Explanatory Note
This Amendment No. 2 on Form 8-A/A is being filed by the registrant for the purpose of amending
and supplementing the description of the registrants securities contained in the Form 8-A filed by the registrant with the Securities and Exchange Commission (the SEC) on April 17, 2024,
as amended by the Form 8-A/A filed by the registrant with the SEC on May 3, 2024.
Item 1.
Description of Registrants Securities to be Registered.
On August 7, 2024, Vanda Pharmaceuticals Inc., a Delaware
corporation (the Company), entered into Amendment No. 2 (the Amendment) to that certain Rights Agreement, dated as of April 17, 2024, as amended by that certain Amendment No. 1 to the Rights Agreement, dated as
of May 3, 2024 (Amendment No. 1), in each case by and between the Company and Equiniti Trust Company, LLC, a limited trust company organized under the laws of the State of New York, as rights agent (as amended, the
Rights Agreement).
The Amendment (i) made certain punctuation corrections to the definition of Acquiring
Person and (ii) amended and restated the definitions of Acting in Concert and Beneficial Owner to make certain clarifying changes. Copies of the original Rights Agreement and Amendment No. 1 were filed with
the SEC on the Companys Current Reports on Form 8-K as Exhibits 4.1 on April 17, 2024 and May 3, 2024, respectively.
The foregoing summary description of the terms of the Amendment does not purport to be complete and is qualified in its entirety by the full
text of the Amendment, which is attached hereto as Exhibit 4.3 and is incorporated herein by reference.