Study finds that the aggressive lone star tick
is no match for Credelio
GREENFIELD, Ind., Aug. 15,
2024 /PRNewswire/ -- Parasites & Vectors,
a leading peer-reviewed journal focused on parasites and
vector-borne pathogens published the results of a head-to-head
study demonstrating that Credelio, a prescription flea and tick
protection product from Elanco Animal Health, has the fastest
initial speed of tick kill in just 12 hours and sustains that
advantage throughout the dosing
interval.1,2,3 According to the Centers for Disease
Control (CDC), during 2019 – 2022, state and local health
departments reported more than 45,000 human cases of tickborne
disease to CDC.4 The Companion Animal Parasite Council
(CAPC) recommends using products on pets that kill and/or repel
ticks before pathogens are transmitted.5
The 2023 head-to-head study compared three popular prescription
flea and tick treatment products for dogs, Credelio (lotilaner),
Simparica TRIO (sarolaner, moxidectin, pyrantel), and NexGard
(afoxolaner), tracking the comparative data for the relative speeds
of kill of Amblyomma americanum (lone star tick) – an
aggressive and expanding tick found in the United States that is one of the hardest
to kill. Not only is this tick hard to kill, but it can also
transmit dangerous disease-causing pathogens to pets and people.
The CDC recently provided in-depth tick surveillance information
regarding the aggressive nature of the lone star tick that can bite
humans and transmit bacterial and viral pathogens, as well as cause
alpha-gal syndrome (red meat allergy).6
"The results of this head-to-head study establishes Credelio as
the front runner in speed of tick kill in prescription flea and
tick treatment products for dogs.1 This is important
because the longer a tick is attached, the greater the risk of
pathogen transmission," said Dr. Kathryn
Reif, Bailey-Goodwin Endowed Associate Professor in
Parasitology at Auburn University.
"These pathogens can cause serious diseases, such as Rocky Mountain
Spotted Fever and ehrlichiosis, so it is critical that
veterinarians talk with pet owners about year-round parasite
protection. Credelio's rapid and sustained speed of tick kill helps
protect pets against pathogen-carrying ticks which can result in
dangerous diseases."1
The study included dogs that were randomly allocated to one of
four treatment groups: Credelio, Simparica TRIO, NexGard or
untreated control.
- Live tick counts were performed on dogs by blinded
investigators during regular intervals.1
- The study results found that by all 12-hour evaluation
intervals, only the Credelio group significantly reduced lone star
ticks as compared to the untreated control group.
- The study observed that the Simparica TRIO and NexGard groups
were not significantly different from the untreated control group
by any of the 12-hour evaluation intervals.
- The study also showed that Credelio significantly reduced ticks
at all 12- and 24-hour evaluation time points and only Credelio
provides a rapid speed of kill throughout the entire month-long
treatment period.1,2,3
- Of the evaluated products, only Credelio killed ticks as fast
at the end of the month as at the beginning of the month.
"This study sets Credelio apart from competitors as it maintains
a rapid speed of tick kill throughout the entire monthly dosing
period," said David Gosche, DVM,
Elanco Sr. Director of Technical Marketing.1,2,3 "This
product maintains consistent levels of efficacy in tick kill
throughout the month, outperforming the competitors tested."
1,2,3
Learn more about Credelio for dogs here. To read the full study
findings, click here.
ABOUT ELANCO
Elanco Animal Health Incorporated (NYSE: ELAN) is a global
leader in animal health dedicated to innovating and delivering
products and services to prevent and treat disease in farm animals
and pets, creating value for farmers, pet owners, veterinarians,
stakeholders, and society as a whole. With nearly 70 years of
animal health heritage, we are committed to helping our customers
improve the health of animals in their care, while also making a
meaningful impact on our local and global communities. At Elanco,
we are driven by our vision of Food and Companionship Enriching
Life and our Elanco Healthy Purpose™ Sustainability Initiatives
–all to advance the health of animals, people, and the planet.
CREDELIO INDICATIONS
Credelio kills adult fleas and is indicated for the treatment
and prevention of flea infestations (Ctenocephalides felis)
and the treatment and control of tick infestations [Amblyomma
americanum (lone star tick), Dermacentor variabilis
(American dog tick), Ixodes scapularis (black-legged tick)
and Rhipicephalus sanguineus (brown dog tick)] for one month
in dogs and puppies 8 weeks of age and older and weighing 4.4
pounds or greater.
CREDELIO IMPORTANT SAFETY INFORMATION
Lotilaner is a member of the isoxazoline class. This class has
been associated with neurologic adverse reactions including
tremors, ataxia, and seizures. Seizures have been reported in dogs
receiving this class of drugs, even in dogs without a history of
seizures. Use with caution in dogs with a history of seizures or
neurologic disorders. The safe use of Credelio in breeding,
pregnant or lactating dogs has not been evaluated. The most
frequently reported adverse reactions are weight loss, elevated
blood urea nitrogen, polyuria, and diarrhea. For full prescribing
information see Credelio package insert.
NexGard is a registered trademark of Boehringer Ingelheim Animal
Health USA Inc. Simparica TRIO is
a registered trademark of Zoetis Services LLC.
Credelio, Elanco and the diagonal bar logo are trademarks of
Elanco or its affiliates. Other company and product names are
trademarks of their respective owners. © 2024 Elanco or its
affiliates
PM-US-24-1168
1 Ambylomma americanum (lone star tick)
2 Reif KE, Kollasch TM, Neilson JC, Herrin BH, Ryan WG,
Bell MC, Beltz MS, Dryden MW, Jesudoss Chelladurai JRJ, Miller KR,
Sutherland CJ. Comparative speed of kill provided by lotilaner
(Credelio™), sarolaner (Simparica Trio™), and afoxolaner (NexGard™)
to control Amblyomma americanum infestations on dogs.
Parasite Vectors. 2024 Jul 20;17(1):313.
3 Based on the time to statistical significance vs
control in a single study on days 21 and 28 for reinfestations.
4 Centers for Disease Control and Prevention. (n.d.).
Tickborne Disease Surveillance Data Summary. Centers for
Disease Control and Prevention. Retrieved August 8, 2024, from
https://www.cdc.gov/ticks/data-research/facts-stats/tickborne-disease-surveillance-data-summary.html?CDC_AAref_Val=https%3A%2F%2Fwww.cdc.gov%2Fticks%2Fdata-summary%2Findex.html
5 Companion Animal Parasite Council | 2023 Annual Pet
Parasite Forecasts (capcvet.org)
6 Centers for Disease Control and Prevention. (n.d.).
Where Ticks Live. Centers for Disease Control and
Prevention. Retrieved August 8, 2024,
from https://www.cdc.gov/ticks/about/where-ticks-live.html
Investor Contact: Katy Grissom
(317) 273-9284 kathryn.grissom@elancoah.com
Media Contact: Season Solorio (765)
316-0233 season.solorio@elancoah.com
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SOURCE Elanco Animal Health