Chiron Announces Update on Tezacitabine Program
19 Marzo 2004 - 2:30PM
PR Newswire (US)
Chiron Announces Update on Tezacitabine Program Company to
Discontinue Development of Compound Based on Analysis of Phase II
Results to Date EMERYVILLE, Calif., March 19 /PRNewswire-FirstCall/
-- Chiron Corporation today announced that the company has decided
to discontinue further development of tezacitabine, a
next-generation nucleoside analog, based on an analysis of the data
from a Phase II trial in patients with gastroesophageal cancer. The
compound did not demonstrate sufficient antitumor activity in the
trial to satisfy Chiron's predetermined criteria to advance the
program. The company had previously announced that it had concluded
Phase II development of tezacitabine in patients with colorectal
cancer. No safety issues were identified in treatment with
tezacitabine. "Data from the Phase II trial failed to meet Chiron's
threshold for moving the program forward," said Dr. Stephen Dilly,
senior vice president of development, Chiron BioPharmaceuticals.
"We had set explicit milestones for ourselves so that we could
quickly and efficiently reach a conclusion about the program. We
are now evaluating our options for the tezacitabine program. We
remain focused on developing new treatments for cancer, including
our programs for Proleukin(R) in combination with rituximab and for
CHIR258, our growth factor kinase inhibitor." Chiron acquired
tezacitabine in January 2002 with the purchase of Matrix
Pharmaceutical. The side effect profile for tezacitabine is
consistent with that of other nucleoside analogs, with fevers and
clinically manageable reductions in white blood cell counts being
the most commonly reported side effects. Chiron BioPharmaceuticals
develops and manufactures high-value therapeutic products to treat
cancer and infectious disease. The flagship of Chiron's oncology
franchise is Proleukin(R) (aldesleukin) interleukin-2 for
metastatic melanoma and metastatic renal cell cancer. Chiron is
currently conducting a Phase II trial evaluating the potential
benefit of Proleukin in combination with rituximab for the
treatment of low-grade non-Hodgkin's lymphoma in patients who have
previously failed rituximab treatment. A second Phase II trial, in
rituximab-naive patients with low-grade non-Hodgkin's lymphoma, is
expected to begin later in 2004. The company's first small molecule
compound, CHIR258, entered Phase I testing in early 2004. Chiron
expects to file an IND later this year for anti-CD40, a monoclonal
antibody with the potential to target B-cell hematologic
malignancies. About Chiron Chiron Corporation, headquartered in
Emeryville, California, is a global pharmaceutical company that
leverages a diverse business model to develop and commercialize
high-value products that make a difference in people's lives. The
company has a strategic focus on cancer and infectious disease.
Chiron applies its advanced understanding of the biology of cancer
and infectious disease to develop products from its platforms in
proteins, small molecules and vaccines. The company commercializes
its products through three business units: BioPharmaceuticals,
Vaccines and Blood Testing. For more information about Chiron,
visit the company's website at http://www.chiron.com/. This news
release contains forward-looking statements, including statements
regarding sales growth, product development initiatives and new
product marketing, that involve risks and uncertainties and are
subject to change. A discussion of Chiron's operations and
financial prospects is contained in documents the company has filed
with the SEC, including the form 10-K for the year ended December
31, 2003, and will be contained in subsequently periodic filings
made with the SEC. These documents identify important factors that
would cause the company's actual performance to differ from current
expectations, including the outcomes of clinical trials, regulatory
reviews and approvals, manufacturing capabilities, intellectual
property protections and defenses, stock-price and interest-rate
volatility, and marketingeffectiveness. In particular, there can be
no assurance that Chiron will increase sales of existing products,
successfully develop and receive approval to market new products,
or achieve market acceptance for such new products. There can be no
assurance that Chiron's out-licensing activities will generate
significant revenue, nor that its in-licensing activities will
fully protect it from claims of infringement by third parties.
Consistent with SEC Regulation FD, we do not undertake an
obligation to update the forward-looking information we are giving
today. NOTE: Proleukin is a trademark of Chiron Corporation.
DATASOURCE: Chiron Corporation CONTACT: media, Chiron Corporate
Communications, +1-510-923-6500, or investors, Chiron Investor
Relations, +1-510-923-2300 Web site: http://www.chiron.com/
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