PTI Protherics

    RNS Number : 7964F
  Credit Suisse Securities (Eur) Ltd
  14 October 2008
   
                                                                 FORM 38.5 (b)
                DEALINGS BY CONNECTED EXEMPT PRINCIPAL TRADERS 
           WITHOUT RECOGNISED INTERMEDIARY STATUS, OR WITH RI STATUS
                 BUT NOT DEALING IN A CLIENT-SERVING CAPACITY
 (Rule 38.5(b) of the Takeover Code)
 AMENDMENT


 The amendment in position represents the effect of a late booked trade, book
 transfer and/or cancel/correct activity

 1.  KEY INFORMATION 
 Name of exempt principal trader     Credit Suisse Securities
                                     (Europe) Limited
 Company dealt in                    Prostherics Plc
 Class of relevant security to       Ordinary Shares
 which the dealings being disclosed
 relate (Note 1)
 Date of dealing                     13-Oct-2008


  
    2.  INTERESTS, SHORT POSITIONS AND RIGHTS TO SUBSCRIBE
      (a) Interests and short positions (following dealing) in the class of relevant security dealt in (Note 2) 
                                                 Long         Short
                                               Number  (%)  Number  (%)
 (1) Relevant securities                        nil         nil
 (2) Derivatives (other than options)                    
 (3) Options and agreements to purchase/sell            
 Total                                                  


  
      (b) Interests and short positions in relevant securities of the company, other than the class dealt in (Note 2) 
   Class Of Relevant Security :                  Long  Short
 (1) Relevant Securities 
 (2) Derivatives (other than options) 
 (3) Options and agreements to purchasesell 
 Total


  
    (c)  Rights to subscribe (Note 2) 
   Class of relevant security:  Details
                               


  
    3.  DEALINGS (Note 3)
      (a) Purchases and sales 
   Purchase/sale  Number of securities  Price per unit (Note 4)
 Purchase       327936                0.327(GBP)


  
    (b) Derivatives transactions (other than options) 
   Product name, e.g. CFD  Long/short (Note 5)  Number of securities  Price per unit (Note
                                              (Note 6)              4)
                                                                     


  
    (c)  Options transactions in respect of existing securities 
      (i)  Writing, selling, purchasing or varying 
   Product name,e.g. call option  Writing, selling,     Number of securities  Exercise price  Type, e.g. American,  Expiry date  Option
money
                                purchasing, varying   to which the option                   European etc.                      paid/received
per
                                etc.                  relates (Note 6)                                                         unit (Note
4)
                                                                                                                                


  
    (ii)  Exercising 
   Product name, e.g. call option  Number of securities  Exercise price per unit
                                                       (Note 4)
                                                        


  
    (d)  Other dealings (including new securities) (Note 3) 
   Nature of transaction (Note 7)  Details  Price per unit (if applicable) (Note
                                          4)
                                           


  
    4.  OTHER INFORMATION 
      Agreements, arrangements or understandings relating to options or derivatives 
   Full details of any agreement, arrangement or understanding between the
 person disclosing and any other person relating to the voting rights of any
 relevant securities under any option referred to on this form or relating to
 the voting rights or future acquisition or disposal of any relevant
 securities to which any derivative referred to on this form is referenced. If
 none, this should be stated.



  
    Is a Supplemental Form 38.5(b) attached?  (Note 8)   No
  
 Date of disclosure                            14-Oct-2008 
 Contact name                                  Collins,Carolyn/ Crawley, Simon
 Telephone number                              44 20 7888 0241
 Name of offeree/offeror with which connected  Rio Tinto Plc
 Nature of connection (Note 9)                 ADVISOR


  
    Notes 
The Notes on Form 38.5(b) can be viewed on the Takeover Panel's website at www.thetakeoverpanel.org.uk. 



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