RGT Argent Biopharma Limited

 
TIDMRGT 
 
For immediate release  1 March 2010 
 
ReGen Therapeutics Plc ('ReGen' or the 'Company') 
 
Further evidence of Colostrinin(TM) Activity in Reducing Cytotoxicity Related to 
Alzheimer's Disease. 
 
ReGen Therapeutics Plc (AIM:RGT) announces an advance e-publication cited on 
PubMed prior to full publication in the Journal of Alzheimer's Disease 
confirming Colostrinin's(TM) activity in Alzheimer's Disease. 
 
*Professor Michael Stewart, one of the co-authors said: 
 
"Alzheimer's disease is the most common form of dementia, affecting 18 million 
people worldwide.  It is characterized by extracellular senile plaques 
consisting mainly of aggregated amyloid-beta (AÃ?) and intracellular 
neurofibrillary tangles, containing the cytoskeletal protein tau.  A recent 
study by Froud et al. in Journal of Alzheimer's disease has demonstrated that 
Colostrinin(TM) significantly relieves amyloid-beta (AÃ?)-induced cytotoxicity." 
 
The Abstract says: 
 
Colostrinin(TM) (CLN) a complex mixture of proline-rich polypeptides derived 
from colostrums, can alleviate cognitive decline in early Alzheimer's disease 
patients.  The molecular basis of the action of CLN has been studied in vitro 
using human neuroblastoma cell lines.  The aim of the present study was to use 
quantitative immunocytochemistry and immunoblotting to investigate the ability 
of CLN to relieve amyloid-beta (AÃ?)-induced cytotoxicity in rat primary 
hippocampal neuronal cells.  Our data confirm that CLN alleviates the effect of 
AÃ?-induced cytotoxicity and causes a significant reduction in the elevated 
levels of the antioxidant enzyme SOD1. 
 
*Professor Michael G Stewart BSc. PhD, Department of Life Sciences of the Open 
University, Milton Keynes, MK7 6AA has been a consultant to ReGen Therapeutics 
Plc. 
 
Note: The reference is DOI: 10.3233/JAD-2010-1382 and the digital object 
identifier can be used in a search engine to find the abstract. 
 
For further information: 
 
Percy Lomax 
ReGen Therapeutics Plc 
Tel No 020 7153 4920 
 
Roland Cornish/Felicity Geidt 
Beaumont Cornish Limited 
Tel No 020 7628 3396 
 
David Scott/Nick Bealer 
Alexander David Securities Limited 
Tel No 020 7448 9800 
 
 
 
[HUG#1389229] 
 

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