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LIVINGSTON, N.J., Dec. 21 /PRNewswire-FirstCall/ -- Milestone Scientific Inc. (AMEX:MSS), today announced that it had begun the process of obtaining FDA acceptance for the marketing and sale of its CompuFlo Computer Controlled Infusion Pump by submitting to the Food & Drug Administration its 510(k) Premarket Notification. The CompuFlo Computer Controlled Infusion Pump enhances the utility of the typical infusion pump by utilizing pressure feedback data to monitor and regulate the delivery to patients of medications and other fluids. The submission of the 510(k) marks Milestone's first step in the commercialization of its patented CompuFlo technology. About Milestone Scientific Inc. Milestone Scientific is the developer, manufacturer and marketer of CompuMed(R) and CompuDent(R) computer controlled local anesthetic delivery systems. These systems comprise a microprocessor controlled drive unit as well as The Wand(R) handpiece, a single patient use product that is held in a pen-like manner for injections. The Company also sells the SafetyWand(R), which incorporates engineered sharps injury protection features to aid in the prevention of accidental needlesticks. Milestone has also developed proprietary consumer (Ionic White) and professional (Cool Blue) teeth whitening systems that were introduced to the market in early 2005. In 2001, Milestone Scientific received broad United States patent protection on an enabling technology for computer controlled, pressure sensitive infusion, perfusion, suffusion and aspiration, which provides real time displays of pressures, fluid densities and flow rates, that advances the delivery and removal of a wide array of fluids. Development of this CompuFlo technology is currently underway. The Company is headquartered in Livingston, New Jersey, and its common stock trades on the American Stock Exchange under the symbol "MSS". CONTACT Thomas Ronca, COO Milestone Scientific Inc (973) 535-2717; (973) 535-2829 (Fax) Web site: http://www.milesci.com/ DATASOURCE: Milestone Scientific Inc. CONTACT: Thomas Ronca, COO of Milestone Scientific Inc, +1-973-535-2717, or fax, +1-973-535-2829 Web site: http://www.milesci.com/

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