NUV-868, BD2-selective
BET inhibitor: Advanced solid tumors
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NUV-868 is being evaluated in a Phase 1b dose escalation study in
combination with olaparib for the treatment of patients with ovarian cancer, pancreatic cancer, metastatic castration-resistant prostate cancer (mCRPC), triple negative breast cancer, and other solid tumors, and in combination with enzalutamide for
the treatment of patients with mCRPC. |
NUV-1511, DDC: Advanced solid tumors
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NUV-1511, the Companys first clinical-stage DDC, is being evaluated
in a Phase 1/2 study for the treatment of patients with advanced solid tumors who previously received and progressed on or after treatment with Enhertu® and/or Trodelvy® per approved U.S. Food and Drug Administration (FDA) labeling, human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer, mCRPC,
advanced pancreatic cancer, and platinum-resistant ovarian cancer (PROC). |
Corporate Updates:
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Announced entry into a definitive agreement to acquire AnHeart Therapeutics in March 2024 and completed the
acquisition in April 2024. |
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Appointed Colleen Sjogren as Chief Commercial Officer. Ms. Sjogren will lead Nuvation Bios commercial
strategy and operations, including marketing, sales, and market access. |
First Quarter 2024 Financial Results
As of March 31, 2024, Nuvation Bio had cash, cash equivalents and marketable securities of $597.0 million.
For the three months ended March 31, 2024, research and development expenses were $12.8 million, compared to $18.8 million for the three months
ended March 31, 2023. The decrease was primarily due to a $6.7 million decrease in third-party research services and drug manufacturing costs as a result of completing the Phase 1 monotherapy study of
NUV-868, offset by a $0.7 million increase in personnel-related costs driven by stock-based compensation and other benefits.
For the three months ended March 31, 2024, general and administrative expenses were $7.3 million, compared to $7.7 million for the three months
ended March 31, 2023. The decrease was due to a $0.5 million decrease in professional fees, $0.4 million decrease in insurance, and a $0.2 million decrease in personnel-related costs, offset by a $0.4 million increase in
legal fees, a $0.2 million increase in occupancy expense, and a $0.1 million increase in miscellaneous expense.
For the three months ended
March 31, 2024, Nuvation Bio reported a net loss of $14.8 million, or $(0.07) per share. This compares to a net loss of $21.7 million, or $(0.10) per share, for the comparable period in 2023.
About Nuvation Bio
Nuvation Bio is a late-stage, global
biopharmaceutical company tackling some of the greatest unmet needs in oncology by developing differentiated and novel therapeutic candidates. Nuvation Bios portfolio of development candidates includes taletrectinib (ROS1), safusidenib
(mIDH1), NUV-868 (BET), and NUV-1511 (DDC). Nuvation Bio was founded in 2018 by biopharma industry veteran David Hung, M.D., who previously founded Medivation, Inc.,
which brought to patients one of the worlds leading prostate cancer medicines. Nuvation Bio has offices in New York, San Francisco, and Shanghai. For more information, please visit www.nuvationbio.com and
https://www.linkedin.com/company/nuvationbio/.