RNS Number:9864Q
Covidien UK Holding Ltd
28 March 2008


                                                                      FORM 8.1

          DEALINGS BY OFFERORS, OFFEREE COMPANIES OR THEIR ASSOCIATES

                  FOR THEMSELVES OR FOR DISCRETIONARY CLIENTS

                 (Rules 8.1(a) and (b)(i) of the Takeover Code)



1.         KEY INFORMATION


Name of person dealing (Note 1)                Covidien UK Holding Ltd (an indirect wholly-owned subsidiary of
                                               Covidien Ltd)
Company dealt in                               Tissue Science Laboratories plc
Class of relevant security to which the        Ordinary shares of 10 pence each
dealings being disclosed relate (Note 2)

Date of dealing                                27 March 2008




2.         INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE



(a)        Interests and short positions (following dealing) in the class of
relevant security dealt in (Note 3)


                                                             Long                              Short


                                               Number                       (%) Number
                                                                                           (%)

(1) Relevant securities                         9,694,245*
                                               (28.0%)

(2) Derivatives (other than options)


(3) Options and agreements to purchase/sell


Total                                            9,694,245*
                                               (28.0%)


* All of the 2,685,026 shares purchased on 27 March 2008 related to a Letter of
Intent granted by Hermes Pensions Management to Covidien UK Holding Ltd as
announced at 07.04 on 12 March 2008 under RNS number 8978P.  Therefore these
shares are no longer included in the total of irrevocables and letters of intent
that Covidien UK Holding Ltd has received.





(b)        Interests and short positions in relevant securities of the company,
other than the class dealt in (Note 3)


Class of relevant security:                                  Long                              Short


                                               Number                           Number
                                                          (%)                              (%)

(1) Relevant securities


(2) Derivatives (other than options)


(3) Options and agreements to purchase/sell


Total





(c)        Rights to subscribe (Note 3)


Class of relevant security:                    Details







3.         DEALINGS (Note 4)



(a)        Purchases and sales


Purchase/sale                          Number of securities                  Price per unit (Note 5)


Purchase                               2,685,026*                            103.5 pence



(b)        Derivatives transactions (other than options)


Product name,         Long/short (Note 6)       Number of securities (Note 7)        Price per unit (Note 5)

e.g. CFD






(c)        Options transactions in respect of existing securities

(i)         Writing, selling, purchasing or varying


Product name,         Writing, selling, Number of securities  Exercise   Type, e.g.      Expiry     Option money
                        purchasing,     to which the option              American,
e.g. call option      varying etc.      relates (Note 7)      price      European etc.   date       paid/received per
                                                                                                    unit (Note 5)





(ii)        Exercising


Product name, e.g. call option         Number of securities                  Exercise price per unit (Note 5)




(d)        Other dealings (including new securities) (Note 4)


Nature of transaction (Note 8)         Details                               Price per unit (if applicable) (Note 5)








4.         OTHER INFORMATION



Agreements, arrangements or understandings relating to options or derivatives




Full details of any agreement, arrangement or understanding between the person disclosing and any other person relating
to the voting rights of any relevant securities under any option referred to on this form or relating to the voting
rights or future acquisition or disposal of any relevant securities to which any derivative referred to on this form is
referenced.  If none, this should be stated.










Is a Supplemental Form 8 attached? (Note 9)
            NO


Date of disclosure                                                28 March 2008

Contact name                                                      Mark Culwick

Telephone number                                                  0121 600 5227

Name of offeree/offeror with which associated                     n.a.
Specify category and nature of associate status (Note 10)         n.a.

































































                      This information is provided by RNS
            The company news service from the London Stock Exchange
END

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