0001426800false00014268002023-08-092023-08-09
UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
WASHINGTON, D.C. 20549
FORM 8-K
CURRENT REPORT
Pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934
Date of Report (Date of earliest event reported): August 9, 2023
Assembly Biosciences, Inc.
(Exact name of Registrant as Specified in Its Charter)
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Delaware |
001-35005 |
20-8729264 |
(State or Other Jurisdiction of Incorporation) |
(Commission File Number) |
(IRS Employer Identification No.) |
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331 Oyster Point Blvd., Fourth Floor, South San Francisco, California |
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94080 |
(Address of Principal Executive Offices) |
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(Zip Code) |
Registrant’s Telephone Number, Including Area Code: (833) 509-4583
Not Applicable
(Former Name or Former Address, if Changed Since Last Report)
Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
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☐ |
Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) |
☐ |
Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) |
☐ |
Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) |
☐ |
Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) |
Securities registered pursuant to Section 12(b) of the Act:
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Title of each class |
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Trading Symbol(s) |
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Name of each exchange on which registered |
Common Stock, par value $0.001 |
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ASMB |
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The Nasdaq Global Select Market |
Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (§ 230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (§ 240.12b-2 of this chapter).
Emerging growth company ☐
If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act. ☐
Item 2.02 Results of Operations and Financial Condition.
On August 9, 2023, Assembly Biosciences, Inc. (the “Company”) issued a press release announcing its financial results for the quarter ended June 30, 2023. A copy of the press release is attached hereto as Exhibit 99.1.
The information furnished with this Item 2.02, including Exhibit 99.1, shall not be deemed “filed” for purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), or otherwise subject to the liabilities of that section, nor shall it be deemed incorporated by reference into any other filing under the Securities Act of 1933, as amended, or the Exchange Act, except as expressly set forth by specific reference in such a filing.
Item 9.01 Financial Statements and Exhibits.
(d) Exhibits.
1
SIGNATURES
Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.
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Assembly Biosciences, Inc. |
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Date: August 9, 2023 |
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By: |
/s/ John O. Gunderson |
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John O. Gunderson |
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VP, General Counsel and Corporate Secretary |
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Exhibit 99.1
Assembly Biosciences Reports Second Quarter 2023 Financial Results and Recent Updates
-Herpesvirus candidate ABI-5366 anticipated to enter clinic in first half of 2024
-New data for several pipeline programs presented at IHW and EASL 2023
-Additional development candidate nomination expected in 2023
SOUTH SAN FRANCISCO, Calif., August 9, 2023 (GLOBE NEWSWIRE) -- Assembly Biosciences, Inc. (Nasdaq: ASMB), a biotechnology company developing innovative antiviral therapeutics targeting serious viral diseases, today reported financial results and recent updates for the second quarter ended June 30, 2023.
“We are excited about the advancement of 5366, our long-acting helicase-primase inhibitor targeting high-recurrence genital herpes, into GLP toxicology studies and are working quickly to begin clinical trials for this candidate in the first half of next year,” said Jason Okazaki, chief executive officer and president of Assembly Bio. “In parallel, our research organization continues to progress towards a second development candidate nomination, which we expect later this year. We are pleased with the progress of our expanded virology pipeline, for which strong preclinical data from multiple programs were highlighted at recent scientific meetings.”
Second Quarter 2023 and Recent Updates
•Continued IND-enabling studies, including initiation of GLP toxicology studies, for development candidate ABI-5366 (5366), a long-acting helicase-primase inhibitor targeting high-recurrence genital herpes
•Presented data highlighting the preclinical characterization of 5366 in one oral presentation and one poster at the 47th Annual International Herpesvirus Workshop (IHW) held July 15-19, 2023
•Presented five posters at the International Liver CongressTM, the Annual Meeting of the European Association for the Study of the Liver (EASL), held June 21-24, 2023, including preclinical data for the company’s oral, small-molecule hepatitis B virus (HBV)/hepatitis delta virus (HDV) entry inhibitor program and results from in vitro and clinical studies of the next-generation core inhibitors ABI-4334 (4334) and ABI-H3733 (3733)
•Presented during the Science of HBV Cure meeting held June 2-3, 2023, on 4334
Anticipated Milestones and Events
•Nominate an additional development candidate from the expanded research portfolio in 2023
•Complete IND/CTA submission for 5366 and initiate clinical studies in the first half of 2024
•Advance an additional development candidate into clinical studies by year-end 2024
Upcoming Conferences
•Three abstracts accepted for presentation at the 2023 International HBV Meeting taking place September 19-23, 2023, in Kobe, Japan, highlighting preclinical and in vitro data for the company’s oral, small-molecule HBV/HDV entry inhibitor program, small-molecule, liver-focused interferon alpha receptor agonist program and next-generation core inhibitor candidate 4334
Second Quarter 2023 Financial Results
•Cash, cash equivalents and marketable securities were $59.8 million as of June 30, 2023, compared to $73.0 million as of March 31, 2023. Assembly Bio’s cash position is projected to fund operations through the third quarter of 2024.
•Research and development expenses were $12.5 million for the three months ended June 30, 2023, compared to $17.8 million for the same period in 2022. The decrease is primarily due to prior year preclinical work and start-up costs preparing for the trials for 3733 and 4334 as well as the discontinued development of vebicorvir and ABI-H2158 and decreases in employee and contractor-related expenses.
•General and administrative expenses were $5.0 million for the three months ended June 30, 2023, compared to $6.8 million for the same period in 2022. The decrease is primarily due to overall cost-saving initiatives.
•Net loss attributable to common stockholders was $16.9 million, or $0.32 per basic and diluted share, for the three months ended June 30, 2023, compared to $24.5 million, or $0.51 per basic and diluted share, for the same period in 2022.
About Assembly Biosciences
Assembly Biosciences is a biotechnology company dedicated to the development of innovative small-molecule antiviral therapeutics designed to change the path of serious viral diseases and improve the lives of patients worldwide. Led by an accomplished team of leaders in virologic drug development, Assembly Bio is committed to improving outcomes for patients struggling with the serious, chronic impacts of herpesvirus, hepatitis B virus (HBV) and hepatitis delta virus (HDV) infections. For more information, visit assemblybio.com.
Forward-Looking Statements
The information in this press release contains forward-looking statements that are subject to certain risks and uncertainties that could cause actual results to materially differ. These risks and uncertainties include: Assembly Bio’s ability to maintain financial resources necessary to continue its clinical studies and fund business operations; Assembly Bio’s ability to initiate and complete clinical studies involving its therapeutic product candidates, including studies contemplated by Assembly Bio’s collaboration agreements, in the currently anticipated timeframes; safety and efficacy data from clinical or nonclinical studies may not warrant further development of Assembly Bio’s product candidates; clinical and nonclinical data presented at conferences may not differentiate Assembly Bio’s product candidates from other companies’ candidates; results of nonclinical studies may not be representative of disease behavior in a clinical setting and may not be predictive of the outcomes of clinical studies; and other risks identified from time to time in Assembly Bio’s reports filed with the U.S. Securities and
Exchange Commission (the SEC). You are urged to consider statements that include the words may, will, would, could, should, might, believes, hopes, estimates, projects, potential, expects, plans, anticipates, intends, continues, forecast, designed, goal or the negative of those words or other comparable words to be uncertain and forward-looking. Assembly Bio intends such forward-looking statements to be covered by the safe harbor provisions contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended. More information about Assembly Bio’s risks and uncertainties are more fully detailed under the heading “Risk Factors” in Assembly Bio’s filings with the SEC, including its most recent Annual Report on Form 10-K, Quarterly Reports on Form 10-Q and Current Reports on Form 8-K. Except as required by law, Assembly Bio assumes no obligation to update publicly any forward-looking statements, whether as a result of new information, future events or otherwise.
Contacts
Investor and Corporate:
Shannon Ryan
SVP, Investor Relations, Corporate Affairs and Alliance Management
(415) 738-2992
sryan@assemblybio.com
Media:
Sam Brown Inc.
Hannah Hurdle
(805) 338-4752
ASMBMedia@sambrown.com
ASSEMBLY BIOSCIENCES, INC.
CONDENSED CONSOLIDATED BALANCE SHEETS
(In thousands except for share amounts and par value)
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June 30, |
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December 31, |
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2023 |
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2022 |
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(Unaudited) |
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ASSETS |
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Current assets |
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Cash and cash equivalents |
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$ |
21,623 |
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$ |
52,418 |
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Marketable securities |
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38,208 |
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39,192 |
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Accounts receivable from collaboration |
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342 |
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944 |
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Prepaid expenses and other current assets |
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3,908 |
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4,413 |
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Total current assets |
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64,081 |
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96,967 |
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Property and equipment, net |
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541 |
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743 |
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Operating lease right-of-use (ROU) assets |
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1,623 |
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3,195 |
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Other assets |
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332 |
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889 |
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Total assets |
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$ |
66,577 |
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$ |
101,794 |
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LIABILITIES AND STOCKHOLDERS' EQUITY |
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Current liabilities |
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Accounts payable |
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$ |
904 |
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$ |
2,493 |
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Accrued research and development expenses |
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2,037 |
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3,122 |
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Other accrued expenses |
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4,188 |
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7,317 |
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Operating lease liabilities - short-term |
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1,702 |
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3,364 |
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Total current liabilities |
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8,831 |
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16,296 |
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Deferred revenue |
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2,733 |
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2,733 |
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Operating lease liabilities - long-term |
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64 |
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101 |
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Total liabilities |
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11,628 |
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19,130 |
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Commitments and contingencies |
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Stockholders' equity |
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Preferred stock, $0.001 par value; 5,000,000 shares authorized; no shares issued or outstanding |
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— |
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— |
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Common stock, $0.001 par value; 150,000,000 shares authorized as of June 30, 2023 and December 31, 2022; 52,450,731 and 48,894,973 shares issued and outstanding as of March 31, 2023 and December 31, 2022, respectively |
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52 |
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49 |
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Additional paid-in capital |
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815,588 |
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807,938 |
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Accumulated other comprehensive loss |
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(325 |
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(803 |
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Accumulated deficit |
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(760,366 |
) |
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(724,560 |
) |
Total stockholders' equity |
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54,949 |
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82,624 |
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Total liabilities and stockholders' equity |
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$ |
66,577 |
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$ |
101,794 |
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ASSEMBLY BIOSCIENCES, INC.
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS
(In thousands except for share and per share amounts)
(Unaudited)
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Three Months Ended June 30, |
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Six Months Ended June 30, |
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2023 |
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2022 |
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2023 |
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2022 |
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Operating expenses |
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Research and development |
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12,523 |
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17,792 |
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27,070 |
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34,997 |
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General and administrative |
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4,965 |
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6,781 |
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9,977 |
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12,738 |
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Total operating expenses |
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17,488 |
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24,573 |
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37,047 |
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47,735 |
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Loss from operations |
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(17,488 |
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(24,573 |
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(37,047 |
) |
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(47,735 |
) |
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Other income |
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Interest and other income, net |
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592 |
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112 |
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1,201 |
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183 |
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Total other income |
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592 |
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112 |
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1,201 |
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183 |
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Net loss |
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$ |
(16,896 |
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$ |
(24,461 |
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$ |
(35,846 |
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$ |
(47,552 |
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Other comprehensive loss |
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Unrealized gain (loss) on marketable securities |
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188 |
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(90 |
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478 |
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(579 |
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Comprehensive loss |
|
$ |
(16,708 |
) |
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$ |
(24,551 |
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$ |
(35,368 |
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$ |
(48,131 |
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Net loss per share, basic and diluted |
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$ |
(0.32 |
) |
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$ |
(0.51 |
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$ |
(0.69 |
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$ |
(0.99 |
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Weighted average common shares outstanding, basic and diluted |
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52,260,088 |
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48,293,495 |
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51,638,928 |
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48,208,735 |
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v3.23.2
Document And Entity Information
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Aug. 09, 2023 |
Cover [Abstract] |
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Entity Registrant Name |
Assembly Biosciences, Inc.
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Document Type |
8-K
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Amendment Flag |
false
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Entity Central Index Key |
0001426800
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Document Period End Date |
Aug. 09, 2023
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Entity Emerging Growth Company |
false
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Entity File Number |
001-35005
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Entity Incorporation, State or Country Code |
DE
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Entity Tax Identification Number |
20-8729264
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Entity Address, Address Line One |
331 Oyster Point Blvd., Fourth Floor
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Entity Address, City or Town |
South San Francisco
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Entity Address, State or Province |
CA
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Entity Address, Postal Zip Code |
94080
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City Area Code |
(833)
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Local Phone Number |
509-4583
|
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false
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Soliciting Material |
false
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Pre-commencement Tender Offer |
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Pre-commencement Issuer Tender Offer |
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