens, notices of noncompliance or violation, investigations or
proceedings relating to any Environmental Law against the Company or any of its subsidiaries and (iv) to the knowledge of the Company,
there are no events or circumstances that would reasonably be expected to form the basis of an order for clean-up or remediation, or an
action, suit or proceeding by any private party or Governmental Entity, against or affecting the Company or any of its subsidiaries relating
to Hazardous Materials or any Environmental Laws.
(aa) Accounting
Controls and Disclosure Controls. The Company and each of its subsidiaries maintain effective internal control over financial
reporting (as defined under Rule 13a-15 and 15d-15 under the Exchange Act) and a system of internal accounting controls sufficient
to provide reasonable assurances that (i) transactions are executed in accordance with management’s general or specific
authorization; (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with GAAP and
to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management’s general or specific
authorization; (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and
appropriate action is taken with respect to any differences and (v) interactive data in eXtensible Business Reporting Language
included or incorporated by reference in the Registration Statement and the Prospectus fairly presents the information called for in
all material respects and is prepared in accordance with the Commission’s rules and guidelines applicable thereto. Except as
described in the Registration Statement and the Prospectus, since the end of the Company’s most recent audited fiscal year, there
has been (1) no material weakness in the Company’s internal control over financial reporting (whether or not remediated) and (2) no
change in the Company’s internal control over financial reporting that has materially affected, or is reasonably likely to
materially affect, the Company’s internal control over financial reporting.
(bb) Compliance
with the Sarbanes-Oxley Act. The Company has taken all necessary actions to ensure that, upon the effectiveness of the Registration
Statement, it will be in compliance with all provisions of the Sarbanes-Oxley Act of 2002 and all rules and regulations promulgated thereunder
or implementing the provisions thereof (the “Sarbanes-Oxley Act”) that are then in effect and with which the Company
is required to comply, and is actively taking all reasonable steps to ensure that it will be in compliance with other provisions of the
Sarbanes-Oxley Act not currently in effect, upon the effectiveness of such provisions, or which will become applicable to the Company.
(cc) Payment
of Taxes. All United States federal income tax returns of the Company and its subsidiaries required by law to be filed have been filed
and all taxes shown by such returns or otherwise assessed, which are due and payable, have been paid, except assessments against which
appeals have been or will be promptly taken and as to which adequate reserves have been provided. The United States federal income tax
returns of the Company through the fiscal year ended June 30, 2024 have been settled and no assessment in connection therewith has been
made against the Company. The Company and its subsidiaries have filed all other tax returns that are required to have been filed by them
pursuant to applicable foreign, state, local or other law except insofar as the failure to file such returns would not result in a Material
Adverse Effect, and has paid all taxes due pursuant to such returns or pursuant to any assessment received by the Company and its subsidiaries,
except for such taxes, if any, as are being contested in good faith and as to which adequate reserves have been established by the Company.
The charges, accruals and reserves on the books of the Company in respect of any income and corporation tax liability for any years not
finally determined are adequate to meet any assessments or re-assessments for additional income tax for any years not finally determined,
except to the extent of any inadequacy that would not result in a Material Adverse Effect.
(dd) Insurance.
The Company and its subsidiaries carry or are entitled to the benefits of insurance, with financially sound and reputable insurers,
in such amounts and covering such risks as is generally maintained by companies of established repute engaged in the same or similar
business, and all such insurance is in full force and effect. The Company has no reason to believe that it or any of its
subsidiaries will not be able (i) to renew its existing insurance coverage as and when such policies expire or (ii) to obtain
comparable coverage from similar institutions as may be necessary or appropriate to conduct its business as now conducted and at a
cost that would not result in a Material Adverse Effect. Neither of the Company nor any of its subsidiaries has been denied any
insurance coverage which it has sought or for which it has applied.
(ee) Investment
Company Act. The Company is not required, and upon the issuance and sale of the Securities as herein contemplated and the application
of the net proceeds therefrom as described in the Registration Statement and the Prospectus will not be required, to register as an “investment
company” under the Investment Company Act of 1940, as amended (the “1940 Act”).
(ff) Absence
of Manipulation. Neither the Company nor, to the knowledge of the Company, any Affiliate of the Company has taken, nor will the Company
take or cause or instruct any Affiliate to take, directly or indirectly, any action which is designed, or would be reasonably expected,
to cause or result in, or which constitutes, the stabilization or manipulation of the price of any security of the Company to facilitate
the sale or resale of the Shares or to result in a violation of Regulation M under the Act.
(gg) Foreign
Corrupt Practices Act. None of the Company, any of its subsidiaries or, to the knowledge of the Company, any director, officer, agent,
employee, Affiliate or other person acting on behalf of the Company or any of its subsidiaries is aware of or has taken any action, directly
or indirectly, that would result in a violation by such persons of the Foreign Corrupt Practices Act of 1977, as amended, and the rules
and regulations thereunder (the “FCPA”), including, without limitation, making use of the mails or any means or instrumentality
of interstate commerce corruptly in furtherance of an offer, payment, promise to pay or authorization of the payment of any money, or
other property, gift, promise to give, or authorization of the giving of anything of value to any “foreign official” (as such
term is defined in the FCPA) or any foreign political party or official thereof or any candidate for foreign political office, in contravention
of the FCPA and the Company and, to the knowledge of the Company, its Affiliates have conducted their businesses in compliance with the
FCPA and have instituted and maintain policies and procedures designed to ensure, and which are reasonably expected to continue to ensure,
continued compliance therewith.
(hh) Money
Laundering Laws. The operations of the Company and its subsidiaries are and have been conducted at all times in compliance with
applicable financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as
amended, the money laundering statutes of all applicable jurisdictions, the rules and regulations thereunder and any related or
similar applicable rules, regulations or guidelines, issued, administered or enforced by any Governmental Entity (collectively, the
“Money Laundering Laws”); and no action, suit or proceeding by or before any Governmental Entity involving the
Company or any of its subsidiaries with respect to the Money Laundering Laws is pending or, to the best knowledge of the Company,
threatened.
(ii) OFAC.
None of the Company, any of its subsidiaries or, to the knowledge of the Company, any director, officer, agent, employee, Affiliate or
representative of the Company or any of its subsidiaries is an individual or entity (“Person”) currently the subject
or target of any sanctions administered or enforced by the United States Government, including, without limitation, the U.S. Department
of the Treasury’s Office of Foreign Assets Control (“OFAC”), the United Nations Security Council (“UNSC”),
the European Union, His Majesty’s Treasury (“HMT”), or other relevant sanctions authority (collectively, “Sanctions”),
nor is the Company located, organized or resident in a country or territory that is the subject of Sanctions, including, without limitation,
the Crimea Region and the non-government controlled areas of the Zaporizhzhia and Kherson Regions of Ukraine, the so-called Donetsk People’s
Republic, the so-called Luhansk People’s Republic, Cuba, Iran, North Korea and Syria; and the Company will not directly or indirectly
use the proceeds of the sale of the Shares, or lend, contribute or otherwise make available such proceeds to any subsidiaries, joint venture
partners or other Person, to fund any activities of or business with any Person, or in any country or territory, that, at the time of
such funding, is the subject of Sanctions or in any other manner that will result in a violation by any Person (including any Person participating
in the transaction, whether as underwriter, advisor, investor or otherwise) of Sanctions.
(jj) Lending
Relationship. Except as disclosed in the Registration Statement and the Prospectus, the Company (i) does not have any material lending
or other relationship with any bank or lending Affiliate of the Manager and (ii) does not intend to use any of the proceeds from the sale
of the Shares to repay any outstanding debt owed to any Affiliate of the Manager.
(kk) Statistical
and Market-Related Data. Any statistical and market-related data included in the Registration Statement or the Prospectus are based
on or derived from sources that the Company believes, after reasonable inquiry, to be reliable and accurate and, to the extent required,
the Company has obtained the written consent to the use of such data from such sources.
(ll) Cybersecurity.
Except as would not be expected to result in a Material Adverse Effect, (i) there has been no security breach or incident, unauthorized
access or disclosure, or other compromise of or relating to the Company or its subsidiaries information technology and computer systems,
networks, hardware, software, data and databases (including the data and information of their respective customers, employees, suppliers,
vendors and any third party data maintained, processed or stored by the Company and its subsidiaries, and any such data processed or
stored by third parties on behalf of the Company and its subsidiaries), equipment or technology (collectively, “IT Systems and
Data”); (ii) neither the Company nor its subsidiaries have been notified, and each of them have no knowledge of any event or
condition that could result in, any security breach or incident, unauthorized access or disclosure or other compromise to their IT Systems
and Data; (iii) the Company and its subsidiaries have implemented commercially reasonable controls, policies, procedures, and technological
safeguards designed, consistent with industry standards and practices, to maintain and protect the integrity, continuous operation, redundancy
and security of their IT Systems and Data as required by applicable regulatory standards; and (iv) the Company and its subsidiaries are
presently in compliance with all applicable laws or statutes and all judgments, orders, rules and regulations of any court or arbitrator
or governmental or regulatory authority, internal policies and contractual obligations relating to the privacy and security of IT Systems
and Data and to the protection of such IT Systems and Data from unauthorized use, access, misappropriation or modification.
(mm) ERISA.
Except as would not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect, with respect to
each “employee benefit plan” (within the meaning of Section 3(3) of the Employee Retirement Income Security Act of 1974,
as amended (“ERISA”)) that is sponsored, maintained or contributed to by the Company or any of its subsidiaries (each, a
“Plan”), (i) no failure to satisfy the minimum funding standards of Sections 302 and 303 of ERISA or Section 412 of
the Internal Revenue Code of 1986, as amended from time to time (“Code”), or other event of the kind described in
Section 4043(c) of ERISA (other than events with respect to which the 30-day notice requirement under Section 4043 of ERISA has been
waived) has occurred, (ii) to the extent required by applicable law to be funded, the fair market value of the assets under each
Plan exceeds the present value of all benefits accrued under such Plan (determined based on those assumptions used to fund such
Plan), (iii) no prohibited transaction, within the meaning of Section 406 of ERISA or Section 4975 of the Code, has occurred,
excluding transactions effected pursuant to a statutory or administrative exemption, and (iv) each Plan is in material compliance
with applicable law, including, without limitation, ERISA and the Code. Except as would not have a Material Adverse Effect, neither
the Company nor, to the knowledge of the Company, any entity, whether or not incorporated, that is under common control with the
Company or treated as a “single employer” within the meaning of Section 4001(b) of ERISA or Section 414(b), (c), (m) or
(o) of the Code (an “ERISA Affiliate”) with the Company has incurred or reasonably expects to incur any liability
with respect to any Plan under Title IV of ERISA (other than contributions to the Plan or premiums to the Pension Benefit Guaranty
Corporation in the ordinary course and without default). Except as would not have a Material Adverse Effect, neither the Company nor
any of its subsidiaries has any material liability in respect of any post-employment health, medical or life insurance benefits for
former, current or future employees of the Company or any subsidiary, except as required to avoid excise tax under Section 4980B of
the Code or any similar law. None of the Company, any of its subsidiaries or, except as would not reasonably be expected to have a
Material Adverse Effect to the Company or any of its subsidiaries, any of its ERISA Affiliates, sponsors, contributes to or has any
obligation to contribute to any “multiemployer plan” (as defined in Section 3(37) of ERISA). Each Plan that is intended to
be qualified under Section 401(a) of the Code has received a favorable determination or opinion letter from the Internal Revenue
Service upon which it can rely and, to the knowledge of the Company, nothing has occurred, whether by action or by failure to act,
which could reasonably be expected to cause the loss of such qualification. To the knowledge of the Company, there is no pending
audit or investigation by the Internal Revenue Service, the U.S. Department of Labor, the Pension Benefit Guaranty Corporation or
any other governmental agency or any foreign regulatory agency with respect to any Plan that, individually or in the aggregate,
could reasonably be expected to have a Material Adverse Effect to the Company or its subsidiaries.
(nn) [Reserved]
(oo) Board
of Directors. The Board of Directors of the Company is comprised of the persons disclosed in the Registration Statement and the Prospectus,
or as otherwise incorporated by reference therein. The qualifications of the persons serving as board members and the overall composition
of the board comply with the Act, the Sarbanes-Oxley Act applicable to the Company and the listing rules of the Trading Market. At least
one member of the Audit Committee of the Board of Directors of the Company qualifies as an “audit committee financial expert,”
as such term is defined under the listing rules of the Trading Market.
(pp) [Reserved]
(qq) [Reserved]
(rr) Margin
Rules. Neither the issuance, sale and delivery of the Shares nor the application of the proceeds thereof by the Company as described
in the Registration Statement and the Prospectus will violate Regulation T, U or X of the Board of Governors of the Federal Reserve System
or any other regulation of such Board of Governors.
(ss) Manager
Purchases. The Company acknowledges and agrees that Manager has informed the Company that the Manager may, to the extent permitted
under the Act and the Exchange Act, purchase and sell Shares for its own account while this Agreement is in effect, provided, that (i)
no such purchase or sales shall take place while a Sales Notice is in effect (except to the extent the Manager may engage in sales of
Shares purchased or deemed purchased from the Company as a “riskless principal” or in a similar capacity) and (ii) the Company
shall not be deemed to have authorized or consented to any such purchases or sales by the Manager.
4. Agreements.
The Company agrees with the Manager that:
(a) Right
to Review Amendments and Supplements to Registration Statement and Prospectus. During any period when the delivery of a prospectus
relating to the Shares is required (including in circumstances where such requirement may be satisfied pursuant to Rule 172, 173
or any similar rule) to be delivered under the Act in connection with the offering or the sale of Shares, the Company will not file any
amendment to the Registration Statement or supplement (including any Prospectus Supplement) to the Base Prospectus unless the Company
has furnished to the Manager a copy for its review prior to filing and will not file any such proposed amendment or supplement to which
the Manager reasonably objects (provided, however, that the Company will have no obligation to provide the Manager any advance copy of
such filing or to provide the Manager an opportunity to object to such filing if the filing does not name the Manager and does not relate
to the transactions under this Agreement). The Company will cause any supplement to the Prospectus filed after the Effective Time to be
properly completed, in a form approved by the Manager, and will file such supplement with the Commission pursuant to the applicable paragraph
of Rule 424(b) within the time period prescribed thereby and will provide evidence reasonably satisfactory to the Manager of such
timely filing. The Company will promptly advise the Manager (i) when the Prospectus, and any supplement thereto, shall have been
filed (if required) with the Commission pursuant to Rule 424(b), (ii) when, during any period when the delivery of a prospectus
(whether physically or through compliance with Rule 172, 173 or any similar rule) is required under the Act in connection with the
offering or sale of the Shares, any amendment to the Registration Statement shall have been filed or become effective (other than any
annual report of the Company filed pursuant to Section 13(a) or 15(d) of the Exchange Act), (iii) of any request by the Commission
or its staff for any amendment of the Registration Statement, or for any supplement to the Prospectus or for any additional information,
(iv) of the issuance by the Commission of any stop order suspending the effectiveness of the Registration Statement or of any notice
objecting to its use or the institution or threatening of any proceeding for that purpose and (v) of the receipt by the Company of
any notification with respect to the suspension of the qualification of the Shares for sale in any jurisdiction or the institution or
threatening of any proceeding for such purpose. The Company will use its best efforts to prevent the issuance of any such stop order or
the occurrence of any such suspension or objection to the use of the Registration Statement and, upon such issuance, occurrence or notice
of objection, to obtain as soon as possible the withdrawal of such stop order or relief from such occurrence or objection, including,
if necessary, by filing an amendment to the Registration Statement or a new registration statement and using its best efforts to have
such amendment or new registration statement declared effective as soon as practicable.
(b) Subsequent
Events. If, at any time on or after an Applicable Time but prior to the related Settlement Date, any event occurs as a result of
which the Registration Statement or Prospectus would include any untrue statement of a material fact or omit to state any material
fact necessary to make the statements therein in the light of the circumstances under which they were made or the circumstances then
prevailing not misleading, the Company will (i) notify promptly the Manager so that any use of the Registration Statement or
Prospectus may cease until such are amended or supplemented; (ii) amend or supplement the Registration Statement or Prospectus
to correct such statement or omission; and (iii) supply any such amendment or supplement to the Manager in such quantities as
the Manager may reasonably request.
(c) Notification
of Subsequent Filings. During any period when the delivery of a prospectus relating to the Shares is required (including in circumstances
where such requirement may be satisfied pursuant to Rule 172, 173 or any similar rule) to be delivered under the Act, any event occurs
as a result of which the Prospectus as then supplemented would include any untrue statement of a material fact or omit to state any material
fact necessary to make the statements therein in the light of the circumstances under which they were made not misleading, or if it shall
be necessary to amend the Registration Statement, file a new registration statement or supplement the Prospectus to comply with the Act
or the Exchange Act or the respective rules thereunder, including in connection with use or delivery of the Prospectus, the Company promptly
will (i) notify the Manager of any such event, (ii) subject to Section 4(a), prepare and file with the Commission an amendment
or supplement or new registration statement which will correct such statement or omission or effect such compliance, (iii) use its
best efforts to have any amendment to the Registration Statement or new registration statement declared effective as soon as practicable
in order to avoid any disruption in use of the Prospectus and (iv) supply any supplemented Prospectus to the Manager in such quantities
as the Manager may reasonably request.
(d) Earnings
Statements. As soon as practicable, the Company will make generally available to its security holders and to the Manager an earnings
statement or statements of the Company and its Subsidiaries which will satisfy the provisions of Section 11(a) of the Act and Rule 158.
For the avoidance of doubt, the Company’s compliance with the reporting requirements of the Exchange Act shall be deemed to satisfy
the requirements of this Section 4(d).
(e) Delivery
of Registration Statement. Upon the request of the Manager, the Company will furnish to the Manager and counsel for the Manager, without
charge, signed copies of the Registration Statement (including exhibits thereto) and, so long as delivery of a prospectus by the Manager
or dealer may be required by the Act (including in circumstances where such requirement may be satisfied pursuant to Rule 172, 173
or any similar rule), as many copies of the Prospectus and each Issuer Free Writing Prospectus and any supplement thereto as the Manager
may reasonably request. The Company will pay the expenses of printing or other production of all documents relating to the offering. Notwithstanding
any provision of this subsection (e), the Company may satisfy the obligations of this section by providing the Manager with electronic
access to the Registration Statement filed with the SEC’s EDGAR website.
(f) Qualification
of Shares. The Company will arrange, if necessary, for the qualification of the Shares for sale under the laws of such jurisdictions
as the Manager may designate and will maintain such qualifications in effect so long as required for the distribution of the Shares; provided
that in no event shall the Company be obligated to qualify to do business in any jurisdiction where it is not now so qualified or to take
any action that would subject it to service of process in suits.
(g) Free
Writing Prospectus. The Company agrees that, unless it has or shall have obtained the prior written consent of the Manager, and the
Manager agrees with the Company that, unless it has or shall have obtained, as the case may be, the prior written consent of the Company,
it has not made and will not make any offer relating to the Shares that would constitute an Issuer Free Writing Prospectus or that would
otherwise constitute a “free writing prospectus” (as defined in Rule 405) required to be filed by the Company with the
Commission or retained by the Company under Rule 433. Any such free writing prospectus consented to by the Manager or the Company
is hereinafter referred to as a “Permitted Free Writing Prospectus.” The Company agrees that (i) it has treated
and will treat, as the case may be, each Permitted Free Writing Prospectus as an Issuer Free Writing Prospectus and (ii) it has complied
and will comply, as the case may be, with the requirements of Rules 164 and 433 applicable to any Permitted Free Writing Prospectus,
including in respect of timely filing with the Commission, legending and record keeping.
(h) Subsequent
Equity Issuances. The Company shall not deliver any Sales Notice hereunder (and any Sales Notice previously delivered shall not apply
during such two (2) Trading Days) for at least two (2) Trading Days prior to any date on which the Company or any Subsidiary offers, sells,
issues, contracts to sell, contracts to issue or otherwise disposes of, directly or indirectly, any other shares of Common Stock or securities
exercisable, exchangeable or convertible into Common Stock (“Common Stock Equivalents”) (other than the Shares pursuant
to this Agreement), subject to Manager’s right to waive this obligation, provided that, without compliance with the foregoing obligation,
the Company may issue and sell Common Stock pursuant to any employee equity plan, stock ownership plan or dividend reinvestment plan of
the Company in effect at the Execution Time and the Company may issue Common Stock issuable upon the conversion or exercise of Common
Stock Equivalents outstanding at the Execution Time.
(i) Market
Manipulation. Until the termination of this Agreement, the Company will not take, directly or indirectly, any action designed to or
that would constitute or that might reasonably be expected to cause or result in, under the Exchange Act or otherwise, stabilization or
manipulation in violation of the Act, Exchange Act or the rules and regulations thereunder of the price of any security of the Company
to facilitate the sale or resale of the Shares or otherwise violate any provision of Regulation M under the Exchange Act.
(j) Notification
of Incorrect Certificate. The Company will, at any time during the term of this Agreement, as supplemented from time to time, advise
the Manager immediately after it shall have received notice or obtained knowledge thereof, of any information or fact that would alter
or affect any opinion, certificate, letter and other document provided to the Manager pursuant to Section 6 herein.
(k) Certification
of Accuracy of Disclosure. Upon commencement of the offering of the Shares under this Agreement (and upon the recommencement of the
offering of the Shares under this Agreement following the termination of a suspension of sales hereunder lasting more than 30 Trading
Days), and each time that (i) a new Registration Statement is filed and declared effective, (ii) the Registration Statement or Prospectus
shall be amended or supplemented, other than by means of Incorporated Documents, (iii) the Company files its Annual Report on Form 10-K
under the Exchange Act, (iv) the Company files its quarterly reports on Form 10-Q under the Exchange Act, (v) the Company files a Current
Report on Form 8-K containing amended financial information (other than information that is furnished and not filed), if the Manager reasonably
determines that the information in such Form 8-K is material, or (vi) the Shares are delivered to the Manager as principal at the Time
of Delivery pursuant to a Terms Agreement (such commencement or recommencement date and each such date referred to in (i), (ii), (iii),
(iv), (v) and (vi) above, a “Representation Date”), unless waived by the Manager, the Company shall furnish or cause
to be furnished to the Manager forthwith a certificate dated and delivered on the Representation Date, in form reasonably satisfactory
to the Manager to the effect that the statements contained in the certificate referred to in Section 6 of this Agreement which were last
furnished to the Manager are true and correct at the Representation Date, as though made at and as of such date (except that such statements
shall be deemed to relate to the Registration Statement and the Prospectus as amended and supplemented to such date) or, in lieu of such
certificate, a certificate of the same tenor as the certificate referred to in said Section 6, modified as necessary to relate to the
Registration Statement and the Prospectus as amended and supplemented to the date of delivery of such certificate.
(l) Bring
Down Opinions; Negative Assurance. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, the
Company shall furnish or cause to be furnished forthwith to the Manager and to counsel to the Manager a written opinion of counsel
to the Company (“Company Counsel”) addressed to the Manager and dated and delivered within five (5) Trading Days
of such Representation Date, in form and substance reasonably satisfactory to the Manager, including a negative assurance
representation from Company Counsel. The requirement to furnish or cause to be furnished an opinion (but not with respect to a
negative assurance representation from Company Counsel) under this Section 4(l) shall be waived for any Representation Date other
than a Representation Date on which a new Registration Statement is filed and declared effective or a material amendment to the
Registration Statement or Prospectus is made or the Company files its Annual Report on Form 10-K or a material amendment thereto
under the Exchange Act, unless the Manager reasonably requests such deliverable required by this Section 4(l) in connection with a
Representation Date, upon which request such deliverable shall be deliverable hereunder.
(m) Auditor
Bring Down “Comfort” Letter. Within five (5) Trading Days of each Representation Date, unless waived by the Manager, the
Company shall cause (1) the Company’s auditors (the “Accountants”), or other independent accountants satisfactory
to the Manager forthwith to furnish the Manager a bring down letter, and (2) the Chief Financial Officer of the Company forthwith
to furnish the Manager a certificate, in each case dated within five (5) Trading Days of such Representation Date, in form satisfactory
to the Manager, of the same tenor as the letters and certificate referred to in Section 6 of this Agreement but modified to relate to
the Registration Statement and the Prospectus, as amended and supplemented to the date of such letters and certificate. The requirement
to furnish or cause to be furnished a “comfort” letter under this Section 4(m) shall be waived for any Representation Date
other than a Representation Date on which a new Registration Statement is filed and declared effective or a material amendment to the
Registration Statement or Prospectus is made or the Company files its Annual Report on Form 10-K or a material amendment thereto under
the Exchange Act, unless the Manager reasonably requests the deliverables required by this Section 4(m) in connection with a Representation
Date, upon which request such deliverable shall be deliverable hereunder.
(n) Due
Diligence Session. Upon commencement of the offering of the Shares under this Agreement (and upon the recommencement of the offering
of the Shares under this Agreement following the termination of a suspension of sales hereunder lasting more than 30 Trading Days), and
at each Representation Date, the Company will conduct a due diligence session, in form and substance, reasonably satisfactory to the Manager,
which shall include representatives of management and Accountants. The Company shall cooperate timely with any reasonable due diligence
request from or review conducted by the Manager or its agents from time to time in connection with the transactions contemplated by this
Agreement, including, without limitation, providing information and available documents and access to appropriate corporate officers and
the Company’s agents during regular business hours, and timely furnishing or causing to be furnished such certificates, letters
and opinions from the Company, its officers and its agents, as the Manager may reasonably request. The Company shall reimburse the Manager
for Manager’s counsel’s fees in each such due diligence update session, up to a maximum of $2,500 per update, plus any incidental
expense incurred by the Manager in connection therewith.
(o) Acknowledgment
of Trading. The Company consents to the Manager trading in the Common Stock for the Manager’s own account and for the account
of its clients at the same time as sales of the Shares occur pursuant to this Agreement or pursuant to a Terms Agreement.
(p) Disclosure
of Shares Sold. The Company will disclose in its Annual Reports on Form 10-K and Quarterly Reports on Form 10-Q, as applicable,
the number of Shares sold through the Manager under this Agreement, the Net Proceeds to the Company and the compensation paid by the Company
with respect to sales of Shares pursuant to this Agreement during the relevant quarter; and, if required by any subsequent change in Commission
policy or request, more frequently by means of a Current Report on Form 8-K or a further Prospectus Supplement.
(q) Rescission
Right. If to the knowledge of the Company, the conditions set forth in Section 6 shall not have been satisfied as of the applicable
Settlement Date, the Company will offer to any person who has agreed to purchase Shares from the Company as the result of an offer to
purchase solicited by the Manager the right to refuse to purchase and pay for such Shares.
(r) Bring
Down of Representations and Warranties. Each acceptance by the Company of an offer to purchase the Shares hereunder, and each execution
and delivery by the Company of a Terms Agreement, shall be deemed to be an affirmation to the Manager that the representations and warranties
of the Company contained in or made pursuant to this Agreement are true and correct as of the date of such acceptance or of such Terms
Agreement as though made at and as of such date, and an undertaking that such representations and warranties will be true and correct
as of the Settlement Date for the Shares relating to such acceptance or as of the Time of Delivery relating to such sale, as the case
may be, as though made at and as of such date (except that such representations and warranties shall be deemed to relate to the Registration
Statement and the Prospectus as amended and supplemented relating to such Shares).
(s) [Reserved].
(t) Obligation
Under Exchange Act. During any period when the delivery of a prospectus relating to the Shares is required (including in circumstances
where such requirement may be satisfied pursuant to Rule 172, 173 or any similar rule) to be delivered under the Act, the Company
will file all documents required to be filed with the Commission pursuant to the Exchange Act within the time periods required by the
Exchange Act and the regulations thereunder.
(u) DTC
Facility. The Company shall cooperate with the Manager and use its reasonable efforts to permit the Shares to be eligible for clearance
and settlement through the facilities of DTC.
(v) Use
of Proceeds. The Company will apply the Net Proceeds from the sale of the Shares in the manner set forth in the Prospectus.
(w) Filing
of Prospectus Supplement. If any sales are made pursuant to this Agreement which are not made in “at the market”
offerings as defined in Rule 415, including, without limitation, any Placement pursuant to a Terms Agreement, the Company shall file
a Prospectus Supplement describing the terms of such transaction, the amount of Shares sold, the price thereof, the Manager’s
compensation, and such other information as may be required pursuant to Rule 424 and Rule 430B, as applicable, within the time
required by Rule 424.
(x) Additional
Registration Statement. To the extent that the Registration Statement is not available for the sales of the Shares as contemplated
by this Agreement, the Company shall file a new registration statement with respect to any additional shares of Common Stock necessary
to complete such sales of the Shares and shall cause such registration statement to become effective as promptly as practicable. After
the effectiveness of any such registration statement, all references to “Registration Statement” included in this Agreement
shall be deemed to include such new registration statement, including all documents incorporated by reference therein pursuant to Item 12
of Form S-3, and all references to “Base Prospectus” included in this Agreement shall be deemed to include the final
form of prospectus, including all documents incorporated therein by reference, included in any such registration statement at the time
such registration statement became effective.
5. Payment of
Expenses. The Company agrees to pay the costs and expenses incident to the performance of its obligations under this Agreement,
whether or not the transactions contemplated hereby are consummated, including without limitation: (i) the preparation,
printing or reproduction and filing with the Commission of the Registration Statement (including financial statements and exhibits
thereto), the Prospectus and each Issuer Free Writing Prospectus, and each amendment or supplement to any of them; (ii) the
printing (or reproduction) and delivery (including postage, air freight charges and charges for counting and packaging) of such
copies of the Registration Statement, the Prospectus, and each Issuer Free Writing Prospectus, and all amendments or supplements to
any of them, as may, in each case, be reasonably requested for use in connection with the offering and sale of the Shares;
(iii) the preparation, printing, authentication, issuance and delivery of certificates for the Shares, including any stamp or
transfer taxes in connection with the original issuance and sale of the Shares; (iv) the printing (or reproduction) and
delivery of this Agreement, any blue sky memorandum, if applicable, and all other agreements or documents printed (or reproduced)
and delivered in connection with the offering of the Shares; (v) the registration of the Shares under the Exchange Act, if
applicable, and the listing of the Shares on the Trading Market; (vi) any registration or qualification of the Shares for offer
and sale under the securities or blue sky laws of the several states (including filing fees and the reasonable fees and expenses of
counsel for the Manager relating to such registration and qualification); (vii) the transportation and other expenses incurred
by or on behalf of Company representatives in connection with presentations to prospective purchasers of the Shares; (viii) the
fees and expenses of the Company’s accountants and the fees and expenses of counsel (including local and special counsel) for
the Company; (ix) the filing fee under FINRA Rule 5110; (x) the reasonable fees and expenses of the Manager’s counsel, not to
exceed $50,000 (excluding any periodic due diligence fees provided for under Section 4(n)), which shall be paid upon the Execution
Time; and (xi) all other costs and expenses incident to the performance by the Company of its obligations hereunder.
6. Conditions
to the Obligations of the Manager. The obligations of the Manager under this Agreement and any Terms Agreement shall be subject to
(i) the accuracy of the representations and warranties on the part of the Company contained herein as of the Execution Time, each
Representation Date, and as of each Applicable Time, Settlement Date and Time of Delivery, (ii) the performance by the Company of
its obligations hereunder and (iii) the following additional conditions:
(a) Effectiveness
of the Registration Statement; Filing of Prospectus Supplement. The Registration Statement shall have been declared effective by the
Commission and the Prospectus, and any supplement thereto, required by Rule 424 to be filed with the Commission shall have been filed
in the manner and within the time period required by Rule 424(b) with respect to any sale of Shares; each Prospectus Supplement shall
have been filed in the manner required by Rule 424(b) within the time period required hereunder and under the Act; any other material
required to be filed by the Company pursuant to Rule 433(d) under the Act, shall have been filed with the Commission within the applicable
time periods prescribed for such filings by Rule 433; and no stop order suspending the effectiveness of the Registration Statement
or any notice objecting to its use shall have been issued and no proceedings for that purpose shall have been instituted or threatened.
(b) Delivery
of Opinion. The Company shall have caused the Company Counsel to furnish to the Manager its opinion and negative assurance statement,
dated as of such date and addressed to the Manager in form and substance acceptable to the Manager.
(c) Delivery
of Officer’s Certificate. The Company shall have furnished or caused to be furnished to the Manager a certificate of the Company
signed by the Chief Executive Officer or the President and the principal financial or accounting officer of the Company, dated as of such
date, to the effect that the signers of such certificate have carefully examined the Registration Statement, the Prospectus, any Prospectus
Supplement and any documents incorporated by reference therein and any supplements or amendments thereto and this Agreement and that:
(i) the
representations and warranties of the Company in this Agreement are true and correct on and as of such date with the same effect as if
made on such date and the Company has complied with all the agreements and satisfied all the conditions on its part to be performed or
satisfied at or prior to such date;
(ii) no stop
order suspending the effectiveness of the Registration Statement or any notice objecting to its use has been issued and no
proceedings for that purpose have been instituted or, to the Company’s knowledge, threatened; and
(iii) since
the date of the most recent financial statements included in the Registration Statement, the Prospectus and the Incorporated Documents,
there has been no Material Adverse Effect on the condition (financial or otherwise), earnings, business or properties of the Company and
its subsidiaries, taken as a whole, whether or not arising from transactions in the ordinary course of business, except as set forth in
or contemplated in the Registration Statement and the Prospectus.
(d) Delivery
of Accountants’ “Comfort” Letter. The Company shall have requested and caused the Accountants to have furnished
to the Manager letters (which may refer to letters previously delivered to the Manager), dated as of such date, in form and substance
satisfactory to the Manager, confirming that they are independent accountants within the meaning of the Act and the Exchange Act and the
respective applicable rules and regulations adopted by the Commission thereunder and that they have performed a review of any unaudited
interim financial information of the Company included or incorporated by reference in the Registration Statement and the Prospectus and
provide customary “comfort” as to such review in form and substance satisfactory to the Manager.
(e) No
Material Adverse Event. Since the respective dates as of which information is disclosed in the Registration Statement, the Prospectus
and the Incorporated Documents, except as otherwise stated therein, there shall not have been (i) any change or decrease in previously
reported results specified in the letter or letters referred to in paragraph (d) of this Section 6 or (ii) any change, or any
development involving a prospective change, in or affecting the condition (financial or otherwise), earnings, business or properties of
the Company and its subsidiaries taken as a whole, whether or not arising from transactions in the ordinary course of business, except
as set forth in or contemplated in the Registration Statement, the Prospectus and the Incorporated Documents (exclusive of any amendment
or supplement thereto) the effect of which, in any case referred to in clause (i) or (ii) above, is, in the sole judgment of
the Manager, so material and adverse as to make it impractical or inadvisable to proceed with the offering or delivery of the Shares as
contemplated by the Registration Statement (exclusive of any amendment thereof), the Incorporated Documents and the Prospectus (exclusive
of any amendment or supplement thereto).
(f) Payment
of All Fees. The Company shall have paid or carried forward any previously paid position of the required Commission filing fees relating
to the Shares within the time period required by Rule 456(b)(1)(i) of the Act without regard to the proviso therein and otherwise
in accordance with Rules 456(b) and 457(r) of the Act and, if applicable, shall have updated the “Calculation of Registration
Fee” table in accordance with Rule 456(b)(1)(ii) either in a post-effective amendment to the Registration Statement or on the
cover page of a prospectus filed pursuant to Rule 424(b).
(g) No
FINRA Objections. FINRA shall not have raised any objection with respect to the fairness and reasonableness of the terms and arrangements
under this Agreement.
(h) Shares
Listed on Trading Market. The Shares shall have been listed and admitted and authorized for trading on the Trading Market, and satisfactory
evidence of such actions shall have been provided to the Manager.
(i) Other
Assurances. Prior to each Settlement Date and Time of Delivery, as applicable, the Company shall have furnished to the Manager such
further information, certificates and documents as the Manager may reasonably request.
If any of the conditions specified
in this Section 6 shall not have been fulfilled when and as provided in this Agreement, or if any of the opinions and certificates mentioned
above or elsewhere in this Agreement shall not be reasonably satisfactory in form and substance to the Manager and counsel for the Manager,
this Agreement and all obligations of the Manager hereunder may be canceled at, or at any time prior to, any Settlement Date or Time of
Delivery, as applicable, by the Manager. Notice of such cancellation shall be given to the Company in writing or by telephone and confirmed
in writing by electronic mail.
The documents required to
be delivered by this Section 6 shall be delivered to the office of Ellenoff Grossman & Schole LLP, counsel for the Manager, at 1345
Avenue of the Americas, New York, New York 10105, email: capmkts@egsllp.com, on each such date as provided in this Agreement.
7. Indemnification
and Contribution.
(a) Indemnification
by Company. The Company agrees to indemnify and hold harmless the Manager, the directors, officers, employees and agents of the
Manager and each person who controls the Manager within the meaning of either the Act or the Exchange Act against any and all
losses, claims, damages or liabilities, joint or several, to which they or any of them may become subject under the Act, the
Exchange Act or other Federal or state statutory law or regulation, at common law or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue
statement of a material fact contained in the Registration Statement for the registration of the Shares as originally filed or in
any amendment thereof, or in the Base Prospectus, any Prospectus Supplement, the Prospectus, any Issuer Free Writing Prospectus, or
in any amendment thereof or supplement thereto, or arise out of or are based upon the omission or alleged omission to state therein
a material fact required to be stated therein or necessary to make the statements therein not misleading or arise out of or are
based upon any Proceeding, commenced or threatened (whether or not the Manager is a target of or party to such Proceeding) or result
from or relate to any breach of any of the representations, warranties, covenants or agreements made by the Company in this
Agreement, and agrees to reimburse each such indemnified party for any legal or other expenses reasonably incurred by them in
connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that
the Company will not be liable in any such case to the extent that any such loss, claim, damage or liability arises out of or is
based upon any such untrue statement or alleged untrue statement or omission or alleged omission made therein in reliance upon and
in conformity with written information furnished to the Company by the Manager specifically for inclusion therein. This indemnity
agreement will be in addition to any liability that the Company may otherwise have.
(b) Indemnification
by Manager. The Manager agrees to indemnify and hold harmless the Company, each of its directors, each of its officers who signs the
Registration Statement, and each person who controls the Company within the meaning of either the Act or the Exchange Act, to the same
extent as the foregoing indemnity from the Company to the Manager, but only with reference to written information relating to the Manager
furnished to the Company by the Manager specifically for inclusion in the documents referred to in the foregoing indemnity; provided,
however, that in no case shall the Manager be responsible for any amount in excess of the Broker Fee applicable to the Shares and
paid hereunder. This indemnity agreement will be in addition to any liability which the Manager may otherwise have.
(c) Indemnification
Procedures. Promptly after receipt by an indemnified party under this Section 7 of notice of the commencement of any
action, such indemnified party will, if a claim in respect thereof is to be made against the indemnifying party under this
Section 7, notify the indemnifying party in writing of the commencement thereof; but the failure so to notify the indemnifying
party (i) will not relieve it from liability under paragraph (a) or (b) above unless and to the extent it did not
otherwise learn of such action and such failure results in the forfeiture by the indemnifying party of substantial rights and
defenses and (ii) will not, in any event, relieve the indemnifying party from any obligations to any indemnified party other
than the indemnification obligation provided in paragraph (a) or (b) above. The indemnifying party shall be entitled to
appoint counsel of the indemnifying party’s choice at the indemnifying party’s expense to represent the indemnified
party in any action for which indemnification is sought (in which case the indemnifying party shall not thereafter be responsible
for the fees and expenses of any separate counsel retained by the indemnified party or parties except as set forth below); provided, however,
that such counsel shall be reasonably satisfactory to the indemnified party. Notwithstanding the indemnifying party’s election
to appoint counsel to represent the indemnified party in an action, the indemnified party shall have the right to employ separate
counsel (including local counsel), and the indemnifying party shall bear the reasonable fees, costs and expenses of such separate
counsel if (i) the use of counsel chosen by the indemnifying party to represent the indemnified party would present such
counsel with a conflict of interest, (ii) the actual or potential defendants in, or targets of, any such action include both
the indemnified party and the indemnifying party and the indemnified party shall have reasonably concluded that there may be legal
defenses available to it and/or other indemnified parties which are different from or additional to those available to the
indemnifying party, (iii) the indemnifying party shall not have employed counsel reasonably satisfactory to the indemnified
party to represent the indemnified party within a reasonable time after notice of the institution of such action or (iv) the
indemnifying party shall authorize the indemnified party to employ separate counsel at the expense of the indemnifying party. An
indemnifying party will not, without the prior written consent of the indemnified parties, settle or compromise or consent to the
entry of any judgment with respect to any pending or threatened claim, action, suit or proceeding in respect of which
indemnification or contribution may be sought hereunder (whether or not the indemnified parties are actual or potential parties to
such claim or action) unless such settlement, compromise or consent includes an unconditional release of each indemnified party from
all liability arising out of such claim, action, suit or proceeding.
(d) Contribution.
In the event that the indemnity provided in paragraph (a), (b) or (c) of this Section 7 is unavailable to or
insufficient to hold harmless an indemnified party for any reason, the Company and the Manager agree to contribute to the aggregate
losses, claims, damages and liabilities (including legal or other expenses reasonably incurred in connection with investigating or
defending the same) (collectively “Losses”) to which the Company and the Manager may be subject in such
proportion as is appropriate to reflect the relative benefits received by the Company on the one hand and by the Manager on the
other from the offering of the Shares; provided, however, that in no case shall the Manager be responsible for any
amount in excess of the Broker Fee applicable to the Shares and paid hereunder. If the allocation provided by the immediately
preceding sentence is unavailable for any reason, the Company and the Manager severally shall contribute in such proportion as is
appropriate to reflect not only such relative benefits but also the relative fault of the Company on the one hand and of the Manager
on the other in connection with the statements or omissions which resulted in such Losses as well as any other relevant equitable
considerations. Benefits received by the Company shall be deemed to be equal to the total net proceeds from the offering (before
deducting expenses) received by it, and benefits received by the Manager shall be deemed to be equal to the Broker Fee applicable to
the Shares and paid hereunder as determined by this Agreement. Relative fault shall be determined by reference to, among other
things, whether any untrue or any alleged untrue statement of a material fact or the omission or alleged omission to state a
material fact relates to information provided by the Company on the one hand or the Manager on the other, the intent of the parties
and their relative knowledge, access to information and opportunity to correct or prevent such untrue statement or omission. The
Company and the Manager agree that it would not be just and equitable if contribution were determined by pro rata allocation or any
other method of allocation which does not take account of the equitable considerations referred to above. Notwithstanding the
provisions of this paragraph (d), no person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. For purposes of
this Section 7, each person who controls the Manager within the meaning of either the Act or the Exchange Act and each
director, officer, employee and agent of the Manager shall have the same rights to contribution as the Manager, and each person who
controls the Company within the meaning of either the Act or the Exchange Act, each officer of the Company who shall have signed the
Registration Statement and each director of the Company shall have the same rights to contribution as the Company, subject in each
case to the applicable terms and conditions of this paragraph (d).
8. Termination.
(a) The
Company shall have the right, by giving written notice as hereinafter specified, to terminate the provisions of this Agreement relating
to the solicitation of offers to purchase the Shares in its sole discretion at any time upon ten (10) Business Days’ prior written
notice. Any such termination shall be without liability of any party to any other party except that (i) with respect to any pending
sale, through the Manager for the Company, the obligations of the Company, including in respect of compensation of the Manager, shall
remain in full force and effect notwithstanding the termination and (ii) the provisions of Sections 5, 6, 7, 8, 9, 10, 12, 14
and 15 of this Agreement shall remain in full force and effect notwithstanding such termination.
(b) The
Manager shall have the right, by giving written notice as hereinafter specified, to terminate the provisions of this Agreement relating
to the solicitation of offers to purchase the Shares in its sole discretion at any time. Any such termination shall be without liability
of any party to any other party except that the provisions of Sections 5, 6, 7, 8, 9, 10, 12, 14 and 15 of this Agreement shall remain
in full force and effect notwithstanding such termination.
(c) This
Agreement shall remain in full force and effect until such date that this Agreement is terminated pursuant to Sections 8(a) or (b) above
or otherwise by mutual agreement of the parties, provided that any such termination by mutual agreement shall in all cases be deemed to
provide that Sections 5, 6, 7, 8, 9, 10, 12, 14 and 15 of this Agreement shall remain in full force and effect.
(d) Any
termination of this Agreement shall be effective on the date specified in such notice of termination, provided that such termination shall
not be effective until the close of business on the date of receipt of such notice by the Manager or the Company, as the case may be.
If such termination shall occur prior to the Settlement Date or Time of Delivery for any sale of the Shares, such sale of the Shares shall
settle in accordance with the provisions of Section 2(b) of this Agreement.
(e) In the
case of any purchase of Shares by the Manager pursuant to a Terms Agreement, the obligations of the Manager pursuant to such Terms
Agreement shall be subject to termination, in the absolute discretion of the Manager, by prompt oral notice given to the Company
prior to the Time of Delivery relating to such Shares, if any, and confirmed promptly by electronic mail, if since the time of
execution of the Terms Agreement and prior to such delivery and payment, (i) trading in the Common Stock shall have been
suspended by the Commission or the Trading Market or trading in securities generally on the Trading Market shall have been suspended
or limited or minimum prices shall have been established on such exchange, (ii) a banking moratorium shall have been declared
either by Federal or New York State authorities or (iii) there shall have occurred any outbreak or escalation of hostilities,
declaration by the United States of a national emergency or war, or other calamity or crisis the effect of which on financial
markets is such as to make it, in the sole judgment of the Manager, impractical or inadvisable to proceed with the offering or
delivery of the Shares as contemplated by the Prospectus (exclusive of any amendment or supplement thereto).
9. Representations
and Indemnities to Survive. The respective agreements, representations, warranties, indemnities and other statements of the Company
or its officers and of the Manager set forth in or made pursuant to this Agreement will remain in full force and effect, regardless of
any investigation made by the Manager or the Company or any of the officers, directors, employees, agents or controlling persons referred
to in Section 7, and will survive delivery of and payment for the Shares.
10. Notices.
All communications hereunder will be in writing and effective only on receipt, and will be mailed, delivered, or e-mailed to the addresses
of the Company and the Manager, respectively, set forth on the signature page hereto.
11. Successors.
This Agreement will inure to the benefit of and be binding upon the parties hereto and their respective successors and the officers, directors,
employees, agents and controlling persons referred to in Section 7, and no other person will have any right or obligation hereunder.
12. No
Fiduciary Duty. The Company hereby acknowledges that (a) the purchase and sale of the Shares pursuant to this Agreement is an
arm’s-length commercial transaction between the Company, on the one hand, and the Manager and any Affiliate through which it may
be acting, on the other, (b) the Manager is acting solely as sales agent and/or principal in connection with the purchase and sale
of the Company’s securities and not as a fiduciary of the Company and (c) the Company’s engagement of the Manager in
connection with the offering and the process leading up to the offering is as independent contractors and not in any other capacity. Furthermore,
the Company agrees that it is solely responsible for making its own judgments in connection with the offering (irrespective of whether
the Manager has advised or is currently advising the Company on related or other matters). The Company agrees that it will not claim that
the Manager has rendered advisory services of any nature or respect, or owe an agency, fiduciary or similar duty to the Company, in connection
with such transaction or the process leading thereto.
13. Integration.
This Agreement and any Terms Agreement supersede all prior agreements and understandings (whether written or oral) between the Company
and the Manager with respect to the subject matter hereof.
14. Amendments;
Waivers. No provision of this Agreement may be waived, modified, supplemented or amended except in a written instrument signed, in
the case of an amendment, by the Company and the Manager. No waiver of any default with respect to any provision, condition or requirement
of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent default or a waiver of any other
provision, condition or requirement hereof, nor shall any delay or omission of any party to exercise any right hereunder in any manner
impair the exercise of any such right.
15. Applicable
Law. This Agreement and any Terms Agreement will be governed by and construed in accordance with the laws of the State of New York
applicable to contracts made and to be performed within the State of New York. Each of the Company and the Manager: (i) agrees that
any legal suit, action or proceeding arising out of or relating to this Agreement shall be instituted exclusively in New York Supreme
Court, County of New York, or in the United States District Court for the Southern District of New York, (ii) waives any objection which
it may have or hereafter to the venue of any such suit, action or proceeding, and (iii) irrevocably consents to the exclusive jurisdiction
of the New York Supreme Court, County of New York, and the United States District Court for the Southern District of New York in any such
suit, action or proceeding. Each of the Company and the Manager further agrees to accept and acknowledge service of any and all process
which may be served in any such suit, action or proceeding in the New York Supreme Court, County of New York, or in the United States
District Court for the Southern District of New York and agrees that service of process upon the Company mailed by certified mail to the
Company’s address shall be deemed in every respect effective service of process upon the Company, in any such suit, action or proceeding,
and service of process upon the Manager mailed by certified mail to the Manager’s address shall be deemed in every respect effective
service process upon the Manager, in any such suit, action or proceeding. If either party shall commence an action or proceeding to enforce
any provision of this Agreement, then the prevailing party in such action or proceeding shall be reimbursed by the other party for its
reasonable attorney’s fees and other costs and expenses incurred with the investigation, preparation and prosecution of such action
or proceeding.
16. Waiver
of Jury Trial. The Company hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial
by jury in any legal proceeding arising out of or relating to this Agreement, any Terms Agreement or the transactions contemplated hereby
or thereby.
17. Counterparts.
This Agreement and any Terms Agreement may be executed in one or more counterparts, each one of which shall be an original, with the
same effect as if the signatures thereto and hereto were upon one and the same agreement. Counterparts may be delivered via
electronic mail (including any electronic signature covered by the U.S. federal ESIGN Act of 2000, Uniform Electronic Transactions
Act, the Electronic Signatures and Records Act or other applicable law, e.g., www.docusign.com) or other transmission method and any
counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.
***************************
18. Headings.
The section headings used in this Agreement and any Terms Agreement are for convenience only and shall not affect the construction hereof.
If the foregoing is in accordance
with your understanding of our agreement, please sign and return to us the enclosed duplicate hereof, whereupon this letter and your acceptance
shall represent a binding agreement among the Company and the Manager.
Very truly yours, |
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Neuphoria Therapeutics
Inc. |
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By: |
/s/ Spyridon (Spyros) Papapetropoulos |
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Name: |
Spyridon (Spyros) Papapetropoulos |
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Title: |
President and CEO |
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Address for Notice:
100 Summit Dr
Burlington, Massachusetts 01803
Attention: Spryidon (Spyros) Papapetropoulos
E-mail: spyros@bionomics.com.au
The foregoing Agreement is hereby
confirmed and accepted as of the date first written above. |
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H.C. WAINWRIGHT & CO., LLC |
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By: |
/s/ Edward D. Silvera |
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Name: |
Edward D. Silvera |
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Title: |
Chief Operating Officer |
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Address for Notice:
430 Park Avenue,
New York, New York 10022
Attention: Chief Executive Officer
E-mail: notices@hcwco.com
Form of Terms Agreement
ANNEX I
Neuphoria
Therapeutics Inc.
TERMS AGREEMENT
Dear Sirs:
Neuphoria
Therapeutics Inc. (the “Company”) proposes, subject to the terms and conditions stated herein and in the At The Market
Offering Agreement, dated January ___, 2025 (the “At The Market Offering Agreement”), between the Company and H.C.
Wainwright & Co., LLC (“Manager”), to issue and sell to Manager the securities specified in the Schedule I
hereto (the “Purchased Shares”).
Each
of the provisions of the At The Market Offering Agreement not specifically related to the solicitation by the Manager, as agent of the
Company, of offers to purchase securities is incorporated herein by reference in its entirety, and shall be deemed to be part of this
Terms Agreement to the same extent as if such provisions had been set forth in full herein. Each of the representations and warranties
set forth therein shall be deemed to have been made at and as of the date of this Terms Agreement and the Time of Delivery, except that
each representation and warranty in Section 3 of the At The Market Offering Agreement which makes reference to the Prospectus (as
therein defined) shall be deemed to be a representation and warranty as of the date of the At The Market Offering Agreement in relation
to the Prospectus, and also a representation and warranty as of the date of this Terms Agreement and the Time of Delivery in relation
to the Prospectus as amended and supplemented to relate to the Purchased Shares.
An
amendment to the Registration Statement (as defined in the At The Market Offering Agreement), or a supplement to the Prospectus, as the
case may be, relating to the Purchased Shares, in the form heretofore delivered to the Manager is now proposed to be filed with the Securities
and Exchange Commission.
Subject
to the terms and conditions set forth herein and in the At The Market Offering Agreement which are incorporated herein by reference, the
Company agrees to issue and sell to the Manager and the latter agrees to purchase from the Company the number of shares of the Purchased
Shares at the time and place and at the purchase price set forth in the Schedule I hereto.
If
the foregoing is in accordance with your understanding, please sign and return to us a counterpart hereof, whereupon this Terms Agreement,
including those provisions of the At The Market Offering Agreement incorporated herein by reference, shall constitute a binding agreement
between the Manager and the Company.
Neuphoria Therapeutics
Inc. |
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By: |
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Name: |
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Title: |
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ACCEPTED
as of the date first written above.
H.C. WAINWRIGHT & CO., LLC |
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By: |
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Name: |
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Title: |
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39
Exhibit 5.1
January 6, 2025
Neuphoria Therapeutics Inc.
100 Summit Dr
Burlington, Massachusetts 01803
Ladies and Gentlemen:
We have acted as counsel to Neuphoria Therapeutics
Inc., a Delaware corporation (the “Company”), in connection with the Company’s proposed issuance and sale, through
H.C. Wainwright & Co., LLC, as sales agent (the “HCW”), of up to $2,000,000 of shares of the Company’s common
stock, par value $0.00001 per share (the “Shares”), from time to time and at various prices in an “at-the-market”
offering. The proposed issuance and sale of Shares will be conducted pursuant to (i) that certain At The Market Offering Agreement, dated
November 18, 2024 (as amended, the “Offering Agreement”), by and among the Company and HCW, and (ii) the Company’s
Registration Statement on Form S-3 filed by the Company with the Securities and Exchange Commission on November 18, 2024 (File No. 333-283306,
the “Registration Statement”).
As counsel to the Company in connection with the
proposed potential issuance and sale of the Shares, and as a basis for the opinion hereinafter set forth, we have examined originals,
or copies certified or otherwise identified to our satisfaction, of the following documents (collectively, the “Documents”):
(i) the Offering Agreement, (ii) the Registration Statement and a draft of the prospectuses contained in the Registration Statement, (iii)
the Company’s Amended and Restated Certificate of Incorporation and Bylaws, each as currently in effect, and (iv) the proceedings
and actions taken by the Board of Directors of the Company (or a duly authorized committee thereof) to authorize and approve the transactions
contemplated by the Offering Agreement, the execution and delivery of the Offering Agreement, and the issuance and sale of the Shares
(the “Resolutions”). We have also considered such matters of law and of fact, including the examination of originals
or copies, certified or otherwise identified to our satisfaction, of such records and documents of the Company, certificates of officers,
directors and representatives of the Company, certificates of public officials, and such other documents as we have deemed appropriate
as a basis for the opinions set forth below.
In expressing the opinion set forth below, we have
assumed the following:
1. Each individual executing any of the Documents,
whether on behalf of such individual or another person, is legally competent to do so, and that each of the parties executing any of the
Documents have duly and validly done so.
2. Each individual executing any of the Documents
on behalf of a party (other than the Company) is duly authorized to do so.
3. All Documents submitted to us as originals are
authentic. The form and content of all Documents submitted to us as unexecuted drafts do not differ in any respect relevant to this opinion
from the form and content of such Documents as executed and delivered. All Documents submitted to us as certified or photostatic
Australia | Canada | China | Colombia | France
| Germany | Israel | Morocco
South Korea | United Arab Emirates | United Kingdom | United States
copies conform to the original documents. All signatures on all such
Documents are genuine. All public records reviewed or relied upon by us or on our behalf are true and complete. All statements and information
contained in the Documents are true and complete. There has been no oral or written modification or amendment to the Documents, or waiver
of any provision of the Documents, by action or omission of the parties or otherwise.
4. The Company will issue the Shares in accordance
with the Resolutions and, prior to the issuance of any Shares, the Company will have available for issuance, under the Company’s
Amended and Restated Certificate of Incorporation, as amended, the requisite number of authorized but unissued shares of common stock;
however, the Company shall not issue any shares in excess of its then authorized and available Shares. As of the date hereof, the Company
has available for issuance, under the Company’s Amended and Restated Certificate of Incorporation, as amended, the requisite number
of authorized but unissued shares of common stock for the issuance of the Shares.
Our opinions expressed herein
are limited to the General Corporation Law of the State of Delaware, and we express no opinion as to the laws of any other jurisdiction.
Based upon, subject to and limited by the foregoing,
we are of the opinion that, upon the issuance of the Shares pursuant to the terms of the Offering Agreement and the receipt by the Company
of the consideration for the Shares (not less than par value) pursuant to the terms of the Offering Agreement, the Shares will be validly
issued, fully paid, and nonassessable.
This opinion is issued as of the date hereof, and
we assume no obligation to supplement this opinion if any applicable law changes after the date hereof or if we become aware of any fact
that might change the opinion expressed herein after the date hereof. This opinion is limited to the matters set forth herein, and no
other opinion should be inferred beyond the matters expressly stated.
We hereby consent to the filing of this opinion letter
as Exhibit 5.1 to the Registration Statement and to the use of our name under the caption “Legal Matters” in the Registration
Statement. In giving this consent, we do not hereby admit that we are in the category of persons whose consent is required under Section
7 of the Securities Act of 1933, as amended.
Very Truly Yours, |
|
|
|
By: |
/s/ Rimon P.C. |
|
|
RIMON P.C. |
|
Exhibit 10.1
NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS
EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES.
THE SECURITIES MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT FOR THE SECURITIES UNDER APPLICABLE SECURITIES LAWS, OR UNLESS OFFERED, SOLD, PLEDGED, HYPOTHECATED OR TRANSFERRED PURSUANT
TO AN AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THOSE LAWS. THE COMPANY SHALL BE ENTITLED TO REQUIRE AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED TO THE EXTENT THAT SUCH OPINION IS REQUIRED PURSUANT TO THAT CERTAIN
SECURITIES PURCHASE AGREEMENT UNDER WHICH THE SECURITIES WERE ISSUED.
COMMON STOCK PURCHASE WARRANT
Neuphoria
Therapeutics Inc.
Warrant Shares: 1,054,381 |
Initial Exercise Date: December 24, 2024 |
|
Issue Date: December 24, 2024 |
THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”)
certifies that, for value received, Armistice Capital Master Fund Ltd. or its assigns (the “Holder”) is entitled, upon
the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof
(the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on June 2, 2029 (the “Termination
Date”) but not thereafter, to subscribe for and purchase from Neuphoria Therapeutics Inc., a company incorporated under the
laws of Delaware (the “Company”), up to 1,054,381 shares of common stock (as subject to adjustment hereunder, the “Warrant
Shares”). The purchase price of one share of common stock under this Warrant shall be equal to the Exercise Price, as defined
in Section 2(b). Any capitalized terms included in this Warrant which are not otherwise defined herein shall have the meaning ascribed
to them in the Securities Purchase Agreement, dated the date hereof, and entered into by the Holder and such other holders party thereto,
pursuant to which this Warrant is being issued (the “SPA”).
Section 1. Definitions. In addition
to the terms defined elsewhere in this Warrant, the following terms have the meanings indicated in this Section 1:
“Shares” mean the
shares of the Company’s common stock traded and listed on the Principal Trading Market.
“Common Stock Equivalents”
means any securities of the Company or the Subsidiaries which would entitle the holder thereof to acquire at any time Shares, including,
without limitation, any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable
or exchangeable for, or otherwise entitles the holder thereof to receive, Shares.
“Affiliate” means
any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or is under common control with
a Person, as such terms are used in and construed under Rule 405 under the Securities Act.
“Bid Price” means,
for any date, the price determined by the first of the following clauses that applies: (a) if the shares of Common Stock are then listed
or quoted on a Trading Market, the bid price of the Shares for the time in question (or the nearest preceding date) on the Trading Market
on which the Shares is then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time)
to 4:02 p.m. (New York City time)), (b) if OTCQB or OTCQX is not a Trading Market, the volume weighted average price of the Shares
for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable, (c) if the Shares are not then listed or quoted for trading
on OTCQB or OTCQX and if prices for the Shares are then reported on the Pink Open Market (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per Share so reported, or (d) in all other cases, the fair market
value of a Share as determined by an independent appraiser selected in good faith by the Holders of a majority in interest of the Warrants
then outstanding and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.
“Board of Directors”
means the board of directors of the Company.
“Business Day” means
any day other than Saturday, Sunday or other day on which commercial banks in The City of New York are authorized or required by law to
remain closed; provided, however, for clarification, commercial banks shall not be deemed to be authorized or required by
law to remain closed due to “stay at home”, “shelter-in-place”, “non-essential employee” or
any other similar orders or restrictions or the closure of any physical branch locations at the direction of any governmental authority
so long as the electronic funds transfer systems (including for wire transfers) of commercial banks in The City of New York generally
are open for use by customers on such day.
“Commission” means
the United States Securities and Exchange Commission.
“Exchange Act” means
the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.
“Person” means an
individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company, joint
stock company, government (or an agency or subdivision thereof) or other entity of any kind.
“Registrable Securities”
means (i) the Shares, (ii) the Pre-Funded Warrant Shares, (iii) the Shares issuable upon exercise of the Accompanying Warrant and (iv)
any other securities issued upon any stock split, dividend or other distribution, recapitalization or similar event with respect to the
foregoing; provided, however, that any such Registrable Securities shall cease to be Registrable Securities (and the Company shall not
be required to maintain the effectiveness of any, or file another, registration statement hereunder with respect thereto) upon the first
to occur of (A) a registration statement with respect to the sale of such Registrable Securities being declared effective by the SEC under
the 1933 Act and such Registrable Securities having been disposed of or transferred by the holder thereof in accordance with such effective
Registration Statement, (B) such Registrable Securities having been previously sold or transferred in accordance with Rule 144 (or another
exemption from the registration requirements of the 1933 Act), and (C) such securities becoming eligible for resale without volume or
manner-of-sale restrictions and without current public information requirements pursuant to Rule 144.
“Registration
Statement” means the Company’s resale registration statement on Form F-1,
which shall be filed by the Company pursuant to the terms of that Registration Rights Agreement (“RRA”) entered into
on the date hereof and which shall include the Registrable Securities pursuant to the terms of the SPA and RRA.
“Securities Act” means
the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.
“Subsidiary” means
any material subsidiary of the Company and shall, where applicable, also include any direct or indirect subsidiary of the Company formed
or acquired after the date hereof.
“Trading Day” means
a day on which the Shares are traded on a Trading Market.
“Trading Market” means
any of the following markets or exchanges on which the Shares are listed or quoted for trading on the date in question: the NYSE American,
the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market, the New York Stock Exchange (or any successors to
any of the foregoing).
“Transfer Agent” means
Computershare Trust Company, N.A., the current transfer agent of the Company, and any successor transfer agent of the Company.
“VWAP” means, for
any date, the price determined by the first of the following clauses that applies: (a) if the Shares are then listed or quoted on a Trading
Market, the daily volume weighted average price of the Shares for such date (or the nearest preceding date) on the Trading Market on
which the Shares are then listed or quoted as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time)
to 4:02 p.m. (New York City time)), (b) if OTCQB or OTCQX is not a Trading Market, the volume weighted average price of the Shares
for such date (or the nearest preceding date) on OTCQB or OTCQX as applicable, (c) if the Shares are not then listed or quoted for trading
on OTCQB or OTCQX and if prices for the Shares are then reported on the Pink Open Market (or a similar organization or agency succeeding
to its functions of reporting prices), the most recent bid price per Share so reported, or (d) in all other cases, the fair market
value of a Share as determined by an independent appraiser selected in good faith by the holders of a majority in interest of the Warrants
then outstanding and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.
Section 2. Exercise.
a) Exercise of Warrant. Exercise
of the purchase rights represented by this Warrant may be made, in whole or in part, at any time or times on or after the Initial Exercise
Date and on or before the Termination Date by delivery to the Company of a duly executed PDF copy submitted by e-mail (or e-mail attachment)
of the Notice of Exercise in the form annexed hereto (the “Notice of Exercise”). Within the earlier of (i) two (2)
Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period (as defined in Section 2(d)(i) herein) following
the date of exercise as aforesaid, the Holder shall deliver the aggregate Exercise Price for the Shares specified in the applicable Notice
of Exercise by wire transfer or cashier’s check drawn on a United States bank (unless the cashless exercise procedure specified
in Section 2(c) below is specified in the applicable Notice of Exercise). No ink-original Notice of Exercise shall be required, nor shall
any medallion guarantee (or other type of guarantee or notarization) of any Notice of Exercise be required. Notwithstanding anything herein
to the contrary, the Holder shall not be required to physically surrender this Warrant to the Company until the Holder has purchased all
of the Warrant Shares available hereunder and the Warrant has been exercised in full, in which case, the Holder shall surrender this Warrant
to the Company for cancellation within three (3) Trading Days of the date on which the final Notice of Exercise is delivered to the Company.
Partial exercises of this Warrant resulting in purchases of a portion of the total number of Warrant Shares available hereunder shall
have the effect of lowering the outstanding number of Warrant Shares purchasable hereunder in an amount equal to the applicable number
of Warrant Shares purchased. The Holder and the Company shall maintain records showing the number of Warrant Shares purchased and the
date of such purchases. The Company shall deliver any objection to any Notice of Exercise within one (1) Business Day of receipt of such
notice. The Holder and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this
paragraph, following the purchase of a portion of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder
at any given time may be less than the amount stated on the face hereof.
b) Exercise Price. The exercise
price per Share under this Warrant shall be $11.88, subject to adjustment hereunder (the “Exercise Price”).
c) Cashless Exercise. If,
following the period of time provided to the Company to file and have declared effective the resale Registration Statement, and following
such permitted time period(s), then at the time of exercise hereof there is no effective registration statement registering, or the prospectus
contained therein is not available for the issuance of the Warrant Shares to the Holder, then this Warrant may also be exercised, in whole
or in part, at such time by means of a “cashless exercise” in which the Holder shall be entitled to receive elect instead
to receive upon such exercise the “Net Number” of Shares determined according to the following formula (a “Cashless
Exercise”):
Net Number = (A x B) - (A x C)
B
For purposes of the foregoing formula:
|
A |
= |
the total number of shares with respect to which this Warrant is then being exercised. |
|
B |
= |
the arithmetic average of the Closing Sale Prices of the Shares for the five (5) consecutive Trading Days ending on the date immediately preceding the date of the Exercise Notice. |
|
C |
= |
the Exercise Price then in effect for the applicable Warrant Shares at the time of such exercise. |
If Warrant Shares are issued in such
a cashless exercise, the parties acknowledge and agree that in accordance with Section 3(a)(9) of the Securities Act, the Warrant Shares
shall take on the registered characteristics, if any, of the Warrants being exercised. The Company agrees not to take any position contrary
to this Section 2(c).
|
d) |
Mechanics of Exercise. |
i. Delivery of Warrant Shares Upon
Exercise. The Company shall cause the Warrant Shares purchased hereunder to be transmitted by the Transfer Agent to the Holder by
crediting the account of the Holder’s or its designee’s balance account with The Depository Trust Company through its Deposit
or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant in such system and either (A) there
is an effective registration statement permitting the issuance of the Warrant Shares to or resale of the Warrant Shares by Holder or (B)
pursuant to the conditions set forth in Section 2(c), this Warrant is being exercised via cashless exercise, and otherwise by physical
delivery of a certificate, registered in the Company’s share register in the name of the Holder or its designee, for the number
of Warrant Shares to which the Holder is entitled pursuant to such exercise to the address specified by the Holder in the Notice of Exercise
by the date that is the earliest of (i) two (2) Trading Days after the delivery to the Company of the Notice of Exercise, (ii) one (1)
Trading Day after delivery of the aggregate Exercise Price to the Company and (iii) the number of Trading Days comprising the Standard
Settlement Period after the delivery to the Company of the Notice of Exercise (such date, the “Warrant Share Delivery Date”).
Upon delivery of the Notice of Exercise, the Holder shall be deemed for all corporate purposes to have become the holder of record of
the Warrant Shares with respect to which this Warrant has been exercised, irrespective of the date of delivery of the Warrant Shares,
provided that payment of the aggregate Exercise Price (other than in the case of a cashless exercise) is received within the earlier of
(i) two (2) Trading Days and (ii) the number of Trading Days comprising the Standard Settlement Period following delivery of the Notice
of Exercise. If the Company fails for any reason to deliver to the Holder the Warrant Shares subject to a Notice of Exercise by the Warrant
Share Delivery Date, the Company shall pay to the Holder, in cash, as liquidated damages and not as a penalty, for each $10,000 of Warrant
Shares subject to such exercise (based on the VWAP of the Shares on the date of the applicable Notice of Exercise), $10 per Trading Day
(increasing to $20 per Trading Day on the third Trading Day after the Warrant Share Delivery Date) for each Trading Day after such Warrant
Share Delivery Date until such Warrant Shares are delivered or Holder rescinds such exercise. The Company agrees to maintain a transfer
agent that is a participant in the FAST (or such similar or applicable program) program so long as this Warrant remains outstanding and
exercisable. As used herein, “Standard Settlement Period” means the standard settlement period, expressed in a number
of Trading Days, on the Company’s primary Trading Market with respect to the Shares as in effect on the date of delivery of the
Notice of Exercise.
ii. Delivery of New Warrants
Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request of a Holder and upon surrender
of this Warrant certificate, at the time of delivery of the Warrant Shares, deliver to the Holder a new Warrant evidencing the rights
of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant, which new Warrant shall in all other respects be
identical with this Warrant.
iii. Rescission Rights. If
the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares pursuant to Section 2(d)(i) by the Warrant
Share Delivery Date, then the Holder will have the right to rescind such exercise.
iv. Compensation for Buy-In on
Failure to Timely Deliver Warrant Shares Upon Exercise. In addition to any other rights available to the Holder, if the Company fails
to cause the Transfer Agent to transmit to the Holder the Warrant Shares in accordance with the provisions of Section 2(d)(i) above pursuant
to an exercise on or before the Warrant Share Delivery Date, and if after such date the Holder is required by its broker to purchase (in
an open market transaction or otherwise) or the Holder’s brokerage firm otherwise purchases, Shares to deliver in satisfaction of
a sale by the Holder of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”),
then the Company shall (A) pay in cash to the Holder the amount, if any, by which (x) the Holder’s total purchase price (including
brokerage commissions, if any) for the Shares so purchased exceeds (y) the amount obtained by multiplying (1) the number of Warrant Shares
that the Company was required to deliver to the Holder in connection with the exercise at issue times (2) the price at which the sell
order giving rise to such purchase obligation was executed, and (B) at the option of the Holder, either reinstate the portion of the Warrant
and equivalent number of Warrant Shares for which such exercise was not honored (in which case such exercise shall be deemed rescinded)
or deliver to the Holder the number of Shares that would have been issued had the Company timely complied with its exercise and delivery
obligations hereunder. For example, if the Holder purchases Shares having a total purchase price of $11,000 to cover a Buy-In with respect
to an attempted exercise of Shares with an aggregate sale price giving rise to such purchase obligation of $10,000, under clause (A) of
the immediately preceding sentence the Company shall be required to pay the Holder $1,000. The Holder shall provide the Company written
notice indicating the amounts payable to the Holder in respect of the Buy-In and, upon request of the Company, evidence of the amount
of such loss. Nothing herein shall limit a Holder’s right to pursue any other remedies available to it hereunder, at law or in equity
including, without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s failure to
timely deliver Shares upon exercise of the Warrant as required pursuant to the terms hereof.
v. No Fractional Shares
or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant. As to any
fraction of a share which the Holder would otherwise be entitled to purchase upon such exercise, the Company shall, at its election,
either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction multiplied by the Exercise Price or
round up to the next whole share.
vi. Charges, Taxes and Expenses.
Issuance of Warrant Shares shall be made without charge to the Holder for any issue or transfer tax or other incidental expense in respect
of the issuance of such Warrant Shares, all of which taxes and expenses shall be paid by the Company, and such Warrant Shares shall be
issued in the name of the Holder or in such name or names as may be directed by the Holder; provided, however, that, in
the event that Warrant Shares are to be issued in a name other than the name of the Holder, this Warrant when surrendered for exercise
shall be accompanied by the Assignment Form attached hereto duly executed by the Holder and the Company may require, as a condition thereto,
the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto. The Company shall pay all Transfer Agent fees
required for processing of any Notice of Exercise and all fees to the Depository Trust Company (or another established clearing corporation
performing similar functions) required for same-day electronic delivery of the Warrant Shares.
vii. Closing of Books. The
Company will not close its stockholder books or records in any manner which prevents the timely exercise of this Warrant, pursuant to
the terms hereof.
e) Holder’s Exercise Limitations.
The Company shall not effect any exercise of this Warrant, and a Holder shall not have the right to exercise any portion of this Warrant,
pursuant to Section 2 or otherwise, to the extent that after giving effect to such issuance after exercise as set forth on the applicable
Notice of Exercise, the Holder (together with the Holder’s Affiliates, and any other Persons acting as a group together with the
Holder or any of the Holder’s Affiliates (such Persons, “Attribution Parties”)), would beneficially own in excess
of the Beneficial Ownership Limitation (as defined below). For purposes of the foregoing sentence, the number of Shares beneficially
owned by the Holder and its Affiliates and Attribution Parties shall include the number of Shares issuable upon exercise of this Warrant
with respect to which such determination is being made, but shall exclude the number of Shares which would be issuable upon (i) exercise
of the remaining, nonexercised portion of this Warrant beneficially owned by the Holder or any of its Affiliates or Attribution Parties
and (ii) exercise or conversion of the unexercised or nonconverted portion of any other securities of the Company (including, without
limitation, any other Common Stock Equivalents) subject to a limitation on conversion or exercise analogous to the limitation contained
herein beneficially owned by the Holder or any of its Affiliates or Attribution Parties. Except as set forth in the preceding sentence,
for purposes of this Section 2(e), beneficial ownership shall be calculated in accordance with Section 13(d) of the Exchange Act and the
rules and regulations promulgated thereunder, it being acknowledged by the Holder that the Company is not representing to the Holder that
such calculation is in compliance with Section 13(d) of the Exchange Act and the Holder is solely responsible for any schedules required
to be filed in accordance therewith. To the extent that the limitation contained in this Section 2(e) applies, the determination of whether
this Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates and Attribution Parties)
and of which portion of this Warrant is exercisable shall be in the sole discretion of the Holder, and the submission of a Notice of Exercise
shall be deemed to be the Holder’s determination of whether this Warrant is exercisable (in relation to other securities owned by
the Holder together with any Affiliates and Attribution Parties) and of which portion of this Warrant is exercisable, in each case subject
to the Beneficial Ownership Limitation, and the Company shall have no obligation to verify or confirm the accuracy of such determination.
In addition, a determination as to any group status as contemplated above shall be determined in accordance with Section 13(d) of the
Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 2(e), in determining the number of outstanding
securities (Shares), a Holder may rely on the number of outstanding securities as reflected in (A) the Company’s most recent periodic
or annual report filed with the Commission, as the case may be, (B) a more recent public announcement by the Company or (C) a more recent
written notice by the Company or the Transfer Agent setting forth the number of Shares outstanding. Upon the written or oral request
of a Holder, the Company shall within one Trading Day confirm orally and in writing to the Holder the number of Shares then outstanding.
In any case, the number of outstanding Shares shall be determined after giving effect to the actual conversion or exercise of securities
of the Company, including this Warrant, by the Holder or its Affiliates or Attribution Parties since the date as of which such number
of outstanding Shares was reported. The “Beneficial Ownership Limitation” shall be 4.99% (or, upon election by a Holder
prior to the issuance of any Warrants, 9.99%) of the number of Shares outstanding immediately after giving effect to the issuance of Shares
issuable upon exercise of this Warrant. The Holder, upon notice to the Company, may increase or decrease the Beneficial Ownership Limitation
provisions of this Section 2(e), provided that the Beneficial Ownership Limitation in no event exceeds 9.99% of the number of Shares outstanding
immediately after giving effect to the issuance of Shares upon exercise of this Warrant held by the Holder and the provisions of this
Section 2(e) shall continue to apply. Any increase in the Beneficial Ownership Limitation will not be effective until the 61st
day after such notice is delivered to the Company. The provisions of this paragraph shall be construed and implemented in a manner otherwise
than in strict conformity with the terms of this Section 2(e) to correct this paragraph (or any portion hereof) which may be defective
or inconsistent with the intended Beneficial Ownership Limitation herein contained or to make changes or supplements necessary or desirable
to properly give effect to such limitation. The limitations contained in this paragraph shall apply to a successor holder of this Warrant.
Section 3. Certain
Adjustments.
a) Stock Dividends and Splits.
If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend or otherwise makes a distribution or distributions
on Shares or any other equity or equity equivalent securities payable in Shares (which, for avoidance of doubt, shall not include any
Shares issued by the Company upon exercise of this Warrant), (ii) subdivides outstanding Shares into a larger number of Shares, (iii)
combines (including by way of reverse stock split) outstanding Shares into a smaller number of Shares, or (iv) issues by reclassification
of Shares any shares of capital stock of the Company, then in each case the Exercise Price shall be multiplied by a fraction of which
the numerator shall be the number of Shares (excluding treasury shares, if any) outstanding immediately before such event and of which
the denominator shall be the number of Shares outstanding immediately after such event, and the number of shares issuable upon exercise
of this Warrant shall be proportionately adjusted such that the aggregate Exercise Price of this Warrant shall remain unchanged. Any adjustment
made pursuant to this Section 3(a) shall become effective immediately after the record date for the determination of stockholders entitled
to receive such dividend or distribution and shall become effective immediately after the effective date in the case of a subdivision,
combination or re-classification.
b) [RESERVED.]
c) Subsequent Rights Offerings.
In addition to any adjustments pursuant to Section 3(a) above, if at any time the Company grants, issues or sells any Shares Equivalents
or rights to purchase stock, warrants, securities or other property pro rata to the record holders of any class of Shares (the “Purchase
Rights”), then the Holder will be entitled to acquire, upon the terms applicable to such Purchase Rights, the aggregate Purchase
Rights which the Holder could have acquired if the Holder had held the number of Shares acquirable upon complete exercise of this Warrant
(without regard to any limitations on exercise hereof, including without limitation, the Beneficial Ownership Limitation) immediately
before the date on which a record is taken for the grant, issuance or sale of such Purchase Rights, or, if no such record is taken, the
date as of which the record holders of Shares are to be determined for the grant, issue or sale of such Purchase Rights (provided, however,
that, to the extent that the Holder’s right to participate in any such Purchase Right would result in the Holder exceeding the Beneficial
Ownership Limitation, then the Holder shall not be entitled to participate in such Purchase Right to such extent (or beneficial ownership
of such Shares as a result of such Purchase Right to such extent) and such Purchase Right to such extent shall be held in abeyance for
the Holder until such time, if ever, as its right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation).
d) Pro Rata Distributions.
During such time as this Warrant is outstanding, if the Company shall declare or make any dividend or other distribution of its assets
(or rights to acquire its assets) to holders of Shares, by way of return of capital or otherwise (including, without limitation, any distribution
of cash, stock or other securities, property or options by way of a dividend, spin off, reclassification, corporate rearrangement, scheme
of arrangement or other similar transaction) (a “Distribution”), at any time after the issuance of this Warrant, then,
in each such case, the Holder shall be entitled to participate in such Distribution to the same extent that the Holder would have participated
therein if the Holder had held the number of Shares acquirable upon complete exercise of this Warrant (without regard to any limitations
on exercise hereof, including without limitation, the Beneficial Ownership Limitation) immediately before the date of which a record is
taken for such Distribution, or, if no such record is taken, the date as of which the record holders of Shares are to be determined for
the participation in such Distribution (provided, however, that, to the extent that the Holder’s right to participate
in any such Distribution would result in the Holder exceeding the Beneficial Ownership Limitation, then the Holder shall not be entitled
to participate in such Distribution to such extent (or in the beneficial ownership of any Shares as a result of such Distribution to such
extent) and the portion of such Distribution shall be held in abeyance for the benefit of the Holder until such time, if ever, as its
right thereto would not result in the Holder exceeding the Beneficial Ownership Limitation). To the extent that this Warrant has not been
partially or completely exercised at the time of such Distribution, such portion of the Distribution shall be held in abeyance for the
benefit of the Holder until the Holder has exercised this Warrant.
e) Fundamental Transaction.
If, at any time while this Warrant is outstanding, (i) the Company, directly or indirectly, in one or more related transactions effects
any merger or consolidation of the Company with or into another Person, (ii) the Company or any material Subsidiary, directly or indirectly,
effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially all of its assets in one
or a series of related transactions, (iii) any, direct or indirect, purchase offer, tender offer or exchange offer (whether by the Company
or another Person) is completed pursuant to which holders of Common Stock are permitted to sell, tender or exchange their shares for other
securities, cash or property and has been accepted by the holders of 50% or more of the outstanding Shares or 50% or more of the voting
power of the common equity of the Company (excluding in each instance denoted in this Section 3(e) any such occurrence resulting from
the issuance of securities under or resulting from the SPA), (iv) the Company, directly or indirectly, in one or more related transactions
effects any reclassification, reorganization or recapitalization of the Shares or any compulsory share exchange pursuant to which the
Shares are effectively converted into or exchanged for other securities, cash or property, or (v) the Company, directly or indirectly,
in one or more related transactions consummates a stock or share purchase agreement or other business combination (including, without
limitation, a reorganization, recapitalization, spin-off, merger or scheme of arrangement) with another Person or group of Persons whereby
such other Person or group acquires 50% or more of the outstanding Shares or 50% or more of the voting power of the common equity of the
Company (each a “Fundamental Transaction”), then, upon any subsequent exercise of this Warrant, the Holder shall have
the right to receive, for each Warrant Share that would have been issuable upon such exercise immediately prior to the occurrence of such
Fundamental Transaction, at the option of the Holder (without regard to any limitation in Section 2(e) on the exercise of this Warrant),
the number of Shares of the successor or acquiring corporation or of the Company, if it is the surviving corporation, and any additional
consideration (the “Alternate Consideration”) receivable as a result of such Fundamental Transaction by a holder of
the number of Shares for which this Warrant is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation
in Section 2(e) on the exercise of this Warrant). For purposes of any such exercise, the determination of the Exercise Price shall be
appropriately adjusted to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of
one Share in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in a reasonable
manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Shares are given any choice
as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder shall be given the same choice as
to the Alternate Consideration it receives upon any exercise of this Warrant following such Fundamental Transaction. Notwithstanding anything
to the contrary, in the event of a Fundamental Transaction, the Company or any Successor Entity (as defined below) shall, at the Holder’s
option, exercisable at any time concurrently with, or within 30 days after, the consummation of the Fundamental Transaction (or, if later,
the date of the public announcement of the applicable Fundamental Transaction), purchase this Warrant from the Holder by paying to the
Holder an amount of cash equal to the Black Scholes Value (as defined below) of the remaining unexercised portion of this Warrant on the
date of the consummation of such Fundamental Transaction; provided, however, that, if the Fundamental Transaction is not
within the Company’s control, including not approved by the Company’s Board of Directors, Holder shall only be entitled to
receive from the Company or any Successor Entity the same type or form of consideration (and in the same proportion), at the Black Scholes
Value of the unexercised portion of this Warrant, that is being offered and paid to the holders of Common Stock of the Company in connection
with the Fundamental Transaction, whether that consideration be in the form of cash, stock or any combination thereof, or whether the
holders of Common Stock are given the choice to receive from among alternative forms of consideration in connection with the Fundamental
Transaction; provided, further, that if holders of Shares of the Company are not offered or paid any consideration in such
Fundamental Transaction, such holders of Common Stock will be deemed to have received common stock of the Successor Entity (which Entity
may be the Company following such Fundamental Transaction) in such Fundamental Transaction. “Black Scholes Value” means
the value of this Warrant based on the Black-Scholes Option Pricing Model obtained from the “OV” function on Bloomberg, L.P.
(“Bloomberg”) determined as of the day of consummation of the applicable contemplated Fundamental Transaction for pricing
purposes and reflecting (A) a risk-free interest rate corresponding to the U.S. Treasury rate for a period equal to the time between the
date of the public announcement of the applicable Fundamental Transaction and the Termination Date, (B) an expected volatility equal to
the greater of 100% and the 100 day volatility obtained from the HVT function on Bloomberg (determined utilizing a 365 day annualization
factor) as of the Trading Day immediately following the public announcement of the applicable contemplated Fundamental Transaction, (C)
the underlying price per share used in such calculation shall be the greater of (i) the sum of the price per share being offered in cash,
if any, plus the value of any non-cash consideration, if any, being offered in such Fundamental Transaction and (ii) the highest VWAP
during the period beginning on the Trading Day immediately preceding the public announcement of the applicable contemplated Fundamental
Transaction (or the consummation of the applicable Fundamental Transaction, if earlier) and ending on the Trading Day of the Holder’s
request pursuant to this Section 3(e) and (D) a remaining option time equal to the time between the date of the public announcement of
the applicable contemplated Fundamental Transaction and the Termination Date and (E) a zero cost of borrow. The payment of the Black Scholes
Value will be made by wire transfer of immediately available funds (or such other consideration) within five Business Days of the Holder’s
election (or, if later, on the date of consummation of the Fundamental Transaction). The Company shall cause any successor entity in a
Fundamental Transaction in which the Company is not the survivor (the “Successor Entity”) to assume in writing all
of the obligations of the Company under this Warrant in accordance with the provisions of this Section 3(e) pursuant to written agreements
in form and substance reasonably satisfactory to the Holder and approved by the Holder (without unreasonable delay) prior to such Fundamental
Transaction and shall, at the option of the Holder, deliver to the Holder in exchange for this Warrant a security of the Successor Entity
evidenced by a written instrument substantially similar in form and substance to this Warrant which is exercisable for a corresponding
number of shares of capital stock of such Successor Entity (or its parent entity) equivalent to the Shares acquirable and receivable upon
exercise of this Warrant (without regard to any limitations on the exercise of this Warrant) prior to such Fundamental Transaction, and
with an exercise price which applies the exercise price hereunder to such shares of capital stock (but taking into account the relative
value of the Shares pursuant to such Fundamental Transaction and the value of such shares of capital stock, such number of shares of capital
stock and such exercise price being for the purpose of protecting the economic value of this Warrant immediately prior to the consummation
of such Fundamental Transaction), and which is reasonably satisfactory in form and substance to the Holder. Upon the occurrence of any
such Fundamental Transaction, the Successor Entity shall be added to the term “Company” under this Warrant (so that from and
after the occurrence or consummation of such Fundamental Transaction, each and every provision of this Warrant and the other Transaction
Documents referring to the “Company” shall refer instead to each of the Company and the Successor Entity or Successor Entities,
jointly and severally), and the Successor Entity or Successor Entities, jointly and severally with the Company, may exercise every right
and power of the Company prior thereto and the Successor Entity or Successor Entities shall assume all of the obligations of the Company
prior thereto under this Warrant and the other Transaction Documents with the same effect as if the Company and such Successor Entity
or Successor Entities, jointly and severally, had been named as the Company herein.
f) Calculations. All calculations
under this Section 3 shall be made to the nearest cent or the nearest 1/100th of a share, as the case may be. For purposes of this Section
3, the number of Shares deemed to be issued and outstanding as of a given date shall be the sum of the number of Shares (excluding treasury
shares, if any) issued and outstanding.
g) Notice to Holder.
i. Adjustment to Exercise Price.
Whenever the Exercise Price is adjusted pursuant to any provision of this Section 3, the Company shall promptly deliver to the Holder
by email a notice setting forth the Exercise Price after such adjustment and any resulting adjustment to the number of Warrant Shares
and setting forth a brief statement of the facts requiring such adjustment.
ii. Notice to Allow Exercise
by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever form) on the Shares, (B) the Company
shall declare a special nonrecurring cash dividend on or a redemption of the Shares, (C) the Company shall authorize the granting to all
holders of the Shares rights or warrants to subscribe for or purchase any shares of capital stock of any class or of any rights, (D) the
approval of any stockholders of the Company shall be required in connection with any reclassification of the Shares, any consolidation
or merger to which the Company (or any of its material Subsidiaries) is a party, any sale or transfer of all or substantially all of its
assets, or any compulsory share exchange whereby the Shares are converted into other securities, cash or property, or (E) the Company
shall authorize the voluntary or involuntary dissolution, liquidation or winding up of the affairs of the Company, then, in each case,
the Company shall cause to be delivered by email to the Holder at its last email address as it shall appear upon the Warrant Register
of the Company, at least 20 calendar days prior to the applicable record or effective date hereinafter specified, a notice stating (x)
the date on which a record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record
is not to be taken, the date as of which the holders of the Shares of record to be entitled to such dividend, distributions, redemption,
rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale, transfer or share
exchange is expected to become effective or close, and the date as of which it is expected that holders of the Shares of record shall
be entitled to exchange their Shares for securities, cash or other property deliverable upon such reclassification, consolidation, merger,
sale, transfer or share exchange; provided that the failure to deliver such notice or any defect therein or in the delivery thereof shall
not affect the validity of the corporate action required to be specified in such notice. To the extent that any notice provided in this
Warrant constitutes, or contains, material, non-public information regarding the Company or any of the material Subsidiaries, the Company
shall simultaneously file such notice with the Commission pursuant to a Current Report on Form 6-K. The Holder shall remain entitled to
exercise this Warrant during the period commencing on the date of such notice to the effective date of the event triggering such notice
except as may otherwise be expressly set forth herein.
h) Voluntary Adjustment By Company.
Subject to the rules and regulations of the Trading Market, the Company may at any time during the term of this Warrant reduce the then
current Exercise Price to any amount and for any period of time deemed appropriate by the board of directors of the Company.
Section 4. Transfer of Warrant.
a) Transferability. This
Warrant and all rights hereunder (including, without limitation, any registration rights) are transferable, in whole or in part, upon
surrender of this Warrant at the principal office of the Company or its designated agent, together with a written assignment of this Warrant
substantially in the form attached hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer
taxes payable upon the making of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver
a new Warrant or Warrants in the name of the assignee or assignees, as applicable, and in the denomination or denominations specified
in such instrument of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so assigned,
and this Warrant shall promptly be cancelled. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically
surrender this Warrant to the Company unless the Holder has assigned this Warrant in full, in which case, the Holder shall surrender this
Warrant to the Company within three (3) Trading Days of the date on which the Holder delivers an assignment form to the Company assigning
this Warrant in full. The Warrant, if properly assigned in accordance herewith, may be exercised by a new holder for the purchase of Warrant
Shares without having a new Warrant issued.
b) New Warrants. This Warrant
may be divided or combined with other Warrants owned by Holder, if any, upon presentation hereof at the aforesaid office of the Company,
together with a written notice specifying the names and denominations in which new Warrants are to be issued, signed by the Holder or
its agent or attorney. Subject to compliance with Section 4(a), as to any transfer which may be involved in such division or combination,
the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided or combined in accordance
with such notice. All Warrants issued on transfers or exchanges shall be dated the initial issuance date of this Warrant and shall be
identical with this Warrant except as to the number of Warrant Shares issuable pursuant thereto.
c) Warrant Register. The
Company shall register this Warrant, upon records to be maintained by the Company for that purpose (the “Warrant Register”),
in the name of the record Holder hereof from time to time. The Company may deem and treat the registered Holder of this Warrant as the
absolute owner hereof for the purpose of any exercise hereof or any distribution to the Holder, and for all other purposes, absent actual
notice to the contrary.
Section 5. Miscellaneous.
a) No Rights as Stockholder Until
Exercise; No Settlement in Cash. This Warrant does not entitle the Holder to any voting rights, dividends or other rights as a stockholder
of the Company prior to the exercise hereof as set forth in Section 2(d)(i), except as expressly set forth in Section 3. Without limiting
any rights of a Holder to receive Warrant Shares on a “cashless exercise” pursuant to Section 2(c) or to receive cash payments
pursuant to Section 2(d)(i) and Section 2(d)(iv) herein, in no event shall the Company be required to net cash settle an exercise of this
Warrant.
b) Loss, Theft, Destruction or
Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence reasonably satisfactory to it of the loss,
theft, destruction or mutilation of this Warrant or any stock certificate relating to the Warrant Shares, and in case of loss, theft or
destruction, of indemnity or security reasonably satisfactory to it (which, in the case of the Warrant, shall not include the posting
of any bond), and upon surrender and cancellation of such Warrant or stock certificate, if mutilated, the Company will make and deliver
a new Warrant or stock certificate of like tenor and dated as of such cancellation, in lieu of such Warrant or stock certificate.
c) Saturdays, Sundays, Holidays,
etc. If the last or appointed day for the taking of any action or the expiration of any right required or granted herein shall not
be a Business Day, then such action may be taken or such right may be exercised on the next succeeding Business Day.
d) Authorized Shares.
The Company covenants that its issuance of
this Warrant shall constitute full authority to its officers who are charged with the duty of issuing the necessary Warrant Shares upon
the exercise of the purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to assure
that such Warrant Shares may be issued as provided herein without violation of any applicable law or regulation, or of any requirements
of the Trading Market upon which the Shares may be listed. The Company covenants that all Warrant Shares which may be issued upon the
exercise of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and
payment for such Warrant Shares in accordance herewith, be duly authorized, validly issued, fully paid and nonassessable and free from
all taxes, liens and charges created by the Company in respect of the issue thereof (other than taxes in respect of any transfer occurring
contemporaneously with such issue).
Except and to the extent as waived or consented
to by the Holder, the Company shall not by any action, including, without limitation, amending its certificate of incorporation or through
any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in
the carrying out of all such terms and in the taking of all such actions as may be necessary or appropriate to protect the rights of Holder
as set forth in this Warrant against impairment. Without limiting the generality of the foregoing, the Company will (i) take all such
action as may be necessary or appropriate in order that the Company may validly and legally issue fully paid and nonassessable Warrant
Shares upon the exercise of this Warrant and (ii) use commercially reasonable efforts to obtain all such authorizations, exemptions or
consents from any public regulatory body having jurisdiction thereof, as may be, necessary to enable the Company to perform its obligations
under this Warrant.
Before taking any action which would result
in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the Exercise Price, the Company shall obtain
all such authorizations or exemptions thereof, or consents thereto, as may be necessary from any public regulatory body or bodies having
jurisdiction thereof.
e) Governing Law. All questions
concerning the construction, validity, enforcement and interpretation of this Warrant shall be governed by and construed and enforced
in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each party
agrees that all legal proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Warrant
(whether brought against a party hereto or their respective affiliates, directors, officers, shareholders, partners, members, employees
or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York. Each party hereby irrevocably
submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan for the adjudication
of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably
waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of
any such court, that such suit, action or proceeding is improper or is an inconvenient venue for such proceeding. Each party hereby irrevocably
waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof
via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices
to it under this Warrant and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing
contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by law.
f) Restrictions. The Holder
acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not registered, and the Holder does not utilize cashless
exercise, will have restrictions upon resale imposed by state and federal securities laws.
g) Nonwaiver and Expenses.
No course of dealing or any delay or failure to exercise any right hereunder on the part of Holder shall operate as a waiver of such right
or otherwise prejudice the Holder’s rights, powers or remedies. Without limiting any other provision of this Warrant, if the Company
is found by a court of competent jurisdiction, and upon final adjudication, including the completion any legal appeals related thereto,
to have willfully and knowingly failed to comply with any lawful provision of this Warrant, which results in any material damages to the
Holder, the Company shall pay to the Holder such amounts as shall be sufficient to cover any costs and expenses incurred by the Holder
in collecting any amounts due pursuant hereto or in otherwise enforcing any of its rights, powers or remedies hereunder.
h) Notices. Any and all notices
or other communications or deliveries to be provided by the Holders hereunder including, without limitation, any Notice of Exercise, shall
be in writing and delivered by e-mail, addressed to the Company, Attention: Spyros Papapetropoulos, President and CEO, email address:
Spyros@bionomics.com.au, or such other email address or address as the Company may specify for such purposes by notice to the Holders.
Any and all notices or other communications or deliveries to be provided by the Company hereunder shall be in writing and delivered personally,
by e-mail, or sent by a nationally recognized overnight courier service addressed to each Holder at the e-mail address or address of such
Holder appearing on the books of the Company. Any notice or other communication or deliveries hereunder shall be deemed given and effective
on the earliest of (i) the time of transmission, if such notice or communication is delivered via e-mail at the e-mail address set forth
in this Section prior to 5:30 p.m. (New York City time) on any date, (ii) the next Trading Day after the time of transmission, if such
notice or communication is delivered via e-mail at the e-mail address set forth in this Section on a day that is not a Trading Day or
later than 5:30 p.m. (New York City time) on any Trading Day, (iii) the second Trading Day following the date of mailing, if sent by U.S.
nationally recognized overnight courier service, or (iv) upon actual receipt by the party to whom such notice is required to be given.
To the extent that any notice provided hereunder constitutes, or contains, material, non-public information regarding the Company or any
Subsidiaries, the Company shall simultaneously file such notice with the Commission pursuant to a Current Report on Form 8-K.
i) [Reserved]
j) Remedies. The Holder,
in addition to being entitled to exercise all rights granted by law, including recovery of damages, will be entitled to specific performance
of its rights under this Warrant. The Company agrees that monetary damages would not be adequate compensation for any loss incurred by
reason of a breach by it of the provisions of this Warrant and hereby agrees to waive and not to assert the defense in any action for
specific performance that a remedy at law would be adequate.
k) Successors and Assigns.
Subject to applicable securities laws, this Warrant and the rights and obligations evidenced hereby shall inure to the benefit of and
be binding upon the successors and permitted assigns of the Company and the successors and permitted assigns of Holder. The provisions
of this Warrant are intended to be for the benefit of any Holder from time to time of this Warrant and shall be enforceable by the Holder
or holder of Warrant Shares.
l) Amendment. This Warrant
may be modified or amended or the provisions hereof waived with the written consent of the Company, on the one hand, and the Holder or
the beneficial owner of this Warrant, on the other hand.
m) Severability. Wherever
possible, each provision of this Warrant shall be interpreted in such manner as to be effective and valid under applicable law, but if
any provision of this Warrant shall be prohibited by or invalid under applicable law, such provision shall be ineffective to the extent
of such prohibition or invalidity, without invalidating the remainder of such provisions or the remaining provisions of this Warrant.
n) Headings. The headings
used in this Warrant are for the convenience of reference only and shall not, for any purpose, be deemed a part of this Warrant.
********************
(Signature Page Follows)
IN WITNESS WHEREOF, the Company has caused this Warrant
to be executed by its officer thereunto duly authorized as of the date first above indicated.
|
Neuphoria Therapeutics Inc. |
|
|
|
|
By: |
/s/ Spyros Papapetropoulos |
|
|
Name: |
Spyros Papapetropoulos |
|
|
Title: |
President and CEO |
NOTICE OF EXERCISE
To: Neuphoria Therapeutics
Inc.
(1) The undersigned hereby elects to purchase
________ Warrant Shares of the Company pursuant to the terms of the attached Warrant (only if exercised in full), and tenders herewith
payment of the exercise price in full, together with all applicable transfer taxes, if any.
(2) Payment shall take the form of (check applicable
box):
☐ in lawful money of the United States; or
☐ if permitted the cancellation of such number of Warrant
Shares as is necessary, in accordance with the formula set forth in subsection 2(c), to exercise this Warrant with respect to the maximum
number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in subsection 2(c).
(3) Please issue said Warrant Shares in the
name of the undersigned or in such other name as is specified below:
_______________________________
The Warrant Shares shall be delivered to the following DWAC Account
Number:
_______________________________
_______________________________
_______________________________
[SIGNATURE OF HOLDER]
Name of Investing Entity:
_______________________________________________________________________________________________
Signature of Authorized Signatory of Investing Entity:
_______________________________________________________________________________________________
Name of Authorized Signatory:
_______________________________________________________________________________________________
Title of Authorized Signatory:
_______________________________________________________________________________________________
Date:
_______________________________________________________________________________________________
ASSIGNMENT FORM
(To assign the foregoing Warrant, execute this form and supply required
information. Do not use this form to purchase shares.)
FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced
thereby are hereby assigned to
Name: |
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(Please Print) |
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Address: |
|
|
(Please Print) |
|
|
Phone Number: |
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|
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Email Address: |
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Dated: _______________ __, ______ |
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Holder’s Signature: _________________________________ |
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Holder’s Address: __________________________________ |
|
Exhibit 23.1
Consent of Independent Registered
Public Accounting Firm
We consent to the incorporation by reference in this Amendment No.
2 to the Registration Statement (No. 333-283306) on Form S-3 and related Prospectus of Neuphoria Therapeutics Inc. of our report dated
September 30, 2024, relating to the consolidated financial statements of Bionomics Limited, appearing in the Annual Report on Form 10-K
of Bionomics Limited for the fiscal year ended June 30, 2024.
We also consent to the reference to our firm under the heading “Experts”
in such Prospectus.
/s/ Wolf & Company, P.C.
Boston, Massachusetts
January 6, 2025
Exhibit 107
Calculation of Filing Fee Tables
Form S-3
(Form Type)
Neuphoria Therapeutics Inc.
(Exact Name of Registrant as Specified in its Charter)
Table 1: Newly Registered and Carry Forward
Securities
|
|
Security
Type |
|
Security
Class
Title |
|
Fee
Calculation
or Carry
Forward
Rule |
|
Amount
Registered |
|
|
Proposed
Maximum
Offering
Price Per
Unit |
|
|
Maximum
Aggregate
Offering
Price |
|
|
Fee
Rate |
|
|
Amount
of
Registration
Fee |
|
|
Carry
Forward Form Type |
|
|
Carry
Forward File Number |
|
|
Carry Forward Initial
Effective Date |
|
|
Filing
Fee
Previously Paid
In Connection with Unsold
Securities to be
Carried Forward |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fees
to be paid |
|
Equity |
|
Common
stock, par value $0.00001 |
|
Rule
457(o) |
|
|
|
(1)(2)(3) |
|
|
|
(4) |
|
$ |
100,000,000 |
|
|
|
0.00015310 |
|
|
$ |
15,310 |
|
|
|
F-3 |
|
|
|
333-271696 |
|
|
|
5/17/23 |
|
|
$ |
19,836 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Fees
Previously Paid |
|
N/A |
|
N/A |
|
N/A |
|
|
N/A |
|
|
|
N/A |
|
|
|
N/A |
|
|
|
|
|
|
|
N/A |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry Forward
Securities |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Carry
Forward Securities |
|
Equity |
|
Common
stock, par value $0.00001 |
|
Rule
457(o) |
|
|
|
(1)(2)(3) |
|
|
|
(4) |
|
|
100,000,000 |
|
|
|
|
|
|
$ |
15,310 |
|
|
|
F-3 |
|
|
|
333-271696 |
|
|
|
5/17/23 |
|
|
$ |
19,836 |
|
|
|
|
|
|
|
|
|
|
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|
Total
Offering Amounts |
|
|
|
$ |
100,000,000 |
|
|
|
|
|
|
$ |
15,310 |
|
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|
Total
Fees Previously Paid |
|
|
|
|
|
|
|
|
|
|
|
$ |
19,386 |
|
|
|
|
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|
Total
Fee Offsets |
|
|
|
|
|
|
|
|
|
|
|
|
N/A |
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|
Net
Fee Due |
|
|
|
|
|
|
|
|
|
|
|
$ |
0 |
|
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|
(1) |
The securities registered
hereunder include such indeterminate number of shares of common stock, as may be sold from time to time by the registrant. There are
also being registered hereunder an indeterminate number of shares of common stock as shall be issuable upon conversion, exchange or
exercise of any securities that provide for such issuance. On December 23, 2024, the redomiciliation of Bionomics Limited ("Bionomics"), an Australian corporation, was implemented under Australian
law between Bionomics and Neuphoria Therapeutics Inc., a Delaware corporation (“Neuphoria”), as a result of which Bionomics
became a wholly-owned subsidiary of Neuphoria. |
(2) |
Pursuant to Rule 416 under the Securities Act of 1933, as amended, this registration statement shall also cover any additional shares of the registrant’s securities that become issuable by reason of any stock splits, stock dividend or similar transaction. |
(3) |
Includes rights to acquire shares of common stock of the registrant under any shareholder rights plan then in effect, if applicable under the terms of any such plan. |
(5) |
The proposed maximum offering price per share of common stock will be determined from time to time by the registrant in connection with the issuance by the registrant of the securities registered hereunder. |
Grafico Azioni Neuphoria Therapeutics (NASDAQ:NEUP)
Storico
Da Dic 2024 a Gen 2025
Grafico Azioni Neuphoria Therapeutics (NASDAQ:NEUP)
Storico
Da Gen 2024 a Gen 2025